LOCUS       NM_001011972            1330 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit D2 (Atp6v0d2),
            mRNA.
ACCESSION   NM_001011972 XM_216358
VERSION     NM_001011972.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1330)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1330)
  AUTHORS   Smith,A.N., Francis,R.W., Sorrell,S.L. and Karet,F.E.
  TITLE     The d subunit plays a central role in human vacuolar H(+)-ATPases
  JOURNAL   J Bioenerg Biomembr 40 (4), 371-380 (2008)
   PUBMED   18752060
REFERENCE   3  (bases 1 to 1330)
  AUTHORS   Pietrement,C., Sun-Wada,G.H., Silva,N.D., McKee,M., Marshansky,V.,
            Brown,D., Futai,M. and Breton,S.
  TITLE     Distinct expression patterns of different subunit isoforms of the
            V-ATPase in the rat epididymis
  JOURNAL   Biol Reprod 74 (1), 185-194 (2006)
   PUBMED   16192400
REFERENCE   4  (bases 1 to 1330)
  AUTHORS   Smith,A.N., Jouret,F., Bord,S., Borthwick,K.J., Al-Lamki,R.S.,
            Wagner,C.A., Ireland,D.C., Cormier-Daire,V., Frattini,A., Villa,A.,
            Kornak,U., Devuyst,O. and Karet,F.E.
  TITLE     Vacuolar H+-ATPase d2 subunit: molecular characterization,
            developmental regulation, and localization to specialized proton
            pumps in kidney and bone
  JOURNAL   J Am Soc Nephrol 16 (5), 1245-1256 (2005)
   PUBMED   15800125
REFERENCE   5  (bases 1 to 1330)
  AUTHORS   Hackam,D.J., Rotstein,O.D., Zhang,W., Gruenheid,S., Gros,P. and
            Grinstein,S.
  TITLE     Host resistance to intracellular infection: mutation of natural
            resistance-associated macrophage protein 1 (Nramp1) impairs
            phagosomal acidification
  JOURNAL   J Exp Med 188 (2), 351-364 (1998)
   PUBMED   9670047
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089917.1.
            
            On Feb 11, 2005 this sequence version replaced XM_216358.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN09767679
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..1330
                     /gene="Atp6v0d2"
                     /note="ATPase H+ transporting V0 subunit D2"
                     /db_xref="GeneID:297932"
                     /db_xref="RGD:1306900"
     exon            1..227
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1150
                     /gene="Atp6v0d2"
                     /EC_number="7.1.2.2"
                     /note="V-ATPase subunit d 2; vacuolar proton pump subunit
                     d 2; ATPase, H+ transporting, V0 subunit D; ATPase, H+
                     transporting, lysosomal 38kDa, V0 subunit d2; ATPase, H+
                     transporting, lysosomal V0 subunit D2"
                     /codon_start=1
                     /product="V-type proton ATPase subunit d 2"
                     /protein_id="NP_001011972.1"
                     /db_xref="GeneID:297932"
                     /db_xref="RGD:1306900"
                     /translation="MLETAELYFNVDHGYLEGLVRGCKASLLTQQDYVNLVQCETLED
                     LKIHLQTTDYGNFLAHETNPLTVSKIDTEMRKKLCREFDYFRNHSLEPLSTFFTYMTC
                     SYMIDNIILLMNGALQKKSVKEVLAKCHPLGRFTEMEAVNIAESASELFKAVLVETPL
                     APFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKDHGDVTAEVMCPILEFEADR
                     RALIITLNSFGTELSKEDRETLFPTCGKLYPEGLRLLAQAEDFEHMKRVADNYGVYKP
                     LFDAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAEC
                     ISQRHRTKINSYIPIL"
     exon            228..399
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..578
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..658
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..736
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            737..913
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..988
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1306
                     /gene="Atp6v0d2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgactatca gctgagcgac cacgacaccc acacttcccc agaccaaggc cagttcagtg
       61 gctctccagg actcagagcc gattcagcct gagcaagatg cttgagacgg cagagctgta
      121 cttcaatgtg gaccatggct acctggaggg cctggtgcga gggtgcaaag ccagcctcct
      181 aactcagcag gactatgtca acttagtgca gtgtgagacc ttggaagatt tgaaaattca
      241 tctccagacc actgactatg gcaacttcct ggctcatgaa acaaaccctc tcactgtttc
      301 caaaattgac acggagatga ggaagaagct atgcagagag tttgactatt tccgaaatca
      361 ttccttggag cccctcagca catttttcac ctacatgacg tgcagctata tgatagacaa
      421 cataattcta ctgatgaatg gggcattgca aaagaaatcc gtgaaagaag ttctagccaa
      481 gtgtcaccca ttgggccgct tcactgaaat ggaagccgtc aacattgcag agagcgcctc
      541 agagctcttc aaggctgtgc tggttgaaac accattagct ccattcttcc aagattgtat
      601 gtctgaaaat actcttgatg aactgaatat tgaattactg cgcaataaac tatacaagtc
      661 ttacctcgag gcattctaca aattctgcaa ggatcacggt gatgtcacag cagaagttat
      721 gtgtcccatt cttgagtttg aggccgacag acgcgcttta atcatcactc tgaactcatt
      781 tggcactgaa ctgagcaaag aagacaggga gaccctcttc cccacctgcg gcaagctcta
      841 tccggaggga ctgcggctgt tagcccaagc cgaagacttc gagcacatga agagagtggc
      901 agataattac ggagtttaca agcctttgtt tgacgccgta ggtggcagtg ggggaaagac
      961 actggaagat gttttctatg agcgagaggt acagatgaat gtgctggcgt tcaacaggca
     1021 attccactat ggtgtgtttt atgcctatgt aaagttgaag gagcaggaga tgagaaatat
     1081 cgtgtggata gcagaatgca tctcacagcg acatcgaact aaaatcaaca gctacattcc
     1141 aattttataa gccaggttgg aggccacaag tgcagaaatg acaggaagtt attgaacaaa
     1201 ggaaagggga ttgtgttaca ttatgtagat tatataaaag tcagtcatac cacttttctc
     1261 tgaactgtgt gtccactgga agcccagtaa acagacttga aacaaaaaaa aaaaaaaaaa
     1321 aaaaaaaaaa
//
