LOCUS       NM_001107867            2487 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit B1 (Atp6v1b1),
            mRNA.
ACCESSION   NM_001107867 XM_001073086 XM_232119
VERSION     NM_001107867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2487)
  AUTHORS   Gueutin,V., Vallet,M., Jayat,M., Peti-Peterdi,J., Corniere,N.,
            Leviel,F., Sohet,F., Wagner,C.A., Eladari,D. and Chambrey,R.
  TITLE     Renal beta-intercalated cells maintain body fluid and electrolyte
            balance
  JOURNAL   J Clin Invest 123 (10), 4219-4231 (2013)
   PUBMED   24051376
REFERENCE   2  (bases 1 to 2487)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   3  (bases 1 to 2487)
  AUTHORS   Vedovelli,L., Rothermel,J.T., Finberg,K.E., Wagner,C.A.,
            Azroyan,A., Hill,E., Breton,S., Brown,D. and Paunescu,T.G.
  TITLE     Altered V-ATPase expression in renal intercalated cells isolated
            from B1 subunit-deficient mice by fluorescence-activated cell
            sorting
  JOURNAL   Am J Physiol Renal Physiol 304 (5), F522-F532 (2013)
   PUBMED   23269648
REFERENCE   4  (bases 1 to 2487)
  AUTHORS   Paunescu,T.G., Rodriguez,S., Benz,E., McKee,M., Tyszkowski,R.,
            Albers,M.W. and Brown,D.
  TITLE     Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal
            cells of the mouse olfactory epithelium impairs olfactory function
  JOURNAL   PLoS One 7 (9), e45395 (2012)
   PUBMED   23028982
REFERENCE   5  (bases 1 to 2487)
  AUTHORS   Sharifian,M., Esfandiar,N., Mazaheri,S., Kariminejad,A., Mohkam,M.,
            Dalirani,R., Esmaili,R., Ahmadi,M. and Hassas-Yeganeh,M.
  TITLE     Distal renal tubular acidosis and its relationship with hearing
            loss in children: preliminary report
  JOURNAL   Iran J Kidney Dis 4 (3), 202-206 (2010)
   PUBMED   20622307
REFERENCE   6  (bases 1 to 2487)
  AUTHORS   Dou,H., Finberg,K., Cardell,E.L., Lifton,R. and Choo,D.
  TITLE     Mice lacking the B1 subunit of H+ -ATPase have normal hearing
  JOURNAL   Hear Res 180 (1-2), 76-84 (2003)
   PUBMED   12782355
REFERENCE   7  (bases 1 to 2487)
  AUTHORS   Stover,E.H., Borthwick,K.J., Bavalia,C., Eady,N., Fritz,D.M.,
            Rungroj,N., Giersch,A.B., Morton,C.C., Axon,P.R., Akil,I.,
            Al-Sabban,E.A., Baguley,D.M., Bianca,S., Bakkaloglu,A., Bircan,Z.,
            Chauveau,D., Clermont,M.J., Guala,A., Hulton,S.A., Kroes,H., Li
            Volti,G., Mir,S., Mocan,H., Nayir,A., Ozen,S., Rodriguez
            Soriano,J., Sanjad,S.A., Tasic,V., Taylor,C.M., Topaloglu,R.,
            Smith,A.N. and Karet,F.E.
  TITLE     Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal
            renal tubular acidosis with new evidence for hearing loss
  JOURNAL   J Med Genet 39 (11), 796-803 (2002)
   PUBMED   12414817
REFERENCE   8  (bases 1 to 2487)
  AUTHORS   Breton,S., Wiederhold,T., Marshansky,V., Nsumu,N.N., Ramesh,V. and
            Brown,D.
  TITLE     The B1 subunit of the H+ATPase is a PDZ domain-binding protein.
