LOCUS       NM_001105757           10573 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ATRX, chromatin remodeler (Atrx), mRNA.
ACCESSION   NM_001105757 XM_001057806 XM_017588263 XM_017602341 XM_217570
VERSION     NM_001105757.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10573)
  AUTHORS   Gong,Z., Shi,X., Xu,W., Fang,Y., Fang,M., Yao,M., Jiang,Y., Sui,H.
            and Luo,M.
  TITLE     LncRNA PWRN2 promotes polycystic ovary syndrome progression via
            epigenetically reducing ATRX by recruiting LSD1
  JOURNAL   Reprod Biol 23 (3), 100782 (2023)
   PUBMED   37320994
  REMARK    GeneRIF: LncRNA PWRN2 promotes polycystic ovary syndrome
            progression via epigenetically reducing ATRX by recruiting LSD1.
REFERENCE   2  (bases 1 to 10573)
  AUTHORS   Terra Md,S.B.S.P., Xie Md PhD,H., Boland Md,J.M., Mansfield
            Md,A.S., Molina Md PhD,J.R. and Roden Md,A.C.
  TITLE     Loss of ATRX expression predicts worse prognosis in pulmonary
            carcinoid tumors
  JOURNAL   Hum Pathol 94, 78-85 (2019)
   PUBMED   31499081
REFERENCE   3  (bases 1 to 10573)
  AUTHORS   Buentzel,J., Yao,S., Elakad,O., Lois,A.M., Brunies,J., Konig,J.,
            Hinterthaner,M., Danner,B.C., Strobel,P., Emmert,A. and
            Bohnenberger,H.
  TITLE     Expression and prognostic impact of alpha thalassemia/mental
            retardation X-linked and death domain-associated protein in human
            lung cancer
  JOURNAL   Medicine (Baltimore) 98 (31), e16712 (2019)
   PUBMED   31374064
REFERENCE   4  (bases 1 to 10573)
  AUTHORS   Du,M., Thompson,J., Fisher,H., Zhang,P., Huang,C.C. and Wang,L.
  TITLE     Genomic alterations of plasma cell-free DNAs in small cell lung
            cancer and their clinical relevance
  JOURNAL   Lung Cancer 120, 113-121 (2018)
   PUBMED   29748005
REFERENCE   5  (bases 1 to 10573)
  AUTHORS   Chaurasia,A., Park,S.H., Seo,J.W. and Park,C.K.
  TITLE     Immunohistochemical Analysis of ATRX, IDH1 and p53 in Glioblastoma
            and Their Correlations with Patient Survival
  JOURNAL   J Korean Med Sci 31 (8), 1208-1214 (2016)
   PUBMED   27478330
REFERENCE   6  (bases 1 to 10573)
  AUTHORS   Yntema,H.G., Poppelaars,F.A., Derksen,E., Oudakker,A.R., van
            Roosmalen,T., Jacobs,A., Obbema,H., Brunner,H.G., Hamel,B.C. and
            van Bokhoven,H.
  TITLE     Expanding phenotype of XNP mutations: mild to moderate mental
            retardation
  JOURNAL   Am J Med Genet 110 (3), 243-247 (2002)
   PUBMED   12116232
REFERENCE   7  (bases 1 to 10573)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   8  (bases 1 to 10573)
  AUTHORS   Guerrini,R., Shanahan,J.L., Carrozzo,R., Bonanni,P., Higgs,D.R. and
            Gibbons,R.J.
  TITLE     A nonsense mutation of the ATRX gene causing mild mental
            retardation and epilepsy
  JOURNAL   Ann Neurol 47 (1), 117-121 (2000)
   PUBMED   10632111
REFERENCE   9  (bases 1 to 10573)
  AUTHORS   Ohsawa,K., Imai,Y., Ito,D. and Kohsaka,S.
  TITLE     Molecular cloning and characterization of annexin V-binding
            proteins with highly hydrophilic peptide structure
  JOURNAL   J Neurochem 67 (1), 89-97 (1996)
   PUBMED   8667030
REFERENCE   10 (bases 1 to 10573)
  AUTHORS   Villard,L., Gecz,J., Mattei,J.F., Fontes,M., Saugier-Veber,P.,
            Munnich,A. and Lyonnet,S.
