LOCUS       NM_031351               8729 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus attractin (Atrn), mRNA.
ACCESSION   NM_031351
VERSION     NM_031351.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8729)
  AUTHORS   Liu,M.Q., Xue,C., Li,X.H., Ding,H.Q., Zhang,M.Y., Chen,K., Li,Y.,
            Gao,S.Z., Xu,X.J. and Zhang,W.N.
  TITLE     Mutation of the attractin gene impairs working memory in rats
  JOURNAL   Brain Behav 13 (2), e2876 (2023)
   PUBMED   36621889
  REMARK    GeneRIF: Mutation of the attractin gene impairs working memory in
            rats.
REFERENCE   2  (bases 1 to 8729)
  AUTHORS   Cooray,S.N. and Clark,A.J.
  TITLE     Melanocortin receptors and their accessory proteins
  JOURNAL   Mol Cell Endocrinol 331 (2), 215-221 (2011)
   PUBMED   20654690
  REMARK    Review article
REFERENCE   3  (bases 1 to 8729)
  AUTHORS   Izawa,T., Yamate,J., Franklin,R.J. and Kuwamura,M.
  TITLE     Abnormal myelinogenesis both in the white and gray matter of the
            attractin-deficient mv rat
  JOURNAL   Brain Res 1312, 145-155 (2010)
   PUBMED   19931230
  REMARK    GeneRIF: This study indicated that myelinogenesis but not
            oligodendrogenesis is severely altered both in the white and gray
            matter of attractin-deficient mv rats.
REFERENCE   4  (bases 1 to 8729)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 8729)
  AUTHORS   Nakadate,K., Sakakibara,S. and Ueda,S.
  TITLE     Attractin/mahogany protein expression in the rodent central nervous
            system
  JOURNAL   J Comp Neurol 508 (1), 94-111 (2008)
   PUBMED   18302151
  REMARK    GeneRIF: Atrn is more widely expressed throughout the CNS than
            previously reported, and expression of Atrn by various cell types
            suggests that Atrn may serve multiple functions in the CNS.
REFERENCE   6  (bases 1 to 8729)
  AUTHORS   Kuwamura,M., Maeda,M., Kuramoto,T., Kitada,K., Kanehara,T.,
            Moriyama,M., Nakane,Y., Yamate,J., Ushijima,T., Kotani,T. and
            Serikawa,T.
  TITLE     The myelin vacuolation (mv) rat with a null mutation in the
            attractin gene
  JOURNAL   Lab Invest 82 (10), 1279-1286 (2002)
   PUBMED   12379762
  REMARK    GeneRIF: There is myelin vacuolation in rats with a null mutation
            in the gene.
REFERENCE   7  (bases 1 to 8729)
  AUTHORS   Kuramoto,T., Nomoto,T., Fujiwara,A., Mizutani,M., Sugimura,T. and
            Ushijima,T.
  TITLE     Insertional mutation of the Attractin gene in the black tremor
            hamster
  JOURNAL   Mamm Genome 13 (1), 36-40 (2002)
   PUBMED   11773967
REFERENCE   8  (bases 1 to 8729)
  AUTHORS   Kuramoto,T., Kitada,K., Inui,T., Sasaki,Y., Ito,K., Hase,T.,
            Kawagachi,S., Ogawa,Y., Nakao,K., Barsh,G.S., Nagao,M., Ushijima,T.
            and Serikawa,T.
  TITLE     Attractin/mahogany/zitter plays a critical role in myelination of
            the central nervous system
  JOURNAL   Proc Natl Acad Sci U S A 98 (2), 559-564 (2001)
   PUBMED   11209055
REFERENCE   9  (bases 1 to 8729)
  AUTHORS   He,L., Gunn,T.M., Bouley,D.M., Lu,X.Y., Watson,S.J.,
            Schlossman,S.F., Duke-Cohan,J.S. and Barsh,G.S.
