LOCUS       XM_003750561            8030 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ATR serine/threonine kinase (Atr),
            transcript variant X1, mRNA.
ACCESSION   XM_003750561
VERSION     XM_003750561.5
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051343.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Jan 10, 2024 this sequence was replaced by
            NM_001427167.1.
            
            On Jan 21, 2021 this sequence version replaced XM_003750561.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8030
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8030
                     /gene="Atr"
                     /note="ATR serine/threonine kinase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 7
                     ESTs, 2 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 84 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:685055"
                     /db_xref="RGD:1305796"
     CDS             82..7992
                     /gene="Atr"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ATR isoform X1"
                     /protein_id="XP_003750609.1"
                     /db_xref="GeneID:685055"
                     /db_xref="RGD:1305796"
                     /translation="MGDHGLELASMIPALRELGSATPEEYNTVVQKPRQILCQFIDRI
                     LTDVNVVALELVKKTDTQPTSVMLLDFIQHIMKSSPLMFVNVNGSQGQNEAKDSCIEF
                     SHWIITRLLRIAATPSCHMLHKKICEVICSLLFLFKSKNPAIFGVLTRELLYLFEDLI
                     YLHKRNAVGDVMEWPVVVSRFLSRLDEHMGCLQPAPLQFMNMQNVEFIEVTLLMVLIH
                     IVPTVFFRRQELLLWQIGCALLEHGSPKIRSLAISLLTELFELGGLPAQPASTFFSLF
                     LELLQHLIGMDADQLKLYEEPLSKLVKTLFPFEAEAYRNIEPVYLNVLLEKLRVMFED
                     RVLMRLKSDLLKAALCHLLQYFLTFVPAGYESALQVRKVYVTDICRALVDVLGVQTHV
                     GYLLGPFYAALKMESTEIIERIQCQAQQENLRGSNDGVSPKRRRLSSSLSSYKRPSRQ
                     SEEINHVDMDKKSILWNVLKQKAESLQISLECGTLKNSVAEALEGITIVLQLTALCTV
                     HCSHQDMDGHNAKDCQHKYKKKPPVVITWMSLDFYTKVLKSCKSLLESVQKHELELVI
                     DSVVRIYDALMYIQVKSSFQDHVLEELCGMLSLPWIYSYSDDNSLKMTTFATNLLRLS
                     QRVWESYSPQAQSQCVFLLTLFPKRIFLDWRTTVYNWALKSSHEVIRTSCVKGFFILL
                     QQENSCNQIPKMLIDRVKDDSHVVKKEFASVLGQLVCTLHGMFYLTSSSVEPFFGPVD
                     LFCKNLKATSQHECSSSQVKASVCKPFLFLLTKNTPSPVKLAFIDNLHHLCKHLDFQE
                     DETEVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSEDGFIKELFVLRMKEAYT
                     HAQISRSNELKDTLILTTGDIGRAAKGDLIPFALLHLLHCLLSKSASVSGAAYTEIRA
                     LVAAKSVKLQNFFSQYKKPICQFLVESLHSSQMTALPSTPCQTAEMRKQHVAHHREMA
                     LNTLSEIANVFDFPDLNRFLTRTLQVLLPDLAAKASPAASALIRTLGKQLNVNRREIL
                     INNFKYIFSHLVCSCSKDELERALHYLKNETEIELGSLLRQDFQGLHNELLLRIGEHY
                     QQVFNGLSILASFASSDDPYQGPRDITSPELMADYLQPKLLGILAFFNMQLLSSSVGI
                     EDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDFPELCCRAWDCFVRCL
                     DHAYLGPLLSHVIVALLPLIQMQPKETAAIFHYLIIENRVAVQDFLHEIYFLPDHPEL
