LOCUS       NM_016992                585 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus arginine vasopressin (Avp), mRNA.
ACCESSION   NM_016992
VERSION     NM_016992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Kola,P.K., Oraegbuna,C.S. and Lei,S.
  TITLE     Ionic mechanisms involved in arginine vasopressin-mediated
            excitation of auditory cortical and thalamic neurons
  JOURNAL   Mol Cell Neurosci 130, 103951 (2024)
   PUBMED   38942186
  REMARK    GeneRIF: Ionic mechanisms involved in arginine vasopressin-mediated
            excitation of auditory cortical and thalamic neurons.
REFERENCE   2  (bases 1 to 585)
  AUTHORS   Yamamoto,K., Nakano,Y., Iwata,N., Soejima,Y., Suyama,A.,
            Hasegawa,T. and Otsuka,F.
  TITLE     Stimulatory effects of vasopressin on progesterone production and
            BMP signaling by ovarian granulosa cells
  JOURNAL   Biochem Biophys Res Commun 667, 132-137 (2023)
   PUBMED   37224632
  REMARK    GeneRIF: Stimulatory effects of vasopressin on progesterone
            production and BMP signaling by ovarian granulosa cells.
REFERENCE   3  (bases 1 to 585)
  AUTHORS   Ramdin,S., Naicker,T., Baijnath,S. and Govender,N.
  TITLE     Kidney injury molecule-1 and podocalyxin dysregulation in an
            arginine vasopressin induced rodent model of preeclampsia
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 284, 58-65 (2023)
   PUBMED   36934678
  REMARK    GeneRIF: Kidney injury molecule-1 and podocalyxin dysregulation in
            an arginine vasopressin induced rodent model of preeclampsia.
REFERENCE   4  (bases 1 to 585)
  AUTHORS   Mardanpour,M., Ghavidel,N., Asadi,S. and Khodagholi,F.
  TITLE     Paternal stress in rats increased oxytocin, oxytocin receptor, and
            arginine vasopressin gene expression in the male offspring amygdala
            with no effect on their social interaction behaviors
  JOURNAL   Neuroreport 33 (2), 48-54 (2022)
   PUBMED   35007255
  REMARK    GeneRIF: Paternal stress in rats increased oxytocin, oxytocin
            receptor, and arginine vasopressin gene expression in the male
            offspring amygdala with no effect on their social interaction
            behaviors.
REFERENCE   5  (bases 1 to 585)
  AUTHORS   Munoz-Ortega,M., Macias-Segura,N., Ventura-Juarez,J.,
            Avila-Blanco,M.E., Ponce-Damian,L.D., Gonzalez-Blas,D.,
            Sanchez-Aleman,E. and Quintanar-Stephano,A.
  TITLE     Recovery from Liver Failure and Fibrosis in a Rat Portacaval
            Anastomosis Model after Neurointermediate Pituitary Lobectomy
  JOURNAL   J Immunol Res 2021, 5529784 (2021)
   PUBMED   34926704
  REMARK    GeneRIF: Recovery from Liver Failure and Fibrosis in a Rat
            Portacaval Anastomosis Model after Neurointermediate Pituitary
            Lobectomy.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 585)
  AUTHORS   Foo,N.C., Carter,D., Murphy,D. and Ivell,R.
  TITLE     Vasopressin and oxytocin gene expression in rat testis
  JOURNAL   Endocrinology 128 (4), 2118-2128 (1991)
   PUBMED   1706268
REFERENCE   7  (bases 1 to 585)
  AUTHORS   Schmitz,E., Mohr,E. and Richter,D.
  TITLE     Rat vasopressin and oxytocin genes are linked by a long
            interspersed repeated DNA element (LINE): sequence and
            transcriptional analysis of LINE
  JOURNAL   DNA Cell Biol 10 (2), 81-91 (1991)
   PUBMED   1706187
REFERENCE   8  (bases 1 to 585)
  AUTHORS   Jones,M.A., Bushardt,S.C. and Cadenhead,G.