  TITLE     XNP mutation in a large family with Juberg-Marsidi syndrome
  JOURNAL   Nat Genet 12 (4), 359-360 (1996)
   PUBMED   8630485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Nov 16, 2019 this sequence version replaced
            XM_017602341.1, XM_017588263.1, NM_001105757.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760386, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000021.1  75062604-75062880   c
            278-390             JAXUCZ010000021.1  75020760-75020872   c
            391-446             JAXUCZ010000021.1  75010459-75010514   c
            447-499             JAXUCZ010000021.1  75009010-75009062   c
            500-624             JAXUCZ010000021.1  75008163-75008287   c
            625-738             JAXUCZ010000021.1  75005255-75005368   c
            739-848             JAXUCZ010000021.1  75001011-75001120   c
            849-916             JAXUCZ010000021.1  74999425-74999492   c
            917-3945            JAXUCZ010000021.1  74995507-74998535   c
            3946-4018           JAXUCZ010000021.1  74989163-74989235   c
            4019-4155           JAXUCZ010000021.1  74978463-74978599   c
            4156-4329           JAXUCZ010000021.1  74977886-74978059   c
            4330-4423           JAXUCZ010000021.1  74975231-74975324   c
            4424-4526           JAXUCZ010000021.1  74973846-74973948   c
            4527-4748           JAXUCZ010000021.1  74972932-74973153   c
            4749-4890           JAXUCZ010000021.1  74968906-74969047   c
            4891-5000           JAXUCZ010000021.1  74968015-74968124   c
            5001-5147           JAXUCZ010000021.1  74967222-74967368   c
            5148-5325           JAXUCZ010000021.1  74966907-74967084   c
            5326-5463           JAXUCZ010000021.1  74961417-74961554   c
            5464-5639           JAXUCZ010000021.1  74959970-74960145   c
            5640-5757           JAXUCZ010000021.1  74958379-74958496   c
            5758-5888           JAXUCZ010000021.1  74955274-74955404   c
            5889-5977           JAXUCZ010000021.1  74953953-74954041   c
            5978-6150           JAXUCZ010000021.1  74953615-74953787   c
            6151-6304           JAXUCZ010000021.1  74946013-74946166   c
            6305-6411           JAXUCZ010000021.1  74944129-74944235   c
            6412-6520           JAXUCZ010000021.1  74942134-74942242   c
            6521-6698           JAXUCZ010000021.1  74940700-74940877   c
            6699-6893           JAXUCZ010000021.1  74939451-74939645   c
            6894-7043           JAXUCZ010000021.1  74923121-74923270   c
            7044-7169           JAXUCZ010000021.1  74922055-74922180   c
            7170-7265           JAXUCZ010000021.1  74921260-74921355   c
            7266-7394           JAXUCZ010000021.1  74920637-74920765   c
            7395-10573          JAXUCZ010000021.1  74916548-74919726   c
FEATURES             Location/Qualifiers
     source          1..10573
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..10573
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /note="ATRX, chromatin remodeler"
                     /db_xref="GeneID:246284"
                     /db_xref="RGD:619795"
     exon            1..277
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..7673
