LOCUS       NM_001419737            4240 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ataxin 2 (Atxn2), mRNA.
ACCESSION   NM_001419737 XM_039090143
VERSION     NM_001419737.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4240)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   2  (bases 1 to 4240)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (bases 1 to 4240)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 4240)
  AUTHORS   Nonis,D., Schmidt,M.H.H., van de Loo,S., Eich,F., Dikic,I.,
            Nowock,J. and Auburger,G.
  TITLE     Ataxin-2 associates with the endocytosis complex and affects EGF
            receptor trafficking
  JOURNAL   Cell Signal 20 (10), 1725-1739 (2008)
   PUBMED   18602463
REFERENCE   5  (bases 1 to 4240)
  AUTHORS   Nonhoff,U., Ralser,M., Welzel,F., Piccini,I., Balzereit,D.,
            Yaspo,M.L., Lehrach,H. and Krobitsch,S.
  TITLE     Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and
            interferes with P-bodies and stress granules
  JOURNAL   Mol Biol Cell 18 (4), 1385-1396 (2007)
   PUBMED   17392519
REFERENCE   6  (bases 1 to 4240)
  AUTHORS   Huynh,D.P., Yang,H.T., Vakharia,H., Nguyen,D. and Pulst,S.M.
  TITLE     Expansion of the polyQ repeat in ataxin-2 alters its Golgi
            localization, disrupts the Golgi complex and causes cell death
  JOURNAL   Hum Mol Genet 12 (13), 1485-1496 (2003)
   PUBMED   12812977
REFERENCE   7  (bases 1 to 4240)
  AUTHORS   Kiehl,T.R., Shibata,H., Vo,T., Huynh,D.P. and Pulst,S.M.
  TITLE     Identification and expression of a mouse ortholog of A2BP1
  JOURNAL   Mamm Genome 12 (8), 595-601 (2001)
   PUBMED   11471052
REFERENCE   8  (bases 1 to 4240)
  AUTHORS   Huynh,D.P., Figueroa,K., Hoang,N. and Pulst,S.M.
  TITLE     Nuclear localization or inclusion body formation of ataxin-2 are
            not necessary for SCA2 pathogenesis in mouse or human
  JOURNAL   Nat Genet 26 (1), 44-50 (2000)
   PUBMED   10973246
REFERENCE   9  (bases 1 to 4240)
  AUTHORS   Shibata,H., Huynh,D.P. and Pulst,S.M.
  TITLE     A novel protein with RNA-binding motifs interacts with ataxin-2
  JOURNAL   Hum Mol Genet 9 (9), 1303-1313 (2000)
   PUBMED   10814712
  REMARK    Erratum:[Hum Mol Genet 2000 Jul 22;9(12):1903]
REFERENCE   10 (bases 1 to 4240)
  AUTHORS   Nechiporuk,T., Huynh,D.P., Figueroa,K., Sahba,S., Nechiporuk,A. and
            Pulst,S.M.
  TITLE     The mouse SCA2 gene: cDNA sequence, alternative splicing and
            protein expression
  JOURNAL   Hum Mol Genet 7 (8), 1301-1309 (1998)
   PUBMED   9668173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Apr 17, 2023 this sequence version replaced XM_039090143.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.32604.1,
                                           SRR26643295.45547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               JAXUCZ010000012.1  40509241-40509672   c
            433-469             JAXUCZ010000012.1  40480737-40480773   c
            470-529             JAXUCZ010000012.1  40479034-40479093   c
            530-601             JAXUCZ010000012.1  40478526-40478597   c
            602-752             JAXUCZ010000012.1  40477856-40478006   c
            753-877             JAXUCZ010000012.1  40455832-40455956   c
            878-969             JAXUCZ010000012.1  40451348-40451439   c
            970-1167            JAXUCZ010000012.1  40450724-40450921   c
            1168-1346           JAXUCZ010000012.1  40449316-40449494   c
