LOCUS       NM_001107136            6200 bp    mRNA    linear   ROD 12-MAY-2023
DEFINITION  Rattus norvegicus activator of transcription and developmental
            regulator AUTS2 (Auts2), mRNA.
ACCESSION   NM_001107136 XM_001071840 XM_222103
VERSION     NM_001107136.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6200)
  AUTHORS   Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi
            T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K,
            Kaibuchi K and Hoshino M.
  TITLE     Cytoskeletal regulation by AUTS2 in neuronal migration and
            neuritogenesis
  JOURNAL   Cell Rep 9 (6), 2166-2179 (2014)
   PUBMED   25533347
REFERENCE   2  (bases 1 to 6200)
  AUTHORS   Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A and
            Reinberg D.
  TITLE     An AUTS2-Polycomb complex activates gene expression in the CNS
  JOURNAL   Nature 516 (7531), 349-354 (2014)
   PUBMED   25519132
REFERENCE   3  (bases 1 to 6200)
  AUTHORS   Bedogni F, Hodge RD, Nelson BR, Frederick EA, Shiba N, Daza RA and
            Hevner RF.
  TITLE     Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein
            expressed in developing brain regions implicated in autism
            neuropathology
  JOURNAL   Gene Expr Patterns 10 (1), 9-15 (2010)
   PUBMED   19948250
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000227.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107136.4.
            
            On Mar 4, 2021 this sequence version replaced NM_001107136.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-524               JACYVU010000227.1  5373927-5374450
            525-737             JACYVU010000227.1  5659682-5659894
            738-839             JACYVU010000227.1  5846094-5846195
            840-875             JACYVU010000227.1  5863661-5863696
            876-905             JACYVU010000227.1  6127747-6127776
            906-957             JACYVU010000227.1  6369542-6369593
            958-1426            JACYVU010000227.1  6422469-6422937
            1427-1680           JACYVU010000227.1  6425705-6425958
            1681-1901           JACYVU010000227.1  6428262-6428482
            1902-1946           JACYVU010000227.1  6430207-6430251
            1947-2042           JACYVU010000227.1  6434763-6434858
            2043-2114           JACYVU010000227.1  6439265-6439336
            2115-2144           JACYVU010000227.1  6440455-6440484
            2145-2216           JACYVU010000227.1  6442685-6442756
            2217-2358           JACYVU010000227.1  6447999-6448140
            2359-2436           JACYVU010000227.1  6454230-6454307
            2437-2520           JACYVU010000227.1  6455723-6455806
            2521-2743           JACYVU010000227.1  6457520-6457742
            2744-6200           JACYVU010000227.1  6460407-6463863
FEATURES             Location/Qualifiers
     source          1..6200
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..6200
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /note="activator of transcription and developmental
                     regulator AUTS2"
                     /db_xref="GeneID:304419"
                     /db_xref="RGD:2323959"
     exon            1..524
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..4001
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /note="AUTS2, activator of transcription and developmental
                     regulator; autism susceptibility candidate 2-like 1"
                     /codon_start=1
                     /product="autism susceptibility gene 2 protein"
                     /protein_id="NP_001100606.2"
                     /db_xref="GeneID:304419"