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /EC_number="3.6.4.12"
                     /note="pABP-2; ATP-dependent helicase ATRX; X-linked
                     nuclear protein; helicase II; transcriptional regulator
                     ATRX-like"
                     /codon_start=1
                     /product="transcriptional regulator ATRX"
                     /protein_id="NP_001099227.2"
                     /db_xref="GeneID:246284"
                     /db_xref="RGD:619795"
                     /translation="MTAEPMSESKLNTLVQKLHDFLAHSSEESEETCSSPRLVMNQST
                     DKISASGLNSDMMENSKEEGTSTSEKSKSSGSSRSKRKPSIVTKYVESDDEKPTDENV
                     NEKAATENSENDITMQSLPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRG
                     EDGLHGIVSCTACGQQVNHFQKDSIYRHPSLKVLICKNCFKYYMSDDISRDSDGMDEQ
                     CRWCAEGGNLICCDFCHNAFCKKCILRNLGRKELSTIMDENNQWYCYICQPEPLLDLV
                     TACNSVFENLEQLLQQNKKKIKVDSEKTSKVCDQTSKFSPKKNSSSCNGEEKKLEESG
                     SSSVTSTSSALIVPKELIKKTKKLIETTSNMNSSYIKFLKQAADNSEMSPAMKLRQLK
                     AFKSVLADIKKAHLALEEDLNSEIRALDAVHKEKNTKELKITDAKSETKMQKGEKSYN
                     TEKKDFFKLDARSSVKAVDSERIPGEEHEAHKSTSGEHKGRKDGPQYEPSNSAEDLDM
                     DIVSVPSSVPEDIFESLENAMEVQSSADYQGDGNSANEAELESSSLKLNTSKGSKGNV
                     KSKVTAKVRKELYVKLTPVSLSNSPLKGVDCQEAPQEKNARKSSGVARSSEKCRPREE
                     SSDNEHSVEHDVTILLEDSDLRRSPRVKTTPLRRQTESNPAVSNSDEEGNETIKEKQK
                     LSVPVRKKDKRNSSDCAIDNPKPHKVPKAKQPGIGDQNSDSDEMLAILKEASQMCHSS
                     SSDTDINELPINHKSQRGKDDNGKRKRKNSTSGSDFDTKKGKSAESSVISKKKRQNYS
                     ESSNYDSELEREIKTMSRIGAARKSVSDKEEHDFSEDEKQSKKVVDSRGHERRRSAQE
                     GSSGDDTGDAEGGPGGSSSPRQGSVEKGRSVVEFGDMVCKRQQSAVSSAGSEKPSGKE
                     ENVHSPEDKRVTKSKEKSKHLRTRTGRKVKSDVTDRFRKKEQSSESSEGEKKQGRQRT
                     GTRGKKSTDLKEEKVKREREYESSSDGTEKLPEGEEIGLFSKGVKQNKNDTTDGAKKG
                     KKWKDKSCEKKEELSDSVDRLPVKGESCDSSEDKKTRNRVSLREKKQFSLPAKSSGKR
                     PECSSSDTERSVKGECCDSTDKRVKRIDLRERRSSNSKRSTKEVKSGSSSSDAEGSSE
                     DAKKQKKQRMSAKKKTGNTKERKRKSLRATTTKRKQADITSSSSDIGDDDQNSAGEES
                     SDEQKIKPVTENLVLPSHTGFCQSSGDEAFSKSVPATVDDDDDDNDPENRIAKKMLLE
                     EIKANLSSDEDGSSDDEPEEGEKKRIGKQSEETPGDDGSNQVNSESDSDSEESKKPRY
                     RHRLLRHKLSLSDGESGEEKKTKPKEHKETKGRNRRKVSSEDSEDTDFQESGVSEEVS
                     ESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSDNKSHSEEERKDDDDE
                     EDEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREK
                     LREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQVDGVQFMWDC
                     CCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFSTALVVCPLNTAL
                     NWMNEFEKWQEGLNDAEKLEVSELATVKRPQERSYMLQRWQEDGGVMIIGYEMYRNLA
                     QGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIKSRRRIILTG
                     TPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHI
                     LYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTAIQCKLYQYYLDHLTGVGNSTDGG
                     RGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSL
                     SSDEYAKKKKTKGKKGRKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVEETGNNPSV
                     SLKLDESKTTSTSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKV
                     LVFSQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTNAQSR
                     KKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYR
                     FGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFE
                     PDLLDDPNSEKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEE
                     ERKAAWAEYEAEKKGLTMRFNIPTGTNLPPVTFTSQTPYIPFNLGALSAMSNQQLEDL
                     INQGREKVVEATNSVTSVRIQPLEDIISTVWKENMNLSEAQVQALALSRQASQELDVK
                     RREAIYNDVLTKQQMLISCVQRILMNRRLQQQYTQQQQQQLTYQQATLSHLMMPKPPN
                     LIMTPSNYQQIDMRGMYQSVAGGMQPPPLQRAPPPMRSKNPGPSPGKSM"
     exon            278..390
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            391..446
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            447..499
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            500..624
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            625..738
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            739..848
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            849..916
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            917..3945
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4018
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4019..4155
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4156..4329
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4423
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4526
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4748
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..4890
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            4891..5000
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5001..5147
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5148..5325
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5326..5463
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5464..5639
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5640..5757
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5758..5888
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5889..5977
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            5978..6150
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..6304
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6305..6411
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6412..6520
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6521..6698
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6699..6893
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            6894..7043
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            7044..7169
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            7170..7265
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            7266..7394
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
     exon            7395..10573
                     /gene="Atrx"
                     /gene_synonym="Xnp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaggaaga gggaggacgc gccaattctc ctgcccgagc ctcggcccaa caaaatggcg
       61 tcggcgtcgg cctcgctttg tctccgtggc tctggcagca gcagcagtgg tagcggcctc
