LOCUS       NM_012726               4721 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ataxin 1 (Atxn1), mRNA.
ACCESSION   NM_012726
VERSION     NM_012726.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4721)
  AUTHORS   Marunouchi,T., Sasaki,K., Yano,E. and Tanonaka,K.
  TITLE     Transplantation of cardiac Sca-1-positive cells rather than
            c-Kit-positive cells preserves mitochondrial oxygen consumption of
            the viable myocardium following myocardial infarction in rats
  JOURNAL   J Pharmacol Sci 140 (3), 236-241 (2019)
   PUBMED   31375326
  REMARK    GeneRIF: The possibility that CrCDC and Sca-1(+) cells rather than
            c-Kit(+) cells may be used therapeutically to preserve cardiac
            function and energy metabolism after myocardial infarction.
REFERENCE   2  (bases 1 to 4721)
  AUTHORS   Lu,H.C., Tan,Q., Rousseaux,M.W., Wang,W., Kim,J.Y., Richman,R.,
            Wan,Y.W., Yeh,S.Y., Patel,J.M., Liu,X., Lin,T., Lee,Y., Fryer,J.D.,
            Han,J., Chahrour,M., Finnell,R.H., Lei,Y., Zurita-Jimenez,M.E.,
            Ahimaz,P., Anyane-Yeboa,K., Van Maldergem,L., Lehalle,D.,
            Jean-Marcais,N., Mosca-Boidron,A.L., Thevenon,J., Cousin,M.A.,
            Bro,D.E., Lanpher,B.C., Klee,E.W., Alexander,N., Bainbridge,M.N.,
            Orr,H.T., Sillitoe,R.V., Ljungberg,M.C., Liu,Z., Schaaf,C.P. and
            Zoghbi,H.Y.
  TITLE     Disruption of the ATXN1-CIC complex causes a spectrum of
            neurobehavioral phenotypes in mice and humans
  JOURNAL   Nat Genet 49 (4), 527-536 (2017)
   PUBMED   28288114
REFERENCE   3  (bases 1 to 4721)
  AUTHORS   Lee,Y., Fryer,J.D., Kang,H., Crespo-Barreto,J., Bowman,A.B.,
            Gao,Y., Kahle,J.J., Hong,J.S., Kheradmand,F., Orr,H.T.,
            Finegold,M.J. and Zoghbi,H.Y.
  TITLE     ATXN1 protein family and CIC regulate extracellular matrix
            remodeling and lung alveolarization
  JOURNAL   Dev Cell 21 (4), 746-757 (2011)
   PUBMED   22014525
REFERENCE   4  (bases 1 to 4721)
  AUTHORS   Shiwaku,H., Yoshimura,N., Tamura,T., Sone,M., Ogishima,S.,
            Watase,K., Tagawa,K. and Okazawa,H.
  TITLE     Suppression of the novel ER protein Maxer by mutant ataxin-1 in
            Bergman glia contributes to non-cell-autonomous toxicity
  JOURNAL   EMBO J 29 (14), 2446-2460 (2010)
   PUBMED   20531390
REFERENCE   5  (bases 1 to 4721)
  AUTHORS   Crespo-Barreto,J., Fryer,J.D., Shaw,C.A., Orr,H.T. and Zoghbi,H.Y.
  TITLE     Partial loss of ataxin-1 function contributes to transcriptional
            dysregulation in spinocerebellar ataxia type 1 pathogenesis
  JOURNAL   PLoS Genet 6 (7), e1001021 (2010)
   PUBMED   20628574
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4721)
  AUTHORS   Matilla,A., Roberson,E.D., Banfi,S., Morales,J., Armstrong,D.L.,
            Burright,E.N., Orr,H.T., Sweatt,J.D., Zoghbi,H.Y. and Matzuk,M.M.
  TITLE     Mice lacking ataxin-1 display learning deficits and decreased
            hippocampal paired-pulse facilitation
  JOURNAL   J Neurosci 18 (14), 5508-5516 (1998)
   PUBMED   9651231
REFERENCE   7  (bases 1 to 4721)
  AUTHORS   Skinner,P.J., Koshy,B.T., Cummings,C.J., Klement,I.A., Helin,K.,
            Servadio,A., Zoghbi,H.Y. and Orr,H.T.