                     /db_xref="RGD:2323959"
                     /translation="MDGPTRGHGLRKKRRSRSQRDRERRSRAGLGTGAAGGIGTGRTR
                     APSLASSSGSDKEDNGKPPSSAPSRPRPPRRKRRESTSAEEDIIDGFAMTSFVTFEAL
                     EKDVAVKPQERVEKRQNPLTKKKREALTNGLSFHSKKSRLSHSHHYSSDRENDRNLCQ
                     HLGKRKKMPKGVRQLKPGQNSCRDSDSESASGESKGFQRSSSRERLSDSSAPSSLGTG
                     YFCDSDSDQEEKASDASSEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERS
                     QEKSQDCCKEPVFEPVVLKDPHPQLPQLPSQPQAEPQLQIPSPDPNLVPRTEAPPQFP
                     PPSTQPAPGPPEAQLQPAPLPQVQRPPRPQSPSHLLQQTLPPVQSHPPSQSLSQPLSA
                     YNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPP
                     AHSQHPNMFAPPTALPPPPPLTSGSLQVPGHPAGSTYSEQDILRQELNTRFLASQSAD
                     RGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKY
                     PTKVDPFYRHSLFHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVP
                     HTLLQKDPRLTDPFRPMLRKPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLK
                     PEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTPFGPPPHHSNFLNPAAHL
                     EPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSVFGHKDSPSVQNFSNPHEPWNRLHRT
                     PPSFPTPPPWLKPGELERSASAAAHDRDRDVDKRDSSVSKDDKERESVEKRHPSHPSP
                     APPVPVSALGHNRSSTDPTTRGHLNTEAREKDKPKERERDHSGSRKDLTTEEHKAKEG
                     HLPERDGHSHEGRAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREAEPRKGEPAYE
                     NPKKNAEVKVKEERKEDHDLPTEAPQAHRTSEAPPPSSSASASVHPGPLASMPMTVGV
                     TGIHAMNSIGSLDRTRMMTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDPYRDLDMHR
                     RDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREHE
                     RGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAG
                     HQNGLLNKTPPTAALSAPPPLISTLGGRPGSPRRTTPLSAEIRERPPSHTLKDIEAR"
     exon            525..737
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..839
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..875
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..905
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..957
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1426
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1680
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1901
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1946
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2042
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2114
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2144
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2216
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2358
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2436
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2520
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2743
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..6200
                     /gene="Auts2"
                     /gene_synonym="Auts2l; Auts2l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttttt tattcctccc agccgccttc tcccccgcgc ccttcctcgc ggctggaggg
       61 aaaagcccgt gcaggagaag cgggggggct cggtgtcaat tttttttttc ttcttggtgt
      121 gtgtgtgtgt gtgtgtgtgt gtgtgtggcc gcggcccgag cctgtggcgc gcgggtaggc
      181 gaacggggaa gatccccggc gcggttaaaa gaaccatgga tggcccgacg cggggacatg
      241 gactccggaa aaagcggagg tcgcgatcac agcgagaccg ggagagacgc tcccgggccg
      301 gcttaggaac cggtgcggcg ggtggtatag gaaccggccg gacccgggct ccctcgctgg
      361 cttcatcgtc gggctccgac aaggaagaca atggaaagcc cccatcctcc gccccgtccc