      121 tgagctgtga ggacgatcca gcaccagctg cagtgactac taagatccca gtacttttcg
      181 ttcagccacg ggcgctgagg agcgcagaac ggtacccaag gggttgccga agccaagcgg
      241 ccgtccgagc caaaaacatg accgctgagc ccatgagtga aagcaagttg aatacattgg
      301 tgcagaagct tcatgacttc ttagcacact catcagaaga atctgaggaa acgtgttctt
      361 ctccacgact tgtcatgaac caaagcacag ataaaatcag tgcttctgga cttaattctg
      421 atatgatgga aaatagcaag gaagagggaa ctagcacctc agaaaaatct aagtcttcag
      481 gatcatcgag atcaaagagg aaaccttcaa ttgtgacaaa atatgtagaa tccgatgatg
      541 aaaaacccac ggatgagaat gtaaatgaaa aagctgctac tgagaattca gaaaatgaca
      601 ttactatgca aagcttgcca aaaggtacag tgattgtaca accagagcca gtgctgaatg
      661 aagacaaaga tgattttaaa gggcctgaat ttagaagcag aagtaaaatg aaaactgaaa
      721 atctcaaaaa acgcggagaa gatggacttc atgggatcgt gagttgcaca gcttgtggac
      781 aacaggtcaa tcattttcaa aaagattcca tttatagaca cccttcactg aaagtactta
      841 tttgtaagaa ctgctttaag tattacatga gtgacgacat tagccgtgac tcagatggaa
      901 tggatgaaca atgtagatgg tgtgcagaag gtgggaactt gatttgttgc gacttttgcc
      961 ataatgcctt ctgtaagaaa tgcatactgc gcaacctcgg tcgaaaggag ttatctacaa
     1021 taatggatga aaacaatcag tggtattgct atatttgtca gccagagcct ctattggact
     1081 tggttaccgc atgtaacagt gtatttgaga atttggaaca gttgttgcag caaaacaaga
     1141 agaagataaa agtcgacagt gaaaagacta gtaaagtatg tgaccaaaca tccaagtttt
     1201 ctccaaagaa gaatagttcc agttgtaatg gagaagaaaa gaaattagag gagtcaggtt
     1261 ccagttctgt aacctccact tcctcagcac ttattgtgcc caaagagctg attaagaaga
     1321 caaagaaact gattgagact acatccaaca tgaactccag ttacattaag tttctaaagc
     1381 aggcagccga taattcagaa atgagtcctg ctatgaagtt acgtcaactg aaggctttta
     1441 aatctgtgtt ggctgatatc aagaaggctc atcttgcatt agaggaagat ttgaattcag
     1501 agatccgagc tttggatgct gtacacaagg aaaaaaatac caaagagctt aaaatcacag
     1561 atgctaagtc tgagacaaaa atgcaaaagg gggaaaaatc ctataataca gaaaagaaag
     1621 atttttttaa gttagatgct aggtcgtcag taaaggctgt agatagtgag cgcatcccag
     1681 gagaagaaca cgaagcacat aaaagtacta gtggtgaaca taagggtagg aaagatggcc
     1741 ctcagtacga acccagtaac agtgctgagg acttagatat ggatattgtg tctgttcctt
     1801 cctcggttcc agaagacatc tttgagagcc ttgagaatgc catggaagtt cagagttcag
     1861 ctgattatca aggggatggc aacagtgcga atgaggcaga actggagagc tcatctctaa
     1921 agttaaacac ttcaaaaggc agcaaaggga atgttaaatc aaaagtcaca gcaaaagtaa
     1981 gaaaagaatt atatgttaaa ctcaccccag tttccctgtc taattctcca cttaaaggtg
     2041 ttgactgtca ggaagctcca caagagaaga atgctcgtaa aagctctggg gtggcccgca
     2101 gctcagagaa atgtagaccc agagaggaga gtagtgataa tgagcattca gttgaacacg
     2161 atgtcacaat acttttagaa gactcagatc ttcgaagatc cccacgtgta aaaactacac
     2221 cattgaggcg acagacagaa agcaaccctg ctgtgtccaa ttcggatgaa gaaggtaacg
     2281 aaaccataaa ggagaaacaa aagctgtcag ttccagtaag gaaaaaggat aagcgaaact
     2341 catctgactg tgctattgat aaccctaaac ctcataaggt acccaaagct aagcaaccag
     2401 ggattgggga tcagaattca gattctgatg aaatgctagc aatcctcaaa gaggcaagcc
     2461 agatgtgtca cagttcttcc tcggacactg acattaatga actaccgata aatcataaaa
     2521 gtcaaagggg gaaagatgac aacggaaaaa ggaaacggaa aaattctact tctgggtcag
     2581 attttgacac taaaaaagga aaatcggctg aaagctctgt catttctaaa aagaaacgcc
     2641 aaaactactc agagtcctct aactatgact cagagttaga aagagagata aaaactatga
     2701 gcagaattgg ggctgccaga aaaagtgttt ctgataaaga agaacatgac ttctctgaag
