LOCUS       NM_057213               2717 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit B2 (Atp6v1b2),
            mRNA.
ACCESSION   NM_057213
VERSION     NM_057213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2717)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 2717)
  AUTHORS   Yang,D.Q., Feng,S., Chen,W., Zhao,H., Paulson,C. and Li,Y.P.
  TITLE     V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast
            differentiation, extracellular acidification, lysosomal
            trafficking, and protease exocytosis in osteoclast-mediated bone
            resorption
  JOURNAL   J Bone Miner Res 27 (8), 1695-1707 (2012)
   PUBMED   22467241
REFERENCE   3  (bases 1 to 2717)
  AUTHORS   Bronckers,A.L., Lyaruu,D.M., Bervoets,T.J., Medina,J.F.,
            DenBesten,P., Richter,J. and Everts,V.
  TITLE     Murine ameloblasts are immunonegative for Tcirg1, the v-H-ATPase
            subunit essential for the osteoclast plasma proton pump
  JOURNAL   Bone 50 (4), 901-908 (2012)
   PUBMED   22245629
REFERENCE   4  (bases 1 to 2717)
  AUTHORS   Chintagari,N.R., Mishra,A., Su,L., Wang,Y., Ayalew,S., Hartson,S.D.
            and Liu,L.
  TITLE     Vacuolar ATPase regulates surfactant secretion in rat alveolar type
            II cells by modulating lamellar body calcium
  JOURNAL   PLoS One 5 (2), e9228 (2010)
   PUBMED   20169059
  REMARK    GeneRIF: Data show that silencing of V-ATPase a1 and B2 subunits
            decreased stimulated surfactant secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2717)
  AUTHORS   Carraro-Lacroix,L.R., Girardi,A.C. and Malnic,G.
  TITLE     Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in
            proximal tubule cells
  JOURNAL   Pflugers Arch 458 (5), 969-979 (2009)
   PUBMED   19396617
  REMARK    GeneRIF: Long-term exposure of proximal tubule cells to angiotensin
            II causes upregulation of H(+)-ATPase activity due to increased
            B2-subunit cell-surface expression, which is dependent on
            mechanisms involving tyrosine kinase, p38 MAPK, and PI3K
            activation.
REFERENCE   6  (bases 1 to 2717)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 2717)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 2717)
  AUTHORS   Da Silva,N., Shum,W.W., El-Annan,J., Paunescu,T.G., McKee,M.,
            Smith,P.J., Brown,D. and Breton,S.
  TITLE     Relocalization of the V-ATPase B2 subunit to the apical membrane of
            epididymal clear cells of mice deficient in the B1 subunit
  JOURNAL   Am J Physiol Cell Physiol 293 (1), C199-C210 (2007)
   PUBMED   17392376
REFERENCE   9  (bases 1 to 2717)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   10 (bases 1 to 2717)
  AUTHORS   Paunescu,T.G., Da Silva,N., Marshansky,V., McKee,M., Breton,S. and
            Brown,D.
  TITLE     Expression of the 56-kDa B2 subunit isoform of the vacuolar
            H(+)-ATPase in proton-secreting cells of the kidney and epididymis
  JOURNAL   Am J Physiol Cell Physiol 287 (1), C149-C162 (2004)
   PUBMED   15013950
  REMARK    GeneRIF: expressed in most, if not all, proton-secreting cells in
            the epithelium lining the nephron and the collecting ducts, and it
            is also present in proton-secreting clear cells of the epididymis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085714.1.
            
            On Nov 15, 2004 this sequence version replaced NM_057213.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085714.1, Y12635.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2717
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..2717
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /note="ATPase H+ transporting V1 subunit B2"
                     /db_xref="GeneID:117596"
                     /db_xref="RGD:620284"
     exon            1..149
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1549
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /EC_number="7.1.2.2"
                     /note="V-ATPase subunit B 2; vacuolar proton pump subunit
                     B 2; endomembrane proton pump 58 kDa subunit; ATPase, H+
                     transporting, lysosomal (vacuolar proton pump), beta 56/58
                     kDa; vacuolar H+ATPase B2; ATPase, H+ transporting, V1
                     subunit B; ATPase, H transporting, lysosomal V1 subunit
                     B2"
                     /codon_start=1
                     /product="V-type proton ATPase subunit B, brain isoform"
                     /protein_id="NP_476561.1"
                     /db_xref="GeneID:117596"
                     /db_xref="RGD:620284"
                     /translation="MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPR
                     LTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGT
                     SGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINP
                     QCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKD
                     VVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPR
                     LALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATI
                     YERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPI
                     NVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLL
                     YLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDS
                     AKH"
     exon            150..205
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            206..304
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            305..398
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            399..476
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            477..616
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            617..718
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            719..816
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            817..940
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1091
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1174
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1279
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1409
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2695
                     /gene="Atp6v1b2"
                     /gene_synonym="Atp6b1b2; Atp6b2; Vatb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggagac aagatggcgt tgcgagcgat gcggggaatc gtgaacgggg ccgcgcccga
       61 gctgcccgtg cccaccggtg ggccgatggc cggagctcgg gagcaggcgc tggcggtgag
      121 ccggaactac ctctcccagc ctcgtctcac ctacaagact gtctctggag tgaatggtcc
      181 actagtgatc ttagatcatg taaagtttcc cagatatgct gagattgtcc acttgacatt
      241 accagatggc acaaaaagaa gtgggcaagt tctagaagtt agtggctcca aagccgtggt
      301 tcaggtattt gaaggaacat ccggcataga tgccaagaaa acatcctgtg agtttactgg
      361 agatattctc cgcacaccag tgtctgagga tatgcttggt cgagtattca atggatcagg
      421 aaaacccatt gaccgaggtc ctgtggtgtt ggccgaagac ttccttgaca tcatgggtca
      481 gccaatcaac cctcagtgtc gcatctaccc agaagagatg attcagacgg gcatttctgc
      541 catcgatggc atgaacagta ttgcgagggg acagaaaatc cccatctttt ctgctgccgg
      601 gttaccacac aacgagattg cagctcagat ctgtcgccag gctggtttgg taaagaaatc
      661 caaagacgtg gtagactaca gtgaagaaaa ctttgccatt gtgtttgctg ctatgggagt
      721 aaacatggaa acagcccggt tcttcaaatc tgactttgaa gaaaatggct caatggacaa
      781 tgtctgcctt ttcttgaatc tggctaatga cccaactatc gagaggatca tcactcctcg
      841 cctggctctg accaccgctg agtttctggc ttaccagtgt gagaagcatg tcctggtcat
      901 cctgacagat atgagttctt acgctgaagc acttcgagag gtttcagctg ccagggaaga
      961 ggttcctggt cggcgaggct tccccggcta catgtatacg gatttagcca ccatctatga
     1021 acgcgctggg cgagtggaag gtagaaatgg ctctattacc caaatcccta ttctcaccat
     1081 gcccaatgat gatatcactc atcctatccc tgacttgact gggtatatta ctgagggcca
     1141 gatctatgtg gacagacagc tgcacaacag acagatttac cctcctatta atgtgctgcc
     1201 ctcactctct cggttaatga agtcagctat tggagaagga atgaccagga aggatcatgc
     1261 tgatgtgtct aaccagttgt acgcatgcta tgctatcggt aaggatgtgc aagccatgaa
     1321 agctgtggtg ggagaagaag ccctgacctc agatgacctc ctttacttgg aatttctgca
     1381 gaagtttgag aaaaacttca ttactcaggg tccctatgaa aatcgaactg tctatgagac
     1441 tttggacatt ggctggcagt tgcttcgaat cttccccaaa gaaatgctga agaggatccc
     1501 tcagagtacc ctgagcgaat tttaccctcg agactctgca aagcactagc tgctgctgct
     1561 tgtgcggctc gaccctcttg tgaagtgctg gttctgtttg ctgattcctt ttgcactcct
     1621 ccatcccacc tgtgtgtggg agttcacctg ttaccctgta attaaagaca aaggctaggt
     1681 aactgttgtg ccagtgttca gcgtttaaac tgctaaccga ttgagagatc cccgctcaga
     1741 acctcacctt ctgtgctgtc tttaaagtgg cggaggtgag gcttgcttac cggtgtatct
     1801 atttgtacat agtggagagc tagttgcgaa taatgtcttg tttgggtctc ccaaacccta
     1861 cctctcaact cccttaagag tatcactgtt ttgaagttaa aatgcttcag tctcaaattt
     1921 aggggcaagg tggagactgg aagaattctc ctttcagaag aaccatgagg ctcgtggctg
     1981 agcctccctc tggagtacta gtgtacctgt gggtctgtcc tctgctctgt gcagatgggt
     2041 tttactgtct gcttgagttt tcttaggaaa agagttctgt tctgccagtg ctgcgagttg
     2101 ggattcctgt gtggccatct ttctctttga ggcctaaaga gtcaggcacc actgtgcagc
     2161 ggcattctcc tgcaggggtg gcgtgccttg tgctgatgac ccccactggg ctgcagtcat
     2221 aggagaactg agacttggaa aatgctgggg cacagttaag aaaacctaca tcccaccctc
     2281 atcttgtgtt tatggtggct taggtctctg cattgccctc cagatcctga ggtggggcat
     2341 ggagatgact tgccttaggt ttgtggatgc tttaaactct gctcagtcct caagctttct
     2401 gactcagctc tcccttttct gggtgatctt gtggcacgtg tagcaatgtt tctttcattc
     2461 ctgtcccttc ctggcttgag ctcttagctg tattctgtgt gcctctgccg tgtctgctgt
     2521 ttgggtctct gtgctgtgtg ttctcaggtg cagccataac ttccccactc cgagcattcc
     2581 accttccagt tgtttttctc tgaggggatg ggggggcggt cagcatgatt atattttaat
     2641 gtagaaaatg tgacatctcg ttataaatga aaataaatgt taaattaaat ggaaaaaaaa
     2701 aaaaaaaaaa aaaaaaa
//
