LOCUS       NM_001399250            1324 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus AU RNA binding methylglutaconyl-CoA hydratase
            (Auh), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001399250 XM_006253674
VERSION     NM_001399250.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1324)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   2  (bases 1 to 1324)
  AUTHORS   IJlst,L., Loupatty,F.J., Ruiter,J.P., Duran,M., Lehnert,W. and
            Wanders,R.J.
  TITLE     3-Methylglutaconic aciduria type I is caused by mutations in AUH
  JOURNAL   Am J Hum Genet 71 (6), 1463-1466 (2002)
   PUBMED   12434311
  REMARK    Erratum:[Am J Hum Genet. 2003 Sep;73(3):709]
REFERENCE   3  (bases 1 to 1324)
  AUTHORS   Brennan,L.E., Nakagawa,J., Egger,D., Bienz,K. and Moroni,C.
  TITLE     Characterisation and mitochondrial localisation of AUH, an
            AU-specific RNA-binding enoyl-CoA hydratase
  JOURNAL   Gene 228 (1-2), 85-91 (1999)
   PUBMED   10072761
REFERENCE   4  (bases 1 to 1324)
  AUTHORS   Nakagawa,J., Waldner,H., Meyer-Monard,S., Hofsteenge,J., Jeno,P.
            and Moroni,C.
  TITLE     AUH, a gene encoding an AU-specific RNA binding protein with
            intrinsic enoyl-CoA hydratase activity
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2051-2055 (1995)
   PUBMED   7892223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 5, 2022 this sequence version replaced XM_006253674.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218844.1, CF108964.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               JAXUCZ010000017.1  12481421-12481630
            211-278             JAXUCZ010000017.1  12493368-12493435
            279-366             JAXUCZ010000017.1  12493543-12493630
            367-453             JAXUCZ010000017.1  12513581-12513667
            454-546             JAXUCZ010000017.1  12522808-12522900
            547-603             JAXUCZ010000017.1  12524594-12524650
            604-791             JAXUCZ010000017.1  12570955-12571142
            792-842             JAXUCZ010000017.1  12572394-12572444
            843-890             JAXUCZ010000017.1  12573773-12573820
            891-1324            JAXUCZ010000017.1  12576315-12576748
FEATURES             Location/Qualifiers
     source          1..1324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..1324
                     /gene="Auh"
                     /note="AU RNA binding methylglutaconyl-CoA hydratase"
                     /db_xref="GeneID:361215"
                     /db_xref="RGD:1306087"
     exon            1..210
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..968
                     /gene="Auh"
                     /EC_number="4.2.1.18"
                     /EC_number="4.2.1.56"
                     /note="AU RNA binding protein/enoyl-coenzyme A hydratase;
                     AU RNA binding protein/enoyl-CoA hydratase; itaconyl-CoA
                     hydratase; AU-binding enoyl-CoA hydratase; AU-specific
                     RNA-binding enoyl-CoA hydratase; 3-MG-CoA hydratase"
                     /codon_start=1
                     /product="methylglutaconyl-CoA hydratase, mitochondrial"
                     /protein_id="NP_001386179.1"
                     /db_xref="GeneID:361215"
                     /db_xref="RGD:1306087"
                     /translation="MAAAAAPGALGALSAGRVRLVAACCARLGSAAWARGTAPRRGYS
                     SEVKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRT
                     IIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLAL
                     GGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARV
                     LDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVD
                     LVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE"
     exon            211..278
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            279..366
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            367..453
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            454..546
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            547..603
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            604..791
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            792..842
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            843..890
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1324
                     /gene="Auh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccgctgta aacatacaat atggcggcgg cggctgctcc cggcgctctg ggcgccttga
       61 gtgcgggtcg ggtccgcctg gtggccgcgt gctgcgcgcg actaggctct gcggcatggg
      121 ctaggggtac cgccccgagg aggggctaca gctctgaggt gaaaaccgag gatgagctgc
      181 gcgtgcggca cctggaggag gagaaccgag gcattgtggt gcttggaatt aacagagctt
      241 atgggaaaaa ttcactcagt aaaaatcttc tcaaaatgtt atcaaaagcg gtggacgcat
      301 taaaatcgga taagaaagtt cggaccatta tcatcagaag cgaagtccct gggatattct
      361 gtgctggcgc tgaccttaag gaaagagcca agatgcattc cagtgaagtc ggtccctttg
      421 tctccaagat ccgagcagtg atcaatgaca tcgctaacct tcctgtgccc accatcgctg
      481 ccatagatgg cctggcccta ggagggggcc tggagctggc tttagcgtgt gacattcgag
      541 tagcagcttc ttctgcaaaa atgggcctgg tggaaacgaa gttggcgatt atccctggtg
      601 gaggagggac acagagatta ccacgtgcca tcgggatggc cctggcaaag gagctcatct
      661 tctctgcacg cgttcttgac ggtcaggagg ccaaagccgt gggcttgatc agccacgtgt
      721 tagaacagaa ccaggaaggg gatgctgcct acaggaaggc gctggacctg gcaagagagt
      781 ttctacctca ggggcctgtt gccatgagag tggccaaact agcaattaac caaggcatgg
      841 aggttgactt agtgacaggg ttagccatag aagaagcctg ctatgctcag accatctcaa
      901 cgaaggacag actggaaggt cttcttgctt tcaaggagaa aagaccccct cgctacaagg
      961 gagagtaggg ggagcgcccg agacgccctc cctggagtgc cagaagtgtt tcagagccgc
     1021 cccacgctgc cacggggaat ctcgatgacc aaagtggaga gtgggttctc actacacctg
     1081 gagcaggccc gtctatactc aagccactgt gcgccatgtc ctatttattc agatttataa
     1141 agctagccat gtccgcagtc agaacacata aaaattaggt gtatgttttt aatatttccc
     1201 gcatatcagg ctttgtcgtt aattttttaa tgtgaataat ttatattgca cactctaggg
     1261 aataatcgat tgtatgtcta ctgtgctgca ttaagaaaat aaaactattt ctgtatccca
     1321 aaaa
//