                     EKIKAVLQEYRKETSESTDLQTTLQLSMKAIQHENVDVRIHALTSLKETLYKNQEKLI
                     KYATDSETVEPVISQLVTVILKGCQDANSQARLLCGECLGELGAIDPGRLDFSTTETQ
                     GKDFTFVTGVEDLSFAYGLLMELTRAYLAYADNSRAQDSAAYAIQELLSIYDCREMQS
                     NGPGHQLWKRFPEHVREILEPHLNTRYKSSQKSTDWSGVTKPIYLSKLGNNFAEWSSS
                     WAGYLITKVRDNLASKIFTCCSIMMKHDFKVTIYLLPHILVYVLLGCSQEDQQEVYAE
                     IMAVLKHDDQHAISTQDSASDLCQLSTQTVFSMLDHLTQWARHKFQALNAEKLAQNKP
                     KGVSSVNFEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQKHL
                     GFLQKLYAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATACYDRAIQLEPD
                     QIIHYHGVVKSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDLVEN
                     YLAADGKSTTWSVRLGQLLLSAKKRDTTAFYDTLKLVRAEQIVPLSAASFERGSYQRG
                     YEFIVRLHMLCELEHSLKPLFHKFPGDSCNEDSLNWAARLEMTQNSYRAKEPILALRR
                     ALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWL
                     WSKGDVHQALIVLQKGVELCFPENKSPTESKHMLIHGRATLLVGRFMEETANFESNAI
                     MKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYG
                     NQFIYQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDLAKINSVLTEHTNRLAPYQ
                     FLTAFSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCK
                     EILTKAIHMKKSLEKFVGDATRLTDKLLELCNKSVDGSNSTLSMSTHFKMLKKLVEDP
                     TFSEILIPLQSVMIPTLPSILGAHANHDPFPGHWAYLAGFDDVVEILSSLQKPKKISL
                     KGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLND
                     ECGIIEWVNNTAGLRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFQEILLP
                     RHPPVFHEWFLRTFPDPTSWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSFTG
                     ECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPMGTEGLFRRACEVTLRLMRDQ
                     REPLMSVLKTFLHDPLVEWSKPVKGHSKAPPNETGEVVNEKAKTHVLDIEQRLQGVIK
                     TRNRVTGLPLSIEGHVHYLIQEATDENLLCQMYLGWTPYM"
ORIGIN      
        1 cgctccgcct tctcctccgg gcgcgactgt agagaagccc ggcactggcg gcggctgttt
       61 tgagagccgc tcggtgtcac catgggtgac cacgggctgg agctggcgtc catgattccc
      121 gccctgcggg agttgggcag tgctactcca gaggaatata atactgttgt gcagaaacca
      181 agacaaattc tctgccaatt cattgaccga atacttacag atgtaaatgt tgttgctctc
      241 gaacttgtaa agaaaactga cactcagccg acctctgtga tgttacttga ttttatccag
      301 cacatcatga agtcttctcc acttatgttt gtaaatgtga atggaagcca gggccaaaat
      361 gaggccaaag acagttgtat tgaattcagt cattggatca ttacaagact tttacggatt
      421 gcagcaactc catcctgcca catgctacac aagaaaatat gtgaagttat ctgctcatta
      481 ttatttcttt ttaaaagcaa gaatcctgct atttttgggg tactcacaag agaattactt
      541 tatctttttg aagacttgat ttacctccac aaaagaaatg cagtgggtga tgttatggaa
      601 tggccagtgg ttgtcagtcg atttttaagc cgattggatg aacacatggg atgtttacag
      661 ccagctcctt tgcagttcat gaacatgcaa aatgtagaat ttattgaagt cactttatta
      721 atggttctta ttcatattgt tccaactgtg ttttttagac gacaagaatt gttactgtgg
      781 cagattggct gtgctctgct agagcatggt agtcccaaga tcagatcttt agcaattagc