  TITLE     A biochemical function for attractin in agouti-induced pigmentation
            and obesity
  JOURNAL   Nat Genet 27 (1), 40-47 (2001)
   PUBMED   11137996
REFERENCE   10 (bases 1 to 8729)
  AUTHORS   Nagle,D.L., McGrail,S.H., Vitale,J., Woolf,E.A., Dussault,B.J. Jr.,
            DiRocco,L., Holmgren,L., Montagno,J., Bork,P., Huszar,D.,
            Fairchild-Huntress,V., Ge,P., Keilty,J., Ebeling,C., Baldini,L.,
            Gilchrist,J., Burn,P., Carlson,G.A. and Moore,K.J.
  TITLE     The mahogany protein is a receptor involved in suppression of
            obesity
  JOURNAL   Nature 398 (6723), 148-152 (1999)
   PUBMED   10086355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031351.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038387.1, SRR26643290.13254.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               JAXUCZ010000003.1  138563379-138563857
            480-563             JAXUCZ010000003.1  138599067-138599150
            564-677             JAXUCZ010000003.1  138601334-138601447
            678-806             JAXUCZ010000003.1  138607740-138607868
            807-1012            JAXUCZ010000003.1  138609066-138609271
            1013-1181           JAXUCZ010000003.1  138610492-138610660
            1182-1272           JAXUCZ010000003.1  138620374-138620464
            1273-1516           JAXUCZ010000003.1  138621210-138621453
            1517-1700           JAXUCZ010000003.1  138623833-138624016
            1701-1855           JAXUCZ010000003.1  138625006-138625160
            1856-1940           JAXUCZ010000003.1  138628381-138628465
            1941-2161           JAXUCZ010000003.1  138633451-138633671
            2162-2283           JAXUCZ010000003.1  138635617-138635738
            2284-2422           JAXUCZ010000003.1  138636728-138636866
            2423-2613           JAXUCZ010000003.1  138639197-138639387
            2614-2833           JAXUCZ010000003.1  138642987-138643206
            2834-3019           JAXUCZ010000003.1  138644975-138645160
            3020-3253           JAXUCZ010000003.1  138645663-138645896
            3254-3391           JAXUCZ010000003.1  138649621-138649758
            3392-3485           JAXUCZ010000003.1  138656067-138656160
            3486-3538           JAXUCZ010000003.1  138656965-138657017
            3539-3633           JAXUCZ010000003.1  138660949-138661043
            3634-3712           JAXUCZ010000003.1  138664589-138664667
            3713-3870           JAXUCZ010000003.1  138666272-138666429
            3871-3932           JAXUCZ010000003.1  138680145-138680206
            3933-4011           JAXUCZ010000003.1  138685358-138685436
            4012-4119           JAXUCZ010000003.1  138687839-138687946
            4120-4234           JAXUCZ010000003.1  138690155-138690269
            4235-8729           JAXUCZ010000003.1  138692866-138697360
FEATURES             Location/Qualifiers
     source          1..8729
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..8729
                     /gene="Atrn"