            1347-1556           JAXUCZ010000012.1  40447337-40447546   c
            1557-1739           JAXUCZ010000012.1  40444692-40444874   c
            1740-1937           JAXUCZ010000012.1  40443093-40443290   c
            1938-2045           JAXUCZ010000012.1  40442676-40442783   c
            2046-2116           JAXUCZ010000012.1  40442145-40442215   c
            2117-2421           JAXUCZ010000012.1  40436135-40436439   c
            2422-2485           JAXUCZ010000012.1  40434785-40434848   c
            2486-2638           JAXUCZ010000012.1  40433946-40434098   c
            2639-2705           JAXUCZ010000012.1  40433526-40433592   c
            2706-2893           JAXUCZ010000012.1  40427966-40428153   c
            2894-3026           JAXUCZ010000012.1  40427203-40427335   c
            3027-3080           JAXUCZ010000012.1  40424027-40424080   c
            3081-3226           JAXUCZ010000012.1  40418943-40419088   c
            3227-3454           JAXUCZ010000012.1  40418212-40418439   c
            3455-3623           JAXUCZ010000012.1  40416264-40416432   c
            3624-4240           JAXUCZ010000012.1  40414851-40415467   c
FEATURES             Location/Qualifiers
     source          1..4240
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4240
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /note="ataxin 2"
                     /db_xref="GeneID:288663"
                     /db_xref="RGD:1306637"
     exon            1..432
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..3652
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /note="spinocerebellar ataxia 2 (olivopontocerebellar
                     ataxia 2, autosomal dominant, ataxin 2)"
                     /codon_start=1
                     /product="ataxin-2"
                     /protein_id="NP_001406666.1"
                     /db_xref="GeneID:288663"
                     /db_xref="RGD:1306637"
                     /translation="MSLKPQPQPPAPASGRKPGGGLLSSPGAAPASAASTSSSVVPAP
                     AAPVASSSAVAGGGRPGLGRGRNSSKGLPQPTISFDGIYANVRMVHILTSVVGSKCEV
                     QVKNGGVYEGVFKTYSPKCDLVLDAAHEKSTESSSGPKREEIMESVLFKCSDFVVVQF
                     KDTDSSYARRDAFTDSALSAKVNGEHKEKDLEPWDAGELTASEELEALENDVSNGWDP
                     NDMFRYNEENYGVVSTYDSSLSSYTVPLERDNSEEFLKREARANQLAEEIESSAQYKA
                     RVALENDDRSEEEKYTAVQRNCSDREGHGTNTRENKYIPPGQRNREVISWGSGRQSSP
                     RMGQPGPGSMPSRATSHTSDFNPNAGSDQRVVNGGVPWPSPCPSPSSRPPSRYQSGPN
                     SLPPRAATPTRPPSRPPSRPSRPPSHPSAHGSPAPVSTMPKRMSAEGPPRMSPKAQRH
                     PRNHRVSAGRGSMSSGLEFVSHNPPSEAAAPPVARTSPAGGTWSSVVSGVPRLSPKTH
                     RPRSPRQNSAGNSPSGPVLASPQAGITPAEAVSMPVPAASPTPASPASNRALTPSIEA
                     KDSRLQDQRQNSPAGNKENIKASETSPSFSKAENKGVSPVISEHRKQIDDLKKFKNDF
                     RLQPSSTSESMDQLLSKNREGEKSRDLMKDKTEASAKDSFIDSGSSSCTSSSSKTNSP
                     SASPSVLSNAEHKRGPEVTSQGVQTSSPACKQEKDDREERKDTTEQVRKSTLNPNAKE
                     FNPRSFSQPKPSTTPTSPRPQAQPSPSMVGHQQPAPVYTQPVCFAPNMMYPVPVSPGV
                     QPLYPIPMTPMPVNQAKTYRAGKVPNMPQQRQEQHHQSTMMHPASAAGPPIVATPPAA
                     YSTQYVAYSPQQFPNQPLVQHVPHYQSQHPHVYSPVIQGNARMMAPPAHAQPGLVSSS
                     AAQFGAHEQTHAMYACPKLPYNKETSPSFYFAISTGSLAQQYAHPNATLHPHPPHPQP
                     SATPTGQQQSQHGGSHPAPSPVQHHQHQAAQALHLASPQQQSAIYHAGLAPTPPSMTP
                     ASNTQSPQSSFPAAPQTVFTIHPSHVQPAYTTPPHMAHVPQAHVQSGMVPSHPTAHAP