      841 cttttaactg agctctttga gctgggagga ttaccagcac agccagccag cacctttttc
      901 agcctatttt tggagttgct acaacacctt ataggaatgg atgctgacca actgaaattg
      961 tatgaagagc cattgtcaaa gctggtaaaa acactgttcc cctttgaggc agaggcttat
     1021 agaaatattg aacctgttta cttaaatgtg ctgctggaaa aactccgagt catgtttgaa
     1081 gatcgcgtgc tcatgcggct caagtctgat ttgctgaaag cagctctgtg ccatttactg
     1141 cagtatttcc tcacatttgt gccagcgggg tatgagtcgg cgttacaggt caggaaggtt
     1201 tatgtgactg atatttgtag agctcttgta gatgtcctcg gagttcagac acatgtgggg
     1261 tatttgttgg gaccatttta tgcagccttg aaaatggaaa gtacggaaat tattgagaga
     1321 attcaatgtc aagctcaaca ggagaatctc cgtggtagta atgatggtgt gtcaccaaag
     1381 aggcgtagac tcagctcctc tctcagctct tacaaaaggc catccagaca gtctgaagaa
     1441 attaatcatg tggatatgga caaaaagagc atattatgga atgttctgaa acagaaagct
     1501 gaatcccttc agatttccct tgaatgtggt actctaaaga attctgttgc tgaggcatta
     1561 gaaggaatca ctattgtatt acagctgact gctctctgca ctgttcactg ttctcatcaa
     1621 gacatggatg gccataatgc caaggattgt caacacaaat ataagaagaa acctccagta
     1681 gtaataactt ggatgtcttt ggatttttat acaaaagtgc ttaaaagctg taagagtttg
     1741 ttagaatctg ttcagaaaca tgaactggaa ttagtcatcg atagtgtggt gagaatttat
     1801 gatgctttga tgtatataca agtaaaaagt tcatttcaag atcatgttct ggaagagtta
     1861 tgtggaatgc tctcacttcc ttggatttat tcctattctg atgataactc tttaaagatg
     1921 accacatttg ctactaacct tctgcggtta agccagaggg tttgggaaag ttactctcca
     1981 caggcacagt cacaatgcgt gtttcttctg acactgtttc caaaaagaat attccttgac
     2041 tggagaacaa cagtttataa ttgggccttg aagagctccc atgaagtaat ccggactagt
     2101 tgtgttaaag gattttttat cttattgcag caggagaatt cttgtaatca aattcccaag
     2161 atgctaatag atagagtcaa agatgattct cacgtggtca agaaagaatt tgcttctgtc
     2221 cttggtcaac ttgtctgtac tcttcatggc atgttttatt tgacaagttc ctcggtagag
     2281 cctttctttg gacctgtgga cttgttctgt aagaacctga aagccacttc tcaacatgaa
     2341 tgttcatctt ctcaagtaaa agcttccgtt tgcaagccat tccttttcct gctgactaaa
     2401 aatacaccta gtccagtaaa acttgctttc atagacaatc tgcatcatct ttgtaagcat
     2461 cttgattttc aagaagatga aacagaggta aaagcagttc ttggcacttt attaaatttg
     2521 atggaagatc cagacaagga tgttagaata gcttttagtg gaaatatcaa gtatatattg
     2581 gaatctttga actctgaaga tggattcata aaagagcttt ttgtgttaag aatgaaggaa
     2641 gcatatacac atgcccagat atcaaggagt aatgagctga aggacacctt gattcttaca
     2701 acaggggata ttggaagggc agcaaaagga gatttgatac cttttgcact cttgcattta
     2761 ctgcattgct tgttgtctaa gtctgcatcc gtctctggag cggcatacac agagatccga
     2821 gcactagttg cagccaaaag tgttaaacta cagaattttt tcagtcaata taagaaacca
     2881 atctgtcagt ttttggtaga atctctccac tccagtcaga tgacagcact cccaagtact
     2941 ccttgccaga ctgctgagat gcgaaaacaa catgttgctc atcacagaga aatggcttta
     3001 aataccttat cagaaattgc caatgttttt gactttcctg atcttaatcg tttcctgaca
     3061 aggacattac aagttctact tcctgatctg gccgccaaag caagtcctgc agcatcggct
     3121 ctcatccgaa ctttagggaa acaattaaat gtcaaccgtc gagagatttt aataaataac
     3181 ttcaaatata ttttttctca tttggtttgt tcttgttcca aagatgaatt agaacgtgcc