      421 ggcccagacc cccgcggagg aagcgcagag agtccacctc agccgaagag gacatcattg
      481 atggatttgc catgaccagc tttgttactt ttgaagcgct ggagaaagat gtagcagtta
      541 agcctcagga acgtgtggag aaacggcaga atcccctgac caagaaaaaa cgagaagccc
      601 ttaccaatgg cttgtccttt cactcaaaga agagccgact cagccactcg caccactaca
      661 gctcagatcg agaaaatgac cgcaatctct gccagcacct tgggaagaga aagaagatgc
      721 ctaagggagt cagacagctc aagccaggac agaacagctg cagggacagc gacagtgaaa
      781 gcgctagtgg agaatccaag ggtttccaga ggagcagctc tcgggagagg ctcagcgata
      841 gttcagctcc ttccagcttg gggacaggct acttctgtga cagtgacagt gaccaggaag
      901 agaaggcttc ggatgctagc tctgagaaac tcttcaacac tgttcttgta aacaaagatc
      961 cagagttagg tgttggcgca ctgcctgaac acaaccaaga tgcgggacca attgtcccca
     1021 agatctcggg tctagagaga agccaggaga agagccagga ctgttgcaaa gagccagtct
     1081 tcgaacctgt ggtgctcaaa gacccacatc ctcagctccc ccagctacca tcccagcccc
     1141 aggccgagcc ccagctccag attccgtctc cagacccgaa cttggtaccc cgcactgaag
     1201 ctccgcccca gttccctcct ccgagtacac agcccgcccc aggaccccca gaagcccagc
     1261 tgcagcccgc cccgctgcct caggtgcagc ggccacccag gccgcagtct cccagccacc
     1321 tgctccagca gacccttccg cctgtgcagt cgcatccccc ttcccagagc ctctcgcagc
     1381 cactgtccgc ctacaacagc agtagcctga gcctcaacag cttaagcagc agcagaagca
     1441 gtaccccggc caaaacccag cccgcccctc ctcacatctc ccaccacccc tccgcctctc
     1501 cctttcccct ctccctgccc aaccacagcc ccctgcacag ctttacaccc accctccagc
     1561 cccctgccca ctcacagcac cccaatatgt tcgcccctcc cactgctctg cctcctcccc
     1621 cgccgctgac atccggaagt ctgcaggtgc cagggcatcc cgcagggagc acgtactcag
     1681 aacaagatat cttgaggcag gaactgaaca ctcgtttcct ggcctcccag agtgccgacc
     1741 gaggggcgtc cctgggccct ccaccctacc tgcggaccga gttccatcaa caccaacatc
     1801 agcaccagca cacgcaccag cacacgcacc agcacacctt cacaccgttc ccccacgcca
     1861 tcccacccac tgccatcatg ccgacgccag cacctcccat gtttgacaaa taccccacca
     1921 aagttgaccc attctaccgg catagtctct tccactccta tcctcctgcc gtctcgggta
     1981 taccccccat gatcccaccc acgggccctt tcggttcact tcaaggagca ttccagccga
     2041 agacatccaa tcctatcgat gtggctgccc ggcccggaac agtcccacac actctgctcc
     2101 aaaaggaccc aaggttgaca gatcctttca gacccatgct aaggaaacca ggaaagtggt
     2161 gcgccatgca cgtgcatatc gcctggcaga tttaccacca ccaacaaaaa gtcaagaaac
     2221 agatgcagtc agatccgcac aagctggact ttgggctgaa gcctgagttc ctgagtcgtc
     2281 ctccgggccc tagtctcttc ggagccatcc atcaccccca cgatcttgca cgaccttcca
     2341 ctttgttctc tgctgctggt gctgcacatc ctactgggac cccttttggg ccaccacctc
     2401 atcacagcaa ctttctcaac cctgccgctc acctagagcc ttttaaccgg ccgtctacat
     2461 tcacgggcct cgctgcagtc ggtggcaatg ccttcggggg acttggaaac ccttcagtta
     2521 cacccaactc agtgttcggc cacaaggata gccccagtgt gcagaacttt agcaatcctc
     2581 acgaaccctg gaaccggctg caccgaacgc ctccgtcgtt cccgacccct ccgccctggc
     2641 tgaagccagg ggagttggag cgcagtgcgt ccgctgcagc ccatgacaga gatagagatg
     2701 tagataaacg agactcctcc gttagtaagg atgacaagga aagggaaagc gttgagaaaa
     2761 gacaccccag ccatccttcc ccagcacctc ccgtcccggt gagcgccctg ggccataacc
     2821 gcagctctac cgatccgacg accaggggtc atttgaatac tgaggctcgt gagaaagata
     2881 aaccaaaaga gagggagaga gaccactcgg gatcccgaaa ggacctgacc accgaagagc
     2941 acaaagccaa ggaaggccat ctgcccgaga gagatgggca cagccacgag ggacgtgcag
     3001 caggcgagga acccaagcag ctgtcccggg tgccatcgcc ctatgtgagg acaccaggcg
     3061 tggatagcac caggcctaac agcacctcta gtcgggaagc cgagccacgc aagggcgagc
     3121 cggcctacga gaaccccaag aagaacgcgg aggtcaaggt caaagaggaa cgcaaggaag
     3181 accacgacct acctaccgag gctccacaag cccacaggac ctcagaggca cctccgccca
     3241 gctcctcagc cagcgccagc gtgcacccag ggcctctggc atcaatgccc atgaccgtgg
