LOCUS       NM_012511               5506 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Rattus norvegicus ATPase copper transporting beta (Atp7b), mRNA.
ACCESSION   NM_012511
VERSION     NM_012511.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5506)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 5506)
  AUTHORS   Sanchez-Monteagudo,A., Alvarez-Sauco,M., Sastre,I.,
            Martinez-Torres,I., Lupo,V., Berenguer,M. and Espinos,C.
  TITLE     Genetics of Wilson disease and Wilson-like phenotype in a clinical
            series from eastern Spain
  JOURNAL   Clin Genet 97 (5), 758-763 (2020)
   PUBMED   32043565
REFERENCE   3  (bases 1 to 5506)
  AUTHORS   Fujiyoshi,J., Yamaza,H., Sonoda,S., Yuniartha,R., Ihara,K.,
            Nonaka,K., Taguchi,T., Ohga,S. and Yamaza,T.
  TITLE     Therapeutic potential of hepatocyte-like-cells converted from stem
            cells from human exfoliated deciduous teeth in fulminant Wilson's
            disease
  JOURNAL   Sci Rep 9 (1), 1535 (2019)
   PUBMED   30733544
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5506)
  AUTHORS   Platonova,N.A., Orlov,I.A., Klotchenko,S.A., Babich,V.S.,
            Ilyechova,E.Y., Babich,P.S., Garmai,Y.P., Vasin,A.V.,
            Tsymbalenko,N.V. and Puchkova,L.V.
  TITLE     Ceruloplasmin gene expression profile changes in the rat mammary
            gland during pregnancy, lactation and involution
  JOURNAL   J Trace Elem Med Biol 43, 126-134 (2017)
   PUBMED   28089327
REFERENCE   5  (bases 1 to 5506)
  AUTHORS   Papur,O.S., Terzioglu,O. and Koc,A.
  TITLE     Functional characterization of new mutations in Wilson disease gene
            (ATP7B) using the yeast model
  JOURNAL   J Trace Elem Med Biol 31, 33-36 (2015)
   PUBMED   26004889
REFERENCE   6  (bases 1 to 5506)
  AUTHORS   Mercer,J.F., Grimes,A. and Rauch,H.
  TITLE     Hepatic metallothionein gene expression in toxic milk mice
  JOURNAL   J Nutr 122 (6), 1254-1259 (1992)
   PUBMED   1588441
REFERENCE   7  (bases 1 to 5506)
  AUTHORS   Okayasu,T., Tochimaru,H., Hyuga,T., Takahashi,T., Takekoshi,Y.,
            Li,Y., Togashi,Y., Takeichi,N., Kasai,N. and Arashima,S.
  TITLE     Inherited copper toxicity in Long-Evans cinnamon rats exhibiting
            spontaneous hepatitis: a model of Wilson's disease
  JOURNAL   Pediatr Res 31 (3), 253-257 (1992)
   PUBMED   1561010
REFERENCE   8  (bases 1 to 5506)
  AUTHORS   Li,Y., Togashi,Y., Sato,S., Emoto,T., Kang,J.H., Takeichi,N.,
            Kobayashi,H., Kojima,Y., Une,Y. and Uchino,J.
  TITLE     Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats
            with hereditary hepatitis. A model of Wilson's disease
  JOURNAL   J Clin Invest 87 (5), 1858-1861 (1991)
   PUBMED   2022751
REFERENCE   9  (bases 1 to 5506)
  AUTHORS   Biempica,L., Rauch,H., Quintana,N. and Sternlieb,I.
  TITLE     Morphologic and chemical studies on a murine mutation (toxic milk
            mice) resulting in hepatic copper toxicosis
  JOURNAL   Lab Invest 59 (4), 500-508 (1988)
   PUBMED   2845190
REFERENCE   10 (bases 1 to 5506)
  AUTHORS   Masuda,R., Yoshida,M.C., Sasaki,M., Dempo,K. and Mori,M.
  TITLE     Hereditary hepatitis of LEC rats is controlled by a single
            autosomal recessive gene
  JOURNAL   Lab Anim 22 (2), 166-169 (1988)
   PUBMED   3392951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB017792.1 and JAXUCZ010000016.1.
