LOCUS       NM_052803               4677 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase copper transporting alpha (Atp7a), mRNA.
ACCESSION   NM_052803
VERSION     NM_052803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4677)
  AUTHORS   Ashino,T., Kohno,T., Sudhahar,V., Ash,D., Ushio-Fukai,M. and
            Fukai,T.
  TITLE     Copper transporter ATP7A interacts with IQGAP1, a Rac1 binding
            scaffolding protein: role in PDGF-induced VSMC migration and
            vascular remodeling
  JOURNAL   Am J Physiol Cell Physiol 315 (6), C850-C862 (2018)
   PUBMED   30257103
  REMARK    GeneRIF: In cultured rat aortic SMCs, PDGF stimulation rapidly
            promoted ATP7A association with IQGAP1 and Rac1 and their
            translocation to the lipid rafts and leading edge. Cotransfection
            assay revealed that ATP7A directly bound to NH2-terminal domain of
            IQGAP1
REFERENCE   2  (bases 1 to 4677)
  AUTHORS   Platonova,N.A., Orlov,I.A., Klotchenko,S.A., Babich,V.S.,
            Ilyechova,E.Y., Babich,P.S., Garmai,Y.P., Vasin,A.V.,
            Tsymbalenko,N.V. and Puchkova,L.V.
  TITLE     Ceruloplasmin gene expression profile changes in the rat mammary
            gland during pregnancy, lactation and involution
  JOURNAL   J Trace Elem Med Biol 43, 126-134 (2017)
   PUBMED   28089327
REFERENCE   3  (bases 1 to 4677)
  AUTHORS   Perez-Siles,G., Grant,A., Ellis,M., Ly,C., Kidambi,A., Khalil,M.,
            Llanos,R.M., Fontaine,S.L., Strickland,A.V., Zuchner,S., Bermeo,S.,
            Neist,E., Brennan-Speranza,T.C., Takata,R.I., Speck-Martins,C.E.,
            Mercer,J.F., Nicholson,G.A. and Kennerson,M.L.
  TITLE     Characterizing the molecular phenotype of an Atp7a(T985I)
            conditional knock in mouse model for X-linked distal hereditary
            motor neuropathy (dHMNX)
  JOURNAL   Metallomics 8 (9), 981-992 (2016)
   PUBMED   27293072
REFERENCE   4  (bases 1 to 4677)
  AUTHORS   Han,M., Chang,J. and Kim,J.
  TITLE     Loss of divalent metal transporter 1 function promotes brain copper
            accumulation and increases impulsivity
  JOURNAL   J Neurochem 138 (6), 918-928 (2016)
   PUBMED   27331785
REFERENCE   5  (bases 1 to 4677)
  AUTHORS   Cao,Z., Zhang,Y., Sun,T., Zhang,S., Yu,W. and Zhu,J.
  TITLE     Homocysteine induces cardiac hypertrophy by up-regulating ATP7a
            expression
  JOURNAL   Int J Clin Exp Pathol 8 (10), 12829-12836 (2015)
   PUBMED   26722473
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4677)
  AUTHORS   Starcher,B., Madaras,J.A., Fisk,D., Perry,E.F. and Hill,C.H.
  TITLE     Abnormal cellular copper metabolism in the blotchy mouse
  JOURNAL   J Nutr 108 (8), 1229-1233 (1978)
   PUBMED   27591
REFERENCE   7  (bases 1 to 4677)
  AUTHORS   Starcher,B.C., Madaras,J.A. and Tepper,A.S.
  TITLE     Lysyl oxidase deficiency in lung and fibroblasts from mice with
            hereditary emphysema
  JOURNAL   Biochem Biophys Res Commun 78 (2), 706-712 (1977)
   PUBMED   20889
REFERENCE   8  (bases 1 to 4677)
  AUTHORS   Rowe,D.W., McGoodwin,E.B., Martin,G.R. and Grahn,D.
  TITLE     Decreased lysyl oxidase activity in the aneurysm-prone, mottled
            mouse
  JOURNAL   J Biol Chem 252 (3), 939-942 (1977)
   PUBMED   14140
REFERENCE   9  (bases 1 to 4677)
  AUTHORS   Hunt,D.M.
  TITLE     Catecholamine biosynthesis and the activity of a number of
            copper-dependent enzymes in the copper deficient mottled mouse
            mutants
  JOURNAL   Comp Biochem Physiol C Comp Pharmacol 57 (1), 79-83 (1977)
   PUBMED   17511
REFERENCE   10 (bases 1 to 4677)
  AUTHORS   Hunt,D.M.