     2761 atgaaaaaca aagcaaaaaa gtagtagata gcagagggca tgagaggagg aggtccgcac
     2821 aagagggctc gtctggtgat gacactggtg atgctgaagg tgggccggga gggagcagct
     2881 ccccacgaca aggttcagtt gagaaaggca ggagtgtagt ggaattcgga gacatggttt
     2941 gtaagaggca gcagtctgct gtttcctctg ccggttctga aaagccttca gggaaagagg
     3001 agaatgtcca ctctcctgaa gacaaaagag ttactaaaag taaagaaaag agtaaacatc
     3061 tgagaaccag aactggtaga aaagtcaaga gtgatgtcac tgataggttc cggaagaagg
     3121 agcagagctc tgagtcttca gagggtgaaa agaagcaggg cagacagaga actgggacaa
     3181 ggggaaagaa aagtacagac ttaaaggaag aaaaggtgaa gagagagcgg gagtatgagt
     3241 cttcctctga cgggaccgag aaattgcctg agggagaaga aattggtctg ttctctaaag
     3301 gcgtaaagca gaataaaaat gacacaactg atggagcaaa gaaaggcaaa aagtggaaag
     3361 acaaatcatg tgaaaagaag gaagaactat ctgatagtgt tgatcgattg ccagtaaaag
     3421 gagagagttg tgactcttct gaagataaga agaccaggaa tagagtgtct ctgagagaga
     3481 agaaacaatt cagcttgcct gcaaagagtt cagggaagag gccagagtgt tcatcatcag
     3541 atactgagag atccgtgaaa ggagagtgtt gcgactccac cgataagaga gtgaaaagaa
     3601 ttgacttgag agaaagaaga agctcaaatt caaagagaag taccaaggaa gtaaagagtg
     3661 gttcatcatc ttctgatgct gagggaagtt cagaagatgc caaaaagcag aagaaacaaa
     3721 gaatgtcagc caaaaagaag acaggcaata ccaaggagag aaaaagaaaa tccttaagag
     3781 caactactac caaaaggaag caagcagaca ttacttcttc atcttctgat ataggggatg
     3841 atgatcagaa ttctgcaggc gaggaaagca gcgatgaaca gaaaattaaa cccgtgactg
     3901 aaaatctagt gctgccttca catactggat tttgtcagtc ttcaggagat gaagccttct
     3961 ctaaatcagt gcctgccaca gtggatgatg atgacgacga caatgatcct gagaatagaa
     4021 ttgccaagaa gatgctttta gaagaaatta aagccaatct ttcctctgat gaggatggat
     4081 cttcagatga tgaacctgaa gagggagaga agaaaagaat tggaaaacag agtgaagaaa
     4141 caccaggtga tgatggctcc aaccaagtca attctgaatc ggattccgat tctgaagaat
     4201 ctaagaagcc aagatataga catagacttt tgaggcataa actgtctttg agtgatggag
     4261 aatctggaga agagaaaaag acaaagccta aagagcataa agaaaccaaa ggaagaaata
     4321 gaaggaaggt gagcagtgag gattcagaag acactgactt tcaggagtca ggtgttagtg
     4381 aagaagtcag tgaatctgag gatgaacagc ggcctagaac aaggtctgcg aagaaagcag
     4441 aattggagga aaatcagcga agttataaac aaaagaagaa aagacggcgc attaaggttc
     4501 aagaggattc ctccagtgac aataagagcc attctgagga agaaagaaag gatgatgatg
     4561 atgaggagga tgaagaggag gaagatgaaa atgatgattc taagtcacct ggaaaaggca
     4621 gaaagaaaat tcggaagatt cttaaagatg ataaactaag aacagaaaca caaaatgccc
     4681 ttaaagaaga ggaagagagg cgaaaacgga ttgcagagag ggaacgtgaa agagagaaat
     4741 taagagaggt gatagaaatt gaggatgctt cgcctactaa atgtccaata acaaccaagc
     4801 tggttttaga tgaagatgaa gaaaccaaag aaccattagt gcaggttcat agaaacatgg
     4861 ttataaaatt gaaaccccat caagtggatg gtgttcagtt tatgtgggat tgctgctgtg
     4921 agtctgtgaa gaagacaaag aagtctccag gttcaggatg tattcttgcc cattgcatgg
     4981 gccttggcaa gaccctgcag gtggtgagtt ttcttcacac agttcttttg tgtgacaaat
     5041 tggatttcag tacagcttta gtggtttgtc ctcttaacac tgctttgaat tggatgaatg
     5101 aatttgagaa gtggcaggag ggattaaatg atgctgaaaa gcttgaggtt tctgagttgg
     5161 caactgtgaa gcgtcctcag gagagaagtt acatgctcca gagatggcaa gaagacggcg
     5221 gtgtcatgat catagggtat gaaatgtacc gaaatcttgc tcaaggaagg aacgtgaaga
     5281 gtcggaaact gaaggaaata tttaacaaag ctttggttga tccaggccct gattttgttg
