LOCUS       NM_001308536            1427 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aurora kinase C (Aurkc), mRNA.
ACCESSION   NM_001308536 NM_001106221 XM_001067866 XM_214811
VERSION     NM_001308536.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Hached,K., Xie,S.Z., Buffin,E., Cladiere,D., Rachez,C., Sacras,M.,
            Sorger,P.K. and Wassmann,K.
  TITLE     Mps1 at kinetochores is essential for female mouse meiosis I
  JOURNAL   Development 138 (11), 2261-2271 (2011)
   PUBMED   21558374
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   Price,D.M., Kanyo,R., Steinberg,N., Chik,C.L. and Ho,A.K.
  TITLE     Nocturnal activation of aurora C in rat pineal gland: its role in
            the norepinephrine-induced phosphorylation of histone H3 and gene
            expression
  JOURNAL   Endocrinology 150 (5), 2334-2341 (2009)
   PUBMED   19116339
  REMARK    GeneRIF: Activation of the mitotic kinase Aurkc can be induced by
            extracellular signals to participate in the transcriptional
            induction of a subset of genes in the rat pineal gland.
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Yan,X., Wu,Y., Li,Q., Cao,L., Liu,X., Saiyin,H. and Yu,L.
  TITLE     Cloning and characterization of a novel human Aurora C splicing
            variant
  JOURNAL   Biochem Biophys Res Commun 328 (1), 353-361 (2005)
   PUBMED   15670791
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Parra,M.T., Viera,A., Gomez,R., Page,J., Carmena,M., Earnshaw,W.C.,
            Rufas,J.S. and Suja,J.A.
  TITLE     Dynamic relocalization of the chromosomal passenger complex
            proteins inner centromere protein (INCENP) and aurora-B kinase
            during male mouse meiosis
  JOURNAL   J Cell Sci 116 (Pt 6), 961-974 (2003)
   PUBMED   12584241
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Tseng,T.C., Chen,S.H., Hsu,Y.P. and Tang,T.K.
  TITLE     Protein kinase profile of sperm and eggs: cloning and
            characterization of two novel testis-specific protein kinases
            (AIE1, AIE2) related to yeast and fly chromosome segregation
            regulators
  JOURNAL   DNA Cell Biol 17 (10), 823-833 (1998)
   PUBMED   9809744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On May 8, 2015 this sequence version replaced NM_001106221.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on orthologus alignments with the mouse
            transcript AF054620.1 (Gene ID 20871).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.1956389.1,
                                           SRR26643293.1251.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-442               JAXUCZ010000001.1  75882452-75882893   c
            443-476             JAXUCZ010000001.1  75881908-75881941   c
            477-668             JAXUCZ010000001.1  75881499-75881690   c
            669-807             JAXUCZ010000001.1  75880545-75880683   c
            808-956             JAXUCZ010000001.1  75879042-75879190   c
            957-1131            JAXUCZ010000001.1  75877452-75877626   c
            1132-1427           JAXUCZ010000001.1  75876773-75877068   c
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1427
                     /gene="Aurkc"
                     /note="aurora kinase C"
                     /db_xref="GeneID:292554"
                     /db_xref="RGD:1309573"
     exon            1..442
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     exon            443..476
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..1302
                     /gene="Aurkc"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase 13; zinc finger
                     protein 264-like; zinc finger protein 805-like"
                     /codon_start=1
                     /product="aurora kinase C"
                     /protein_id="NP_001295465.1"
                     /db_xref="GeneID:292554"
                     /db_xref="RGD:1309573"
                     /translation="MEPSTSTKKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVAL
                     KVLFKSEIGKEGLEHQLRREVEIQSHLQHPNILRLYNYFYDDSRVYLILEYAPRGELY
                     KELQRNQKLNQQRTATIIEELSDALIYCHRNKVIHRDLKPENLLLGLKGEVKIADFGW
                     SVHTPSLRRKTMCGTLDYLPPEMIEGKSYNETVDLWCIGVLCYELLVGKPPFESSTSS
                     ETCRRICQVDFRFPSSMPAGAQDLISKLLRHHPSERLSLAQVLKHPWVRKHSQRMLPP
                     CAQMAS"
     exon            477..668
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     exon            669..807
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     exon            808..956
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1131
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1427
                     /gene="Aurkc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgctgatct cagcaaataa gtactccagc aagtaccttg ctggaggttt taggcttcca
       61 gtgtcctcct tctggtcccg cctgcaccat cctatagggt gagcggcctg ggagaagctc
      121 ttgcttctca ggcacgccta ttgggcacgc ccgacttcag aaagatagcc tacggttttc
      181 agttgggatc tactagtctc tgccaaagcg gactctgcaa accgctcgag tgctgctgtg
      241 ctagtggatt accggtgcgt gggtctcggg tgtcctaggg tgggtgagac attctgagcg
      301 gttggggaag ccgcagtcag agcgttaccc gtttactctt tccagggact aagcggctag
      361 taggatttta gcttgtcctc acctctttag aggtcaggga agagagtcac tgcgtccggc
      421 tgggttcact cacaagtaag agccactggc cagatggagc ccagcacctc aaccaagaag
      481 catttcacca tcaatgactt tgaaatcggg cgtcctctgg gcagggggaa atttgggcgt
      541 gtgtacctgg ctcggctcaa ggaaaatcat ttcatcgtgg ccctgaaggt cctcttcaag
      601 tctgagatag ggaaggaggg attggaacac caacttcgca gggaagtgga gatccagtcg
      661 cacttacaac acccgaatat ccttcgcttg tacaactact tctacgatga cagtcgggtg
      721 tacttaattc tggaatatgc tccaagaggt gagctctata aggagcttca gagaaaccag
      781 aaattgaacc agcagcgtac agccacgata atagaggagt tgtcagatgc tctgatctac
      841 tgccatagga acaaggtgat tcatagggac ctcaagccag agaatctcct gctgggcctc
      901 aagggcgagg tgaagatcgc agacttcggg tggtctgtgc ataccccctc tctcaggaga
      961 aagacaatgt gtgggactct ggactactta ccccccgaaa tgatagaggg gaaatcctac
     1021 aacgagacgg tggatctgtg gtgcattggg gtgctctgct atgagctgct ggtgggaaag
     1081 ccgcccttcg agagcagcac ctccagtgag acatgcagac gcatctgcca ggtggatttt
     1141 aggttccctt catcaatgcc tgcaggggcc caggacttga tctccaagct tcttaggcac
     1201 catccgtcag agcggctgag cctggcccag gtcctgaagc acccctgggt caggaaacac
     1261 tctcaaagga tgctacctcc ctgtgctcag atggcttcct gagccctgtc tgtctcttct
     1321 atgtgtttct tcaaggagct ctctaggctc tgtttgttac tgcatgtggt ttgcttgttt
     1381 tctcttttat cacgtgatga taattaaaac tgattaattt agcatca
//
