LOCUS       NM_001106140            4167 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATPase phospholipid transporting 8B1 (Atp8b1),
            mRNA.
ACCESSION   NM_001106140 XM_001064261 XM_214553
VERSION     NM_001106140.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4167)
  AUTHORS   Ansari,I.U., Longacre,M.J., Paulusma,C.C., Stoker,S.W.,
            Kendrick,M.A. and MacDonald,M.J.
  TITLE     Characterization of P4 ATPase Phospholipid Translocases (Flippases)
            in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING
            INHIBITS INSULIN SECRETION
  JOURNAL   J Biol Chem 290 (38), 23110-23123 (2015)
   PUBMED   26240149
  REMARK    GeneRIF: the predominant P4 ATPases in pure pancreatic beta cells
            and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A.
            ATP8B1 and CDC50A were highly concentrated in ISG
REFERENCE   2  (bases 1 to 4167)
  AUTHORS   Haas,M.J., Shah,G.N., Onstead-Haas,L.M. and Mooradian,A.D.
  TITLE     Identification of ATP8B1 as a blood-brain barrier-enriched protein
  JOURNAL   Cell Mol Neurobiol 34 (4), 473-478 (2014)
   PUBMED   24643366
  REMARK    GeneRIF: ATP8B1, a P-type aminophospholipid translocase, is
            enriched in cerebral microvessels and may have a role in plasma
            membrane lipid transport
REFERENCE   3  (bases 1 to 4167)
  AUTHORS   Takatsu,H., Baba,K., Shima,T., Umino,H., Kato,U., Umeda,M.,
            Nakayama,K. and Shin,H.W.
  TITLE     ATP9B, a P4-ATPase (a putative aminophospholipid translocase),
            localizes to the trans-Golgi network in a CDC50 protein-independent
            manner
  JOURNAL   J Biol Chem 286 (44), 38159-38167 (2011)
   PUBMED   21914794
  REMARK    Erratum:[J Biol Chem. 2015 Jan 9;290(2):886]
REFERENCE   4  (bases 1 to 4167)
  AUTHORS   van der Velden,L.M., Wichers,C.G., van Breevoort,A.E.,
            Coleman,J.A., Molday,R.S., Berger,R., Klomp,L.W. and van de
            Graaf,S.F.
  TITLE     Heteromeric interactions required for abundance and subcellular
            localization of human CDC50 proteins and class 1 P4-ATPases
  JOURNAL   J Biol Chem 285 (51), 40088-40096 (2010)
   PUBMED   20947505
REFERENCE   5  (bases 1 to 4167)
  AUTHORS   Ray,N.B., Durairaj,L., Chen,B.B., McVerry,B.J., Ryan,A.J.,
            Donahoe,M., Waltenbaugh,A.K., O'Donnell,C.P., Henderson,F.C.,
            Etscheidt,C.A., McCoy,D.M., Agassandian,M., Hayes-Rowan,E.C.,
            Coon,T.A., Butler,P.L., Gakhar,L., Mathur,S.N., Sieren,J.C.,
            Tyurina,Y.Y., Kagan,V.E., McLennan,G. and Mallampalli,R.K.
  TITLE     Dynamic regulation of cardiolipin by the lipid pump Atp8b1
            determines the severity of lung injury in experimental pneumonia
  JOURNAL   Nat Med 16 (10), 1120-1127 (2010)
   PUBMED   20852622
REFERENCE   6  (bases 1 to 4167)
  AUTHORS   Pawlikowska,L., Groen,A., Eppens,E.F., Kunne,C., Ottenhoff,R.,
            Looije,N., Knisely,A.S., Killeen,N.P., Bull,L.N., Elferink,R.P. and
            Freimer,N.B.
  TITLE     A mouse genetic model for familial cholestasis caused by ATP8B1
            mutations reveals perturbed bile salt homeostasis but no impairment
            in bile secretion
  JOURNAL   Hum Mol Genet 13 (8), 881-892 (2004)
   PUBMED   14976163
REFERENCE   7  (bases 1 to 4167)
  AUTHORS   Eppens,E.F., van Mil,S.W., de Vree,J.M., Mok,K.S., Juijn,J.A., Oude
            Elferink,R.P., Berger,R., Houwen,R.H. and Klomp,L.W.
