LOCUS       NM_198745               1229 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit E1 (Atp6v1e1),
            mRNA.
ACCESSION   NM_198745 XM_216251
VERSION     NM_198745.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1229)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 1229)
  AUTHORS   Oehlke,O., Martin,H.W., Osterberg,N. and Roussa,E.
  TITLE     Rab11b and its effector Rip11 regulate the acidosis-induced traffic
            of V-ATPase in salivary ducts
  JOURNAL   J Cell Physiol 226 (3), 638-651 (2011)
   PUBMED   20717956
REFERENCE   3  (bases 1 to 1229)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1229)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1229)
  AUTHORS   Paunescu,T.G., Jones,A.C., Tyszkowski,R. and Brown,D.
  TITLE     V-ATPase expression in the mouse olfactory epithelium
  JOURNAL   Am J Physiol Cell Physiol 295 (4), C923-C930 (2008)
   PUBMED   18667600
REFERENCE   6  (bases 1 to 1229)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   7  (bases 1 to 1229)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 1229)
  AUTHORS   Lu,M., Vergara,S., Zhang,L., Holliday,L.S., Aris,J. and Gluck,S.L.
  TITLE     The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase
            (V-ATPase) interacts with the H subunit and is required for
            V-ATPase function
  JOURNAL   J Biol Chem 277 (41), 38409-38415 (2002)
   PUBMED   12163484
REFERENCE   9  (bases 1 to 1229)
  AUTHORS   Sun-Wada,G.H., Imai-Senga,Y., Yamamoto,A., Murata,Y., Hirata,T.,
            Wada,Y. and Futai,M.
  TITLE     A proton pump ATPase with testis-specific E1-subunit isoform
            required for acrosome acidification
  JOURNAL   J Biol Chem 277 (20), 18098-18105 (2002)
   PUBMED   11872743
REFERENCE   10 (bases 1 to 1229)
  AUTHORS   Kobayashi,K., Uchida,S., Mizutani,S., Sasaki,S. and Marumo,F.
  TITLE     Intrarenal and cellular localization of CLC-K2 protein in the mouse
            kidney
  JOURNAL   J Am Soc Nephrol 12 (7), 1327-1334 (2001)
   PUBMED   11423561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_198745.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213001.1, FQ214920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840115, SAMN12840129
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               JAXUCZ010000004.1  155716524-155716660 c
            138-203             JAXUCZ010000004.1  155712120-155712185 c
            204-313             JAXUCZ010000004.1  155707884-155707993 c
            314-380             JAXUCZ010000004.1  155707106-155707172 c
            381-470             JAXUCZ010000004.1  155703520-155703609 c
            471-539             JAXUCZ010000004.1  155702689-155702757 c
            540-634             JAXUCZ010000004.1  155700259-155700353 c
            635-722             JAXUCZ010000004.1  155697353-155697440 c
            723-1229            JAXUCZ010000004.1  155694534-155695040 c
FEATURES             Location/Qualifiers
     source          1..1229
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1229
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /note="ATPase H+ transporting V1 subunit E1"
                     /db_xref="GeneID:297566"
                     /db_xref="RGD:735157"
     exon            1..137
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..785
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /EC_number="7.1.2.2"
                     /note="vacuolar H(+)-ATPase, E subunit; ATPase, H+
                     transporting, lysosomal 31kDa, V1 subunit E; V-ATPase
                     subunit E 1; vacuolar proton pump subunit E 1; ATPase, H+
                     transporting, V1 subunit E; vacuolar H+ ATPase E1;
                     VATPase, H+ transporting, lysosomal V1 subunit E1; ATPase,
                     H+ transporting, lysosomal V1 subunit E1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit E 1"
                     /protein_id="NP_942040.2"
                     /db_xref="GeneID:297566"
                     /db_xref="RGD:735157"
                     /translation="MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGR
                     LVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRL
                     SKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATK
                     KDVDVQIDQEAYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGA
                     NANRKFLD"
     exon            138..203
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            204..313
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            314..380
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..470
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            471..539
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            540..634
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            635..722
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1229
                     /gene="Atp6v1e1"
                     /gene_synonym="Atp6e; Atp6e2; P31; Vma4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaattaaagg aagctgagtc tcactgggtt ttcttgtcgg gtttgctcct ccgcctcttt
       61 gaacccagat tcgaggcttc ccctggccga gctttgtctt cgccatggcg ctcagcgatg
      121 cagatgtaca gaagcagatt aagcacatga tggctttcat cgaacaagaa gccaatgaga
      181 aagcagaaga aatcgatgca aaggcagaag aagagttcaa cattgagaaa ggtcgtcttg
      241 tgcaaaccca gagattgaag attatggaat actatgagaa gaaggaaaag cagatcgagc
      301 agcagaagaa aattcaaatg tccaacttga tgaatcaagc aagactcaaa gtcctcagag
      361 caagagatga cctcatcact gatctgctga atgaggcaaa acagagactc agcaaggtgg
      421 taaaagatac gaccaggtac caggtgctgc tggacgggct ggtcctccag ggcttgtacc
      481 agctgttgga acctcgaatg attgtgcgct gcagaaaaca agatttccct ttggtgaagg
      541 ctgcagtaca gaaagcaata cctatgtata aaattgccac caaaaaagat gttgacgtcc
      601 agattgacca ggaggcctac ctgcctgagg acatagctgg tggagttgaa atctataatg
      661 gggaccgcaa gataaaggtt tccaacactc tggaaagccg actggaccta atagcccagc
      721 agatgatgcc agaagtccgc ggagccttgt ttggtgcaaa tgccaatagg aagtttctgg
      781 actgagccta aggaggtgca gttcacccac ggctgtactc ttggagaaac agattaactg
      841 tgtggcttcc tctttctgtt ctaatactgg taatcagtgg acaccctcta cagctactgc
      901 ccttggctca gtgtcaacag aagggccact ggtgtgggca agaacccagc ccatctgacg
      961 ccacagctgt gcactggttt acagtgggat gggtggggtc agttgtgtgc agccctcaaa
     1021 gacccattct ttccctgttc ctgctctcgt ctagagtgag tcgtgcatgc tgtcccctgc
     1081 tctttgggcg taaggtgcat gtggggcgta cattcctcca ggaacactag ctgcactgtt
     1141 actatttagg tctagtcttc cttatctgta aatgtgattc aaaatctaag ccacaaatat
     1201 tatttattaa aacaaaaggt ttatgtgga
//