                     MMLMTTQPPGGPQAALAQSALQPIPVSTTAHFPYMTHPSVQAHHQQQL"
     exon            433..469
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..529
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..601
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..752
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..877
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            878..969
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1167
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1346
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1556
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1739
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1937
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            1938..2045
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2116
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2421
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2485
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2638
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2705
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2893
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3026
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3080
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3226
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3227..3454
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3455..3623
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..4240
                     /gene="Atxn2"
                     /gene_synonym="Sca2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgtttt ggtagcaacg gcaacggcgc gtcccggccc ggctcccggc ggctgttcgg
       61 tgtctgcggg cctccccgcc ccttcgtcgt cgtcctgctg cctctggcac ccgcgaccgc
      121 gccagcccgc gcctgcccgc tcggcgtccg cgcgtccccg ccgcgctccg gcgtctcctc
      181 agcgcgcccg gctcccggct gtccccgccc ggcgtgcgag ccggtgtatg ggccgctcac
      241 catgtcgctg aagccgcagc cgcagccgcc cgcgcccgcc agtggccgca agcccggcgg
      301 cggcctgctc tcgtcgcccg gcgccgcgcc ggcctcggcc gcgtcgacct cgtcttccgt
      361 ggtgccggcc cctgccgcgc cggtggcgtc ttcctcggcg gtcgcgggcg gcgggcgtcc
      421 cggcctgggc agaggtcgga acagtagcaa aggactgcct cagcctacga tttcttttga
      481 cggaatctat gcaaacgtga ggatggttca tatacttaca tcggttgtgg gatcgaaatg
      541 tgaagtacaa gtgaaaaacg gaggtgtata tgaaggagtt tttaaaacat acagtcctaa
      601 gtgtgatttg gtacttgatg ctgcacatga gaaaagtaca gaatccagtt cggggccaaa
      661 acgtgaagaa ataatggaga gtgttttgtt caaatgctca gacttcgttg tggtacaatt
      721 taaagataca gactcgagtt atgcacgaag agatgctttc actgactctg ctctcagtgc
      781 taaagtgaat ggtgaacaca aggagaagga cctggagccc tgggatgcag gggagctcac
      841 agccagcgag gagctggagg ctctggagaa tgatgtgtct aacggatggg atcccaatga
      901 tatgtttcga tataatgaag agaattacgg tgtggtgtcc acatacgata gtagtttatc
      961 ttcatatacg gttcccttag aaagggacaa ctcagaagaa tttctaaaac gggaggcaag
     1021 ggcaaaccag ttagcagaag aaatcgagtc cagtgctcag tacaaagctc gtgtggccct
     1081 tgagaatgat gaccggagtg aggaagagaa gtacacagca gtccagagaa actgcagtga
     1141 ccgggaaggt catggcacca acactaggga aaataaatat attcctcctg gacaaagaaa
     1201 cagagaagtc atatcctggg gaagtgggag acagagctca ccacggatgg gccagcctgg
     1261 accaggctcc atgccatcaa gagctacttc tcacacttca gatttcaacc cgaatgctgg
     1321 ctcagaccaa agagtagtta atggaggtgt tccctggcca tcgccttgcc catctccttc
     1381 ctctcgccca ccttctcgct accagtcagg tcccaactct cttccacctc gggcagccac
     1441 ccctacacgg ccgccctcca ggcccccctc gaggccctcc agacccccgt ctcacccctc