                     /note="attractin"
                     /db_xref="GeneID:83526"
                     /db_xref="RGD:69063"
     exon            1..479
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..4359
                     /gene="Atrn"
                     /note="protein zitter; membrane attractin"
                     /codon_start=1
                     /product="attractin precursor"
                     /protein_id="NP_112641.1"
                     /db_xref="GeneID:83526"
                     /db_xref="RGD:69063"
                     /translation="MVAAAAAAEATEARLRGYTTATAAPAGWKERQHRPCAATGAWRP
                     WPRAGLCLPRVLSRALSPPPLLPLLPLLFSLLLLPLPREAEAAAVAAAVSGSAAAEAK
                     ECDRPCVNGGRCNPGTGQCVCPTGWVGEQCQHCGGRFRLTGSSGFVTDGPGNYKYKTK
                     CTWLIEGQPNKIMRLRFNHFATECSWDHLYVYDGDSIYAPLIAAFSGLIVPERDGNET
                     APEVTVTSGYALLHFFSDAAYNLTGFNITYNFDMCPNNCSGRGECKSSNSSSTVECEC
                     SENWKGESCDIPHCTDNCGFPHRGICNASDTRGCSCFPHWQGPGCSIPVPANQSFWTR
                     EEYSDLKLPRASHKAVVNGNIMWVVGGYMFNHSDYSMVLAYDLASREWLSLNHSVNSV
                     VVRYGHSLALHKDKIYMYGGKIDSTGNVTNELRVFHIHNESWVLLTPKAKDQYAVVGH
                     SAHIVTLSSGRVVMLVIFGHCPLYGYISVVQEYDLEKNTWSILQTQGALVQGGYGHSS
                     VYDHRTKALYVHGGYKAFSANKYRLADDLYRYHVDTQMWTILKDSRFFRYLHTAVIVS
                     GTMLVFGGNTHNDTSMSHGAKCFSSDFMAYDIACDRWSVLPRPELHHDVNRFGHSAVL
                     HNSTMYVFGGFNSLLLSDVLVFTSEQCDAHRSEAACVAAGPGIRCLWDTQSSRCTSWE
                     LATEEQAEKLKSECFSKRTLDHDRCDQHTDCYSCTANTNDCHWCNDHCVPVNHSCTEG
                     QISIAKYDNCPKDNPMYYCNKKTSCRSCALDQNCQWEPRNQECIALPENICGIGWHLV
                     GNSCLKITTAKENYDNAKLSCRNHNAFLASLTSQKKVEFVLKQLRLMQSSQSTSKLTL
                     TPWVGLRKINVSYWCWEDMSPFTNSLLQWMPSEPSDAGFCGILSEPSTRGLKAATCIN
                     PLNGSVCERPANHSAKQCRTPCALRTACGECTSSSSECMWCSNMKQCVDSNAYVASFP
                     FGQCMEWYTMSSCPPENCSGYCTCSHCLEQPGCGWCTDPSNTGKGKCIEGSYKGPVKM
                     PSHASTGNVYPQPLLNSSMCLEDSRYNWSFIHCPACQCNGHSKCINQSICEKCEDLTT
                     GKHCETCISGFYGDPTNGGKCQPCKCNGHASLCNTNTGKCFCTTKGVKGEECQLCEVE
                     NRYQGNPLKGTCYYTLLIDYQFTFSLSQEDDRYYTAINFVATPDEQNRDLDMFINASK
                     NFNLNITWATSFPAGTQTGEEVPVVSKTNIKEYKDSFSNEKFDFRNHPNITFFVYVSN
                     FTWPIKIQIAFSQHSNFMDLVQFFVTFFSCFLSLLLVAAVVWKIKQSCWASRRREQLL
                     REMQQMASRPFASVNVALETDEEPPDLIGGSIKTVPKPIALEPCFGNKAAVLSVFVRL
                     PRGLGGIPPPGQSGLAVASALVDISQQMPIVYKEKSGAVRNRKQQPPAQPGTCI"
     exon            480..563
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            564..677
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            678..806
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1012
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1181
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1272
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1516
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1700
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1855
