LOCUS       NM_153296               2356 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus aurora kinase A (Aurka), mRNA.
ACCESSION   NM_153296
VERSION     NM_153296.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Baltzer,S., Bulatov,T., Schmied,C., Kramer,A., Berger,B.T.,
            Oder,A., Walker-Gray,R., Kuschke,C., Zuhlke,K., Eichhorst,J.,
            Lehmann,M., Knapp,S., Weston,J., von Kries,J.P., Sussmuth,R.D. and
            Klussmann,E.
  TITLE     Aurora Kinase A Is Involved in Controlling the Localization of
            Aquaporin-2 in Renal Principal Cells
  JOURNAL   Int J Mol Sci 23 (2), 763 (2022)
   PUBMED   35054947
  REMARK    GeneRIF: Aurora Kinase A Is Involved in Controlling the
            Localization of Aquaporin-2 in Renal Principal Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Yang,C., You,D., Huang,J., Yang,B., Huang,X. and Ni,J.
  TITLE     Effects of AURKA-mediated degradation of SOD2 on mitochondrial
            dysfunction and cartilage homeostasis in osteoarthritis
  JOURNAL   J Cell Physiol 234 (10), 17727-17738 (2019)
   PUBMED   30811038
  REMARK    GeneRIF: AURKA ubiquitination influences mitochondrial dysfunction
            and suppresses the occurrence of OA via degradation of SOD2.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Kamran,M., Long,Z.J., Xu,D., Lv,S.S., Liu,B., Wang,C.L., Xu,J.,
            Lam,E.W. and Liu,Q.
  TITLE     Aurora kinase A regulates Survivin stability through targeting
            FBXL7 in gastric cancer drug resistance and prognosis
  JOURNAL   Oncogenesis 6 (2), e298 (2017)
   PUBMED   28218735
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Chung,H.J., Park,K.R., Lee,H.J., Lee,J., Kim,J.H., Kim,Y.C. and
            Han,S.Y.
  TITLE     Effects of KRC-108 on the Aurora A activity and growth of
            colorectal cancer cells
  JOURNAL   Biochem Biophys Res Commun 461 (4), 605-611 (2015)
   PUBMED   25912878
  REMARK    GeneRIF: This study suggests that KRC-108 has potential for
            development as an anti-tumor agent, although further studies are
            needed.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Hobson,A., Draney,C., Stratford,A., Becker,T.C., Lu,D., Arlotto,M.
            and Tessem,J.S.
  TITLE     Aurora Kinase A is critical for the Nkx6.1 mediated beta-cell
            proliferation pathway
  JOURNAL   Islets 7 (1), e1027854 (2015)
   PUBMED   26030060
  REMARK    GeneRIF: AURKA upregulation by Nkx6.1 results in phosphorylation
            and degradation of p53, thus removing a key inhibitory factor and
            permitting engagement of the beta-cell proliferation pathway.
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Bayliss,R., Sardon,T., Vernos,I. and Conti,E.
  TITLE     Structural basis of Aurora-A activation by TPX2 at the mitotic
            spindle
  JOURNAL   Mol Cell 12 (4), 851-862 (2003)
   PUBMED   14580337
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Hirota,T., Kunitoku,N., Sasayama,T., Marumoto,T., Zhang,D.,
            Nitta,M., Hatakeyama,K. and Saya,H.
  TITLE     Aurora-A and an interacting activator, the LIM protein Ajuba, are
            required for mitotic commitment in human cells
  JOURNAL   Cell 114 (5), 585-598 (2003)
   PUBMED   13678582
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Goepfert,T.M., Adigun,Y.E., Zhong,L., Gay,J., Medina,D. and
            Brinkley,W.R.
  TITLE     Centrosome amplification and overexpression of aurora A are early
            events in rat mammary carcinogenesis
  JOURNAL   Cancer Res 62 (14), 4115-4122 (2002)
   PUBMED   12124350
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Nigg,E.A.
  TITLE     Mitotic kinases as regulators of cell division and its checkpoints
  JOURNAL   Nat Rev Mol Cell Biol 2 (1), 21-32 (2001)
   PUBMED   11413462
  REMARK    Review article
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Gopalan,G., Chan,C.S. and Donovan,P.J.
  TITLE     A novel mammalian, mitotic spindle-associated kinase is related to
            yeast and fly chromosome segregation regulators
  JOURNAL   J Cell Biol 138 (3), 643-656 (1997)
   PUBMED   9245792
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 26, 2024 this sequence was replaced by
            NM_153296.4.