  TITLE     Ataxin-1 with an expanded glutamine tract alters nuclear
            matrix-associated structures
  JOURNAL   Nature 389 (6654), 971-974 (1997)
   PUBMED   9353120
  REMARK    Erratum:[Nature 1998 Jan 15;391(6664):307]
REFERENCE   8  (bases 1 to 4721)
  AUTHORS   Burright,E.N., Davidson,J.D., Duvick,L.A., Koshy,B., Zoghbi,H.Y.
            and Orr,H.T.
  TITLE     Identification of a self-association region within the SCA1 gene
            product, ataxin-1
  JOURNAL   Hum Mol Genet 6 (4), 513-518 (1997)
   PUBMED   9097953
REFERENCE   9  (bases 1 to 4721)
  AUTHORS   Gossen,M., Schmitt,I., Obst,K., Wahle,P., Epplen,J.T. and Riess,O.
  TITLE     cDNA cloning and expression of rsca1, the rat counterpart of the
            human spinocerebellar ataxia type 1 gene
  JOURNAL   Hum Mol Genet 5 (3), 381-389 (1996)
   PUBMED   8852664
REFERENCE   10 (bases 1 to 4721)
  AUTHORS   Servadio,A., Koshy,B., Armstrong,D., Antalffy,B., Orr,H.T. and
            Zoghbi,H.Y.
  TITLE     Expression analysis of the ataxin-1 protein in tissues from normal
            and spinocerebellar ataxia type 1 individuals
  JOURNAL   Nat Genet 10 (1), 94-98 (1995)
   PUBMED   7647801
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012726.2.
            
            Sequence Note: The sequence X91619.1 is from a chimeric clone. Only
            the ataxin 1 region was propagated into this RefSeq record.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.52015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JAXUCZ010000017.1  18943769-18943961
            194-322             JAXUCZ010000017.1  18952696-18952824
            323-416             JAXUCZ010000017.1  18985899-18985992
            417-545             JAXUCZ010000017.1  19056349-19056477
            546-674             JAXUCZ010000017.1  19112325-19112453
            675-738             JAXUCZ010000017.1  19169286-19169349
            739-859             JAXUCZ010000017.1  19208200-19208320
            860-2861            JAXUCZ010000017.1  19333303-19335304
            2862-4721           JAXUCZ010000017.1  19346673-19348532
FEATURES             Location/Qualifiers
     source          1..4721
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..4721
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /note="ataxin 1"
                     /db_xref="GeneID:25049"
                     /db_xref="RGD:3624"
     exon            1..193
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..322
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..416
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..545
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            546..674
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..738
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..859
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..2861
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1023..3392
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /note="spinocerebellar ataxia type 1 protein homolog;
                     spinocerebellar ataxia 1"
                     /codon_start=1
                     /product="ataxin-1"
                     /protein_id="NP_036858.1"
                     /db_xref="GeneID:25049"
                     /db_xref="RGD:3624"
                     /translation="MKSNQERSNECLPPKKREIPATSRPSEEKATALPSDNHCVEGVA
                     WLPSTPGSRGHGGGRHGPAGTSGEHGLQGMGLHKALSAGLDYSPPSAPRSVPTANTLP
                     TVYPPPQSGTPVSPVQYAHLSHTFQFIGSSQYSGPYAGFIPSQLISPPGNPVTSAVAS