     5341 tctgtgatga aggccatatt ctaaaaaatg aagcatctgc tgtttcaaaa gctatgaact
     5401 ctataaaatc gaggaggagg atcattttaa caggaacacc acttcaaaat aacctaattg
     5461 agtatcattg catggttaac tttatcaagg agaatttgct tggatccatc aaggaattca
     5521 ggaatagatt tataaatcca atccaaaacg gacagtgtgc agactctacc atggtagatg
     5581 tgagagtgat gaaaaaacgt gctcatattc tctatgagat gttagccgga tgtgttcaga
     5641 ggaaagatta cacagcatta accaagttct tgcctccaaa acatgaatac gtgttagctg
     5701 ttaggatgac tgctattcag tgcaagctct atcaatacta cttggaccat ttaacaggtg
     5761 taggcaatag cactgatggt ggaagaggaa aggccggtgc aaagctcttc caagatttcc
     5821 agatgttaag cagaatctgg acccatcctt ggtgtttgca actggactac attagcaaag
     5881 aaaataaggg ctattttgat gaagatagta tggatgaatt tatagcttca gattctgatg
     5941 aaacttctat gagtttaagc tcagatgagt atgcaaaaaa gaagaaaaca aaggggaaga
     6001 aggggaggaa ggacagcagc tcaagcggga gtggtagtga caacgatgtt gaagtcatca
     6061 aagtctggaa ttccagatct agagggggtg gagaaggaaa tgtggaggag acgggaaaca
     6121 acccttcagt ttctctgaag ctagatgaaa gtaaaactac ttccacttct aacccaagta
     6181 gcccagctcc agattggtac aaagattttg ttacagatgc tgatgctgag gttttagaac
     6241 attctggaaa aatggtactt ctttttgaaa ttcttcgaat ggcagaagaa attggggata
     6301 aagttcttgt ttttagtcag tcgctcatat ctctggactt gattgaagat tttcttgaat
     6361 tggctagtag ggagaaaaca gaagataaag ataaacctct tatttataaa ggtgaaggaa
     6421 agtggctccg aaatattgac tattaccgtt tggatggttc tactaatgca cagtcaagga
     6481 agaagtgggc tgaagaattt aatgatgaaa ccaatgtgag agggcgattg tttatcattt
     6541 ccactaaagc aggatctctt gggattaacc tggtagctgc taatagagtg attatatttg
     6601 atgcttcgtg gaatccatct tatgacatcc agagtatatt cagagtttat cgctttggac
     6661 aaactaagcc tgtttatgta tataggttct tagctcaggg aaccatggaa gataagattt
     6721 acgatcgtca ggtaacaaag cagtcactat ctttccgagt tgttgatcaa cagcaggttg
     6781 agcgtcattt taccatgaat gagcttactg aactttatac ttttgagcca gacttattag
     6841 atgaccctaa ttcagaaaag aagaagaaaa gggatacccc catgctgcca aaggatacca
     6901 tacttgcaga acttcttcag atacataagg agcacattgt aggatatcat gaacatgatt
     6961 ctcttttgga ccataaagaa gaagaagagc tgactgaaga agaaagaaaa gcagcttggg
     7021 ccgaatatga agcagaaaag aagggattga ccatgcgttt caacatacct actgggacca
     7081 atttaccccc tgtcactttc acctctcaaa ctccttatat tcctttcaat ttgggagccc
     7141 tgtctgcaat gagtaatcag cagctggagg atcttattaa tcaaggaaga gaaaaagtag
     7201 tagaagcaac gaacagtgtg acatcagtga ggattcagcc tctcgaagac atcatttcca
     7261 ctgtatggaa agaaaacatg aatctctctg aggcccaagt ccaagcacta gcattaagta
     7321 gacaagccag ccaggagctt gacgtgaaac gaagagaagc aatttacaac gatgtattga
     7381 caaaacaaca aatgttaatc agctgtgttc agcgaatact catgaacaga cggcttcagc
     7441 agcagtatac tcagcagcaa cagcaacaat tgacttatca gcaagcaaca ctgagtcacc
     7501 tcatgatgcc aaagcctcca aatttaatca tgactccttc caactaccag cagattgata
     7561 tgagaggaat gtatcagtca gtggctggtg gtatgcagcc accaccctta cagcgtgcac
     7621 cacccccaat gagaagcaaa aatccaggac cttccccagg gaaatcaatg tgattttgca
     7681 ctaaaacttt aaaggattat taaaatcata gaaagatctt ttattttttt aggaatcaat
     7741 gacttaacag aactcaactg tataaatagt ttggacccct taaatgccaa tcttccatat
     7801 tagtttaaat tttttttaaa tagggcatac catttctctc tgacatttgt cagtgatgtt
     7861 gcctacaatc ttcttacaca cattgagtac agaagatatt tcaaattgtt ttcagtgaaa
     7921 acaaatcctt ccataacagt aacagttcca cagatttcct ctctaaattt ttatgcctgc
