LOCUS       NM_001106859            2549 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ATR interacting protein (Atrip), mRNA.
ACCESSION   NM_001106859 XM_001055797 XM_001076248
VERSION     NM_001106859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Marechal A, Li JM, Ji XY, Wu CS, Yazinski SA, Nguyen HD, Liu S,
            Jimenez AE, Jin J and Zou L.
  TITLE     PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and
            drives ATR activation via a ubiquitin-mediated circuitry
  JOURNAL   Mol Cell 53 (2), 235-246 (2014)
   PUBMED   24332808
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Pabla N, Huang S, Mi QS, Daniel R and Dong Z.
  TITLE     ATR-Chk2 signaling in p53 activation and DNA damage response during
            cisplatin-induced apoptosis
  JOURNAL   J Biol Chem 283 (10), 6572-6583 (2008)
   PUBMED   18162465
  REMARK    GeneRIF: an important role for the DNA damage response mediated by
            ATR-Chk2 in p53 activation and renal cell apoptosis during
            cisplatin nephrotoxicity.
            Erratum:[J Biol Chem. 2008 May 30;283(22):15512]
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Cortez D, Guntuku S, Qin J and Elledge SJ.
  TITLE     ATR and ATRIP: partners in checkpoint signaling
  JOURNAL   Science 294 (5547), 1713-1716 (2001)
   PUBMED   11721054
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001076248.1, XM_001055797.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2549
                     /gene="Atrip"
                     /note="ATR interacting protein"
                     /db_xref="GeneID:301014"
                     /db_xref="RGD:1626390"
     exon            1..357
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..2462
                     /gene="Atrip"
                     /note="ATR-interacting protein-like"
                     /codon_start=1
                     /product="ATR-interacting protein"
                     /protein_id="NP_001100329.1"
                     /db_xref="GeneID:301014"
                     /db_xref="RGD:1626390"
                     /translation="MAGTPAPNSHRKQSGGLEPFLGLSRSIENPPSKRARSFSETTVP
                     DPEDPFGEHAEFTADDLEELDILASQALSQCPVAPPNLSCAHKVRRLDGLPNSPIRKN
                     REDIPVKDNFELEVLQIQYRELKEKLKAMEEEILIKNGEIKILRDSLHQTESVLEEQK
                     RSHFLLEQEKTQALSEKEKEFSKKLQSLQSELQFKDAEMNELRTKLQSNERTNKLTIP
                     SVSQVSPRKGSSVVVKSEACSPHVGKTTFPTKESFSANTPLFHPCQTEAGHKFLVGQE
                     VSDNKAHVGGNLLKQDVQQKILTDSWVQRKNTQGSILINLLLKQPLVPGSSLGLCHLL
                     SSGAEVPTGPILQPAGLSTLPGTSGLRTISSSDGPFSPSALREAQNLAFTGLNLVARS
                     ESSHDGDVAGRRVFPLCQLPGAVHILPLVQFFIGLHCQALQDLTPAKKNGAPGASPTD
                     TSHMSSGVEASPEDSVCSLESTSVASLSVLQHLVCHSGAVVCLLLSGMGTNAAAREGD
                     LSQTCADTVSASREDAHGQNQHPLLKMLLQLMAFSSTTSGQFQASVLSQCLKVLVKLA
                     ENASSDLLPRFSFVFPMLPQCLCSELPLSCVLLAVELLSVLVDQDSLAQQLCSHSEGC
                     LLLRLYMYITSRPDKTASETQWLQLEQEVVWLLAKLSVQSPSPAGIVSDCQCNVEAVR
                     ALTVMLHRQWLTVRRAGGPRTHQQKQTVRCLRDTVLLLHSLSQKDKLFTVHCVEVLHQ
                     YDQVMPGVSMLIRALPDVTDCEEAALDDLCAAETDLEDAEMDCS"
     exon            358..488
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            489..659
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            660..778
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            779..936
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1035
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1162
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1834
