LOCUS       NM_001011992            1785 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit C1 (Atp6v1c1),
            mRNA.
ACCESSION   NM_001011992 XM_216940
VERSION     NM_001011992.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1785)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 1785)
  AUTHORS   Oliveira Alves,M.G., Carta,C.F., Padin-Iruegas,M.E.,
            Perez-Sayans,M., Suarez-Penaranda,J.M., Issa,J.S., Garcia-Garcia,A.
            and Almeida,J.D.
  TITLE     Expression of ATP6V1C1 during oral carcinogenesis
  JOURNAL   Biotech Histochem 91 (4), 263-268 (2016)
   PUBMED   26984774
REFERENCE   3  (bases 1 to 1785)
  AUTHORS   Cheng,L., Zhang,Q., Yang,S., Yang,Y., Zhang,W., Gao,H., Deng,X. and
            Zhang,Q.
  TITLE     A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer
            patients
  JOURNAL   Genomics 102 (4), 323-330 (2013)
   PUBMED   23722107
REFERENCE   4  (bases 1 to 1785)
  AUTHORS   Feng,S., Zhu,G., McConnell,M., Deng,L., Zhao,Q., Wu,M., Zhou,Q.,
            Wang,J., Qi,J., Li,Y.P. and Chen,W.
  TITLE     Silencing of atp6v1c1 prevents breast cancer growth and bone
            metastasis
  JOURNAL   Int J Biol Sci 9 (8), 853-862 (2013)
   PUBMED   24155661
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1785)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 1785)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 1785)
  AUTHORS   Pietrement,C., Sun-Wada,G.H., Silva,N.D., McKee,M., Marshansky,V.,
            Brown,D., Futai,M. and Breton,S.
  TITLE     Distinct expression patterns of different subunit isoforms of the
            V-ATPase in the rat epididymis
  JOURNAL   Biol Reprod 74 (1), 185-194 (2006)
   PUBMED   16192400
REFERENCE   8  (bases 1 to 1785)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   9  (bases 1 to 1785)
  AUTHORS   Sun-Wada,G.H., Yoshimizu,T., Imai-Senga,Y., Wada,Y. and Futai,M.
  TITLE     Diversity of mouse proton-translocating ATPase: presence of
            multiple isoforms of the C, d and G subunits
  JOURNAL   Gene 302 (1-2), 147-153 (2003)
   PUBMED   12527205
REFERENCE   10 (bases 1 to 1785)
  AUTHORS   Philippe,J.M., Dubois,J.M., Rouzaire-Dubois,B., Cartron,P.F.,
            Vallette,F. and Morel,N.
  TITLE     Functional expression of V-ATPases in the plasma membrane of glial
            cells
  JOURNAL   Glia 37 (4), 365-373 (2002)
   PUBMED   11870875
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089961.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216940.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089961.1, SRR8487227.85851.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1785
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1785
                     /gene="Atp6v1c1"
                     /note="ATPase H+ transporting V1 subunit C1"
                     /db_xref="GeneID:299971"
                     /db_xref="RGD:1311082"
     exon            1..62
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..226
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1243
                     /gene="Atp6v1c1"
                     /EC_number="7.1.2.2"
                     /note="V-ATPase subunit C 1; vacuolar proton pump subunit
                     C 1; ATPase, H+ transporting, lysosomal V1 subunit C1;
                     ATPase, H+ transporting, V1 subunit C"
                     /codon_start=1
                     /product="V-type proton ATPase subunit C 1"
                     /protein_id="NP_001011992.1"
                     /db_xref="GeneID:299971"