     7981 ttttagcaac catgaaattg tcataaaatt aatgaattta gaaattaata aagatttata
     8041 tattcgctct ttacatataa aaacacacag ctgagttctt agagttgatt cctcaagtta
     8101 taaaatactt ttgtactaat tccatttctt gattagagtg attgaaatgg tcttaatatt
     8161 cttttgactg aagtttgaaa ctgggctcct gcttaaatat tgtctctgtg attaaaagcg
     8221 tgtgcaatat tcttaaatac tactactaat ctaaaggtga ggagccttgt atcttagcat
     8281 tgtagaaaca gccttaagta cagtctaaga cgagaaaatt ccttttctta tttagtcttc
     8341 ctgccatttt ttattttcag ttgtatgtga tttcagggtt gtgaattatc ctctgcatat
     8401 gagtttcctg tctcctggca ctaatggaag tccgatccat cagccaagga gccagtgctg
     8461 gtgcttcatc ctgttgctgg cagtgggatg caaactaaga aaaccaagtt agagcgcttg
     8521 aaaagcttcg cgctgaaatt gtggttttag gctcacaccc tgttttataa acaacatcaa
     8581 aatggcagaa cctttgctga ctttgaagtt cacatgagga atgtgctttc ctagtctcca
     8641 gtactgtcag tattgtgaaa taattcctct taacgataag gatcactggc ttctatgctc
     8701 ctcttttcac tcatcacact ttccctcttt caagctcctt tacagtttag taaattgttt
     8761 tcaagtttga tcccccaccc cattttgatc tctgagttgg tttcctttct tttcttttct
     8821 tttctttttt tggagctggg gactgaaccc agggccttga gcttgctagg caagcgctct
     8881 accactgagc taaatcccca acccctgttt cctttctttt cattcctctt cctcctcttc
     8941 ctcttcctct tggataaagt tattaattca cctaatactc ttttatttct gttttgtttt
     9001 gttttggttt ggtttggttt tttttttaac tagaaaaatc agtgtatttc tttttctaga
     9061 tccaagtttt tgaaaaataa cctataattt cattcatgtt caatttgatc attttaagtg
     9121 tcttcagtaa gaagattgtg tttgactatg ggtcaactca tgacgatagc atttttgaaa
     9181 taagtagtag aaacagctaa agaaaagctg ggtggagtat ttgttctagg cctcactgga
     9241 cgtgattgat attgaattga acatgaactt aaaatggttt tagttgtttg gataataaaa
     9301 gatttccatc tttatcttgt aagaactggt ggttaaaata tccacacgca ccaggtttgt
     9361 gatgaagaat aagtgaggtg tggcggctgt accttcccat gatcaaacac actaatgaac
     9421 tctgcgtatt tggatactgt gccagccatg taataaagct tatttaattg ggggtggggg
     9481 gcagatgtgc atttcctttg gaagaagtga aagaagcaag acttgtgaga taagtatttg
     9541 aaagcagtat gctctggcca actgttacca gaatacgttc aagctgatgt actagacatg
     9601 ggaactttta catgctctaa ttatttactc aaagacatag atatgacaat tttaggcaac
     9661 attatagtcc attttcataa tggatgaaac tataacttga aaaaatagta attagaagga
     9721 ctcattggaa atcagagcat ttgaaataga tcttggacca cttgcataca ctcttctcac
     9781 ttgatatgtt agcaacataa tatatgtact ttgagtataa catcaagttt taacaaataa
     9841 agacaaaaaa agtcacataa gatactaaaa gctcattttt atatttgttt tagatgtttt
     9901 aaatagttgc aatggcttaa atgacgattt aaaatgttgc ttgtaataca gttttgcctg
     9961 ctaaattctc cacattttgt aacctgtttt atttctttgg gtgtaaagcg tttggcctag
    10021 aattgtgata ttgtacatgt tttgtcccgg ttgtatagta atgtttcagt ccatcatcca
    10081 gctttggctg ctgaaatcat acagctgtga agacttgcct ttatttctgt tagactgctt
    10141 tttggttctg tattgagtat cttaagtact gtagaaaaga tgtcacttct tcctttaagg
    10201 ctgttttgta atatatataa ggactggaat tgtgttttta aagaaaagca ttcaagtatg
    10261 acaatatact atctgtgttt tcaccattca aagtgctgtt tagtagttga aacttaaact
    10321 atttaatgtc atttaataaa gtgaccaaaa tgtgttgtgc tctttattgc attttcacag
    10381 ctttgaaaaa tctgtgcaca tattgtttca taggacctgt atagcttttg atgtcctgtt
    10441 taatggtggt tcttttgcac atttagttgt tttactattt gggaggtcaa gaagtttggt
    10501 tttggaatct gttatatact aaattctgta aaaggagatc tctaacctca aaaagaattt
    10561 aacataccag gaa
//
