LOCUS       NM_021702               3066 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ataxin 3 (Atxn3), mRNA.
ACCESSION   NM_021702
VERSION     NM_021702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Matos,C.A., Nobrega,C., Louros,S.R., Almeida,B., Ferreiro,E.,
            Valero,J., Pereira de Almeida,L., Macedo-Ribeiro,S. and
            Carvalho,A.L.
  TITLE     Ataxin-3 phosphorylation decreases neuronal defects in
            spinocerebellar ataxia type 3 models
  JOURNAL   J Cell Biol 212 (4), 465-480 (2016)
   PUBMED   26880203
  REMARK    GeneRIF: Ataxin-3 phosphorylation decreases neuronal defects in
            spinocerebellar ataxia type 3 models.
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Durcan,T.M. and Fon,E.A.
  TITLE     The three 'P's of mitophagy: PARKIN, PINK1, and post-translational
            modifications
  JOURNAL   Genes Dev 29 (10), 989-999 (2015)
   PUBMED   25995186
  REMARK    Review article
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Neves-Carvalho,A., Logarinho,E., Freitas,A., Duarte-Silva,S., Costa
            Mdo,C., Silva-Fernandes,A., Martins,M., Serra,S.C., Lopes,A.T.,
            Paulson,H.L., Heutink,P., Relvas,J.B. and Maciel,P.
  TITLE     Dominant negative effect of polyglutamine expansion perturbs normal
            function of ataxin-3 in neuronal cells
  JOURNAL   Hum Mol Genet 24 (1), 100-117 (2015)
   PUBMED   25143392
  REMARK    GeneRIF: Data support the importance of ATXN3 in neuronal cells and
            indicate that an expanded polyQ tract leads to a partial loss of
            the cellular function of ATXN3 that may be relevant to
            neurodegeneration.
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Liman,J., Deeg,S., Voigt,A., Vossfeldt,H., Dohm,C.P., Karch,A.,
            Weishaupt,J., Schulz,J.B., Bahr,M. and Kermer,P.
  TITLE     CDK5 protects from caspase-induced Ataxin-3 cleavage and
            neurodegeneration
  JOURNAL   J Neurochem 129 (6), 1013-1023 (2014)
   PUBMED   24548080
REFERENCE   5  (bases 1 to 3066)
  AUTHORS   Bernardi,K.M., Williams,J.M., Inoue,T., Schultz,A. and Tsai,B.
  TITLE     A deubiquitinase negatively regulates retro-translocation of
            nonubiquitinated substrates
  JOURNAL   Mol Biol Cell 24 (22), 3545-3556 (2013)
   PUBMED   24068323
REFERENCE   6  (bases 1 to 3066)
  AUTHORS   Beuckmann,C.T., Sinton,C.M., Williams,S.C., Richardson,J.A.,
            Hammer,R.E., Sakurai,T. and Yanagisawa,M.
  TITLE     Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons
            induces narcolepsy-cataplexy in the rat
  JOURNAL   J Neurosci 24 (18), 4469-4477 (2004)
   PUBMED   15128861
REFERENCE   7  (bases 1 to 3066)
  AUTHORS   Albrecht,M., Hoffmann,D., Evert,B.O., Schmitt,I., Wullner,U. and
            Lengauer,T.
  TITLE     Structural modeling of ataxin-3 reveals distant homology to
            adaptins
  JOURNAL   Proteins 50 (2), 355-370 (2003)
   PUBMED   12486728
REFERENCE   8  (bases 1 to 3066)
  AUTHORS   Schmidt,T., Landwehrmeyer,G.B., Schmitt,I., Trottier,Y.,
            Auburger,G., Laccone,F., Klockgether,T., Volpel,M., Epplen,J.T.,
            Schols,L. and Riess,O.
  TITLE     An isoform of ataxin-3 accumulates in the nucleus of neuronal cells
            in affected brain regions of SCA3 patients
  JOURNAL   Brain Pathol 8 (4), 669-679 (1998)
   PUBMED   9804376
REFERENCE   9  (bases 1 to 3066)
  AUTHORS   Schmitt,I., Brattig,T., Gossen,M. and Riess,O.