                     /db_xref="RGD:1311082"
                     /translation="MTEFWLISAPGEKTCQQTWEKLHAATTKNNNLAVSSKFNIPDLK
                     VGTLDVLVGLSDELAKLDAFVEGVVKKVAQYMADVLEDSKDKVQENLLASGVDLVTYI
                     TRFQWDMAKYPIKQSLKNISEIIAKGVTQIDNDLKSRASAYNNLKGNLQNLERKNAGS
                     LLTRSLAEIVKKDDFVLDSEYLVTLLVVVPKLNHNDWIKQYETLAEMVVPRSSNVLSE
                     DQDSYLCNVTLFKKAVDDFRHKARENKFIVRDFQYNEEEMRADKEEMNRLSTDKKKQF
                     GPLVRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAMLLQPNKKSVKKLREV
                     LHELYKHLDSSAAAIIDAPMDIPGLNLSQQEYYPYVYYKIDCNLLEFK"
     exon            227..294
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..380
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..475
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..567
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..666
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..735
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..828
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..922
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1020
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1147
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1744
                     /gene="Atp6v1c1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgctagg cttcctgcct ccacacctgc cgctgccgcc gcctcctgag acaccttctc
       61 ggcttctccc tgggttgcca aagaggtaac aaacatgact gagttctggc tgatatctgc
      121 tcctggggag aaaacctgtc agcaaacatg ggagaaacta catgcagcga ccaccaagaa
      181 caataacctt gctgtctctt ccaagttcaa cattcctgac ttaaaggttg gcacgttgga
      241 tgtcttggtt ggcttgtcgg atgaactggc taaactggat gcatttgtag aaggggtggt
      301 caagaaagtg gctcagtaca tggctgatgt gctggaggac agcaaagata aagttcagga
      361 gaacttgctg gccagtggag ttgacttggt cacttacata acaaggttcc agtgggatat
      421 ggccaaatat ccaatcaagc agtctctgaa aaatatctct gaaataattg ccaagggagt
      481 gactcagatt gataatgacc taaagtctcg ggcgtctgca tacaataacc tgaaagggaa
      541 tcttcagaat ttggagcgaa agaatgcggg aagtttacta actcgaagcc tggcggaaat
      601 tgtgaagaaa gatgactttg ttcttgattc ggagtatctt gtcacattat tggtggtagt
      661 tcccaagttg aaccacaatg actggattaa gcagtatgaa acacttgcag aaatggtagt
      721 accaaggtcg agcaatgttc tttcagagga ccaagacagt tatctttgta acgtcacctt
      781 gtttaaaaaa gcagttgatg atttcagaca caaagccaga gaaaacaagt tcatcgtccg
      841 tgacttccag tataacgagg aggagatgag agccgacaaa gaggagatga accggctgtc
      901 cactgacaag aagaagcagt ttggaccact tgtgcggtgg cttaaagtga atttcagtga
      961 ggcctttatt gcgtggattc atataaaagc attacgggtt tttgtggagt ctgttttaag
     1021 gtatggcttg ccggtgaact tccaagcaat gctccttcaa cctaataaga aatcagtgaa
     1081 gaagctaaga gaagtgttgc atgagttgta caagcatctg gacagcagtg cagctgccat
     1141 cattgatgct cctatggata ttcctggcct gaacctgagt cagcaagaat actaccccta
     1201 tgtgtactac aagattgatt gcaacttgct ggaattcaag taaaaacaag ctcctcccag
     1261 tcagtcctgt cctcgtgttg gtgtgtgctc acagagttaa ctcataactc tcctgcccca
     1321 tgcttgctcc ctacccttcc ccaggtggat ttctatgtgg tccatatctc aacatttgct
     1381 ttttaaagaa aaaaaaaata tatatatata tattgtttct ttttattgat caggtctgta
     1441 aatgtgtact gagaaaatca gagtttattt ataaatagaa tagtttattt aaagaggtat
     1501 tttcctcctt gatatcatgg tatgcataat cctgtgttac tgtagtgcac agccttgttt
     1561 acagggaatg gtgtgagcag atgtttcatt cactgtatta gtagacataa ctgttcagta
     1621 gttaccaagt tgtgatgtag tgcaatgtaa caacattcag gtgtgtgctt tccgaatgtt
     1681 ccaacactat cctgtcagca ctgttgacac ccacaggaca gaataaaaga acctgtgcac
     1741 ggtgaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