  TITLE     A study of copper treatment and tissue copper levels in the murine
            congenital copper deficiency, mottled
  JOURNAL   Life Sci 19 (12), 1913-1919 (1976)
   PUBMED   187892
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U59245.1.
            
            On Feb 21, 2013 this sequence version replaced NM_052803.1.
            
            Summary: This gene encodes a transmembrane protein that functions
            in copper transport across membranes. The protein localizes to the
            trans-Golgi network, where it is predicted to supply copper to
            copper-dependent enzymes in the secretory pathway. The protein
            relocalizes to the plasma membrane under conditions of elevated
            extracellular copper and functions in the efflux of copper from
            cells. In human, mutations in this gene result in Menkes disease,
            X-linked cutis laxa, and occipital horn syndrome. [provided by
            RefSeq, Nov 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U59245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4677              U59245.1           6-4682
FEATURES             Location/Qualifiers
     source          1..4677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..4677
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /note="ATPase copper transporting alpha"
                     /db_xref="GeneID:24941"
                     /db_xref="RGD:2179"
     exon            1..141
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..4500
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /EC_number="7.2.2.8"
                     /function="pump copper out of cells"
                     /note="copper pump 1; menkes disease-associated protein
                     homolog; ATPase, Cu++ transporting, alpha polypeptide"
                     /codon_start=1
                     /product="copper-transporting ATPase 1"
                     /protein_id="NP_434690.1"
                     /db_xref="GeneID:24941"
                     /db_xref="RGD:2179"
                     /translation="MEPNMDANSITITVEGMTCISCVRTIEQQIGKVNGVHHIKVSLE
                     EKSATVIYNPKLQTPKTLQEAIDDMGFDALLHNANPLPVLTNTVFLTVTAPLALPWDH
                     IQSTLLKTKGVTGVKISPQQRSAVVTIIPSVVSANQIVELVPDLSLDMGTQEKKSGTS
                     EEHSTPQAGEVLLKMRVEGMTCHSCTSTIEGKVGKLQGVQRIKVSLDNQEATIVYQPH
                     LITAEEIKKQIEAVGFPAFIKKQPKYLKLGAIDVERLKSTPVKSSEGSQQKSPAYPSD
                     SAITFTIDGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEILRKA
                     IEAVSPGQYRVSISSEVESPTSSPSSSSLQKMPLNLVSQPLTQEVVININGMTCNSCV
                     QSIEGVISKKPGVKSIHVSLTNSTGTIEYDPLLTSPEPLREAIEDMGFDAVLPADMKE
                     PLVVIAQPSLETPLLPSTTEPENVMTPVQNKCYIQVSGMTCASCVANIERNLRREEGI
                     YSVLVALMAGKAEVRYNPAVIQPRVIAELIRELGFGAVVMENAGEGNGILELVVRGMT
                     CASCVHKIESTLTKHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGNLGFEASLV
                     KKDRSANHLDHKREIKQWRGSFLVSLFFCIPVMGLMIYMMVMDHHLATLNHNQNMSNE
                     EMINMHSSMFLERQILPGLSIMNLLSLLLCLPVQFCGGWYFYIQAYKALRHKTANMDV
                     LIVLATTIAFAYSLVILLVAMYERAKVNPITFFDTPPMLFVFIALGRWLEHIAKGKTS
                     EALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRGDIIKVVPGGKFPVDGRVIE
                     GHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGADTTLSQIVKLVEE
                     AQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVEAYFPGYNRSISR
                     TETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKV
                     KVVVFDKTGTITHGTPVVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYC
                     KQELDTETLGTCTDFQVVPGCGISCKVTNIEGLLHKSNLKIEENNIKNASLVQIDAIN
                     EQSSPSSSMIIDAHLSNAVNTQQYKVLIGNREWMIRNGLVISNDVDESMIEHERRGRT
