LOCUS       NM_024401               3020 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus advillin (Avil), mRNA.
ACCESSION   NM_024401
VERSION     NM_024401.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Rao,J., Ashraf,S., Tan,W., van der Ven,A.T., Gee,H.Y., Braun,D.A.,
            Feher,K., George,S.P., Esmaeilniakooshkghazi,A., Choi,W.I.,
            Jobst-Schwan,T., Schneider,R., Schmidt,J.M., Widmeier,E.,
            Warejko,J.K., Hermle,T., Schapiro,D., Lovric,S., Shril,S., Daga,A.,
            Nayir,A., Shenoy,M., Tse,Y., Bald,M., Helmchen,U., Mir,S.,
            Berdeli,A., Kari,J.A., El Desoky,S., Soliman,N.A., Bagga,A.,
            Mane,S., Jairajpuri,M.A., Lifton,R.P., Khurana,S., Martins,J.C. and
            Hildebrandt,F.
  TITLE     Advillin acts upstream of phospholipase C 1 in steroid-resistant
            nephrotic syndrome
  JOURNAL   J Clin Invest 127 (12), 4257-4269 (2017)
   PUBMED   29058690
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Kim,J., Lee,J.E., Heynen-Genel,S., Suyama,E., Ono,K., Lee,K.,
            Ideker,T., Aza-Blanc,P. and Gleeson,J.G.
  TITLE     Functional genomic screen for modulators of ciliogenesis and cilium
            length
  JOURNAL   Nature 464 (7291), 1048-1051 (2010)
   PUBMED   20393563
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Shibata,M., Ishii,J., Koizumi,H., Shibata,N., Dohmae,N., Takio,K.,
            Adachi,H., Tsujimoto,M. and Arai,H.
  TITLE     Type F scavenger receptor SREC-I interacts with advillin, a member
            of the gelsolin/villin family, and induces neurite-like outgrowth
  JOURNAL   J Biol Chem 279 (38), 40084-40090 (2004)
   PUBMED   15247299
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Ravenall,S.J., Gavazzi,I., Wood,J.N. and Akopian,A.N.
  TITLE     A peripheral nervous system actin-binding protein regulates neurite
            outgrowth
  JOURNAL   Eur J Neurosci 15 (2), 281-290 (2002)
   PUBMED   11849295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Mar 15, 2022 this sequence version replaced NM_024401.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF099929.1, SRR26643288.30195.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000007.1  64711403-64711502
            101-185             JAXUCZ010000007.1  64713548-64713632
            186-260             JAXUCZ010000007.1  64714944-64715018
            261-457             JAXUCZ010000007.1  64716311-64716507
            458-566             JAXUCZ010000007.1  64717395-64717503
            567-677             JAXUCZ010000007.1  64717591-64717701
            678-880             JAXUCZ010000007.1  64718008-64718210
            881-959             JAXUCZ010000007.1  64718639-64718717
            960-1058            JAXUCZ010000007.1  64718824-64718922
            1059-1212           JAXUCZ010000007.1  64719615-64719768
            1213-1313           JAXUCZ010000007.1  64719863-64719963
            1314-1451           JAXUCZ010000007.1  64720404-64720541
            1452-1610           JAXUCZ010000007.1  64720624-64720782
            1611-1790           JAXUCZ010000007.1  64721380-64721559
            1791-1936           JAXUCZ010000007.1  64722849-64722994
            1937-2081           JAXUCZ010000007.1  64723415-64723559
            2082-2270           JAXUCZ010000007.1  64724697-64724885
            2271-2339           JAXUCZ010000007.1  64725362-64725430
            2340-2465           JAXUCZ010000007.1  64726869-64726994
            2466-3020           JAXUCZ010000007.1  64728880-64729434
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3020
                     /gene="Avil"
                     /note="advillin"
                     /db_xref="GeneID:79253"
                     /db_xref="RGD:620301"
     exon            1..100
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            101..185
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2579
                     /gene="Avil"
                     /note="peripheral nervous system villin-like protein;
                     pervin"
                     /codon_start=1
                     /product="advillin"
                     /protein_id="NP_077377.2"
                     /db_xref="GeneID:79253"
                     /db_xref="RGD:620301"
                     /translation="MSLSSAFRTVTNDPGIITWRIEKMELVLVPLSAHGNFYEGDCYI
                     ILSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESD
                     TFRGYFKRGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNQG
                     DVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPE
                     LMTVLQNTLGRRSIIKPAVPDEVTDQQQKSTIMLYHVSDTTGQLSVTEVATRPLVQEL
                     LNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGA
                     ESAMFKQLFQKWSVKDQTTGLGKTFSIGKIAKIFQDKFDVTLLHTKPEVAAQERMVDD
                     GNGKVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPCYILYIWQGRHASQ
                     DELAASAYQAVEVDQQFGGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEP
                     DPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLWTQAEHYLWYGKGSSGDERAM
                     AKELAELLCDGDADTVAEGQEPPEFWDLLGGKAPYANDKRLQQETLDIQVRLFECSNK
                     TGRFLVTEVTDFTQDDLSPGDVMLLDTWDQVFLWIGAEANATEKEGALSTAQEYLVTH