  TITLE     Characterization of the rat spinocerebellar ataxia type 3 gene
  JOURNAL   Neurogenetics 1 (2), 103-112 (1997)
   PUBMED   10732811
REFERENCE   10 (bases 1 to 3066)
  AUTHORS   Kawaguchi,Y., Okamoto,T., Taniwaki,M., Aizawa,M., Inoue,M.,
            Katayama,S., Kawakami,H., Nakamura,S., Nishimura,M., Akiguchi,I. et
            al.
  TITLE     CAG expansions in a novel gene for Machado-Joseph disease at
            chromosome 14q32.1
  JOURNAL   Nat Genet 8 (3), 221-228 (1994)
   PUBMED   7874163
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_021702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y12319.1, SRR26643290.23877.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               JAXUCZ010000006.1  126872653-126872781 c
            130-294             JAXUCZ010000006.1  126864483-126864647 c
            295-339             JAXUCZ010000006.1  126864220-126864264 c
            340-425             JAXUCZ010000006.1  126862346-126862431 c
            426-492             JAXUCZ010000006.1  126861917-126861983 c
            493-580             JAXUCZ010000006.1  126859179-126859266 c
            581-713             JAXUCZ010000006.1  126854933-126855065 c
            714-880             JAXUCZ010000006.1  126851849-126852015 c
            881-977             JAXUCZ010000006.1  126850592-126850688 c
            978-1075            JAXUCZ010000006.1  126844227-126844324 c
            1076-3066           JAXUCZ010000006.1  126839327-126841317 c
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3066
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /note="ataxin 3"
                     /db_xref="GeneID:60331"
                     /db_xref="RGD:621567"
     exon            1..129
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1173
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /EC_number="3.4.19.12"
                     /note="machado-Joseph disease protein 1 homolog"
                     /codon_start=1
                     /product="ataxin-3"
                     /protein_id="NP_067734.1"
                     /db_xref="GeneID:60331"
                     /db_xref="RGD:621567"
                     /translation="MESIFHEKQEGSLCAQHCLNNLLQGEYFSPVELSSIAHQLDEEE
                     RLRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELILFNSPEYQRL
                     RIDPINERSFICNYKEHWFTVRKLGKQWFNLNSLLTGPELISDTYLALFLAQLQQEGY
                     SIFVVKGDLPDCEADQLLQMIKVQQMHRPKLIGEELAHLKEQSALKADLERVLEAADG
                     PGMFDDDEDDLQRALAMSRQEIDMEDEEADLRRAIQLSMQGSSRGMCEDSPQTSSTDL
                     SSEELRKRREAYFEKQQHQQQEADRPGYLSYPCERPTTSSGGLRSNQAGNAMSEEDVL
                     RATVTVSLETAKDSLKAERKK"
     exon            130..294
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            295..339
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            340..425
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..492
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            493..580
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            581..713
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..880
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            881..977
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1075
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..3066
                     /gene="Atxn3"
                     /gene_synonym="MJD1; Rsca3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacgtgggta gggcggggcg ggccggggcg gaggggtggg gccgggggcg gagctgctgg
       61 agggggctgc tccgcgccgg ggccgttggc tccagacaaa taaacatgga gtccatcttc
      121 cacgagaaac aagaaggctc cctttgcgct cagcattgct tgaataacct cttacaagga