                     AVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARSIASQVGI
                     TKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMASVGIAIGTGTDVAIEA
                     ADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLIGIPIAAGVFLPIGLVLQP
                     WMGSAAMAASSVSVVLSSLFLKLYRKPTYDNYELRPRSHTGQRSPSEISVHVGIDDTS
                     RNSPRLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTTL"
     exon            142..631
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1357
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1540
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1704
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1866
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1943
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2169
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2403
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2495
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2623
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2778
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2913
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3108
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3291
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3508
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3655
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            3656..3798
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..4002
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4120
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4223
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4677
                     /gene="Atp7a"
                     /gene_synonym="Mnk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggaatgta aagacatcaa aatggaacca aatatggatg caaattcaat tactatcact
       61 gttgagggaa tgacatgtat ttcctgtgtc cggaccattg agcagcagat tgggaaagtg
      121 aatggtgtcc atcacattaa agtttcccta gaagaaaaaa gtgcaactgt tatttataac
      181 cctaaacttc agactccaaa gaccctccaa gaagctatcg atgacatggg ctttgatgct
      241 cttcttcaca atgctaaccc tcttcctgtc ttaaccaata ctgtgtttct gactgttact
      301 gctccactgg ctctgccatg ggaccatatc caaagtacat tgctcaagac caagggtgtg
      361 actggggtta agatttcccc tcagcaaaga agtgcagtgg ttaccataat cccatctgtg
      421 gtgagtgcta atcagatcgt ggagctggtc ccagacctca gtttagacat gggaactcag
      481 gagaaaaagt caggaacttc tgaagagcat agcacacctc aggcagggga agtcctgctg
      541 aagatgagag tggaagggat gacctgccat tcatgcacta gcaccattga aggaaaagtt
      601 ggaaagctgc aaggtgtaca acgcattaaa gtgtccctag acaaccaaga agctactatt
      661 gtgtatcaac ctcatctgat cacagcagag gaaataaaga agcagattga agctgtgggt
      721 tttccagcct tcataaaaaa acagccaaag tacctcaaat tgggagccat tgacgttgag
      781 cgcctgaaga gtacaccagt caaatcttca gaaggatctc agcaaaagag cccagcgtat
      841 cccagtgact cagcaatcac atttaccata gacggcatgc attgtaaatc atgtgtgtca
      901 aatatcgaaa gtgctttatc tacactccag tatgtaagca gcatagtagt ttctttagag
      961 aataggtcag ccattgtaaa gtacaatgca agcttagtca ctccagaaat actgagaaaa
     1021 gcgatagagg ccgtttctcc agggcaatac agagttagta tttcaagtga agttgaaagt
     1081 cccaccagct ctccctccag ctcatctctt cagaagatgc ctttgaactt agtgagccag
     1141 cctctgaccc aagaagttgt aatcaacatt aatggcatga cttgtaattc ttgtgtgcag
     1201 tcgatagagg gtgtaatatc gaagaagcca ggtgtaaaat ccatccacgt ttccctcaca
     1261 aatagcaccg ggactattga atatgatcct ctactaacct ctccagaacc cttgcgagaa
     1321 gcaattgaag acatgggatt tgatgctgtc cttccagcag acatgaaaga gccactggtc
     1381 gtgatagctc agccctcact ggaaacacct cttttgccct caactactga gccagaaaat
     1441 gtgatgacac cagttcagaa caagtgttac atacaggtct cggggatgac gtgtgcttct
     1501 tgtgtagcaa acattgaacg gaacttaaga cgagaagaag gaatatattc tgtacttgta
     1561 gccctaatgg ctggcaaggc ggaagtaaga tataacccag ctgttatcca accccgagtg