     3241 cttcattatc tgaagaatga aacagaaatt gagttgggga gcctgttaag acaggatttt
     3301 caaggattgc acaatgaatt attgctgcgt attggagaac attatcaaca agttttcaat
     3361 ggtttgtcaa tccttgcctc atttgcatct agtgatgatc cgtatcaagg accacgagat
     3421 atcacatcgc ctgaactgat ggctgattat ttgcaaccga aattgttggg cattctagcc
     3481 ttttttaata tgcagttact gagctccagt gttggtattg aagataaaaa aatggccttg
     3541 actagtttga tgtctttgat gaagttgatg ggacctaagc atgttagttc tgtgagagta
     3601 aagatgatga ccacactgag aactggactg agattcaagg atgatttccc tgagttatgc
     3661 tgcagagcat gggactgctt tgttcgttgt ctggaccacg cttacctggg acccctgctc
     3721 agtcatgtca tagtggcttt gctacctctc atacagatgc agcctaaaga aactgcggct
     3781 atctttcact acctcatcat tgaaaacagg gttgccgtgc aagattttct tcatgaaata
     3841 tattttctgc ctgatcatcc agaattagaa aagataaaag cagttctgca ggaatataga
     3901 aaggaaacct ctgagagtac tgatcttcaa accactctcc agctctctat gaaagcaatt
     3961 cagcatgaaa atgtagatgt tcgtattcat gctcttacca gcttgaagga aaccttgtac
     4021 aaaaaccagg aaaaactgat aaaatatgca actgatagtg aaacagtgga gcctgttatc
     4081 tcccagcttg tgacagtaat tttgaaaggc tgccaagatg caaactctca agctcgcttg
     4141 ctctgtgggg aatgtttagg agaactggga gcaatagacc caggacgatt agatttctca
     4201 acaacagaaa ctcagggaaa agattttaca tttgtgactg gagtagaaga tttaagcttt
     4261 gcctatggat tgctgatgga gctaacaaga gcttaccttg cgtatgccga taacagccga
     4321 gcacaagatt cagctgctta tgccattcag gagttacttt ctatttatga ctgtagagag
     4381 atgcagagca atggcccagg ccaccagttg tggaagagat tccctgagca cgtccgagaa
     4441 atattagaac ctcatcttaa tactagatat aagagttccc agaagtcaac agattggtct
     4501 ggagtaacga agccaattta cttaagtaaa ctaggtaata actttgcaga atggtcatca
     4561 tcttgggcag gttatcttat aacaaaggtc cgggataatc ttgccagtaa aatcttcacc
     4621 tgctgtagta taatgatgaa gcatgatttc aaagtcacca tctatctcct tccacatatc
     4681 ctagtatatg tcttgttggg ttgtagtcaa gaagatcagc aagaggttta tgcagaaatt
     4741 atggcagtac ttaagcatga tgatcagcat gccatcagta cccaggacag tgcatcggat
     4801 ctgtgccagt tgagtacaca gactgtgttc tctatgcttg accatctcac ccaatgggca
     4861 aggcacaaat ttcaggcatt gaatgctgag aaacttgcac aaaacaaacc aaaaggagta
     4921 tcaagtgtga attttgaaga ctatcagagt gtaactcgtt ttctagacct catacctcag
     4981 gatactctgg ctgtagcctc ctttcgttcc aaagcataca cacgagccgt aatgcacttt
     5041 gagtcattta ttacagaaaa gaagcaaaat attcaaaagc atcttggatt tctacagaaa
     5101 ttgtatgctg ctatgcatga accagatgga gtggctggag taagtgcaat tcgaaaagca
     5161 gagccatcac tgaaggaaca gattcttgag catgaaagta ttggcttgct gagggatgcc
     5221 actgcctgtt atgacagggc tattcagcta gaaccggacc agatcattca ttatcatggt
     5281 gtcgtgaagt ccatgttagg tcttggtcag ctgtccactg taatcaccca ggtcaatgga
     5341 gtgcatgcta ataggtctga atggacagat gaattaaaca catacagagt tgaagcagct
     5401 tggaaactgt cacagtggga tttggtggaa aactacttgg cagcagatgg gaaatccaca
     5461 acgtggagtg tcagactagg acagctactg ttatcagcta aaaagaggga caccacagct
     5521 ttctatgaca cactgaaact agtgagagca gaacaaattg tacctctctc agctgcaagc
     5581 ttcgaaagag gctcctacca acgaggatat gaatttattg tcaggttaca catgttgtgt