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1940
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2161
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2283
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2422
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2613
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2833
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..3019
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3253
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..3391
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3485
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3486..3538
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3633
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3712
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3713..3870
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..3932
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4011
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4119
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4234
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
     exon            4235..8729
                     /gene="Atrn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agggtagccg gcgtgcgggg tgtgtatgtg ttcgctgggc gccggctcag ccccaggaag
       61 atggtggcgg cggcggcggc ggcggaggcg actgaggcgc ggttgagggg gtacacgacg
      121 gcgacagcag cgcccgcggg ctggaaggag aggcagcacc gaccctgcgc cgcgacaggg
      181 gcctggaggc cgtggccgcg cgccgggctg tgtctcccgc gggtgctgtc gcgggcgcta
      241 tccccgccgc cgctgctgcc gctgctgccg ctgctctttt cgctattgct gctgccactg
      301 ccccgggagg ccgaggccgc tgcggtggcg gcggctgtgt caggctcggc cgcagctgag
      361 gccaaggaat gtgaccggcc gtgtgtcaac ggcggccgct gcaaccctgg caccggccag
      421 tgcgtctgcc ccacgggctg ggtgggcgag caatgccagc actgcggggg ccgcttcaga
      481 ctaactggat cttctggatt tgtaacagat ggacctggga attataaata taaaacgaaa
      541 tgcacatggc tcattgaagg acagccaaat aagataatga gacttcgatt caaccatttt
      601 gctactgaat gtagctggga ccatttatat gtttatgatg gggactcaat ttacgcacct
      661 ctgattgctg cctttagtgg cctcattgtt cctgaaagag atggcaatga gacggcccct
      721 gaagtcactg tcacttcagg ttatgcacta ctgcattttt tcagtgatgc tgcttataat
      781 ctgactggat ttaatatcac ttacaatttt gacatgtgcc cgaataattg ctcaggccga
      841 ggagaatgta agagcagtaa cagcagcagc actgttgagt gtgaatgttc tgaaaactgg
      901 aaaggggagt cctgtgacat tcctcactgt acagacaact gtggctttcc tcaccgaggc
      961 atctgtaacg caagtgacac cagagggtgc tcctgcttcc ctcactggca gggtcctgga
     1021 tgttcaattc ctgtgccagc taaccagtct ttttggactc gagaagaata ttctgactta
     1081 aagcttccca gagcctctca taaagctgtg gtcaatggaa atataatgtg ggttgttggc
     1141 gggtatatgt tcaaccattc agattacagc atggttttag cgtatgacct ggcttctagg
     1201 gaatggcttt cactaaacca ttctgtgaac agtgtggttg taagatatgg tcattctttg
     1261 gcattacata aggataaaat ctacatgtat ggaggaaaaa ttgattcaac agggaatgtg
     1321 accaacgagc tgagagtatt tcatattcat aatgaatcat gggtattgtt aacccccaaa
     1381 gctaaggatc agtatgcagt ggttggacac tcagcacaca ttgttacact gtcatctggc
     1441 cgtgtggtca tgttggtcat cttcggtcat tgtccgctct acggatatat aagtgttgtg