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1971
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2063
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2144
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2394
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2549
                     /gene="Atrip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagtagct gaggggaacg gcggcgcgcg ggcggttggg ccatctcagg ctttctgccg
       61 atcaacctgt gcttggcgtc ctcagatgct gcgagctgaa ggtagtcatg gccgggactc
      121 ccgcaccgaa cagccacagg aagcagagtg gcggcctgga gcctttcctc ggtctgtctc
      181 ggtccatcga gaaccctccg agcaagcggg cccggagctt ctctgagacc acagttccgg
      241 accccgaaga cccattcggc gagcacgcgg aatttactgc ggacgaccta gaggaactgg
      301 acatcctcgc gtcacaggcc ctgagccagt gtccggtcgc gcctccgaac ctgtcctgtg
      361 ctcataaggt ccgtcgacta gatgggttac caaatagtcc tataaggaaa aacagagaag
      421 atattccagt taaagataac tttgaactag aagtacttca gatacagtac agagaactta
      481 aagaaaagct gaaagcaatg gaagaagaaa tcctaattaa gaatggagaa attaaaattt
      541 tgcgtgactc actgcatcag acagaatccg ttctagaaga acagaaaaga tcacattttc
      601 ttcttgagca agaaaagact caagcactca gtgaaaagga aaaggaattc tccaaaaagc
      661 tccaatcact gcagtctgaa ctccagttta aagatgcaga aatgaatgaa ttaaggacaa
      721 agcttcagag caacgaacga acaaataaac taaccattcc gtcagtctcc caagtcagtc
      781 ctaggaaagg ctcttctgtg gttgtaaagt cagaagcatg ttctccacat gttggaaaaa
      841 caactttccc tacaaaggag tcttttagtg ctaacacgcc tctcttccac ccctgtcaga
      901 ctgaggcagg acacaaattt ctggtgggcc aagaggtttc ggataataaa gcccatgtgg
      961 gaggtaacct cctgaagcaa gacgtgcagc agaaaattct cactgacagc tgggtacaga
     1021 gaaaaaacac tcaaggttct atcttgataa acttgctcct gaagcaacct ttggtgccag
     1081 ggtcatctct aggtctttgt caccttctga gcagtggagc tgaggttccc actggcccca
     1141 tcttgcagcc agcagggctc agtactttgc ctgggacttc aggcctcagg accatcagct
     1201 cttctgatgg gccattttcc ccctctgccc tgagagaagc acagaacttg gcattcactg
     1261 gattaaatct ggttgccagg agtgagagct cacatgacgg agatgtagca ggcagaagag
     1321 tcttcccact ctgccagctt cctggagctg tgcatatcct ccctcttgta cagttcttca
     1381 ttggcttaca ctgccaggct ctacaagact taaccccagc taagaagaac ggggcacctg
     1441 gggcctctcc gacagacacc tcccacatga gctctggggt agaggctagc ccagaggact
     1501 ccgtttgtag cttggaaagt acttctgtgg cttcgctcag cgtccttcag cacctggtgt
     1561 gccacagtgg ggcagtggtc tgcctgttac tgtcaggcat ggggaccaat gctgctgccc
     1621 gggaaggaga cttaagtcag acttgtgcag atacagtctc agcctccagg gaagacgctc
     1681 atggccaaaa ccagcaccca ctattgaaga tgcttcttca gctgatggcg ttctcttcta
     1741 caacatcagg tcaatttcaa gccagtgtcc tgagccagtg cctcaaagtt ttggtgaagt
     1801 tagctgaaaa cgcttcctct gatttgttgc ccaggttctc cttcgtgttc ccgatgttgc
     1861 cacagtgcct ctgctcagag ctgccactgt cgtgtgtgct gctggctgtc gagctgctct
     1921 ctgttctggt ggaccaggac agcctagcac agcagctgtg ctcccactca gaaggctgcc
     1981 ttctcctgag gctgtacatg tacattacat caaggcctga caaaacggcc tcagagacac
     2041 agtggcttca gctggaacaa gaggtagtgt ggctcttggc caagctgagt gtgcagagcc
     2101 cttcccccgc tggcattgtt tctgactgtc agtgcaatgt agaggcagtc agagcactca
     2161 ctgtgatgtt gcacaggcaa tggctgactg tgcggcgggc agggggtcca aggacccacc
     2221 agcagaagca gacggtccgc tgtctgcggg acactgtgct gctgctgcac agcctatctc
     2281 agaaggacaa gctctttact gtgcactgtg tcgaggtcct gcatcagtac gaccaggtga
     2341 tgccaggggt cagcatgctg attcgagccc ttcctgatgt gactgactgt gaagaggctg
     2401 ccctggatga cctctgtgct gcagagacag atttggaaga cgccgagatg gactgtagct
     2461 gagggcctga gcatccagcc acaaggtggc actagcccca ccgtctttgc cacatccact
     2521 gattaaaact gcacttcctg ctgagaacc
//