      181 gagtatttta gccccgtgga gctgtcctca attgcacacc agctggatga agaggagagg
      241 ctgcggatgg cggaaggagg ggtcaccagc gaagactacc gcacattttt acagcagcct
      301 tctggaaata tggacgacag cggctttttc tctattcaag ttataagcaa tgccttgaaa
      361 gtttggggtt tagaactaat cctattcaac agtccagagt accagaggct cagaatcgat
      421 cctataaatg aaagatcctt tatatgcaat tataaagaac actggtttac agttagaaaa
      481 ttaggaaaac agtggtttaa cttgaattct ttgttgactg gtccagagct aatatcagat
      541 acatacctcg cactgttctt ggctcagtta cagcaagaag gttattctat atttgttgtt
      601 aagggtgatc tgccagattg tgaagctgac caacttttac agatgatcaa ggtccaacag
      661 atgcatcgac caaaacttat tggagaagaa ctcgcacatc tgaaagagca gagcgccctc
      721 aaagcagatc tggagcgagt cttagaggcg gctgacgggc cgggaatgtt tgatgatgat
      781 gaggacgatt tacagagggc tctggccatg agtcgccagg aaatcgacat ggaggacgaa
      841 gaagccgatc tccgcagggc cattcagctc agtatgcaag gtagttccag aggtatgtgt
      901 gaagatagtc cgcagacatc aagcacagat ctttcttcag aagagctgcg gaagaggaga
      961 gaagcctact ttgaaaagca acagcatcag caacaggaag cagaccgacc tggatacctt
     1021 tcatacccat gtgaaagacc caccacaagt tcaggaggac tccggagcaa ccaagcaggc
     1081 aatgctatga gtgaagagga cgtgcttcgg gcaactgtga ctgtgtcttt agaaactgct
     1141 aaagacagtt tgaaagcaga aagaaaaaaa tagtcccttt aaaaatcatt ttgccaccat
     1201 gctttgtaac attgtttgtg tgatcacagt gtaaggtcca ctttggcagc agtgtgttca
     1261 ccggaaggca gcagacactg catggtttgt aagcagaaag ggcagaagcg tcctaggact
     1321 aaagaaccac gagatgctag ccaaagaggc agtcagcaat gaaagaaaca acgtagtttt
     1381 ctaaatgtcc ctccttgttt ttcaaatgtg caatatctga ctgaaattat ggaattttcc
     1441 ttggctcttt tggaccaact cgttagctct tgccacagaa cttgatcctg tagagttccg
     1501 tcttctctct gcattggagc tggcttggct tgtttgggct tttcttcatt tcacaccaac
     1561 cttttgtgaa atatcgtttg tatgtcttgc tatggaaaga tcagtctgtc ttttcgtgta
     1621 tgtgtcaggc acatggatgc ttcctggtgt tattttctct ggttttggtt attttcctgc
     1681 aagtctaaca tggtgatctg ttggttttaa agcctttttt agtgggatca ttatttaact
     1741 ctggtgcatt cctctactct aaagtcagcc ctgttcttct aaacgagctg aggttttttg
     1801 tgagcacgtg ctttctcgat gccctgcgaa ggatttcagc tgtgtcctgg ctgacttatt
     1861 tcctttcttt tccagttgag aaaggagaga cagaggatac aaatatattt ccttctactt
     1921 aacgttctcc atgaatgtac cacaggagaa cccgcccttc agtgctggtg gtgggttcgt
     1981 tccagtgttt cttctgtgtc aagagcttag tgttctgtat atgattaagt cctggaaaat
     2041 aggtgcctgc ttcacttttt aatttttaaa aataaatttt tttttatttt agtagaaaat
     2101 aggctgctag gatgatggtc taggatgtga aagtaattta ctaatgaaaa tatatttaaa
     2161 tatactgtgg ttgacccttg ctaccatgtt aaaattgtta agaattacag aagtcacaat
     2221 acttaaagga tctgtttgta aatacgaaag tccttagttt tgataaacat taagtgagat
     2281 gcacatctgg tcttgctggg tcaatgcttt ggtatgattt gggtggaaat taactatgtg
     2341 tgtttgtcct gggtgtcata gatcctgata ctgttttccc ctccctaccc tttttgaagc
     2401 ccctttgaat gttaacttgt acataggtaa aatcaagaag aaattttagc caacagctta
     2461 gtaaggtgaa gcatggtata ttgctctact gatgtgtgtt ctgcacacgt ttttatcagg
     2521 gaaagttttt gatgtaggat ttattgctat ctaactgaaa atgatacaaa tatttttatt
     2581 tatgattatg aaatagcttt ctcttggata ggatggattg ttttgtttgg ctgtgctagg
     2641 gattgaaccc agagcctcgt gtgtgctagg taagcgctct acctctgagc tagatcccca
     2701 gatccaaaac atgtgtttct cttttgtttg ttttttttct tagccatttt gtgccaatta
     2761 cagtttctct ttttgaaatt tgcctcatga aaaattagac agtcctattt tcaaatctat
     2821 gaagttttct tttagtaatt gcaaaggttc agaattatgc agctgtaggc tgttgggtta
     2881 ggcctttgct tacagtggat ttttacactg aagtatgcag ctaccccaag tgtgctggtc
     2941 acatgtcgag cattgaccct ttcctttacc ctttgaaaaa ccacattaca ctttccgcac
     3001 actcagattg atgtgctgcc tgacagccat ttcagtttta acttcagagt ttataaaacg
     3061 ttcatg
//