            Colocalization with NHE-RF in renal B-intercalated cells
  JOURNAL   J Biol Chem 275 (24), 18219-18224 (2000)
   PUBMED   10748165
REFERENCE   9  (bases 1 to 2487)
  AUTHORS   Karet,F.E., Finberg,K.E., Nelson,R.D., Nayir,A., Mocan,H.,
            Sanjad,S.A., Rodriguez-Soriano,J., Santos,F., Cremers,C.W., Di
            Pietro,A., Hoffbrand,B.I., Winiarski,J., Bakkaloglu,A., Ozen,S.,
            Dusunsel,R., Goodyer,P., Hulton,S.A., Wu,D.K., Skvorak,A.B.,
            Morton,C.C., Cunningham,M.J., Jha,V. and Lifton,R.P.
  TITLE     Mutations in the gene encoding B1 subunit of H+-ATPase cause renal
            tubular acidosis with sensorineural deafness
  JOURNAL   Nat Genet 21 (1), 84-90 (1999)
   PUBMED   9916796
REFERENCE   10 (bases 1 to 2487)
  AUTHORS   Wax,M.B., Saito,I., Tenkova,T., Krupin,T., Becker,B., Nelson,N.,
            Brown,D. and Gluck,S.L.
  TITLE     Vacuolar H+-ATPase in ocular ciliary epithelium
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6752-6757 (1997)
   PUBMED   9192637
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 11, 2008 this sequence version replaced NM_001107867.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.18781.1,
                                           SRR26643287.11447.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000004.1  117781444-117781622
            180-235             JAXUCZ010000004.1  117787952-117788007
            236-334             JAXUCZ010000004.1  117792767-117792865
            335-428             JAXUCZ010000004.1  117793031-117793124
            429-506             JAXUCZ010000004.1  117793531-117793608
            507-646             JAXUCZ010000004.1  117794459-117794598
            647-748             JAXUCZ010000004.1  117795348-117795449
            749-846             JAXUCZ010000004.1  117796020-117796117
            847-970             JAXUCZ010000004.1  117796881-117797004
            971-1121            JAXUCZ010000004.1  117797199-117797349
            1122-1204           JAXUCZ010000004.1  117797498-117797580
            1205-1309           JAXUCZ010000004.1  117798572-117798676
            1310-1439           JAXUCZ010000004.1  117798837-117798966
            1440-2170           JAXUCZ010000004.1  117799052-117799782
            2171-2487           JAXUCZ010000004.1  117799787-117800103
FEATURES             Location/Qualifiers
     source          1..2487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2487
                     /gene="Atp6v1b1"
                     /note="ATPase H+ transporting V1 subunit B1"
                     /db_xref="GeneID:312488"
                     /db_xref="RGD:1310619"
     exon            1..179
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1603
                     /gene="Atp6v1b1"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, V1 subunit B; ATPase, H
                     transporting, lysosomal V1 subunit B1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit B, kidney isoform"
                     /protein_id="NP_001101337.2"
                     /db_xref="GeneID:312488"
                     /db_xref="RGD:1310619"
                     /translation="MATQVDGRPSGFTSNSCDPGTAREHVQVVTRNYITHPRVTYRTV
                     CSVNGPLVVLDQVKFAQYAEIVNFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDSQ
                     KTTCEFTGDILRTPVSEDMLGRIFNGSGKPIDKGPAVMAEDFLDINGQPINPHDRIYP
                     EEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHE
                     DNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTA
                     EFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGR
                     VEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQVYPPINVLPSL
                     SRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQ
                     KFEKNFINQGPYENRTVFESLDLGWKLLRIFPKEMLKRIPQSVTDEFYSRQGAQQDPA
                     SDTAL"
     exon            180..235
