LOCUS       XM_017599991            7555 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ATPase copper transporting beta
            (Atp7b), transcript variant X1, mRNA.
ACCESSION   XM_017599991
VERSION     XM_017599991.2
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051351.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_017599991.3.
            
            On Jan 21, 2021 this sequence version replaced XM_017599991.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..7555
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 16 ESTs, 11 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 8 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:24218"
                     /db_xref="RGD:2180"
     CDS             1103..5644
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X1"
                     /protein_id="XP_017455480.1"
                     /db_xref="GeneID:24218"
                     /db_xref="RGD:2180"
                     /translation="MEKAQGKMHQTPEQSFLASLSNPQVTLLSVQKRCTFRRSSGLGS
                     LARSDSSDEKDPPQPEEESSPGVLARTPERRSQILSKLALPTRPWGQSMKQSFAFDNV
                     GYEGGLDSTCSSSTTTGVVSILGMTCHSCVKSIEDRISSLKGIVSIKVSLEQGSATVK
                     YVPSVLNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVS
                     SIEGKIRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPL
                     RLGPIDINKLESTNLKRAAVPPIQNSNHLETPGHQQNHLATLPLRIDGMHCKSCVLNI
                     EGNIGQLPGVQNIHVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLPDGLEK
                     ESGSSSVPSLGSSQRQQEPGPCRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISL
                     AEGTGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRVSSGNSVPQAVGDSPGS
                     VQNMASDTRGLLTHQGPGYLSDSPPSPGGTASQKCFVQIKGMTCASCVSNIERSLQRH
                     AGILSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGDIELIIT
                     GMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEIGFHA
                     SLAHRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSSKPHETMVLDHN
                     IIPGLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSANMDVLIVLATTIAYAYSL
                     VILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEA
                     TVVTLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEA
                     MPVTKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADR
                     FSGYFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKHISQTEVIIRFAFQTSIT
                     VLCIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHG
                     VPRVMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTD
                     FQAVPGCGISCKVSNVESILAHRGPTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRR
                     NGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGV
                     DVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDS
                     PALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALI
                     YNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQA
                     HGRMKPLSASQVSVHVGMDDRRRDSPRATPWDQVSYVSQVSLSSLTSDRLSRHGGMAE