            
            On Oct 11, 2007 this sequence version replaced NM_012511.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017792.1, AB017791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4370              AB017792.1         1-4370
            4371-5506           JAXUCZ010000016.1  76724957-76726092
FEATURES             Location/Qualifiers
     source          1..5506
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..5506
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /note="ATPase copper transporting beta"
                     /db_xref="GeneID:24218"
                     /db_xref="RGD:2180"
     exon            1..52
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..4363
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /EC_number="7.2.2.8"
                     /note="copper pump 2; pineal night-specific ATPase; wilson
                     disease-associated protein homolog; ATPase, Cu++
                     transporting, beta polypeptide (same as Wilson disease);
                     PINA gene, promoter"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="NP_036643.2"
                     /db_xref="GeneID:24218"
                     /db_xref="RGD:2180"
                     /translation="MPEQERKVTAKEASRKILSKLALPTRPWGQSMKQSFAFDNVGYE
                     GGLDSTCSSSTTTGVVSILGMTCHSCVKSIEDRISSLKGIVSIKVSLEQGSATVKYVP
                     SVLNLQQICLQIEDMGFEASAAEGKAASWPSRSSPAQEAVVKLRVEGMTCQSCVSSIE
                     GKIRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHICDMGFEAAIKNRTAPLRLG
                     PIDINKLESTNLKRAAVPPIQNSNHLETPGHQQNHLATLPLRIDGMHCKSCVLNIEGN
                     IGQLPGVQNIHVSLENKTAQVQYDSSCITPLFLQTAIEALPPGYFKVSLPDGLEKESG
                     SSSVPSLGSSQRQQEPGPCRTAVLTITGIPRDSSVQPMEDMLSQMKGVQQIDISLAEG
                     TGAVLYDPSVVSSDELRTAVEDMGFEVSVNPENITTNRVSSGNSVPQAVGDSPGSVQN
                     MASDTRGLLTHQGPGYLSDSPPSPGGTASQKCFVQIKGMTCASCVSNIERSLQRHAGI
                     LSVLVALMSGKAEVKYDPEVIQSPRIAQLIEDLGFEAAIMEDNTVSEGDIELIITGMT
                     CASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIIKVIEEIGFHASLA
                     HRNPNAHHLDHKTEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSSKPHETMVLDHNIIP
                     GLSVLNLIFFILCTFVQFLGGWYFYVQAYKSLRHKSANMDVLIVLATTIAYAYSLVIL
                     VVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVV
                     TLGEDNLILREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPV
                     TKKPGSIVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSG
                     YFVPFIIIISTLTLVVWIIIGFVDFGIVQKYFPSPSKHISQTEVIIRFAFQTSITVLC
                     IACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPR
                     VMRFLLLVDVATLSLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYSTDFQA
                     VPGCGISCKVSNVESILAHRGPTAHPIGVGNPPIGEGTGPQTFSVLIGNREWMRRNGL
                     TISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADAVKPEAALAIYTLKSMGVDVA
                     LITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNKGKKVAMVGDGVNDSPAL
                     AQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNM
                     VGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHGR
                     MKPLSASQVSVHVGMDDRRRDSPRATPWDQVSYVSQVSLSSLTSDRLSRHGGMAEDGG
                     DKWSLLLSDRDEEQCI"
     exon            53..1274
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1523
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1687
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1849
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1926
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2101
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2335
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2427
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2555