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            236..334
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..428
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..506
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..646
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..748
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            749..846
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..970
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1121
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1204
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1309
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1439
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..2487
                     /gene="Atp6v1b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgaagtc ttagagctac caccagtctc ctcaggcact gactgcagct ctccacacgc
       61 catggccaca caagtagacg gcaggccctc gggattcact agcaatagct gcgacccagg
      121 cacagcccga gagcatgtgc aggttgtgac ccgaaactac atcacccacc cccgtgtcac
      181 ctacaggaca gtatgcagcg tcaatgggcc tctggtggtg ctggaccaag tcaagtttgc
      241 ccagtacgct gagattgtca actttaccct ccctgatggt actcagagga gtggccaagt
      301 gcttgaagtg gctgggacca aagccattgt tcaggtgttt gaggggacct cagggatcga
      361 ttcccagaag accacatgtg aattcacagg cgacatcctg cggactccag tgtcagagga
      421 catgctgggt cggattttca atggctctgg caaacccatt gacaaaggac ctgctgtcat
      481 ggcagaggac tttctggaca tcaatggcca gccaatcaat ccccatgacc gaatctaccc
      541 tgaggagatg atccagacgg gaatctcccc catcgatgtc atgaacagca tcgcccgtgg
      601 ccagaagatt cccatcttct ctgcagcggg gctcccccac aatgagattg cagcccagat
      661 ctgccgccaa gctgggctgg tgaagaaatc caaggctgtg ctggattatc atgaagacaa
      721 cttcgccatt gtctttgcag ccatgggggt gaacatggag acagccaggt tcttcaagtc
      781 agatttcgag cagaatggaa ccatggggaa tgtctgtctc ttcctgaatt tggccaatga
      841 ccctacgatt gagcggatca tcaccccacg tctggcactg accacagctg agttccttgc
      901 ctaccagtgt gagaagcatg tgctggtcat attgactgac atgagctcct atgcggaagc
      961 tttgcgggag gtctcagctg cccgagagga agtaccagga cgccgtggct tccccggata
     1021 tatgtacaca gacttggcca ccatctatga gcgagccggc cgtgtggagg gccggggtgg
     1081 ctccataacc cagatcccca ttctcactat gcctaatgac gatattaccc accccatccc
     1141 agacctgact ggcttcatca cagagggaca gatttatgtg gacagacagc tacataaccg
     1201 gcaggtctac ccacccatca atgtgctccc ttccctctca cgactgatga agtcggccat
     1261 aggtgagggc atgaccagaa aggaccacgg agatgtctcc aaccagctgt acgcctgcta
     1321 cgccatcggg aaggacgtgc aggccatgaa agcggtggtg ggggaggagg cgctcacctc
     1381 cgaggacctg ctctacctgg agttcctgca gaagttcgag aagaatttca tcaaccaagg
     1441 tccctacgag aaccgcacag tgttcgagtc gctggacctg ggctggaaac tgctgcgcat
     1501 ctttcctaaa gagatgctga agcgcattcc gcagagcgtg acggacgagt tctactctcg
     1561 ccagggggcg cagcaggacc ccgcatccga cacggcgctc taaagcaacc cccagccgca
     1621 gccttctttt tagacaggag tgatgtaggt gggtgggtgg gctttttttc tttaggggct
     1681 tgctgagaat ggaagcgggg gagggcatca tccagaatat taagcaggcg ctcttactac
     1741 ggaactccac ctcgggccta tgtttttatt ttagaagccc cgcctccaga gatgtaactg
     1801 aaatggaaaa caaaacagta acaaacgaat ttatctctgg tgaaaacaag agtgggaata
     1861 gctgattgtt gaaagtgcag attatatcat gtatttacaa agtatttaca aaggaaactc
     1921 tagttgggca caatggagca tggttttaat cccagtactc aggatgtcag gtagacagat
     1981 ctctgtgagt tcaaagttag tcaggactaa gtagccaaac tctgtcagaa agaaagaaag
     2041 aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag
     2101 aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag
     2161 aaagaaagaa ggaaggaaag aaagaaagaa ggaaagaaag aaagaaagga aggaaggaag
     2221 aagaaaagag aaaaataaaa gaaaagacag acagacagac agatagacag aaagaaagaa
     2281 agaaagaaag agagaaagaa agaaaagaaa gaaaaaggga aaagtcagga aaactcagtt
     2341 gaattagtac cctaacagaa ttccacttag ggaagtattt ctgttaaaat gagagctgag
     2401 ctgatgtggc tgagtattca gcattcagga aaccctgggt cccagtccct gcactgcaca
     2461 gaccaggcat gactacatgt aactata
//