                     AAGATTPSQRSQLEAYSTLLANMGSLSQAPGHKVEPPPQQHLGRAAGLVNPGSPPPTQ
                     QNQYIHISSSPQSSGRATSPPIPVHLHPHQTMIPHTLTLGPSSQVVVQYSDAGGHFVP
                     RESTKKAESSRLQQAMQAKEVLNGEMEKSRRYGASSSVELSLGKTSSKSVPHPYESRH
                     VVVHPSPADYSSRDTSGVRGSVMVLPNSSTPSADLETQQATHREASPSTLNDKSGLHL
                     GKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGAQPPVIGYLSSQQQAITYAG
                     GLPQHLVIPGTQPLLIPVGSPDMDTPGAASAIVTSSPQFAAVPHTFVTTALPKSENFN
                     PEALVTQAAYPAMVQAQIHLPVVQSVASPAAASPTLPPYFMKGSIIQLANGELKKVED
                     LKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPF
                     FVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASALL
                     KHAKTDSLAGSRHRYAEQENGINQGSAQVLSENGELKFPEKIGLPAAPFLTKIEPSKP
                     TATRKRRWSAPETRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK"
     exon            2862..4721
                     /gene="Atxn1"
                     /gene_synonym="Sca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggagagag cagagtatac cgcagacatc atttctacta cagtggagga gccgtacagg
       61 acctgtttca ctgcaggggg atccaaaaca agccccgtgg agccgcagct agagctacaa
      121 cagccgcagg acactgtgtc tctccctctg ttcccccttc cccacgcaac cccagatcca
      181 tttacacttt acatccgtag acgtatcctg caccgttcaa cgagtcacca gggtggtccc
      241 ttcacgctac gaatctgtct gccatcctga tccaacagtc tcttcctcca ctccctctgc
      301 agagaagggc atcacatgtc agacagcctg taagaaccac tcactgagaa ccaagacgca
      361 gaagtgcctg agaaaaacca ctcagaggga tgccgattcg gacctaatta caggaaattg
      421 cagcatcctg gaacggaatg aaaggatctg tgcagagacg gcaaaagtcg ggttacagta
      481 gaccctgagc aaaacagagt ggactccagc ctgcgtggat gatcttgaaa caggaatggt
      541 ttggggttcg ggcctcttac actgaatttc cctactgcca ccctttctac tcaagcaaaa
      601 tcttcaagaa aagatcgcct gggagggagg tagctgcttg tggctttgca ctgtgatgag
      661 ggcaaatgat acagttttcc aaagaaaata gaccaaaact ttcttcttga caagaaacaa
      721 acctgctgtc gtcagagggt atttctaacc tctctgtgaa agaaagacaa caccagagcc
      781 tgggcggccc agttgctgag ggaagtttcc atggtgaagt ctcagggagg cttcctggga
      841 gcagaacata gtgaatgcta atccggagct gctactgcca gcctagagaa cccacgggga
      901 gatgattcct catgaagggc ctggatcccc tacagaaatc caatgtgact ctctgtttat
      961 cagactaaaa ccagagccag ccagacagtg aaacagccac cgtggagggg ggacggcgaa
     1021 aaatgaaatc taaccaagag cggagcaatg aatgcctgcc tcccaagaaa cgtgagatcc
     1081 ccgccaccag tcggccctcc gaggagaagg ccactgctct gcccagcgac aaccactgcg
     1141 tggagggtgt ggcatggctc cccagcaccc ctggcagccg cggccacggg ggtgggcggc
     1201 acgggccagc agggacttcc ggggaacatg gtttacaagg aatgggttta cataaagcac
     1261 tgtccgcagg gctggattac tccccaccca gtgcccccag gtcggtcccc acagccaaca
     1321 cgctgcccac cgtgtaccct cctcctcagt cagggacgcc ggtgtctcct gtgcagtacg
     1381 cccacctatc acataccttc cagttcattg ggtcctccca gtatagtggg ccttacgcgg
     1441 gctttatccc ttcccagctg atctccccac caggcaaccc agtcaccagt gcggtggcct
     1501 cggctgcagg ggccaccact ccatcacagc gctcccagct ggaggcatat tccaccctgc
     1561 tggccaacat gggcagtctg agccaggcac caggacacaa ggttgagccc cctccgcagc
     1621 agcacctcgg cagggctgcg ggattagtca acccggggtc ccctccacct acccagcaga
     1681 accagtacat tcacatttcc agctctccac agagctccgg gcgggcaaca tctccaccca
     1741 tcccggtcca cctccatccc catcagacga tgatcccgca cacgctcacc ctggggcctt
     1801 catcccaggt ggtcgtgcaa tacagtgacg ccggaggcca ctttgttcct cgagagtcca
     1861 ccaaaaaagc agaaagcagc aggttgcagc aggctatgca ggccaaggag gtcctcaatg