     1501 caggaatatg acttggaaaa gaacacatgg agtatattac aaactcaagg tgctctagtg
     1561 caagggggtt atggccacag cagtgtttat gatcacagga ccaaggctct gtatgttcat
     1621 ggtggctaca aggctttcag cgccaacaag taccggcttg cagatgacct ctacagatac
     1681 catgtggaca ctcagatgtg gaccattctt aaggacagcc gatttttccg ttacttgcat
     1741 acagctgtga tagtgagtgg aaccatgctg gtgttcggag ggaacacaca caatgacact
     1801 tccatgagcc acggtgccaa atgcttctcc tcagacttca tggcttatga cattgcttgt
     1861 gaccgatggt cagttctccc cagacctgag ctccatcacg atgtcaaccg atttggccac
     1921 tcagcagtct tgcacaacag caccatgtat gtgttcggcg gcttcaacag cctcctcctc
     1981 agtgacgtct tagtcttcac ctcggagcag tgtgatgcac accgcagcga agctgcttgt
     2041 gtggcagcag gacctggcat ccggtgtctg tgggacacac agtcgtctcg atgtacctcc
     2101 tgggagttgg caactgaaga acaagcagaa aagttaaaat cagaatgttt ctctaaaaga
     2161 acccttgacc atgacagatg tgaccagcac acagattgtt acagctgcac agccaatacc
     2221 aatgactgcc actggtgcaa tgatcactgt gtccctgtga accacagctg cacagaaggc
     2281 cagatctcca ttgccaagta tgacaattgc cccaaggata accccatgta ctactgcaat
     2341 aagaaaacca gctgcaggag ctgtgcccta gatcagaatt gccagtggga acctcgaaat
     2401 caagagtgca tcgccctgcc cgaaaacatc tgtggcattg gctggcattt ggtcggaaac
     2461 tcgtgtctga aaatcactac tgctaaggaa aattatgaca atgctaaatt gtcctgtaga
     2521 aaccacaatg cctttttggc ttcgcttacg tcccagaaga aggtggagtt tgtccttaag
     2581 cagcttcgat taatgcaatc atctcagagc acgtccaagc tcactctgac tccatgggtt
     2641 ggtcttcgga agatcaatgt atcttactgg tgctgggagg atatgtctcc attcacaaat
     2701 agtttgctgc agtggatgcc atctgagccc agtgatgccg gcttctgtgg gatcttgtca
     2761 gagcctagta ctcggggact gaaggctgca acctgcatca acccactcaa tggaagtgtt
     2821 tgtgaaaggc ctgcaaacca cagtgccaag cagtgccgga caccctgtgc cctgcggaca
     2881 gcatgtggtg agtgcaccag cagcagctcc gaatgcatgt ggtgcagcaa catgaagcag
     2941 tgcgtagact ccaatgccta cgtagcctcc tttcctttcg gccagtgtat ggagtggtat
     3001 acaatgagca gctgcccacc tgaaaattgc tctggctact gtacctgcag ccattgcttg
     3061 gagcagccag gctgtggttg gtgtactgat cctagcaata ctgggaaagg caaatgtatt
     3121 gagggaagct ataaaggacc cgtgaagatg ccttcacatg cctctacagg aaatgtgtac
     3181 ccacagcccc ttctgaactc cagcatgtgt ctagaggaca gcagatacaa ctggtctttt
     3241 attcactgtc cagcttgcca gtgcaatgga cacagcaagt gcatcaacca gagcatctgt
     3301 gagaagtgtg aggacctgac cacaggcaag cactgcgaga cctgcatatc tggcttctat
     3361 ggtgacccga ctaatggagg caaatgtcag ccatgcaagt gcaacgggca cgcatcactg
     3421 tgcaacacca acactggcaa gtgcttctgt accaccaagg gcgtcaaggg agaggagtgc
     3481 cagctatgtg aggtagaaaa tcgataccag ggaaaccctc tcaaaggaac atgttactat
     3541 acccttctca ttgactatca gttcactttt agcctgtccc aggaagacga ccgctattac
     3601 acagccatca attttgtggc tactcctgat gaacaaaaca gggatttgga catgttcatc
     3661 aatgcctcca aaaacttcaa cctcaacatc acctgggcca ccagtttccc agctggaacc
     3721 cagactggag aagaggtgcc tgttgtttca aaaaccaaca tcaaggaata caaagatagc
     3781 ttctctaatg agaaatttga ttttcgcaac catccaaaca ttactttctt tgtttatgtc
     3841 agtaatttca cttggcccat caaaattcaa attgccttct cccagcacag caattttatg