     3301 gagtgactgg catccacgcc atgaacagta tcggtagtct ggacaggaca cgcatgatga
     3361 ccccatttat gggcctcagt ccgatcccag ggggagagcg cttcccgtac ccctctttcc
     3421 actgggaccc tatgcgggac cccttgaggg atccttaccg tgacttggac atgcaccgaa
     3481 gagaccctct gggcagggac tttctgctca ggaatgaccc cctgcaccgg ctctccacac
     3541 cccggttgta tgaagccgac cgctcgttcc gggacaggga gcctcatgat tacagccacc
     3601 accaccatca ccaccatcac ccgctggccg tggaccctcg acgggagcac gaacggggtg
     3661 gacacctaga tgaacgcgag cggctgcacg tgcttcggga ggactatgag cacccacggt
     3721 tgcaccctgt gcaccccgct tctctagatg gacacctccc acacccgagc ctgctcacac
     3781 caggcctgcc tagtatgcac taccctcgca tcagccctac tgcgggccac cagaatggac
     3841 tacttaacaa gaccccgccc accgcggcgc tcagcgcccc acctccgctc atctccacat
     3901 tggggggccg cccgggatcc ccccggagga ctacgcctct gtcggctgaa atccgagaga
     3961 ggccaccgtc ccacacactg aaggacattg aagctcgata agccaaggag gataaggcag
     4021 acctcgcagt cgggggagaa accccaggga cacccacccc cagactcaag agacaactcc
     4081 tgcaccccca aaactgagag gcgcagagct ccaactcttc ccctgaaaaa aaaaaatgga
     4141 cagagactcc gtttggatgt tgaaatgttt ttgtatatta atgttggaat ttttcagacc
     4201 ttttagccag gtcccgtttg ttcttacctt tctttacttt ttttgttgtt gttccttgca
     4261 taaaactttg atttgaacca aatcggtgaa ggtactgaca gacaaggatc tgatgatcat
     4321 ggggggcggg gcggggggcg gagcctctgt ccatcacccc gagctgtctc ggcaggaggt
     4381 gtgtacatag aatgtaaaaa gagattgctt catgagctga cggttcatat atgcaaaaga
     4441 taaagacgaa agctttactt gtacagatgt aaataggtga agagtaacat aatacattaa
     4501 tacttcttca gatgtgctat ttacaagtct aatatccgtg aacccggccg gccctcggag
     4561 gaggccgcgt tcccatctgc taaacccttc aactatgcaa tgaatacgag ggcttttccc
     4621 cccccgaagc ccgtctaact taaaggagcc ttttcaaatc catttacaac atacttaagg
     4681 tcatattttc cctgaacaag cgcttacccg aaatgttaga cagttgtttt cctttttttt
     4741 tttttttttt tttttttttt gatttttgtt tttcaaacga agaaccactt ttttggtttt
     4801 ggtttgtttt tgttgttctt gtttttaaat ctggacccca ggctggaact tggcatcgga
     4861 agttgctgct tgtggccttc cggggagaaa tggggaaagg tccaccccct agaaagtgta
     4921 gctaagaacc ggaagcagct ttgcccaggg aagatgggat tgttctgcca ataatcaggg
     4981 gcaggtaggc tgttgtctgc cagcacaaac aggctcacca gaatttccgg tcacctctga
     5041 tggtgtaatg ttgcaggcaa cttcaagtgg gcaccgtgcc tcctccccaa cccccaaaca
     5101 ccacccccac ccccgtgtcc tagctcataa catgtactca cttccttgtt ctgtagtatg
     5161 atttaaggac actcacacag gtccggaaag aaagaaagct gtctgggttt tctcagacga
     5221 tggatacgtt ttcatggtca ctgacgaagg tacacagagc ccagtgtgaa tcgtttgaat
     5281 tccaatagga aatgaaaacc taggcagagc tgagcagata gatcttgtaa gagccatcag
     5341 aaattaccga gggcgaaagg aggcagagag agagagagag agagagagag agagagagag
     5401 agagagagag agagagagag agagagagag aggagagaat gtgtgtgcgt gttcacgtgc
     5461 atgcaggcgc tcttgtgtgc acttgtatgt atgtgtgtgt tgaattttca tcagtcttaa
     5521 tgtcttcatg acacttttct aaggacatga accctcttgt ctacatattt ggagagaata
     5581 tgactttact agccgagaaa atacaatata tcttgtctac tggcctgtaa aatacatgta
     5641 agaaataaaa attagtcgca tttggtcctc tagtatatta aagtgctatc tgacattgtt
     5701 atcctggttc ttttgttttg ttttcaaaaa aaaaaaaatg taaactacag accattgttt
     5761 ctaaaagcag agagatctat tttagtagtc aacagaaggt ttagttgtga attctgattt
     5821 tgtggacacc agacgtgtgt aatgttctgt tttcctttct ttcattttta ttttattttt
     5881 aaaagacaac aattaaaaag gaaaaaaaaa tcccaaggat tctgtgcact ggaactgtag
     5941 cggtagggtc tcagcattgt aaagagattg ttcttgtaca ggcctctttt tttctttctt
     6001 tttttttttt tgctgtttct cttgtatgta aaaaagaaaa aaaaaaggaa aaaggaaaaa
     6061 aaaaaaaaaa aggaagaaaa aagtcctttc cagaccccac ttgaacagga agggaagcaa
     6121 cgaaatcttc agcatgtctc attggaggag ccttcttgtg tgatgtaaat gtatcatgtt
     6181 attaaaaaaa tgtgaaccaa
//