  TITLE     FIC1, the protein affected in two forms of hereditary cholestasis,
            is localized in the cholangiocyte and the canalicular membrane of
            the hepatocyte
  JOURNAL   J Hepatol 35 (4), 436-443 (2001)
   PUBMED   11682026
REFERENCE   8  (bases 1 to 4167)
  AUTHORS   Ujhazy,P., Ortiz,D., Misra,S., Li,S., Moseley,J., Jones,H. and
            Arias,I.M.
  TITLE     Familial intrahepatic cholestasis 1: studies of localization and
            function
  JOURNAL   Hepatology 34 (4 Pt 1), 768-775 (2001)
   PUBMED   11584374
  REMARK    Erratum:[Hepatology 2002 Jan;35(1):246]
REFERENCE   9  (bases 1 to 4167)
  AUTHORS   Tygstrup,N., Steig,B.A., Juijn,J.A., Bull,L.N. and Houwen,R.H.
  TITLE     Recurrent familial intrahepatic cholestasis in the Faeroe Islands.
            Phenotypic heterogeneity but genetic homogeneity
  JOURNAL   Hepatology 29 (2), 506-508 (1999)
   PUBMED   9918928
REFERENCE   10 (bases 1 to 4167)
  AUTHORS   Bull,L.N., van Eijk,M.J., Pawlikowska,L., DeYoung,J.A., Juijn,J.A.,
            Liao,M., Klomp,L.W., Lomri,N., Berger,R., Scharschmidt,B.F.,
            Knisely,A.S., Houwen,R.H. and Freimer,N.B.
  TITLE     A gene encoding a P-type ATPase mutated in two forms of hereditary
            cholestasis
  JOURNAL   Nat Genet 18 (3), 219-224 (1998)
   PUBMED   9500542
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001064261.1, XM_214553.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5756307, SAMEA5760383
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4167
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..4167
                     /gene="Atp8b1"
                     /note="ATPase phospholipid transporting 8B1"
                     /db_xref="GeneID:291555"
                     /db_xref="RGD:1308488"
     CDS             1..3780
                     /gene="Atp8b1"
                     /EC_number="7.6.2.1"
                     /note="probable phospholipid-transporting ATPase IC;
                     ATPase, Class I, type 8B, member 1; ATPase,
                     aminophospholipid transporter, class I, type 8B, member 1;
                     P4-ATPase flippase complex alpha subunit ATP8B1"
                     /codon_start=1
                     /product="phospholipid-transporting ATPase IC"
                     /protein_id="NP_001099610.1"
                     /db_xref="GeneID:291555"
                     /db_xref="RGD:1308488"
                     /translation="MNTERDSETTFDEDSQPNDEVVPYSDDETEDELEDQGPAVEPEQ
                     NRVNREVEKKKETFRKDCTWQVKANDRKFHEQPHFMNTKFFCIKESKYASNAIKTYKY
                     NALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAIKDL
                     VDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSS
                     EPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFT
                     GTLFWRNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKID
                     YLMNYMVYTIIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATPSYRGFLNFWGY
                     IIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHY
                     IFSDKTGTLTQNIMTFKKCCINGTIYGDHRDASQHSHSKIELVDFSWNEFADGKLAFY
                     DHYLIEQIQSGKEPEVRQFFFLLSICHTVMVDRIDGQINYQAASPDEGALVNAARNFG
                     FAFLARTQNTITVSELGTERTYSVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADTV
                     IYERLHRMNPMKQETQDALDIFASETLRTLCLCYKEIEEKEFAEWNKKFMAASVASSN
                     RDEALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAE
                     NIGFACELLTEDTTICYGEDINSLLHTRMENQRNRGGVSAKFAPPAYEPFFPPGENRA
                     LIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDL
                     ACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQE
                     GMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFN
                     GYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNY
                     KKFFVSLLHGVLTSMVLFFIPFGAYLQTVGQDGEAPSDYQSFAVTMASALVITVNFQI
                     GLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGWCFSDSESTASN
                     ALRQPYIWLTIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWKRRQS
                     VFRRGASSRRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIIADGTAEYRRTVES"
     exon            1..181
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..279
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..393
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            394..492
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..554
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..627
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..698
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            699..781
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            782..940
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1029
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1220
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1429
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1473
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1630
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1819
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1932
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2097
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2209
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2285
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2418
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2707
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2931
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2932..3015
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3261
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3424
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3555
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..4167
                     /gene="Atp8b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacacag aaagggactc ggaaacaaca tttgatgagg attcccagcc caatgatgaa
       61 gtggttccct acagtgatga tgaaaccgaa gacgaacttg aagaccaggg gcctgcagtt
      121 gaaccagaac agaatcgtgt caacagagaa gtcgagaaaa agaaagagac attccggaaa
      181 gattgcacgt ggcaagtcaa agcaaatgat cgaaagttcc acgaacaacc tcattttatg
      241 aacaccaagt tcttttgtat taaggagagc aaatatgcga gtaatgcaat taaaacatac
      301 aagtacaatg cactgacctt tctacccatg aatttgtttg agcaatttaa gagggcagcc
      361 aacttctatt tcctgatcct cctgatcttg caggcaattc ctcaaatctc caccctggca
      421 tggtatacca cacttgtacc tctacttctg gtgctgggca tcacggcaat caaagacctg
      481 gtagatgatg tggctcgcca taaaatggac aaggaaatca acaacaggac atgtgaagtc
      541 attaaggacg gcaggttcaa aatcatcaag tggaaagata tccaggttgg agacgtcatc
      601 cgtctgaaga agaatgattt tattccagcc gacattctgc tattgtccag ctccgagcct
      661 aacagcctct gctatgtaga aacggctgag cttgacggag aaaccaattt gaagttcaaa
      721 atggccctgg aaatcacaga ccagtatctc caaatagaag ataacttggc gacgtttgat
      781 ggtttcatcg aatgtgagga accaaacaac cggttagaca agttcacggg aacgctcttt
      841 tggaggaacc aaagttttcc tttggatgct gataaaatcc tgttgcgggg ctgcgtgatt
      901 aggaacaccg atgtctgcca tggcttggtc atttttgcag gtgctgacac gaagataatg
      961 aagaacagtg ggaaaaccag atttaaaaga actaaaatcg attacttgat gaactacatg
     1021 gtgtacacga tcattattgt cctcatcctg gtttccgctg gccttgccat tggtcacgcg
     1081 tattgggaag cacaaattgg caattattcc tggtacctct atgatggaga aaatgccaca
     1141 ccatcctacc ggggcttcct gaatttctgg ggctacatca ttgtattgaa caccatggtg
