LOCUS       NM_133313               1841 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus ataxin 10 (Atxn10), mRNA.
ACCESSION   NM_133313
VERSION     NM_133313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Cheng,X., Gan,L., Zhao,J., Chen,M., Liu,Y. and Wang,Y.
  TITLE     Changes in Ataxin-10 expression after sciatic nerve crush in adult
            rats
  JOURNAL   Neurochem Res 38 (5), 1013-1021 (2013)
   PUBMED   23462879
  REMARK    GeneRIF: findings suggested that Ataxin-10 may be involved in the
            pathophysiology of sciatic nerve after SNC.
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Marz,P., Stetefeld,J., Bendfeldt,K., Nitsch,C., Reinstein,J.,
            Shoeman,R.L., Dimitriades-Schmutz,B., Schwager,M., Leiser,D.,
            Ozcan,S., Otten,U. and Ozbek,S.
  TITLE     Ataxin-10 interacts with O-linked beta-N-acetylglucosamine
            transferase in the brain
  JOURNAL   J Biol Chem 281 (29), 20263-20270 (2006)
   PUBMED   16714295
  REMARK    GeneRIF: Neurodegenerative disease protein ataxin-10 (Atx-10) is
            associated with cytoplasmic O-linked beta-N-acetylglucosamine
            transferase in in the brain
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Waragai,M., Nagamitsu,S., Xu,W., Li,Y.J., Lin,X. and Ashizawa,T.
  TITLE     Ataxin 10 induces neuritogenesis via interaction with G-protein
            beta2 subunit
  JOURNAL   J Neurosci Res 83 (7), 1170-1178 (2006)
   PUBMED   16498633
  REMARK    GeneRIF: Our data suggest that the ataxin 10-Gbeta2 interaction
            represents a novel mechanism for inducing neuritogenesis in PC12
            cells by activating the Ras-MAP kinase-Elk-1 cascade
REFERENCE   7  (bases 1 to 1841)
  AUTHORS   Matsuura,T., Fang,P., Pearson,C.E., Jayakar,P., Ashizawa,T.,
            Roa,B.B. and Nelson,D.L.
  TITLE     Interruptions in the expanded ATTCT repeat of spinocerebellar
            ataxia type 10: repeat purity as a disease modifier?
  JOURNAL   Am J Hum Genet 78 (1), 125-129 (2006)
   PUBMED   16385455
REFERENCE   8  (bases 1 to 1841)
  AUTHORS   Marz,P., Probst,A., Lang,S., Schwager,M., Rose-John,S., Otten,U.
            and Ozbek,S.
  TITLE     Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative
            disorder protein, is essential for survival of cerebellar neurons
  JOURNAL   J Biol Chem 279 (34), 35542-35550 (2004)
   PUBMED   15201271
  REMARK    GeneRIF: knock down of SCA10 in primary neuronal cells resulted in
            an increased apoptosis of cerebellar neurons
REFERENCE   9  (bases 1 to 1841)
  AUTHORS   Matsuura,T., Yamagata,T., Burgess,D.L., Rasmussen,A., Grewal,R.P.,
            Watase,K., Khajavi,M., McCall,A.E., Davis,C.F., Zu,L., Achari,M.,
            Pulst,S.M., Alonso,E., Noebels,J.L., Nelson,D.L., Zoghbi,H.Y. and
            Ashizawa,T.
  TITLE     Large expansion of the ATTCT pentanucleotide repeat in
            spinocerebellar ataxia type 10
  JOURNAL   Nat Genet 26 (2), 191-194 (2000)
   PUBMED   11017075
REFERENCE   10 (bases 1 to 1841)
  AUTHORS   Zu,L., Figueroa,K.P., Grewal,R. and Pulst,S.M.
  TITLE     Mapping of a new autosomal dominant spinocerebellar ataxia to
            chromosome 22
  JOURNAL   Am J Hum Genet 64 (2), 594-599 (1999)
   PUBMED   9973298
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC062087.1.