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2710
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2845
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..3040
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3223
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3377
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3378..3521
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3664
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3868
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3986
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            3987..4089
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
     exon            4090..5506
                     /gene="Atp7b"
                     /gene_synonym="Hts; PINA; Wd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaatgcct gaacaggaga gaaaggtcac agccaaagag gccagtcgga aaatcttatc
       61 taaacttgct ttgcccacac gaccgtgggg acaatcaatg aagcagagct tcgccttcga
      121 taatgttggc tatgaagggg gcctggacag cacctgctca tcctcaacta ccaccggtgt
      181 ggttagcatc ctgggcatga cttgtcattc ttgcgtcaag tccatcgagg acaggatctc
      241 cagtctgaaa ggcattgtga gcatcaaggt ttctctggag cagggcagcg ccactgtcaa
      301 atatgtaccg tcagtcttga acctgcagca gatttgcctt cagattgagg acatgggctt
      361 tgaggccagc gctgcagaag gaaaggctgc ctcctggcct tccaggtctt ccccagccca
      421 ggaggcagtg gtcaagctcc gggtagaggg catgacctgt cagtcctgtg tcagctccat
      481 cgaaggcaag atccggaagc tgcaaggggt tgtgagagtc aaagtctccc taagcaacca
      541 agaggcagtc attacatatc agccttacct cattcaaccc gaagacctca gggaccacat
      601 ctgcgacatg ggattcgaag ctgccatcaa gaacagaaca gctcccttaa ggctgggacc
      661 aattgatatc aacaagttag aaagcactaa cctaaagaga gcagcagtcc ctcctatcca
      721 gaattccaat catttggaga ccccggggca ccagcagaac cacctggcca ccctcccact
      781 aagaatagac gggatgcact gtaaatcatg tgttttgaat atcgaaggaa atataggcca
      841 acttccaggg gttcaaaata ttcatgtgtc cttggagaac aaaaccgccc aagtacagta
      901 tgactcttct tgtatcaccc ccttgttcct acagacagcc atcgaggcac taccacctgg
      961 gtactttaaa gtatcccttc ccgatggcct agagaaggag agtggatctt ccagtgtccc
     1021 ctcccttggc tcctcccaga gacagcagga gccaggccca tgcaggactg cggtactcac
     1081 catcactggc attccccgtg actcgtctgt tcagcccatg gaagacatgc tgtcccagat
     1141 gaagggtgtg cagcaaatag acatctcttt ggcagagggg actggagcag ttctttacga
     1201 tccctcagta gttagctcgg atgaactccg gacggctgta gaagacatgg gctttgaggt
     1261 gtcagtgaat cccgaaaaca ttactactaa ccgtgtcagc tctgggaatt ctgtgccaca
     1321 agccgtgggt gattcaccag ggtctgtgca aaatatggct tctgacacta gaggactcct
     1381 cacacaccaa ggccctggct acttgtcaga cagcccacca tcccctggag gaacagcatc
     1441 acagaagtgc tttgtacaga tcaaaggcat gacctgtgcg tcctgtgtgt ctaacataga
     1501 aaggagtctg cagagacatg ccggtattct ctccgtgttg gtcgccttga tgtcgggaaa
     1561 ggcagaggtc aagtatgacc cagaggtcat ccagtctccc aggatagctc agctcatcga
     1621 ggacctgggc ttcgaagcag caatcatgga ggacaacaca gtctctgaag gtgacatcga
     1681 actgattatc acagggatga cctgcgcttc ctgtgttcac aacatagaat ctaagctcac
     1741 aaggacaaat ggcatcactt acgcctctgt ggccctcgcc accagcaaag cccatgtgaa
     1801 gtttgaccct gaaatcattg gtccacgtga catcatcaag gtcatcgagg aaatcggctt
     1861 tcatgcttcc ctggcccaca gaaaccccaa cgctcatcac ttggaccaca agacggaaat
     1921 aaaacagtgg aagaaatctt tcctgtgcag cctggtgttt ggcatccccg tcatgggctt
     1981 gatgatctac atgctaatcc ccagcagtaa gccccacgag accatggtcc tggaccacaa
     2041 catcattcca ggactgtccg ttctaaacct cattttcttc atcttgtgta ccttcgtcca
     2101 attcctgggt gggtggtact tctatgtcca agcctacaaa tcgctgagac acaagtcagc
     2161 caacatggat gtgctcatcg tactcgccac gaccattgcc tatgcctact ccctggtcat
     2221 cctggtggtt gccatagctg aaaaggcgga gaagagccca gtgaccttct ttgacacacc
     2281 ccccatgctc ttcgtcttca tcgccctggg acggtggctg gagcacgtgg caaagagcaa
     2341 aacttcagaa gccctcgcaa aactcatgtc actccaagcc acagaagcca cagttgtgac
     2401 cctgggagag gacaacttaa tcctcagaga ggagcaagtg cccatggagc tggtgcagcg