                     PSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITT
                     DMKNATLSLNSSESGPKYYPVEVLLKSQDQELPEDVDPTKKENYLSERDFVSVFGITR
                     GQFVSLPGWKQLQLKKEAGLF"
     exon            186..260
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            261..457
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            458..566
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            567..677
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            678..880
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            881..959
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1058
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1212
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1313
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1451
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1610
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1790
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1936
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2081
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2270
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2339
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2465
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..3020
                     /gene="Avil"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgctgaaa caggcttcag gacccgaggt cgcctgcttc gggaccgctc gtcagtactt
       61 cacctgctgc tttgctggga aagggagaac agagggtcag ttccaggaag acagacacta
      121 tgtctctgag cagtgccttc aggactgtga ccaatgaccc cgggattatc acgtggagaa
      181 ttgagaaaat ggagctggtg ctggtgcccc tgagtgctca tggcaacttc tatgagggag
      241 actgctacat catcctctcg acccggagag tgggcagcct tctctcccaa aacatccact
      301 tttggatcgg gaaggactcc tcccaagatg agcagagctg tgcagccatc tataccacac
      361 agctggatga ctacctggga ggcagccccg tgcagcaccg tgaggtccag taccatgagt
      421 ctgacacctt ccgtggctac ttcaagcggg gcatcatcta taaaaagggg ggtgtggcct
      481 ctgggatgaa gcatgtggag accaacacct atgatgtgaa gaggctgtta catgtgaagg
      541 ggaaaagaaa catcagagcc actgaggtgg aaatgagctg ggacagtttt aaccaaggtg
      601 atgtcttctt gctggacctc gggatggtca tcatccagtg gaatggcccg gagagcaaca
      661 gtggggaacg cctcaaggct atgcttctag caaaggacat tcgggacagg gagcgagggg
      721 gccgagctga aatcggggtg attgagggag acaaagaggc agccagccca gaactgatga
      781 cggttctcca gaataccctt ggccgacgct ccattatcaa gcccgcagtt cctgatgagg
      841 tcaccgatca gcagcagaag tcaaccatca tgttgtatca tgtctccgac acaactgggc
      901 agctgtcggt cacagaagtg gcaacaaggc ccctggtcca ggagctactg aaccatgatg
      961 actgctatat cctggaccaa agtggcacca agatctacgt atggaaaggc aaaggagcca
     1021 ccaaggtgga gaaacaggcg gccatgtcca aagccctgga tttcatcaag atgaagggtt
     1081 atcccagcag caccaacgta gagaccgtca acgatggcgc agagtcggcc atgttcaaac
     1141 agttgttcca gaaatggtcg gtgaaggacc agaccactgg cttggggaaa acattcagca
     1201 ttggtaaaat tgctaaaatc ttccaggaca agttcgacgt gactctgcta cacactaagc
     1261 cagaagtggc tgctcaggaa agaatggtgg acgacggcaa cggcaaggtt gaggtctgga
     1321 gaattgagaa cctggagctg gtccctgtgg aataccagtg gcatggcttc ttctacgggg
     1381 gagactgcta tctggttctc tacacgtatg atgtgaacgg gaaaccctgt tacatcttgt
     1441 atatctggca gggacgccac gcttcccagg atgagctggc agcctcggcc taccaggcgg
     1501 tggaggtgga tcagcagttt ggtggagccc cggtgcaagt ccgggttagc atggggaaag
     1561 agccacgcca cttcatggcc atcttcaaag ggaagctggt tatctatgag ggcgggactt
     1621 ccaggaaggg aaatgtggag cctgaccctc cagtaagact cttccagatc cacgggaacg
     1681 acaaatccaa taccaaagca gtggaagtct cggcctccgc ttcctccctc aactctaatg
     1741 atgtctttct gctttggact caggcggagc actacctgtg gtatggcaag gggtcaagtg
     1801 gggacgaacg ggcgatggct aaggagctgg cagagcttct ctgtgatggt gacgcagaca
     1861 ctgtagctga gggccaggag ccacctgagt tctgggacct tctgggagga aaagccccct
     1921 acgctaacga caaaaggctg cagcaggaaa ccctggacat ccaggtccgg ctttttgaat
     1981 gttctaataa gaccggccgg ttccttgtta ctgaggtcac ggacttcacc caggatgacc
     2041 tgagcccagg tgatgtgatg ctcctggaca cctgggacca ggtgttcctg tggataggag
     2101 cggaggccaa tgccacagag aaggaggggg ccctctcgac tgctcaggag tacctggtaa
     2161 cacaccccag tggccgagac cccgacacac cgatcctgat catcaaacag ggctttgagc
     2221 cccccacttt cacaggctgg ttcctggcat gggaccctca catttggagt gaaggaaaat
     2281 catatgagca gttaaagaac gagctgggag atgccactgc tatcgtgcga atcaccacgg
     2341 acatgaagaa cgcaaccctc tccctgaatt ctagtgaaag tgggccaaag tactaccctg
     2401 tggaggttct gctgaaaagt caggaccagg agctgcctga ggatgtggac cccaccaaaa
     2461 aggagaatta cctctcggaa cgagattttg tctctgtgtt tggcatcacc agagggcagt
     2521 ttgtctctct gcctggctgg aaacagctcc agctgaagaa agaagcaggc cttttctaga
     2581 acaaggcgtg accacaggag agggctaatg cagtgccaac atcagcaaag gttcatctac
     2641 gactgagccc gacacacgct gccctagata cgacagatct cagggtcgtg tattctgtct
     2701 tttgcattca tccttgcatt tctaggttgc tatacactag atgccaacta tttgcctttt
     2761 agctttggtg gtcctttagc gaaagcctca gcagagagag tgaaggcata aaggtagaga
     2821 gaactagaaa ctaagctcaa aatatttaat gcatcaggac ccacatttgc tttgaactat
     2881 accctgcaat ccccaaagtg gtggagtcag cacacgcttc ctgcaggccg gactccaaat
     2941 gcccaggtct accatgtgcc acaccatgtt catgtgccac accatgttca gcctttcaaa
     3001 taaagaggcc atgtgccatg
//