            
            On Jun 10, 2007 this sequence version replaced NM_133313.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062087.1, SRR8487230.148576.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1841
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /note="ataxin 10"
                     /db_xref="GeneID:170821"
                     /db_xref="RGD:621813"
     exon            1..207
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1519
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /note="neuronal beta-catenin-like protein; spinocerebellar
                     ataxia type 10 protein homolog; spinocerebellar ataxia 10
                     homolog; ataxin 10 homolog"
                     /codon_start=1
                     /product="ataxin-10"
                     /protein_id="NP_579847.1"
                     /db_xref="GeneID:170821"
                     /db_xref="RGD:621813"
                     /translation="MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPR
                     TIFQRVLDILKKSTQAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSI
                     RNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEDSQSIVWVHAFPE
                     LFMSCLNHPDKKIVAYCSMILFTSLNSERMKDLEENLNIAINVIEAHQKHPESEWPFL
                     IITDHFLKSPELVEAMYGKLSNQERVTLLDIMIAKIVGDEQLTKDDISIFLRHAELIA
                     NSFVDQCRNVLKLTSEPQTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVI
                     DVLRVIHSVGKDSTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKV
                     NELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDFIAKMEEQGLADASLL
                     KKMGFEVEKSGDKLILKSNNDIPPP"
     exon            208..399
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            400..482
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            483..579
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            580..738
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            739..819
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            820..985
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1094
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1264
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1328
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1516
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1811
                     /gene="Atxn10"
                     /gene_synonym="Sca10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcgtctct gtctcctcgc ctgtcgtctg tctccccttc tctcgctctt ctctccgcct
       61 cgtcaggctc gcccagagag cgagtggcaa gatggcggcg cccaggatgc caccctcccg
      121 gctgtcgggc atcatggtgc cagcacctat ccaggacctg gaggccctgc gcgcgctcac
      181 ggcgctcttc aaggagcagc gtaaccggga aacagcaccc agaacgatct tccagagagt
      241 cctggatatc ttaaagaaat ccactcaggc tgttgagctg gcctgcagag atccctccca
      301 agtggagcac ctggcttcca gtcttcagct gatcaccgag tgcttcagat gccttcgtaa
      361 tgcttgtata gagtgttctg tgaaccagaa ttcaatcagg aacctggata ccattggagt
      421 tgccgttgat ttggttcttc tctttcgtga acttcgggtg gaacaagact ctttgttgac
      481 agctttccgc tgtggcctgc agtttttagg caacgttgcc tcacggaatg aagattccca
      541 gtccattgtt tgggtccacg ccttcccaga actcttcatg tcttgcttaa atcatccaga
      601 caaaaagatt gttgcctact gttccatgat tctgttcaca tctcttaatt ctgaaaggat
      661 gaaggacctg gaagagaacc tcaatattgc aattaacgtc atagaagctc accaaaagca
      721 cccagagtca gagtggccgt tcttgatcat tacagaccac tttctgaaaa gcccggaatt
      781 ggtggaagct atgtatggca aactcagcaa tcaggaaagg gtcacactgt tagacatcat
      841 gatagccaag atcgtgggtg acgagcagtt gacaaaggat gacatctcta tatttttgcg
      901 ccatgctgag ttgattgcaa actcattcgt ggatcagtgt cggaatgtgc tgaagttgac
      961 ctcagaacct cagacggagg acaaggaagc actggttacg attcggctcc tggatgtctt
     1021 gtgtgaaatg acgtccaaca ctgagctgct cggctacctg caggtttttc ctggcctgat
     1081 ggaacgcgtg attgatgttt tacgagtgat tcattcagtt ggaaaagata gcacgaacat
     1141 cttcagtccc tccgactctc taaaagcaga gggtgatatc gaacacatga ctgaagggtt
     1201 taagtctcac ctcatccgtc tgattggaaa tctgtgctac aagaataaag aaaaccaaga
     1261 caaagtgaat gagctggatg gcattcctct gatcctggac agcagcaaca tcgatgacaa
     1321 caaccccttt atgatgcagt gggtggtgta tgccgtgcga aatctcactg aagacaacag
     1381 ccaaaaccaa gatttcattg ccaagatgga ggagcagggg ttggcagatg cgtccctact
     1441 gaagaagatg ggctttgagg ttgagaagag tggggacaaa ctgattctga agtccaataa
     1501 tgacatcccc ccaccttgaa tgccctcttc gtctgaacac actcagattc catctcacgg
     1561 acctctcgtc tctgcggtgt atgaactcag aagtatcgga agtgtaggcg ccgatgcggg
     1621 gcctcccgtc agttctttag aattaatgtg tgtaagctac aagtgagcgt tttctttagt
     1681 tctctgcagt gagtatcact gtctgcctca cctttgttcc tctgggtggg actcttccca
     1741 gtcatatgca ttgtgcttac tgtcgtagtg agtaataaac gtttttgtgg gcacagccct
     1801 cactcggcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