     1201 cccatctctc tctatgtcag tgtggaagtg atccgtctgg gacagagtca tttcatcaac
     1261 tgggacctgc agatgtacta cgctgagaag gacactcctg ccaagtcgag gactaccaca
     1321 ctgaatgagc agctagggca gatccattac attttctctg acaagacggg gactctcacc
     1381 caaaacatca tgaccttcaa gaagtgctgc atcaacggga ccatctatgg agaccatcga
     1441 gatgcttctc agcacagcca cagcaaaata gagctagtgg actttagctg gaatgaattt
     1501 gctgatggga agcttgcatt ttatgaccat tatcttattg agcaaatcca gtcaggaaaa
     1561 gagccagaag tacgacagtt cttctttttg ctttccattt gccatacggt catggtggac
     1621 agaattgatg gtcagatcaa ctaccaggcg gcctctcctg acgaaggcgc cctggtgaac
     1681 gccgccagga acttcggctt tgcctttctt gccaggacgc agaacaccat caccgtcagc
     1741 gaactgggca cagaaaggac ctacagtgtg cttgccattt tggacttcaa cagcgaccga
     1801 aagcggatgt ctatcatcgt gaggacccca gaaggtagca tcaggctata ctgtaaaggt
     1861 gctgacacgg tgatttatga acgactccat cggatgaatc ccatgaagca ggaaacacag
     1921 gatgccctgg atatctttgc aagtgagact ctcagaaccc tgtgcctgtg ctacaaggaa
     1981 attgaagaaa aagagtttgc agagtggaat aagaagttca tggctgccag tgtggcctca
     2041 agcaaccgag acgaagcgtt ggataaagtg tacgaggaga tcgagaggga cttgattctc
     2101 ctgggagcca ctgctattga agacaagcta caggatggag ttccagaaac catttcaaaa
     2161 cttgcaaagg ctgacattaa gatctgggta cttaccggag acaagaagga aactgcagaa
     2221 aacataggct ttgcctgtga acttctgaca gaagacacta ctatctgcta tggggaggac
     2281 ataaactctc ttcttcacac caggatggag aatcagagaa acagaggcgg agtctctgcg
     2341 aaatttgcac cccccgcgta tgaacccttt tttccacctg gagaaaaccg tgccttaatc
     2401 atcactggct cgtggttgaa tgagatcctt ctagagaaga agaccaagag aagtaagatc
     2461 ctgaagctga agttcccaag gaccgaggag gagaggcgga tgcggagcca gagtcggagg
     2521 cggctggaag agaagaaaga gcagcggcag aagaattttg tggacctggc ctgtgagtgc
     2581 agcgctgtca tctgctgccg cgtcacaccc aagcagaagg ccatggtggt ggacctggtg
     2641 aagaggtaca agaaggccat cacgctggcc atcggagacg gggccaacga tgtgaacatg
     2701 atcaaaactg cccacattgg agttggaata agcggacaag aaggcatgca agctgtcatg
     2761 tccagtgact attcttttgc tcagttcaga tacctgcagc gcttgctgct ggtccatggc
     2821 cggtggtctt acataaggat gtgcaagttc ctacgctatt tcttttacaa gaactttgca
     2881 tttactttgg ttcatttctg gtactccttc ttcaatggct actcagccca gacggcgtat
     2941 gaggactggt ttatcaccct gtacaatgtg ctgtactcca gtttgcctgt gctcctcatg
     3001 gggctgctcg atcaggatgt gagcgacaag ctgagcctcc gattccctgg gttgtatgta
     3061 gtgggacaga gagacttgct gttcaactat aagaagttct ttgtcagttt gctgcacggg
     3121 gtcttaacct caatggtcct cttcttcata ccgtttggcg cttacctgca aacagtggga
     3181 caggatggag aggcaccttc agactaccag tcctttgccg tcacaatggc ctcggctcta
     3241 gtgataacgg tcaatttcca gatcggcttg gatacgtcgt actggacgtt cgtgaatgcc
     3301 ttttccattt ttggaagcat cgcgctgtac tttggcatca tgtttgattt ccatagtgct
     3361 gggatccatg ttctcttccc atctgcattc cagttcacag gttggtgttt ctcagattct
     3421 gaaagtacgg cttccaatgc cctgagacag ccgtatattt ggctgacgat catcctgacg
     3481 gttgcagttt gcttgttacc tgtcgtcgcc atccgtttcc tgtcaatgac catctggcca
     3541 tcagaaagtg ataagatcca gaagcatcga aagcgattga aggccgaaga gcagtggaaa
     3601 cggcggcaga gcgtgttccg gaggggagca tcttcccggc gctccgccta cgccttctcg
     3661 caccagaggg gctatgcgga cctcatctcc tctggccgca gcatccgcaa gaagcgctcg
     3721 cccctggacg ccatcatcgc agatggcaca gcggagtacc gacgcacagt ggagagctga
     3781 ggggcactgc tctgctgaga gaccggagct ctgggaaaat gtcttttttt tttttttctt
     3841 taatgaacaa ctcaggactt tttaaaaaaa aaaaataaac tgaggttgtc acagtgacac
     3901 tgatgacaat aaccttttca ataaacttct aggattgtgc tcttaagcag tagcaaagcc
     3961 aagagaccac ctgttattca gctgactgcc tcgctgagat tcaaagggaa cgcttctttt
     4021 ttttaaatcc aggcctaatg gaagacggca gaatttagaa aagtctcctt ttcagcttga
     4081 aggatactac tacactacaa agttacaatc acactctcct atctctggcc tcaagcatgg
     4141 atttctcaga cgcactcctc cctctgc
//
