LOCUS       NM_001014199            1595 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit C2 (Atp6v1c2),
            mRNA.
ACCESSION   NM_001014199 XM_343129
VERSION     NM_001014199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Rahman,S., Ishizuka-Katsura,Y., Arai,S., Saijo,S., Yamato,I.,
            Toyama,M., Ohsawa,N., Inoue,M., Honda,K., Terada,T., Shirouzu,M.,
            Yokoyama,S., Iwata,S. and Murata,T.
  TITLE     Expression, purification and characterization of isoforms of
            peripheral stalk subunits of human V-ATPase
  JOURNAL   Protein Expr Purif 78 (2), 181-188 (2011)
   PUBMED   21356312
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Cruciat,C.M., Ohkawara,B., Acebron,S.P., Karaulanov,E.,
            Reinhard,C., Ingelfinger,D., Boutros,M. and Niehrs,C.
  TITLE     Requirement of prorenin receptor and vacuolar H+-ATPase-mediated
            acidification for Wnt signaling
  JOURNAL   Science 327 (5964), 459-463 (2010)
   PUBMED   20093472
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1595)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 1595)
  AUTHORS   Feng,N.H., Lin,H.I., Wang,J.S., Chou,S.T., Ma,H.K., Rooney,S.A. and
            Lu,J.F.
  TITLE     Differential expression of a V-type ATPase C subunit gene,
            Atp6v1c2, during culture of rat lung type II pneumocytes
  JOURNAL   J Biomed Sci 12 (6), 899-911 (2005)
   PUBMED   16283434
  REMARK    GeneRIF: analysis of V-type ATPase C subunit gene, Atp6v1c2, during
            culture of rat lung type II pneumocytes
REFERENCE   6  (bases 1 to 1595)
  AUTHORS   Sun-Wada,G.H., Murata,Y., Namba,M., Yamamoto,A., Wada,Y. and
            Futai,M.
  TITLE     Mouse proton pump ATPase C subunit isoforms (C2-a and C2-b)
            specifically expressed in kidney and lung
  JOURNAL   J Biol Chem 278 (45), 44843-44851 (2003)
   PUBMED   12947086
REFERENCE   7  (bases 1 to 1595)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079083.1.
            
            On Apr 20, 2005 this sequence version replaced XM_343129.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079083.1, AY594319.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..1595
                     /gene="Atp6v1c2"
                     /note="ATPase H+ transporting V1 subunit C2"
                     /db_xref="GeneID:362802"
                     /db_xref="RGD:1359430"
     exon            1..87
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            88..260
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1409
                     /gene="Atp6v1c2"
                     /EC_number="7.1.2.2"
                     /note="V-ATPase subunit C 2; vacuolar proton pump subunit
                     C 2; vacuolar H+ ATPase C2; ATPase, H+ transporting, V1
                     subunit C; ATPase, H+ transporting, lysosomal V1 subunit
                     C2"
                     /codon_start=1
                     /product="V-type proton ATPase subunit C 2"
                     /protein_id="NP_001014221.1"
                     /db_xref="GeneID:362802"
                     /db_xref="RGD:1359430"
                     /translation="MSEFWLISAPGDKENLQALERMNSVTSKSNLSHNTKFAIPDFKV
                     GTLDSLVGLSDELGKLDTFAESLIKRMAQSVVEVMEDSKGKVHENLLANGVDLTSFVT
                     HFEWDMAKYPAKQPLVSVVDTLAKQLAQIETDLKSRTAAYSVLKANLENLEKKSTGNL
                     FTRTLSDIVSKEDFVLDSEYLITLLVIVPKSSYVQWQKTYESLSDMVVPRSTKLIAED
                     NEGGLFTVTLFRKVIEDFKVKAKENKFIVREFYYDEKEIKREREEMTRLLSDKKQQYQ
                     TSCVALKKGSATYRDHKVKVTPLGNPTRPTAGQNDRESEGEGEGPLLRWLKVNFSEAF
                     IAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSATKRLREVLNSVFRHLDEVAAA
                     SILDASVEIPGLQLSNQDYFPYVYFHIDLSLLD"
     exon            261..328
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..414
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..509
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..601
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..700
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..769
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..862
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..956
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1088
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1186
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1319
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1566
                     /gene="Atp6v1c2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggagccgg ccgtgcgctc ccgcggagcc tcccacccgg tgtccccgcg tgtcgtccac
       61 agctcagata gtctcccgcc tctcctgtct tggtgcctgt cagtaactag ataacaagaa
      121 gacttacaaa catgtccgag ttttggctta tttcggcccc tggcgataag gaaaatttac
      181 aagctctgga gaggatgaac agcgtaactt caaagtctaa cctgtcccac aacactaaat
      241 ttgccatccc agacttcaag gtggggacct tggattccct tgttggtctc tctgatgagt
      301 tggggaaact cgataccttt gctgaaagcc tcataaagag aatggcacag agtgtggtgg
      361 aggtcatgga agactccaag ggaaaagtac acgagaacct cctggctaat ggagttgacc
      421 tgacatcctt tgtgacacac ttcgagtggg acatggccaa atatcctgcc aagcagccac
      481 tggtgagcgt ggtggataca ctggccaagc aactggcaca aatcgagaca gacctgaagt
      541 cgcgaacagc cgcctacagt gttctgaagg ccaacctgga gaacttggag aagaaatcca
      601 cggggaacct cttcactcgg acactgagtg atattgtcag caaggaagac ttcgtactcg
      661 attctgaata tctcataacc ctgctggtca tcgtccccaa gtcaagctat gtacagtggc
      721 agaagacata tgagtcccta tcggacatgg tggtccctcg gtcaaccaaa ttgatcgctg
      781 aggacaatga aggtggtctc ttcacagtga ctcttttccg aaaagtgatt gaagacttca
      841 aagtcaaagc caaagaaaac aagttcattg tccgggaatt ttactatgat gagaaagaaa
      901 ttaaaagaga gagggaagag atgaccaggt tgctgtctga taagaaacaa cagtatcaaa
      961 cttcctgtgt tgctcttaaa aagggatcag ccacctaccg tgaccacaag gttaaggtaa
     1021 ccccgctagg taaccctact aggcctactg cggggcagaa cgacagagag agtgagggcg
     1081 agggtgaggg acctctgctg cgctggctca aggtgaactt cagcgaggcc tttattgcct
     1141 ggatccacat aaaggccctg agagtgtttg tggagtctgt gctcaggtat ggacttccag
     1201 tgaacttcca ggctgtgctc ctgcagcccc ataaaaagtc tgccaccaaa cgcctgagag
     1261 aggtgctcaa ttcggtcttc cggcacctgg atgaagttgc tgcagcaagc atactggatg
     1321 catccgtgga gatccctggc ctgcagctca gcaaccagga ctatttcccc tacgtgtact
     1381 tccacatcga cctcagcctt cttgactagc tggccagcct gcttcactca agcctcagac
     1441 cttgtcagac aactgagtcc tgccggattc tgactcagaa gatactcaca gatattagtt
     1501 agagtgtatt tattttttta agatacaata aagtactcag tcctgagtct tgtgttctaa
     1561 tgttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