     3901 gacctggtgc agttcttcgt gactttcttc agctgtttcc tctctctgct tctggtggcg
     3961 gcagtggtct ggaagatcaa gcagagctgt tgggcatcca ggaggagaga gcaacttctt
     4021 cgggagatgc aacagatggc cagccgccct tttgcttctg taaatgttgc cttggaaaca
     4081 gatgaagaac ctcctgatct cattggggga agtataaaga ctgttcctaa gcccattgcc
     4141 ctggagccct gctttggtaa caaagctgct gtcctctctg tgtttgtgag gctccctcga
     4201 ggactgggag gaatccctcc tcctggtcag tcaggtcttg ctgtggccag tgccctggtg
     4261 gacatttctc agcagatgcc aatagtgtac aaggagaagt caggagctgt aaggaaccgg
     4321 aagcagcagc cccctgcaca gcctggaacc tgcatttgat actggggcag gaactctccc
     4381 tcacagaggg gcatgtggtc cactaagctg tctacagggg aggctgcagg caggaagctg
     4441 gtgtggggca gaagactgga aacccttgaa gcatccaact cacgtgcatg atcatacaag
     4501 ctgttttgat ggttcatccc ttctgtgtcc agcatctaac cttttacttc tgtgtaggaa
     4561 ataatttaat tacaagtcca ggagtgatct gctctactca tgggtggagg agaccagtgt
     4621 agacccagtg agagctaaaa gtgatgcaga ggtccctgtg gaagctcaac tgcaaaagtg
     4681 atgccctccg tcagcagctc tccagcatgt cctctcgatt gatcctcaga tgaattgttc
     4741 tcatctgaag cttgctgtct ttttacaaga tgtgctttta ctctcttcca ggaagtaggt
     4801 tttttcagct gagaattaat aatgatcttt ctctttggaa gtcatatcaa agtataattg
     4861 atgggggcct tgttttgttt tgttttggag acaaggtctc actgtgtggt cctagctggc
     4921 ctggaactca ccatgtagat caggctggac tgaactctta aaagttgacc tgcctctgcc
     4981 tcataaattc tgggatagaa agcgtgtacc accaggccca gcaaagaggg ctattctaaa
     5041 tgtcacggtc aatggagtta gaatatagac aaatgcagtt gataattccc tatagaaact
     5101 tgatcaattt aattttaatc cattctttcc ttctcttttt tctcactctg tcttacacac
     5161 atacacacgt gcacacacac acacacacta agtgcctaga ctttaattag atctagcaat
     5221 tggaacgtta gtaagcctga gtttttacat gattgcattc ctacatcctt gtaaacttta
     5281 agtaaccacc attgcagttg gttcctttgt taaagtctaa tttgcagcca agaaagaata
     5341 attctcatcc caagaaacac ttaataggga ctactagcaa taggaactaa atgaccctcc
     5401 cccccagcct agtgtcactt ggctccttct gccaaggcac cacagagtgc acttgctcat
     5461 gtcatgtgcc tctctgagca gacgcctggg acacctggct ctgtcttcct acagctgctc
     5521 gcactgacct gtgggaacct gtgggtcatc cccaggctgg atggagtaca cactagaaga
     5581 gggatagtgc ctggcattgg ggcagcatct gctcagcaca cggaaagggg cctggttccc
     5641 tctcccctgg taggagttgg tccagcctcc tcccagaccc agctggaggc tgagaggagg
     5701 tggtgaatgc taatgaggat gaaaagacat ggggtgaaag gaagggacaa gacccacttc
     5761 caaagaagat taccatgtta agaggggtga gcagtcctct gctctgccca ggaccctgcc
     5821 tggacactgc attcccattt atggtgctca gtattctggc attatgcagc agcctcacac
     5881 ctttcctctc ctgcttcata ccctgcagtt ctcctattat ctgactagaa cagccctcta
     5941 ggcaacagtg atcaatttat gagtttggag aagctaataa tcagaaggat aaaagctgta
     6001 gcatttcacc tttaatacag tgctgaagag ggagcctttc tctgagcccc gcactaacct
     6061 cattccacac aagacttctg cagtgacgtc tccacgctga accctaagtc actgatgcac
     6121 aacactgctg taagactcac ctctcaaaac acgacttttt cgtcactatt aaggagcaga
     6181 aagttctaga aatgatccca acctcgtccc ctgtgcagct aggatctccc cacatcccta
     6241 acaaagccga gcacataagt gtctgtggtc tagcgtttca tctccatagc aacccaaggg