     1501 tgctcatggt tctccagctc ctgtctctac tatgcctaaa cgcatgtctg cagaaggccc
     1561 accaaggatg tctccaaagg cacagcggca ccctcggaat catagagtct ccgctgggag
     1621 aggctccatg tctagtggcc tagaatttgt atcccacaat cccccaagtg aagcagctgc
     1681 tcctccagtg gcaaggacca gtcctgcagg gggaacgtgg tcctcagtgg tcagtggggt
     1741 tccaagacta tctcccaaaa ctcacagacc caggtctccc aggcagaaca gcgctggaaa
     1801 ctctcccagc gggcctgtgc tcgcttctcc ccaagctggc atcacccctg ccgaagccgt
     1861 ttccatgccg gtccccgccg cgtcccctac tcctgccagc cctgcgtcca acagagctct
     1921 gaccccatct atcgaggcga aagattccag gcttcaagat cagaggcaga actctcctgc
     1981 agggaataaa gaaaatatta aagcaagtga aacatcacct agcttttcaa aagctgaaaa
     2041 caaaggtgtg tcaccagtta tctctgaaca cagaaaacag atcgatgatt taaagaagtt
     2101 taagaatgat tttaggttac agccaagttc tacgtctgaa tctatggatc aactactaag
     2161 caaaaacaga gaaggagaaa agtcacgaga tttgatgaaa gacaaaacgg aagcaagtgc
     2221 taaggacagc ttcattgaca gtggcagcag cagctgcacc agcagcagca gcaagaccaa
     2281 cagccccagc gcctcccctt ctgtgcttag taatgcagag cacaagaggg ggcctgaggt
     2341 cacgtcccag ggggtgcaga cttccagtcc ggcctgcaaa caagagaagg atgaccgaga
     2401 agagcggaaa gacacaaccg agcaagttag gaagtcgact ttgaatccca atgcaaagga
     2461 gttcaaccct cgttctttct ctcagccaaa gccttctact accccaacgt cgcctcggcc
     2521 tcaagcccag cccagcccgt ccatggtggg tcatcagcag ccagctccag tgtacacgca
     2581 gcctgtgtgc tttgcaccca atatgatgta ccctgtccca gtgagcccag gcgtgcagcc
     2641 tttataccca atacctatga cgcccatgcc agtgaaccaa gccaagacat atagagcagg
     2701 taaagtacca aatatgcccc aacagcgaca agagcagcac catcaaagca ccatgatgca
     2761 ccctgcctcc gcagcagggc cgcctatcgt tgccaccccg cccgccgctt actccacgca
     2821 gtacgttgcc tacagccctc agcagtttcc caaccagcct ttggtccagc acgtgccgca
     2881 ttatcagtct cagcatcctc atgtgtacag tcctgtcata caaggtaatg ccaggatgat
     2941 ggcaccacca gcacatgctc agcctggttt agtgtcgtct tcagctgctc agttcggggc
     3001 tcacgagcag acgcatgcca tgtatgcatg tcccaaatta ccatacaaca aggagacaag
     3061 cccttctttc tactttgcca tttccaccgg ctccctcgct cagcagtacg cacatcctaa
     3121 tgccaccctg catccacacc ctccacatcc tcagccttcg gccactccca ccggacagca
     3181 acaaagccag catggtggaa gtcatcctgc acccagtcct gttcagcacc atcagcacca
     3241 ggccgcccag gctcttcacc tggccagtcc acagcagcag tcggccattt atcacgcggg
     3301 gctggcacca acaccacctt ccatgacacc tgcctctaat acacagtctc cacagagcag
     3361 tttcccagca gcaccacaga cagtcttcac catccatcct tctcatgttc agccggcata
     3421 caccacccca ccccacatgg cccacgtacc tcaggctcat gtacagtcag gaatggttcc
     3481 ttctcatcca actgcccatg cgccaatgat gcttatgacg acacagccac ccggcggtcc
     3541 ccaggccgcc ctcgctcaaa gtgcactaca gcccattcca gtctcgacaa cagcgcattt
     3601 cccctatatg acgcaccctt cagtacaagc ccaccaccaa cagcagttgt aagtctgccc
     3661 tggaggaacc gaaaggccaa atcccctcct cccttctact gcttctgcca actggaagca
     3721 cagaaaacta gaacttcatt tattttgttt ttttttttaa aaaagataca ctgatttaac
     3781 atcggtagga atgctaacag ttcacttgca gtggaggatg ttctggaccg agtagaggca
     3841 tgtagggact tgtggctgtt ccataactcc atgtgctgtt gcagggtcct caagtaccca
     3901 gctctgcttg ctgaaactgg aagttattta ttttttaatg gcccttgaga gtcatgaaca
     3961 catcagctag caacagaagt aacaagagtg attcttgctg ctattaccgc tttaaaaaaa
     4021 aaaaaatcaa gacttggaac gcccttttac taaacttgac agaagttcag taaattctta
     4081 ccgccaaact gacggattat tatttataaa tcaagtttga tgaggcgatc actgtctaca
     4141 gtgattcaac ttttaagtta agggaaaact tttactttgt agataatata aaataaaaac
     4201 taaaaaaaaa ttaaaaaata aaaaaagttt taaaaactga
//