                     DGGDKWSLLLSDRDEEQCI"
ORIGIN      
        1 accactcgcc caagaagaga tcttaaggtc agtttttagg tagggagagg gtgccattgt
       61 gtagacacag aaggggatgg gttctaaaca cacgtcccag cgacctgaaa gggatgcact
      121 cagctgcaag gaccgatgca gacacgagca gggtggctgc cccacagact ggttcagctc
      181 agtccgcacc gtgaaccctc cacacaccaa ccttgtgggc attgccagga ctgtgtctgt
      241 ctgagtggtt cctcccttgg gacaggagcg catgtcccgt gggtcaggtg ggggatgggg
      301 aaggagaccg ccctgcctta cagcgggcga ctgcctggat ttccacactg tgcctgtctc
      361 tgcctgttag gtggaacagc aggtagccgg agaggcctga gttatggatt agttcccacc
      421 agttgtgcca gtataaagga cgaacgagcc tcgtcgccat gagtttgtgc ggtcagttct
      481 gactgaagtc aagaacaaag ctgcaggaga cagggagatt tctaacactt gttgggaatg
      541 caaaccatgc ccgggaaaca cttctctcgg ccagtgggct gccctctgcc agtgctggag
      601 ccctggaaga ggccactgaa attcttccag gaaaaccctt gcagcctggc actacgagga
      661 attggctagc ccagcacttt tgtcgctagc tagccaggtt tctaggagta caggtggcca
      721 aaaggaagct gcgcctggct ttgggagatg gtcaggcgct tggccccagg ttgtactgct
      781 tgctgttcgg tattttgtgt atggattgtg tgctggggcc caaagtagcc cacacctgtg
      841 ccggccgagc cagaggccgc agttggattg ggtggagata aacaaagcaa ataggcccac
      901 agcggcggtg tgcagcgtgt gcaagttcct gagctcccgc agactgaaga ccgcctctcc
      961 ctgcctgcag tttgctgggc tgggaagggt gcctgtccct gctaataagc aagacctctg
     1021 gaaagtattt tcctcacagc accacaagtg tggaagctga accgtgtgag tggggaggga
     1081 aggagtgacg gtggacctcg ctatggagaa agctcagggc aagatgcacc aaactccgga
     1141 gcagtcattc ctggcaagtc tgagtaaccc acaggtgaca ttgctgtccg tgcagaagag
     1201 gtgcaccttc aggaggagct ccgggcttgg gagcttggcc agatcggact cttcagacga
     1261 gaaagatcct ccccagccag aggaagaatc atcaccgggt gttttagcta gaaccccgga
     1321 aaggaggtcc cagatcttat ctaaacttgc tttgcccaca cgaccgtggg gacaatcaat
     1381 gaagcagagc ttcgccttcg ataatgttgg ctatgaaggg ggcctggaca gcacctgctc
     1441 atcctcaact accaccggtg tggttagcat cctgggcatg acttgtcatt cttgcgtcaa
     1501 gtccatcgag gacaggatct ccagtctgaa aggcattgtg agcatcaagg tttctctgga
     1561 gcagggcagc gccactgtca aatatgtacc gtcagtcttg aacctgcagc agatttgcct
     1621 tcagattgag gacatgggct ttgaggccag cgctgcagaa ggaaaggctg cctcctggcc
     1681 ttccaggtct tccccagccc aggaggcagt ggtcaagctc cgggtagagg gcatgacctg
     1741 tcagtcctgt gtcagctcca tcgaaggcaa gatccggaag ctgcaagggg ttgtgagagt
     1801 caaagtctcc ctaagcaacc aagaggcagt cattacatat cagccttacc tcattcaacc
     1861 cgaagacctc agggaccaca tctgcgacat gggattcgaa gctgccatca agaacagaac
     1921 agctccctta aggctgggac caattgatat caacaagtta gaaagcacta acctaaagag
     1981 agcagcagtc cctcctatcc agaattccaa tcatttggag accccggggc accagcagaa
     2041 ccacctggcc accctcccac taagaataga cgggatgcac tgtaaatcat gtgttttgaa
     2101 tatcgaagga aatataggcc aacttccagg ggttcaaaat attcatgtgt ccttggagaa
     2161 caaaaccgcc caagtacagt atgactcttc ttgtatcacc cccttgttcc tacagacagc
     2221 catcgaggca ctaccacctg ggtactttaa agtatccctt cccgatggcc tagagaagga
     2281 gagtggatct tccagtgtcc cctcccttgg ctcctcccag agacagcagg agccaggccc
     2341 atgcaggact gcggtactca ccatcactgg cattccccgt gactcgtctg ttcagcccat
     2401 ggaagacatg ctgtcccaga tgaagggtgt gcagcaaata gacatctctt tggcagaggg
     2461 gactggagca gttctttacg atccctcagt agttagctcg gatgaactcc ggacggctgt
