LOCUS       NM_001108318            4069 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V1 subunit A (Atp6v1a),
            mRNA.
ACCESSION   NM_001108318 XM_001060277
VERSION     NM_001108318.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4069)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 4069)
  AUTHORS   Liu,T., Zhou,J., Cui,H., Li,P., Li,H., Wang,Y. and Tang,T.
  TITLE     Quantitative proteomic analysis of intracerebral hemorrhage in rats
            with a focus on brain energy metabolism
  JOURNAL   Brain Behav 8 (11), e01130 (2018)
   PUBMED   30307711
REFERENCE   3  (bases 1 to 4069)
  AUTHORS   Miles,A.L., Burr,S.P., Grice,G.L. and Nathan,J.A.
  TITLE     The vacuolar-ATPase complex and assembly factors, TMEM199 and
            CCDC115, control HIF1alpha prolyl hydroxylation by regulating
            cellular iron levels
  JOURNAL   Elife 6, e22693 (2017)
   PUBMED   28296633
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4069)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 4069)
  AUTHORS   Chintagari,N.R., Mishra,A., Su,L., Wang,Y., Ayalew,S., Hartson,S.D.
            and Liu,L.
  TITLE     Vacuolar ATPase regulates surfactant secretion in rat alveolar type
            II cells by modulating lamellar body calcium
  JOURNAL   PLoS One 5 (2), e9228 (2010)
   PUBMED   20169059
  REMARK    GeneRIF: Data show that silencing of V-ATPase a1 and B2 subunits
            decreased stimulated surfactant secretion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4069)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 4069)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 4069)
  AUTHORS   Jouret,F., Auzanneau,C., Debaix,H., Wada,G.H., Pretto,C.,
            Marbaix,E., Karet,F.E., Courtoy,P.J. and Devuyst,O.
  TITLE     Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are
            differentially expressed during nephrogenesis
  JOURNAL   J Am Soc Nephrol 16 (11), 3235-3246 (2005)
   PUBMED   16177003
REFERENCE   9  (bases 1 to 4069)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   10 (bases 1 to 4069)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Sep 10, 2008 this sequence version replaced NM_001108318.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.273621.1,
                                           SRR26360190.1434745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000011.1  70067502-70067592
            92-187              JAXUCZ010000011.1  70088770-70088865
            188-316             JAXUCZ010000011.1  70090914-70091042
            317-531             JAXUCZ010000011.1  70094221-70094435
            532-669             JAXUCZ010000011.1  70094711-70094848
            670-821             JAXUCZ010000011.1  70096111-70096262
            822-984             JAXUCZ010000011.1  70098467-70098629
            985-1093            JAXUCZ010000011.1  70099274-70099382
            1094-1216           JAXUCZ010000011.1  70103966-70104088
            1217-1331           JAXUCZ010000011.1  70104172-70104286
            1332-1395           JAXUCZ010000011.1  70105710-70105773
            1396-1599           JAXUCZ010000011.1  70106767-70106970
            1600-1694           JAXUCZ010000011.1  70115051-70115145
            1695-1866           JAXUCZ010000011.1  70116927-70117098
            1867-4069           JAXUCZ010000011.1  70118401-70120603
FEATURES             Location/Qualifiers
     source          1..4069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..4069
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /note="ATPase H+ transporting V1 subunit A"
                     /db_xref="GeneID:685232"
                     /db_xref="RGD:1596464"