     2461 aggtgacatc atcaaggttg tccctggggg caagttccca gtggacggga aagtcctgga
     2521 aggcaacacc atggcagatg agtccctcat cacaggagag gccatgcctg tcaccaagaa
     2581 acccgggagc atagtgattg ctggctctat aaatgctcat ggctctgtgc tcattaaagc
     2641 tacccatgtg ggcaatgaca ctactttggc tcagattgtc aagttggtgg aagaggccca
     2701 gatgtcaaag gctcccattc agcagctggc tgaccggttc agtggatatt tcgtcccatt
     2761 tatcatcatt atttcaacct taacattggt ggtgtggatc atcatcggct ttgtcgattt
     2821 tggtattgtt cagaagtact ttcctagccc tagcaagcat atctcacaga cagaggtgat
     2881 catccgcttt gccttccaga cgtccatcac cgtcctgtgc atcgcctgcc cctgctccct
     2941 cgggctggcc acacccacag cagttatggt gggcactggg gtggctgccc agaacggcgt
     3001 cctaatcaag ggagggaagc ctctggagat ggcacacaag ataaagaccg ttatgtttga
     3061 caaaacgggc accattaccc acggggtccc cagagtcatg cggtttctgc tgcttgtgga
     3121 cgtggctacc ctatccctca ggaaggttct ggctgtggtg ggcaccgcag aggccagcag
     3181 tgagcacccc ttaggcgtgg ccgtcactaa atactgcaaa gaggaactcg ggacggagac
     3241 cctggggtac agcacggact tccaggcagt gccagggtgt ggaattagct gcaaagttag
     3301 caacgtggaa agtatcctgg ctcacagagg tccaaccgct cacccgattg gggttggcaa
     3361 ccctcccata ggagaaggta caggtcccca gactttctct gtgctgattg gaaaccggga
     3421 atggatgagg cgcaatggtt taaccatctc cagtgacatc agtgacgcca tgacagatca
     3481 tgaaatgaaa ggacagacgg ccatcctggt ggccattgat ggtgtgctgt gcgggatgat
     3541 cgccattgca gatgctgtta aaccagaggc tgccctggct atctacaccc tgaaaagcat
     3601 gggcgtggat gtggctctga tcacagggga caaccggaag acagccagag ccattgccac
     3661 tcaggttggc atcaacaaag tctttgctga ggtactgcct tctcacaagg tggccaaggt
     3721 ccaggagctt cagaacaaag ggaaaaaagt cgccatggtg ggagacgggg tgaacgactc
     3781 cccagccttg gcccaggctg acgtgggcat tgctattggg actgggacag atgtcgccat
     3841 cgaagcagcc gacgtggtcc ttataagaaa tgacttactg gacgtggtgg ccagcattca
     3901 tctctccaag aggaccgtcc ggaggatccg ggtcaatctg gtgctggcgt tgatttataa
     3961 catggttggg atacccattg ctgcaggtgt cttcatgccc attggcatcg tgctgcagcc
     4021 atggatgggc tcagcggcca tggccgcctc ctctgtgtcc gtggtgctct cctctcttca
     4081 gctcaagtgc tacagaaagc ccgacctaga gagatatgag gcacaggccc atggacgcat
     4141 gaagcctctg agtgcatccc aagtcagcgt gcacgttggc atggatgacc ggcggcggga
     4201 ttctcccagg gccacaccct gggaccaggt cagctacgtg agccaagtct ctctgtcttc
     4261 cctgacgtca gacagattgt ctcggcatgg cggtatggca gaggatggtg gagacaaatg
     4321 gtccctgctc ctgagtgaca gggatgaaga gcagtgcatc tgagtgttcc cagcagcagc
     4381 cctgggcagg ccgaggtgct ccttccagac gggcctgctc ccgctcactg tggtcgagcc
     4441 agtgcagcct caacgagctg aagcacagcg atgggcgaag cttacgtgag gggcaagcat
     4501 cctgctagcc tcgccagcag tgtgtggtgc atctgcagag gctgggtggg attgctctgt
     4561 cagaagctgc taggccgggc aaaggacact gctctccctg gttttccatg agggcaaggt
     4621 cacaccctgc ttggatttta gtgcaggaga ggaagccagc actcctcaga ggcctgccta
     4681 ctgtgtttgt atctactacc tatgaaatga gaaataggcc catcaggacc gcaggcctag
     4741 ctgagccccc tggagagctc catcctgagc ttccctatac taagagctcc cacaaaggct
     4801 ggagtcaggc agcacccatg ggctgtgtaa gcctaagacg acttcagacg cgtctgttgt
     4861 tctctgcctg ctttagttgg catccttggt actggcactg cctgccctct gttctgaggg
     4921 tagagtttgt gtcttgggtc caatgctttg gctccttcat atctgcctgc ctaaaggtgg
     4981 ccccctggtt tgcagcccaa ccccagagct gcctggcctc cctctttact ctgaggagag
     5041 aatgccatcc tgcttagagc cacacctaca gactcacaca tgccactctc aaacaactgg
     5101 agagacgcct cagaacctga ccagagtcca ttttccctgc tataacctgt agtgagtgaa
     5161 acactgtcca agggaacccc catgtgactt agtagggtcc agtgcagtat gtcacaaatg
     5221 cctggtgtgt gtgcctgaag ggagttgtcc caaccggaag agagccaagt tctcaataga
     5281 gagctctctg ctgctgaggg gccatctaaa caagggacgt ccacagctcc ccagtgaaag
     5341 tgcttttgtc atctataact atctgtgacc aggtggcatc cgagggcagg gatcatgtca
     5401 gagggcaggg atgggccagc ttaactgagc ggctgagcca cccggaacag acggacagaa
     5461 atggattact ctcatttgtg acattaaaaa accaacaaaa ccctcc
//