     2521 agaagacatg ggctttgagg tgtcagtgaa tcccgaaaac attactacta accgtgtcag
     2581 ctctgggaat tctgtgccac aagccgtggg tgattcacca gggtctgtgc aaaatatggc
     2641 ttctgacact agaggactcc tcacacacca aggccctggc tacttgtcag acagcccacc
     2701 atcccctgga ggaacagcat cacagaagtg ctttgtacag atcaaaggca tgacctgtgc
     2761 gtcctgtgtg tctaacatag aaaggagtct gcagagacat gccggtattc tctccgtgtt
     2821 ggtcgccttg atgtcgggaa aggcagaggt caagtatgac ccagaggtca tccagtctcc
     2881 caggatagct cagctcatcg aggacctggg cttcgaagca gcaatcatgg aggacaacac
     2941 agtctctgaa ggtgacatcg aactgattat cacagggatg acctgcgctt cctgtgttca
     3001 caacatagaa tctaagctca caaggacaaa tggcatcact tacgcctctg tggccctcgc
     3061 caccagcaaa gcccatgtga agtttgaccc tgaaatcatt ggtccacgtg acatcatcaa
     3121 ggtcatcgag gaaatcggct ttcatgcttc cctggcccac agaaacccca acgctcatca
     3181 cttggaccac aagacggaaa taaaacagtg gaagaaatct ttcctgtgca gcctggtgtt
     3241 tggcatcccc gtcatgggct tgatgatcta catgctaatc cccagcagta agccccacga
     3301 gaccatggtc ctggaccaca acatcattcc aggactgtcc gttctaaacc tcattttctt
     3361 catcttgtgt accttcgtcc aattcctggg tgggtggtac ttctatgtcc aagcctacaa
     3421 atcgctgaga cacaagtcag ccaacatgga tgtgctcatc gtactcgcca cgaccattgc
     3481 ctatgcctac tccctggtca tcctggtggt tgccatagct gaaaaggcgg agaagagccc
     3541 agtgaccttc tttgacacac cccccatgct cttcgtcttc atcgccctgg gacggtggct
     3601 ggagcacgtg gcaaagagca aaacttcaga agccctcgca aaactcatgt cactccaagc
     3661 cacagaagcc acagttgtga ccctgggaga ggacaactta atcctcagag aggagcaagt
     3721 gcccatggag ctggtgcagc gaggtgacat catcaaggtt gtccctgggg gcaagttccc
     3781 agtggacggg aaagtcctgg aaggcaacac catggcagat gagtccctca tcacaggaga
     3841 ggccatgcct gtcaccaaga aacccgggag catagtgatt gctggctcta taaatgctca
     3901 tggctctgtg ctcattaaag ctacccatgt gggcaatgac actactttgg ctcagattgt
     3961 caagttggtg gaagaggccc agatgtcaaa ggctcccatt cagcagctgg ctgaccggtt
     4021 cagtggatat ttcgtcccat ttatcatcat tatttcaacc ttaacattgg tggtgtggat
     4081 catcatcggc tttgtcgatt ttggtattgt tcagaagtac tttcctagcc ctagcaagca
     4141 tatctcacag acagaggtga tcatccgctt tgccttccag acgtccatca ccgtcctgtg
     4201 catcgcctgc ccctgctccc tcgggctggc cacacccaca gcagttatgg tgggcactgg
     4261 ggtggctgcc cagaacggcg tcctaatcaa gggagggaag cctctggaga tggcacacaa
     4321 gataaagacc gttatgtttg acaaaacggg caccattacc cacggggtcc ccagagtcat
     4381 gcggtttctg ctgcttgtgg acgtggctac cctatccctc aggaaggttc tggctgtggt
     4441 gggcaccgca gaggccagca gtgagcaccc cttaggcgtg gccgtcacta aatactgcaa
     4501 agaggaactc gggacggaga ccctggggta cagcacggac ttccaggcag tgccagggtg
     4561 tggaattagc tgcaaagtta gcaacgtgga aagtatcctg gctcacagag gtccaaccgc
     4621 tcacccgatt ggggttggca accctcccat aggagaaggt acaggtcccc agactttctc
     4681 tgtgctgatt ggaaaccggg aatggatgag gcgcaatggt ttaaccatct ccagtgacat
     4741 cagtgacgcc atgacagatc atgaaatgaa aggacagacg gccatcctgg tggccattga
     4801 tggtgtgctg tgcgggatga tcgccattgc agatgctgtt aaaccagagg ctgccctggc
     4861 tatctacacc ctgaaaagca tgggcgtgga tgtggctctg atcacagggg acaaccggaa
     4921 gacagccaga gccattgcca ctcaggttgg catcaacaaa gtctttgctg aggtactgcc
     4981 ttctcacaag gtggccaagg tccaggagct tcagaacaaa gggaaaaaag tcgccatggt