     1921 gggagatgga gaaaagccgg aggtatgggg cgtcatcttc tgtggagctg agcctgggga
     1981 agacgagcag caagtcagtg cctcacccct atgagtccag gcatgtggtg gtccacccga
     2041 gcccagcaga ctacagcagt cgtgatacct ccggggtccg tggatctgtg atggtcctgc
     2101 ccaacagcag cacaccctca gccgacctgg agacacagca ggccacacat cgagaggcct
     2161 ccccatccac cctcaatgac aagagcggtt tgcacctagg gaagcccggc cacaggtcct
     2221 acgcgctgtc cccacacacg gtcattcaga ccacacacag cgcatcagag cctctcccgg
     2281 tgggcctacc agccacggcc ttctatgctg gcgctcaacc tcctgtcatc ggctatctga
     2341 gtagccagca gcaagcaatc acctatgctg gtggtctgcc ccagcacctg gtgatcccag
     2401 gtacccagcc cctgctcatc ccagtgggca gccctgacat ggacacacct ggggcagcct
     2461 cggccatagt gacgtcatcg ccccagtttg ctgcagtacc tcacacgttt gtcaccaccg
     2521 ccctgcccaa gagcgagaac ttcaacccag aggctctggt cacccaggca gcctacccag
     2581 ccatggtgca ggcccagatc cacctgccgg tggtacagtc cgtggcatcc cctgccgcgg
     2641 catcacccac gctgccgcca tatttcatga aaggctccat catccagctg gccaacgggg
     2701 agctgaagaa ggtagaggat ctgaagacag aggatttcat ccagagtgca gagattagca
     2761 atgacctcaa gatcgactcc agtactgtgg agaggatcga ggacagccac agccccggtg
     2821 tggccgtgat acaatttgct gttggtgaac accgagccca ggtcagtgtc gaagttttgg
     2881 tagagtatcc tttttttgta tttggacagg gctggtcatc ctgctgtccc gagcggacca
     2941 gccagctctt tgatctgccg tgttccaaac tctccgttgg ggacgtctgc atctcgctca
     3001 ccctcaagaa cctgaagaat ggctctgtta aaaagggcca gcccgtggac cctgccagtg
     3061 ccctgctgaa gcacgcaaag accgacagcc tggctggcag cagacacaga tacgccgagc
     3121 aggaaaacgg aatcaaccag gggagcgccc aggtgctctc tgagaacggc gaactgaagt
     3181 ttccagaaaa aattggattg cctgcagcac ccttcctcac caaaatagaa ccgagcaagc
     3241 ccacagccac gaggaagagg aggtggtcgg cgccggagac ccgtaaactg gagaagtcgg
     3301 aggacgagcc acctttgact cttcccaagc cttcgctcat tcctcaggag gttaagatct
     3361 gcatcgaagg ccgatctaac gtgggcaagt agagaccgtg cgggcagccg aggcgtgggc
     3421 cccgtttgct gtctgtatcc agattactgt actgtaggct aaataacaca gtatttacat
     3481 gttatcctct ttaggttcgt gttctaacct tgtcattaga gtcaaacagg tgtgtggcag
     3541 gaaactggtg cgtccgcgtt gtgatgtctg tcgaggagct ggcgggtgga gggtggtcat
     3601 aaccgtggcc atggagctcc ggggcatcct aaggggccct gaaggggggc ttcatcagca
     3661 cctgccttct ccagcagcac agagctgagg ggcgtcagtt cccactggtt tcaagagcaa
     3721 actcagtggg aagtaacttg caagtaacct gcaagggtgt gtctgggtgc gtccctggtg
     3781 aagaaggggt gcgcaggtgc catggcggtg agggagggtc tctctttctc tgcctctgtc
     3841 tccctcactt gctcactctc agcatgggat tgggggacct gggtttccca catgcaaagt
     3901 ggtcaggaac ccagcttcca ggcactgtag ggaaggcatc agactggcag atgggaaact
     3961 agtttcaaag aacgtggttc tctccaacat attttacaat aaaaagcaac ttttaatcat
     4021 agatatagat atatatatat ttccccccat ggggcctgac tgcactgagt tttttgttgt
     4081 tgttgtttta ttttgttatt ttgggttttt tgttttgttt tgttttgttt tgttttgttt
     4141 tgttttgttt tttaagagca gctgccactt ggcaaggatt tcgtccctcc ctgctttacc
     4201 agtccagtga catcgccatg gtgtcgtggt gggcagggac gtccttgctc aggtcactcc
     4261 tggtcaggca ggtagcagtg gggcccaggg acagagggag caccaacact ggtttctgcg
     4321 cagtgttagg aaacccaatc aggttatttg cattgctccc aagaagaaaa tgccagctcc
     4381 cctccccact cccgagaggg tcagggcggc tctcagaccc agctggcagc ataattgtcc
     4441 acctcttagg tctagtactg ttcctgattc tgtgaggaat tcgatccgga agatgctcaa
     4501 tctgttacta tctcgtaaac agttaaaaat gccgtgcagt cttcttaacc aagcaccttg
     4561 ttctgtcatt caacaagtac tgtatctact ttcgactctt tgtgggggaa aaaaaagaca
     4621 aacctaagtt gcttttgatt ttcttcttct tcttcttctt cttcttcttc ttcttcttct
     4681 tcttcttctt cttcttcttc ttcttcttct tcttcctctt c
//