  TITLE     A paradigm for effective resolution of interpersonal conflict
  JOURNAL   Nurs Manage 21 (2), 64B (1990)
   PUBMED   2300336
REFERENCE   9  (bases 1 to 585)
  AUTHORS   Mair,R.G., Langlais,P.J., Mazurek,M.F., Beal,M.F., Martin,J.B. and
            McEntee,W.J.
  TITLE     Reduced concentrations of arginine vasopressin and MHPG in lumbar
            CSF of patients with Korsakoff's psychosis
  JOURNAL   Life Sci 38 (25), 2301-2306 (1986)
   PUBMED   2425205
REFERENCE   10 (bases 1 to 585)
  AUTHORS   Schlesinger,D.H., Pickering,B.T., Watkins,W.B., Peek,J.C.,
            Moore,L.G., Audhya,T.K. and Walter,R.
  TITLE     A comparative study of partial neurophysin protein sequences of
            cod, guinea pig, rat and sheep
  JOURNAL   FEBS Lett 80 (2), 371-373 (1977)
   PUBMED   891987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M25646.1.
            
            On Mar 23, 2010 this sequence version replaced NM_016992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M25646.1, CB794131.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-585               M25646.1           1-585
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..585
                     /gene="Avp"
                     /gene_synonym="ADH; DI; Vas; VP"
                     /note="arginine vasopressin"
                     /db_xref="GeneID:24221"
                     /db_xref="RGD:2184"
     exon            1..152
                     /gene="Avp"
                     /gene_synonym="ADH; DI; Vas; VP"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..527
                     /gene="Avp"
                     /gene_synonym="ADH; DI; Vas; VP"
                     /note="arginine vasopressin (Diabetes insipidus), same as
                     Di (conflicting physical mapping); vasopressin-neurophysin
                     2-copeptin; vasopressin-neurophysin prepropeptide;
                     preprovasopressin-neurophysin; AVP-NPII;
                     prepropressophysin; antidiuretic hormone"
                     /codon_start=1
                     /product="vasopressin-neurophysin 2-copeptin
                     preproprotein"
                     /protein_id="NP_058688.2"
                     /db_xref="GeneID:24221"
                     /db_xref="RGD:2184"
                     /translation="MLAMMLNTTLSACFLSLLALTSACYFQNCPRGGKRATSDMELRQ
                     CLPCGPGGKGRCFGPSICCADELGCFLGTAEALRCQEENYLPSPCQSGQKPCGSGGRC
                     AAAGICCSDESCVAEPECREGFFRLTRAREQSNATQLDGPARELLLRLVQLAGTQESV
                     DSAKPRVY"
     exon            153..354
                     /gene="Avp"
                     /gene_synonym="ADH; DI; Vas; VP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..585
                     /gene="Avp"
                     /gene_synonym="ADH; DI; Vas; VP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcacgca gtgcccacct atgctcgcca tgatgctcaa cactacgctc tctgcttgct
       61 tcctgagcct gctggccctc acctctgcct gctacttcca gaactgccca agaggaggca
      121 agagggccac atccgacatg gagctgagac agtgtctccc ctgcggccct ggcggcaaag
      181 ggcgctgctt cgggccgagc atctgctgcg cggacgagct gggctgcttc ctgggcaccg
      241 ccgaggcgct gcgctgccag gaggagaact acctgccctc gccctgccag tctggccaga
      301 agccttgcgg aagcggaggc cgctgcgctg ccgcgggcat ctgctgcagc gatgagagct
      361 gcgtggccga gcccgagtgt cgagagggtt ttttccgcct cacccgcgct cgggagcaga
      421 gcaacgccac gcagctggac gggccagccc gggagctgct gcttaggctg gtacagctgg
      481 ctgggacaca agagtccgtg gattctgcca agccccgggt ctactgagcc atcgcccccc
      541 acgcctcccc cctacagcat ggaaaataaa cttttaaaaa atgca
//