     6301 actcttggcc agaagaaaga gagagggaag cctcactagg ggttggcctt atggaaggaa
     6361 atcccccctc tgctttgctt taaggaccaa atttctttgg ccaaagaagt tgtttccgtg
     6421 ttagtcccat accttgaaat aatacgtacc atggctccca cctacctgtt tatgtccccc
     6481 caatcacctt tagggatact gtttattctt taaaaagaag cagatggcat ttgtttctgc
     6541 tcctgtaatg gagaaacagc cagcttcacc tgcatcccct ttacagccag cagctccctt
     6601 cagacgtaaa gcagagggga tggcagagaa gagctcagct cagagccagt gacccagtga
     6661 ttctgtcacg agagaacttg tatataaagt agtcatgaag acactgacct tgcacttgta
     6721 cataactata ctatagtgtc cagaatgttc agacattcag ggtgtacata aacagaaaag
     6781 tatcataatg tatttttatt aaacagtaac atcttgagtt tcacctaatc tgtttctgtg
     6841 ccatagactg ggtatccgag ctctgggaga tcatcttccc agaccccagt ccgtcgataa
     6901 ggcattgtac accatgctgg tgtgttcggt agcctcgtgc ccattaggta actaaacaat
     6961 gattcagctc ttagaataca ggaagagagc aagcctggtg acacacagct gtgatccaag
     7021 cattcagaag acagaggcag gaagaaaaaa ttcaaagatg gggctggaga gatgcctcag
     7081 tggttaaggc tgctcttgga caggacactg gttcagttcc cagcactcac atggtggctc
     7141 acaaccttct atgactacaa ccccaggtaa cccaacaccc tcttctgtcc tcctcgggtg
     7201 cctgtggcgg tgtacatggt gcacagcacg aacaggcaaa acacccaata cacacagaaa
     7261 taaagaattc aagaataccc tgggctacat agcaagaccc tgtctcagaa caaaccaacc
     7321 catgaagagc caggcagtgt gtctatttcc atgaccgtac acaagcgaac tcaggaagca
     7381 agagtgtcca tcactgctgt aacgtcaatg ctccttgtga tttcggcatc tctgtggggc
     7441 gaggtgttct atcactctaa agtcaaggac tatgtcacct gtgaacgtca gactttgcaa
     7501 aggggctctc taggctgcat tgttgtggct ttgtctaaaa ttttaatgac atttctgaga
     7561 accatgttct ttttatacta aaaactgggg atgggagggc tcatttgttg ataaatagca
     7621 ctattttccc acacctcagc ctcctgtccc cgtcctggtc ttccctacac agtctggaga
     7681 gggctctgaa aggtccaaat cggtgtggca caaaagcaac ccattgcctc ctgagctaac
     7741 ctggaagatg actgtcagca aaaggaaaat accagaatat cttgaaggct agaagcgtaa
     7801 gatgggatct cattagggaa ctggatgaac aagagcagag agcctctggt gggtaacgct
     7861 gcagcctgcc agcgcccgcc ctctctcaac atagcagagt gtgcatggta aggaagtgaa
     7921 tcacctcctt gggggatggt gctgttttta tgaaaacctt tgatccttgg tgtcctttaa
     7981 ttgatctgtt caacaaatat ttactaaaca cttgtaagct aagctaacat tagggcagtg
     8041 actgaggtga aaacccagct ctttagacag ctatcatcct aggagagctt cctagaagca
     8101 gaaccaagaa gccagaggtt cttcctagga tgagctttgg cttcctaagg aaatctgaaa
     8161 tgttgaccct ggtcacaacc tcccagcaca gctttggaat gagacatcag catggcctcc
     8221 tctggctgag cagagcctct ggagctccac accctgcctg cagggagccc tcagggtgcc
     8281 ctccagagtg cagggagaaa ctggcacctt ctttcctaaa ggcaataaca gaagctgctc
     8341 tcagaacttg actctgcaca aaacactagt gaagcctgct gaactaattc tgcctctgga
     8401 aatcttttct ggttatttac agtttgttgt tttgttttga tccaagctta gtttgttaat
     8461 atgtgtaact tggcatctgt tgcacttgtg taaatatgga gtaagtattg taaactattt
     8521 aattgctggg attggtggtg ttatacatac atttaggact gcaatttttg gtattttttg
     8581 tattgtaaaa taacagctaa tttaatcagg aacaagagaa ttaatggggg ggtctgcatt
     8641 ttaaatgcaa atgtgaagca cttgtatata aacagaagta aatactataa tacaaaattc
     8701 cttctgaaat aaaagtagat ctggtaaaa
//