     5641 gagttggagc acagcctcaa accacttttt cacaagtttc caggtgacag ttgtaatgaa
     5701 gactctctga actgggcagc tcgactagaa atgacccaga attcctacag agcaaaggag
     5761 cctatcctgg ccctccggag ggctttatta agtctcaaca aaaggcctga ttacaatgaa
     5821 atggttggag aatgctggct acagagtgcc agggtagcta gaaaggctgg gcaccatcag
     5881 acagcctaca atgctctcct taatgctgga gagtcacgac ttgccgaact ctatgtggaa
     5941 agggcgaagt ggctgtggtc caagggtgat gttcaccagg cgcttattgt tcttcaaaag
     6001 ggggttgaat tatgttttcc tgaaaataaa tccccaactg agagtaagca catgttaatc
     6061 catggtcgag ctacactgct cgttggccgg tttatggaag aaacagctaa ctttgaaagc
     6121 aacgcaatta tgaagaaata taaggatgtg accttgtttc tgccagagtg ggaagatggg
     6181 catttctacc ttgccaagta ctatgacaag ttgatgccca tggtaacaga taacaaaatg
     6241 gaaaagcaag gcgatctcat ccgatatata gtcctacatt ttggaagatc tcttcagtat
     6301 ggaaatcagt tcatatatca atcaatgcca cgaatgttat cgctatggct tgattttggt
     6361 gctaaggcat acgaatggga aaaaggtggt cgttctgatc gtctgcaaat gagaaatgat
     6421 ttggcaaaaa taaatagtgt actcacagag cacacaaatc ggttagcacc atatcagttt
     6481 ttgactgctt tttcgcagtt gatctctcga atttgtcatt ctcatgatga agtttttgtt
     6541 gtcttgatgg aaataatagc caaggtcttt ctggcctatc ctcagcaagc aatgtggatg
     6601 atgactgctg tgtcaaagtc ttcttatccc atgcgtgtga acagatgcaa ggaaattctt
     6661 accaaagcta tccatatgaa aaagtcttta gaaaagtttg tcggagatgc aactcgccta
     6721 acagacaagc tactagagtt atgcaacaaa tcggttgatg gaagtaattc tacattgagc
     6781 atgagcactc actttaaaat gcttaaaaag ctggtagaag acccaacatt tagtgaaatc
     6841 ctcattcctt tgcagtcagt catgatacct actcttccat caattctggg tgcccatgct
     6901 aatcatgacc cctttcctgg gcattgggcc tatcttgcag gcttcgacga tgtggtagaa
     6961 attctttctt ctcttcagaa accaaagaaa atctccttaa agggctcaga tggaaaattc
     7021 tatatcatga tgtgtaaacc aaaagatgat ttgagaaaag actgtagact aatggaattt
     7081 aattctttga ttaacaagag cttaagaaaa gatgcagaat cacgtcgaag agaacttcat
     7141 atccgaacat atgcagttat tccactgaat gatgagtgtg ggattattga atgggtgaac
     7201 aacactgctg gcttgagacc tattctgacc aaactataca aagaaaaggg agtgtatatg
     7261 acaggaaagg aacttcgcca gtgtatgcta ccaaagtcag cagctttatc tgaaaaactc
     7321 aaagtattcc aagaaatact cctgcccagg caccctcctg tttttcatga gtggtttcta
     7381 agaacattcc ctgatcctac atcatggtac agcagtaggt ccgcatactg ccgttctact
     7441 gcggtcatgt caatggttgg ctatatcctg gggcttggag accgtcatgg tgaaaacatt
     7501 ctttttgatt ctttcactgg tgaatgtgta catgtagact tcaactgtct ttttaataag
     7561 ggagaaactt ttgaagttcc agaaattgta ccatttcgac tgactcataa tatggttaat
     7621 ggaatgggtc ctatgggaac agagggtctg tttcgaagag catgtgaagt tacactgaga
     7681 ctgatgaggg atcagcgcga acctttaatg agtgtcttaa agacttttct gcatgatcct
     7741 ctcgtggaat ggagtaaacc agtgaaagga cactccaaag caccaccgaa tgaaaccggg
     7801 gaagttgtca atgagaaggc taagacccat gttcttgaca ttgaacaacg actacaaggt
     7861 gtaatcaaga cccggaatag agtaacaggg ctgccgttat ctattgaagg acatgtgcat
     7921 tatctcatac aagaagctac tgatgaaaac ttactatgtc agatgtacct tggttggacc
     7981 ccatatatgt aaaataaaat tatttcaaag aacatattaa taatctgaaa
//