     5041 gggagacggg gtgaacgact ccccagcctt ggcccaggct gacgtgggca ttgctattgg
     5101 gactgggaca gatgtcgcca tcgaagcagc cgacgtggtc cttataagaa atgacttact
     5161 ggacgtggtg gccagcattc atctctccaa gaggaccgtc cggaggatcc gggtcaatct
     5221 ggtgctggcg ttgatttata acatggttgg gatacccatt gctgcaggtg tcttcatgcc
     5281 cattggcatc gtgctgcagc catggatggg ctcagcggcc atggccgcct cctctgtgtc
     5341 cgtggtgctc tcctctcttc agctcaagtg ctacagaaag cccgacctag agagatatga
     5401 ggcacaggcc catggacgca tgaagcctct gagtgcatcc caagtcagcg tgcacgttgg
     5461 catggatgac cggcggcggg attctcccag ggccacaccc tgggaccagg tcagctacgt
     5521 gagccaagtc tctctgtctt ccctgacgtc agacagattg tctcggcatg gcggtatggc
     5581 agaggatggt ggagacaaat ggtccctgct cctgagtgac agggatgaag agcagtgcat
     5641 ctgagtgttc ccagcagcag ccctgggcag gccgaggtgc tccttccaga cgggcctgct
     5701 cccgctcact gtggtcgagc cagtgcagcc tcaacgagct gaagcacagc gatgggcgaa
     5761 gcttacgtga ggggcaagca tcctgctagc ctcgccagca gtgtgtggtg catctgcaga
     5821 ggctgggtgg gattgctctg tcagaagctg ctaggccggg caaaggacac tgctctccct
     5881 ggttttccat gagggcaagg tcacaccctg cttggatttt agtgcaggag aggaagccag
     5941 cactcctcag aggcctgcct actgtgtttg tatctactac ctatgaaatg agaaataggc
     6001 ccatcaggac cgcaggccta gctgagcccc ctggagagct ccatcctgag cttccctata
     6061 ctaagagctc ccacaaaggc tggagtcagg cagcacccat gggctgtgta agcctaagac
     6121 gacttcagac gcgtctgttg ttctctgcct gctttagttg gcatccttgg tactggcact
     6181 gcctgccctc tgttctgagg gtagagtttg tgtcttgggt ccaatgcttt ggctccttca
     6241 tatctgcctg cctaaaggtg gccccctggt ttgcagccca accccagagc tgcctggcct
     6301 ccctctttac tctgaggaga gaatgccatc ctgcttagag ccacacctac agactcacac
     6361 atgccactct caaacaactg gagagacgcc tcagaacctg accagagtcc attttccctg
     6421 ctataacctg tagtgagtga aacactgtcc aagggaaccc ccatgtgact tagtagggtc
     6481 cagtgcagta tgtcacaaat gcctggtgtg tgtgcctgaa gggagttgtc ccaaccggaa
     6541 gagagccaag ttctcaatag agagctctct gctgctgagg ggccatctaa acaagggacg
     6601 tccacagctc cccagtgaaa gtgcttttgt catctataac tatctgtgac caggtggcat
     6661 ccgagggcag ggatcatgtc agagggcagg gatgggccag cttaactgag cggctgagcc
     6721 acccggaaca gacggacaga aatggattac tctcatttgt gacattaaaa aaccaacaaa
     6781 accctccttt attggatgtc cttactggcc gtggcagtgt tagtcttttt ttttttcttg
     6841 gagttgggga ccgaacccag ggccttgcgc ttgctaggca agcgctctac cactgagcta
     6901 aatccccaac cccagtgtta gtcttttgtg ggttactcac cttccttcca acccccgccc
     6961 caaaagtagc accatactct catctatgtt tgaaaacaag gaaacagggt ccgagggcct
     7021 cggtgccttc ccaggaactc acagccgata ggcggttccg agagctccgc aggcccttct
     7081 gtaattccac tgctgcctta cttatcagtt tgcttggtga gcgtaaactg gacgagagag
     7141 ggtccttgtc tctggacaag cgaacaagct aggaggtgga ttagcagcct caacttagag
     7201 tgcagtaggt cgcaacgtta cagcccctca cttcccatgg ctggcctggt tgtcatcagt
     7261 gaccctgctt gctgagcttt atcttctaac ctccccctcc cccactcccc accagaacag
     7321 ggttctgtag cactctcagt attttcaccc ccccacgccc tcttcagtga cctctgcccc
     7381 ctcccccccg ccatctattc tgtctacagc tctgttttgg aataaggtga tcattttcta
     7441 aagaatctaa ttgtcttgat ttttaaacct tctgagaata taagcatcat gttcatatgt
     7501 agacatgaaa atatttatat aattatacaa ataaataact ttttagatat ttaaa
//