     exon            1..91
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            92..187
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..1959
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal V1 subunit A"
                     /codon_start=1
                     /product="V-type proton ATPase catalytic subunit A"
                     /protein_id="NP_001101788.1"
                     /db_xref="GeneID:685232"
                     /db_xref="RGD:1596464"
                     /translation="MDFSKLPKIRDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVR
                     VGHSELVGEIIRLEGDMATIQVYEETSGVSVGDPVLRTGKPLSVELGPGIMGAIFDGI
                     QRPLSDISSQTQSIYIPRGVNVSALSRDIKWEFIPSKNLRVGSHITGGDIYGIVNENS
                     LIKHKIMLPPRSRGSVTYIAPPGNYDASDVVLELEFEGVKEKLSMVQVWPVRQVRPVT
                     EKLPANHPLLTGQRVLDALFPCVQGGTTAIPGAFGCGKTVISQSLSKYSNSDVIIYVG
                     CGERGNEMSEVLRDFPELTMEVDGKVESIMKRTALVANTSNMPVAAREASIYTGITLS
                     EYFRDMGYHVSMMADSTSRWAEALREISGRLAEMPADSGYPAYLGARLASFYERAGRV
                     KCLGNPEREGSVSIVGAVSPPGGDFSDPVTSATLGIVQVFWGLDKKLAQRKHFPSVNW
                     LISYSKYMRALDEYYDKHFTEFVPLRTKAKEILQEEEDLAEIVQLVGKASLAETDKIT
                     LEVAKLIKDDFLQQNGYTPYDRFCPFYKTVGMLSNMISFYDMARRAVETTAQSDNKIT
                     WSIIREHMGEILYKLSSMKFKDPVKDGEAKIKADYAQLLEDMQNAFRSLED"
     exon            188..316
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..531
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..669
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..821
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..984
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1093
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1216
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1331
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1395
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1599
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1694
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1866
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..4069
                     /gene="Atp6v1a"
                     /gene_synonym="Atp6v1a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcctcctg cagctgaaga cttcccctct ctcagtgaca gagcctctgg gtccggtcta
       61 ggtacagatt ctgcattgcg agcccgggca ggtaaattta gcacaatgga tttctccaag
      121 ctacccaaaa tccgtgatga agacaaagaa agcacatttg gttatgtgca tggagtctca
      181 gggcctgtgg tcaccgcctg tgacatggcg ggcgctgcca tgtacgagct ggtgagagtg
      241 gggcacagcg agctggtcgg agagattatc cgactggaag gtgacatggc caccattcag
      301 gtgtacgagg aaacttctgg tgtctctgtt ggagaccctg tactccgcac tggtaaacct
      361 ctctcggtag aacttggtcc tggcattatg ggagccattt ttgatggtat tcagagacct
      421 ctatcggata tcagcagtca gacccaaagt atctacatcc ccagaggagt aaatgtgtct
      481 gctcttagca gagatatcaa atgggagttt atacccagca aaaacctacg ggttggtagt
      541 catatcactg gtggagatat ttatgggatt gtcaatgaga actcgctcat caaacacaaa
      601 atcatgctac ccccacgcag ccgaggaagt gtgacttaca tcgcaccgcc tgggaactac
      661 gatgcctctg atgtcgtcct ggagcttgaa tttgaaggtg tgaaggagaa gttgagcatg
      721 gtccaagtgt ggcctgtgcg tcaggtgcgg cctgtcactg aaaagctgcc agccaaccac
      781 cccttgctta ctggccagag agtgctcgat gcccttttcc cgtgtgttca gggaggaact
      841 actgctattc caggtgcttt tggctgtggg aagactgtga tttcccagtc tctatccaag
      901 tactccaaca gcgatgtgat tatctatgtc ggctgcggtg aaagagggaa tgagatgtca
      961 gaagttctcc gggacttccc tgagctcact atggaagttg atggtaaagt agagtccatc
     1021 atgaagagga cagcgctggt agccaatacc tccaatatgc ctgtggctgc aagagaggcc
     1081 tccatttaca ctggaattac actatcagaa tacttccgtg acatggggta ccacgtcagt
