LOCUS       NM_001399518            1421 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus apoptosis and caspase activation inhibitor
            (Aven), mRNA.
ACCESSION   NM_001399518 XM_008762093
VERSION     NM_001399518.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Li,X., Chen,R., Wang,L., Lu,Z., Li,Y. and Tang,D.
  TITLE     Molecular mechanism of CAIF inhibiting myocardial infarction by
            sponging miR-488 and regulating AVEN expression
  JOURNAL   Mol Med Rep 26 (2) (2022)
   PUBMED   35795990
  REMARK    GeneRIF: Molecular mechanism of CAIF inhibiting myocardial
            infarction by sponging miR488 and regulating AVEN expression.
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Laurentino,S., Goncalves,J., Cavaco,J.E., Oliveira,P.F.,
            Alves,M.G., de Sousa,M., Barros,A. and Socorro,S.
  TITLE     Apoptosis-inhibitor Aven is downregulated in defective
            spermatogenesis and a novel estrogen target gene in mammalian
            testis
  JOURNAL   Fertil Steril 96 (3), 745-750 (2011)
   PUBMED   21718987
  REMARK    GeneRIF: The results suggest that deregulation of the expression of
            the apoptosis inhibitor Aven may be related to male factor
            infertility.
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Ozisik,K., Ozisik,P., Yildirim,E., Misirlioglu,M. and Tuncer,S.
  TITLE     Expression of antiapoptotic survivin and aven genes in rat heart
            tissue after traumatic brain injury
  JOURNAL   Transplant Proc 38 (9), 2784-2787 (2006)
   PUBMED   17112829
  REMARK    GeneRIF: Both erythropoitin and methylprednisolone may play
            important roles in the expression of antiapoptotic survivin and
            aven genes in heart tissue after traumatic brain injury.
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Chau,B.N., Cheng,E.H., Kerr,D.A. and Hardwick,J.M.
  TITLE     Aven, a novel inhibitor of caspase activation, binds Bcl-xL and
            Apaf-1
  JOURNAL   Mol Cell 6 (1), 31-40 (2000)
   PUBMED   10949025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jan 10, 2022 this sequence version replaced XM_008762093.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF109625.1, SRR22582419.189899.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000003.1  119753410-119753694
            286-463             JAXUCZ010000003.1  119770754-119770931
            464-534             JAXUCZ010000003.1  119881163-119881233
            535-630             JAXUCZ010000003.1  119882676-119882771
            631-967             JAXUCZ010000003.1  119884487-119884823
            968-1421            JAXUCZ010000003.1  119885556-119886009
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..1421
                     /gene="Aven"
                     /note="apoptosis and caspase activation inhibitor"
                     /db_xref="GeneID:311299"
                     /db_xref="RGD:1309928"
     exon            1..285
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1083
                     /gene="Aven"
                     /note="apoptosis, caspase activation inhibitor"
                     /codon_start=1
                     /product="cell death regulator Aven"
                     /protein_id="NP_001386447.1"
                     /db_xref="GeneID:311299"
                     /db_xref="RGD:1309928"
                     /translation="MQAERGARGGRGRRGGRERPGGDRGPAGAATALARGGCGDGGGR
                     RGRGRGFRRGRGGGAPRGGRREPGGRGGGASTRVEEDSDSETYGEENDEQGHFSRRKI
                     VSNWDRYQDTEKEVNGESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDGETSCSKQ
                     NSALYVDSESLVRALQQLPLAVRLNVASELIQTAVPLELPQAKPRRNDDGKELGMQLR
                     GPLSQLRSAAGGCPRSLGRDSLRQSPSEGSQKASSPPQSAADHLEEELDMLLHLDAPV
                     KEEDSLSPDQTSQDQEPERDGQIAQEEIAPEKPSVTRDKTVEPGQPSTSKTVTEEELE
                     DWLDSMIS"
     exon            286..463
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
     exon            464..534
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
     exon            535..630
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
     exon            631..967
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1421
                     /gene="Aven"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggggcct gcgctctccg ccgcggctcg cgtgctctgc tcgccggcgg cctcatgcag
       61 gctgagagag gggctcgagg cggccgcggg cggcggggag gccgggagcg gcccggaggg
      121 gaccgagggc cggccggggc cgcgacggcg ctggcgagag gaggctgcgg ggacggaggc
      181 ggccggcggg gccgaggccg gggcttccgc cgaggccgag gaggtggcgc cccgcgaggc
      241 ggccgccggg aacctggagg ccggggcggt ggagccagca cgcgggtaga agaggacagt
      301 gattcagaga cctatggaga agagaatgac gagcaaggac atttttctag aagaaagatc
      361 gtctccaact gggatcgata tcaagatact gaaaaggagg tcaatggtga aagtggagaa
      421 tctcagcggg gcacggactt cagtgtcctc ttgagctctg caggggactc cttttcacag
      481 ttccgatttg ctgaggagaa agaatgggat ggtgaaactt catgttcaaa acagaattca
      541 gcgctctacg tggacagtga gtcactggtt cgagcccttc agcagctgcc tcttgcagtc
      601 cgtcttaatg ttgcttcaga gttgatccag accgcagttc ctttagaact tccacaggcg
      661 aaaccaagga gaaacgatga tggcaaggag ctgggcatgc agttaagggg gcccctctcc
      721 cagctcaggt ctgctgctgg tgggtgtccc aggtctctgg gcagagacag tttaagacag
      781 agcccttcag aaggttcgca gaaagcatct tccccaccac agtcagcggc agaccatctg
      841 gaagaagaac tggatatgtt gctacattta gatgcacctg tgaaagagga agacagtctc
      901 tctccagacc agacatctca ggaccaggag ccagaaagag atgggcagat agcccaggag
      961 gaaatagctc ctgaaaaacc atctgtgacc agagacaaaa ctgtggaacc tgggcagcca
     1021 agcacatcga aaactgtcac cgaggaagag ctggaagact ggctggacag catgatttcc
     1081 tgaaaggggg aagagtgctt gaagcaaatg ttggttgctg tctgcgtgag ggtgggctaa
     1141 tttaccagat cccccgtgct aacatgtcct gttatgctta cagcagccaa cacctacctc
     1201 agtgtttgat ggcatctgaa tgcatggctg aggcgtgttt ggggcttcac ttctgtcgtt
     1261 acctggctta gtcatctaca gacttcactg tggacagggg atatcacagc tacactttga
     1321 acctccttcc tgtcaacctt tcagcatagc aggtggtatt taagggaata tactgaagcc
     1381 acaaggcatg cagttggtca aaataaacac cctctgatgt a
//