            
            On Nov 27, 2020 this sequence version replaced NM_153296.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC104676.1, AF537333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000003.1  181560723-181560769 c
            48-303              JAXUCZ010000003.1  181558515-181558770 c
            304-358             JAXUCZ010000003.1  181555070-181555124 c
            359-550             JAXUCZ010000003.1  181554286-181554477 c
            551-689             JAXUCZ010000003.1  181553460-181553598 c
            690-838             JAXUCZ010000003.1  181550626-181550774 c
            839-1013            JAXUCZ010000003.1  181548173-181548347 c
            1014-2356           JAXUCZ010000003.1  181546742-181548084 c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2356
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /note="aurora kinase A"
                     /db_xref="GeneID:261730"
                     /db_xref="RGD:628895"
     exon            1..47
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1199
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /EC_number="2.7.11.1"
                     /note="aurora-A; serine/threonine-protein kinase 6;
                     ratAurA; serine/threonine-protein kinase aurora-A;
                     serine/threonine kinase 6; aurora 2; aurora-related kinase
                     1; aurora/IPL1-related kinase 1; ipl1- and aurora-related
                     kinase 1; serine/threonine-protein kinase 15;
                     serine/threonine-protein kinase Ayk1"
                     /codon_start=1
                     /product="aurora kinase A"
                     /protein_id="NP_695208.2"
                     /db_xref="GeneID:261730"
                     /db_xref="RGD:628895"
                     /translation="MDRCKENCVSRPVKSTVPFGPKRVLVTEQIPSQHPGSASSGQAQ
                     RVLCPSNSQRVPPQAQKPVAGQKPVLKQLPAASGPRPASRLSNPQKSEQPQPAASGNN
                     SEKEQTSIQKTEDSKKRQWTLEDFDIGRPLGKGKFGNVYLAREKQSKFILALKVLFKV
                     QLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKL
                     SKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPS
                     SRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRI
                     SRVEFTFPDFVTEGARDLISRLLKHNSSQRLTLAEVLEHPWIKANSSKPPTGHNSKEA
                     TSKSS"
     exon            48..303
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            304..358
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            359..550
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            551..689
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            690..838
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1013
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..2356
                     /gene="Aurka"
                     /gene_synonym="ARK-1; Stk6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacatgga cagatgtaaa gaaaactgtg tctctaggcc tgtcaagtcc actgttccct
       61 tcggtccgaa acgagtcttg gtgactgagc agattccttc tcagcaccca ggatcagcga
      121 gcagtggcca ggcccagcgg gtcctgtgtc cctccaactc ccagcgtgtc cctccacaag
      181 cacagaaacc tgtcgcaggt cagaagccag tgctcaagca gttgccggct gccagcggtc
      241 ctcgacctgc ttcccggctg agtaaccccc agaagagtga gcagccacag cctgcggcct
      301 cgggaaataa ttctgaaaag gaacagacat ccatccagaa aactgaagac tcaaaaaaaa
      361 ggcagtggac tttggaagat tttgacatcg gccgcccact aggaaaaggg aagtttggaa
      421 atgtctactt ggcgagggag aagcaaagca agttcatcct ggctctgaag gtgctgttta
      481 aagtacagct ggagaaggca ggtgtggagc accagctccg gagagaagtg gagatccagt
      541 cccacctgcg gcaccccaac atcctcaggc tgtatgggta tttccatgac gccaccagag
      601 tttatttaat tctggaatac gcgccccttg gaacagtata tagagagctt caaaaactct
      661 ccaagtttga tgagcagaga acagctacct acatcacgga gttggcgaat gctttgtcct
      721 actgccactc aaagagagtc atccacagag acatcaagcc agagaacctg ctgcttggct
      781 caaatgggga gttgaagatc gcagactttg ggtggtctgt gcatgctccg tcttccagga
      841 gaaccacgct gtgtggcacc ctggactacc tgcccccgga gatgattgaa ggtcggatgc
      901 atgacgagaa ggtggacctc tggagcctgg gggtgctctg ctatgagttc ctagtgggga
      961 tgcctccttt tgaggcacac acttatcagg agacctacag aaggatatca cgggttgaat
     1021 tcacattccc tgactttgtg acggagggag ccagggacct catttcaaga ctgttaaaac
     1081 acaactcaag tcaaaggcta acactagcgg aagtccttga gcacccttgg atcaaagcta
     1141 attcttcaaa acctccgact ggccacaata gcaaagaggc aactagcaaa tcgtcttagg
     1201 gaatctggag ccatgggcat tgtgcaacta actgtgagaa aggtcccatt gaagccgccc
     1261 agaccatcat cgctgccctc agggtgcctt gctgagcaac tagaccttgg ccttgcaccc
     1321 aggaagcccc gcctgttgcc cagcccctaa gaaccatgct gctttttctg atgtaatctg
     1381 gaaggaaggt tccactgcaa ctgtcccccc cggcctatgc tccaaggtgt gggggtctct
     1441 gtgggaaatt accagtgatc acctgtgtct tagcctccaa gtgccagtgt gtgtgtaact
     1501 tattgggtca ccaggcctgg aaaagctgtt ggaatggata tgtaatcttt tagtgtcaaa
     1561 ataaagattt gtatagactg tttttaaggg acacccattc aaggccctcc tgttttaagc
     1621 cttctgaagc ccatgtgggg ttcagatcct caaccactgt tctagagcct gtgcttggga
     1681 cctgcctcag gtgtttctgg atgttaaagg ctacttttta tgttgttctg tcatgtatgc
     1741 aacttgttaa atgtataact ataacacctg cctggagtcc atggctaatc ctttgagcat
     1801 ctcttcactg ctggctcacc atgggcagcc gccgtgcctt tctgacctgc tggatgtgct
     1861 ccagtgctat ctgtccatca accagagggg gacttggaat tagacaaaca ggcttttatg
     1921 gccaacttgg gatagatgtc agatgactgg aaatgcgggt gcccagggct aaatgtcatg
     1981 ccaactggac caccatcatg aagtggagaa catgcttgag tggaactgca gaggccctcc
     2041 agttgggaca agtggccttt ggtccctggt cctgtcctaa actaactggc tttgttgaag
     2101 tagcaactgc ccagctgcag ttaggtgtga ggtggttgag ggaaggaagc cgagcacggg
     2161 acactgcctg ctctgctcat gctctgtgag tgttgttatg tgcagatgac tgacacattc
     2221 ccaccgtgct cttccagtga tggcttacca gatgacagac cacacgcttt tacaaagatt
     2281 tttatttggt tcacagacga agccattcac ttggtctgct taaaaaagta gagacacaat
     2341 gatttacatc ttaaaa
//