     1141 atgatggctg actctacctc tagatgggct gaggccctca gagaaatctc tggtcgctta
     1201 gctgaaatgc ctgcagatag tggataccct gcataccttg gtgcccgact ggcttctttc
     1261 tatgagcgag caggcagagt gaaatgtctt ggaaaccctg agagagaagg gagtgtcagc
     1321 attgtaggag cagtttctcc acctggtggt gatttttctg atccagtcac atctgctact
     1381 ctgggtattg ttcaggtgtt ctggggcttg gataagaagc tagctcagcg caagcacttc
     1441 ccgtccgtca actggctcat tagctacagc aagtacatgc gcgccctgga cgagtactat
     1501 gacaaacact tcacagagtt cgtgcctctg aggaccaaag ctaaggagat tctgcaggaa
     1561 gaggaggatc tggcggaaat cgtgcagctc gtgggaaagg cgtctttagc agagacagat
     1621 aaaatcaccc tggaggtagc aaaacttatc aaagatgact tcctacaaca aaatgggtac
     1681 actccttatg acaggttctg tccattctat aagacggtgg ggatgctgtc caacatgatt
     1741 tcattctatg atatggcccg ccgggctgtg gagaccaccg cccagagtga caataagatc
     1801 acatggtcca ttatccgtga gcacatgggg gagattctct ataaactttc ctccatgaaa
     1861 ttcaaggatc cagtgaagga tggcgaggca aagatcaagg ccgactacgc acagcttctt
     1921 gaagatatgc agaacgcatt ccgtagcctg gaagattaga actgtgactt ctctcctcct
     1981 cttccgcagc tcatatgtgt atattttcct gaatttctca tctccaaccc tttgcttcca
     2041 tattgtgcag ctttgagact agtgcctcgt gcgttctcgt tcattttgct gtttctttgg
     2101 taggtcttat aaaacacaca ttcctgtgct ccgctgtctg aaggagctcc tgacctttgt
     2161 ctgaagtggt gaatgtagtg catatgatac acagtgtaac atacacattg taacatatac
     2221 gttctgtaaa cttgtatgta aggtgactac cccttccctc ctctccagta aactgtaaac
     2281 aggactactg catgtgctct attggggatg gaaggccaga tctccatacc gtggacaggt
     2341 acataaggaa actagaccac ttgcaactta gtgtttgttg agtaaccatt ttgcaggaag
     2401 tatttccatt taaaaaacaa aagattaatg ttccaattat ttgtagcttc cccagtatca
     2461 atcaggactg tttgtggcgc acttgggaac tattttgttt tcctaacaga cgtttgcaag
     2521 gctgaacgta atagataaat cagttccctc tgaaagtgtg aaagtaaaaa gagagctagg
     2581 tggtcagact taaattgaca tcgtcttgtt taagcatatt ttatttcact gagagattta
     2641 atatcaagga cttttatata ctcaattact aggaaatctt tttttaagta caatttaaaa
     2701 atcattgaaa atgtgatcca catcatagcc attttcctta tatttagtca gatgagctca
     2761 gagtggggag ggtgtgggtt agaataccac aaggacacgc agcagtgcct gcaggcagtg
     2821 tggccggggg ccagagcggc attgttttca cgaggtacgt gtgtggcgtg tgtgtttgct
     2881 tgttgacact ctgaaaacag caagcttacc agttccagga aatattttgt tttctttcac
     2941 tggctcagaa agctcctcaa agtacctggt ccctgaagct tcctatctgt taatagagac
     3001 gagagaggtt cttaaattta actggtgaca aaacaaaaag aaaaaaaaga tcgatttttg
     3061 tcttgctgtt ttggtgtgtt taaataataa ttccatattt gcataacgag gctcgcttct
     3121 gagagcttgg agatcgtgct ccctcttcac tctccggggt gataatgctg gcgccatgct
     3181 acctcttcag gaggggaagg ggattgaaca tggctaacac tctcaagtac acaagcgtaa
     3241 cgacaaagta tttattttaa gccttggtat gttgtttaaa ttattaggtg gtgcatttct
     3301 tatggtcttt tgggtagaca tagtatacac ttcagatgta atgtgtaaat ccttgctagt
     3361 gcatgtctac acgatagact gctattcaag aaggatattc ttccacataa caatttaaaa
     3421 actattaaat cagatatgga ttatgcaatg acttgttgag aggtggatta acggtgctgc
     3481 ttaatcagtt tgcttccaat atggcttcgt atccagaagc cctgactagt ggagatgaga
     3541 aagatttcaa aacctgtctg cctacaccta ccagcaacct aggcttgtga tcagaatgaa
     3601 tgatcccaag aaactacttg accaagtgtg ttttgttgtc ctggatttga gatgtgcgtt
     3661 cttcctccct ctgagactgt tgatgtatga gtgtgaagaa gttacagaaa caacgctcag
     3721 attttcacgg taactttccc tctgcccaca ctgtagagtt tcagattgtt cactgatagt
     3781 gcttctttcg taaggatgtg ttaaaatata gcagtctttt taaaagatta tgcagttctc
     3841 tatttattgt gctgtgcctg gtcctaagtg cagccggtta aacaagtttc atatgtattt
     3901 ttccagtgtt aaatctcata cctatgccct ttggaaagct ccatcctgaa caatgaatag
     3961 aagaggctat ataaattgcc tccttatcct taagatttca ctatctttat gttaagagta
     4021 atgtataatt attaaaatct atgaaaaata aaaagtggat ttaaattaa
//