     1621 atagcagagc ttattcgaga gcttggcttt ggagctgtgg tgatggaaaa tgctggagaa
     1681 ggcaatggca ttttggaact tgttgtgaga ggaatgacgt gtgcctcctg tgtccataaa
     1741 attgaatcaa cgctcacaaa acacaaaggg atcttctact gctctgtggc cctggcaacg
     1801 aacaaagcac atattaaata tgatccagaa attattggtc ccagagatat tatccatacc
     1861 attggaaact taggttttga agcttctttg gtcaagaaag atcgatcagc caaccactta
     1921 gatcataaac gagaaataaa acaatggaga gggtctttcc ttgtgagcct gtttttctgt
     1981 atccctgtaa tgggactgat gatctatatg atggttatgg accaccacct tgcaactcta
     2041 aaccataatc agaacatgag taatgaagaa atgatcaaca tgcattcttc tatgttcctg
     2101 gagcgtcaga tcctgccggg actgtccatt atgaatttgt tgtccctttt attgtgtcta
     2161 cctgtacagt tttgtggagg ctggtacttt tacattcagg cttacaaagc gctgaggcat
     2221 aagacagcaa atatggatgt gctgattgtg ttggcaacca ccattgcatt tgcctactct
     2281 ctggtcattc ttctggttgc aatgtatgag agagccaaag tgaaccctat taccttcttt
     2341 gatacacctc ctatgctgtt tgtgtttatc gcactaggcc gatggctgga acacatagcg
     2401 aagggcaaaa cttccgaggc tcttgcaaag ctaatttcct tacaagcaac agaagcaact
     2461 attgtaactc ttaactctga aaatctcctc ctgagtgaag aacaagtgga tgtggaactt
     2521 gtacaacgtg gagatatcat taaggtcgtt ccaggaggca aatttccagt ggatggccgt
     2581 gttattgaag ggcattctat ggtagacgag tccctcatca caggggaagc aatgcctgtg
     2641 gctaagaaac ctggcagcac ggtgattgca ggttccatta accagaatgg atcgctcctc
     2701 atccgggcaa cacacgtagg ggcagataca acactttctc aaattgtcaa acttgtagag
     2761 gaggcacaga catcaaaggc tcctatccag cagtttgcag acaaactcag tggctacttt
     2821 gttcctttta tcgtcttggt ttccattgtt accctcttgg tgtggattat aattggattt
     2881 caaaattttg aaattgtgga agcctacttt cccggctaca acagaagcat ctcccgaaca
     2941 gaaaccataa tccgctttgc tttccaagcg tctatcacag ttctgtgtat cgcatgtccc
     3001 tgttcactgg ggctagccac tccaactgct gtgatggtgg gcacaggagt aggtgctcag
     3061 aatggcatac ttatcaaagg tggggagcca ctggagatgg ctcataaggt aaaggtagtg
     3121 gtgtttgaca agactggaac cattacccat ggaaccccag tagtgaacca agtaaaggtt
     3181 ctggtggaaa gtaacaagat atcacgcaat aagatcctgg ccattgtggg aactgcagaa
     3241 agtaacagtg aacatccttt aggagcagct gtaaccaaat attgcaagca ggagctggac
     3301 actgaaacct tgggtacctg cacagatttc caggttgtac ccggctgtgg aattagctgt
     3361 aaagtcacca atattgaagg tttgctacat aagagtaact tgaagataga agaaaataac
     3421 attaaaaatg catccctggt tcaaattgat gcaattaatg aacagtcatc accttcatcg
     3481 tctatgatta ttgatgctca tctctcaaat gctgttaata ctcagcagta caaagtcctc
     3541 attggtaacc gggaatggat gattagaaat ggtcttgtca taagtaatga tgtggacgag
     3601 tctatgattg aacatgaaag aagaggccgg actgctgtgt tggtgacaat cgatgatgaa
     3661 ctgtgtggct tgatcgctat tgctgatact gtgaaacctg aggcagagct ggctgtgcac
     3721 attctgaaat ctatgggttt ggaagtagtt ctgatgactg gagacaacag taaaacagct
     3781 cggtctattg cttctcaggt tggcattact aaggtgtttg ctgaagttct gccttcccac
     3841 aaagttgcta aggtgaagca gcttcaggag gagggaaagc gcgtagccat ggtaggagat
     3901 ggaatcaatg actctccagc tctggcaatg gcaagcgtcg gaattgccat cggcacaggc
     3961 acagatgtag ccatcgaagc agctgacgtg gttttgataa ggaatgacct tctggatgtt
     4021 gtggcaagta ttgacttgtc aaggaaaaca gtcaagagga ttcgaatcaa ttttgtcttt
     4081 gctctgattt ataatctgat tggaattccc atcgctgctg gagtttttct gcccatcggc
     4141 ttggttttac aaccctggat gggatccgca gccatggccg cttcatctgt ctctgtggta
     4201 ctttcttccc ttttcctcaa gctttacagg aagccaacat atgacaatta tgagttgcgt
     4261 ccccggagcc acacaggaca gaggagtcct tcagaaatca gcgttcacgt tggaatagat
     4321 gatacctcca gaaattctcc aagactgggt ttactggacc ggattgtcaa ttacagcaga
     4381 gcctccataa attcactgct gtctgacaaa cgctccctca acagcgtcgt cactagtgag
     4441 cctgataagc actcacttct ggtgggagac ttccgggaag atgacgacac cacactgtaa
     4501 caggcctttg gggatgctgc tagtcgaagt tcatgtgcac tgacacagca cttacgttga
     4561 tgtagaagga tcttacatca atctcatgct cttatgtgca ggattctatc tgagttttaa
     4621 ttgttaatgg caaaaatacc tttctcaggg caggagctct gaacctggca ttatcta
//
