LOCUS       NM_130823               1185 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit C (Atp6v0c),
            mRNA.
ACCESSION   NM_130823
VERSION     NM_130823.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Rama,S., Boumedine-Guignon,N., Sangiardi,M., Youssouf,F.,
            Maulet,Y., Leveque,C., Belghazi,M., Seagar,M., Debanne,D. and El
            Far,O.
  TITLE     Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit
            Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle
            Acidification
  JOURNAL   Mol Neurobiol 56 (5), 3591-3602 (2019)
   PUBMED   30155790
  REMARK    GeneRIF: V-ATPase c-subunit V0c is a key element in modulating
            neurotransmission and that its specific inactivation rapidly
            inhibited neurotransmission.
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Camargo Barros-Filho,M., Barreto Menezes de Lima,L., Bisarro Dos
            Reis,M., Bette Homem de Mello,J., Moraes Beltrami,C., Lopes
            Pinto,C.A., Kowalski,L.P. and Rogatto,S.R.
  TITLE     PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in
            Well-Differentiated Thyroid Carcinomas
  JOURNAL   Int J Mol Sci 20 (6), 1334 (2019)
   PUBMED   30884810
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Cruciat,C.M., Ohkawara,B., Acebron,S.P., Karaulanov,E.,
            Reinhard,C., Ingelfinger,D., Boutros,M. and Niehrs,C.
  TITLE     Requirement of prorenin receptor and vacuolar H+-ATPase-mediated
            acidification for Wnt signaling
  JOURNAL   Science 327 (5964), 459-463 (2010)
   PUBMED   20093472
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   Liu,Q.Y., Lei,J.X., Sikorska,M. and Liu,R.
  TITLE     A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated
            in the brains of Alzheimer's patients and targets ATP6V0C for
            degradation
  JOURNAL   Mol Neurodegener 3, 4 (2008)
   PUBMED   18298843
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1185)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 1185)
  AUTHORS   Byun,Y.J., Lee,S.B., Kim,D.J., Lee,H.O., Son,M.J., Yang,C.W.,
            Sung,K.W., Kim,H.S., Kwon,O.J., Kim,I.K. and Jeong,S.W.
  TITLE     Protective effects of vacuolar H+ -ATPase c on hydrogen
            peroxide-induced cell death in C6 glioma cells
  JOURNAL   Neurosci Lett 425 (3), 183-187 (2007)
   PUBMED   17845832
REFERENCE   9  (bases 1 to 1185)
  AUTHORS   Galli,T., McPherson,P.S. and De Camilli,P.
  TITLE     The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are
            associated on synaptic vesicles in a Triton X-100-resistant,
            freeze-thawing sensitive, complex
  JOURNAL   J Biol Chem 271 (4), 2193-2198 (1996)
   PUBMED   8567678
REFERENCE   10 (bases 1 to 1185)
  AUTHORS   Nezu,J., Motojima,K., Tamura,H. and Ohkuma,S.
  TITLE     Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit
            of vacuolar H(+)-ATPases: organellar and tissue distribution of 16
            kDa proteolipids
  JOURNAL   J Biochem 112 (2), 212-219 (1992)
   PUBMED   1400263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 29, 2021 this sequence version replaced NM_130823.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ214503.1, FQ234225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840122, SAMN12840130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000010.1  13705578-13705842   c
            266-449             JAXUCZ010000010.1  13701593-13701776   c
            450-1185            JAXUCZ010000010.1  13700764-13701499   c
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1185
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6l"
                     /note="ATPase H+ transporting V0 subunit C"
                     /db_xref="GeneID:170667"
                     /db_xref="RGD:621394"
     exon            1..265
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6l"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..654
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6l"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal (vacuolar proton
                     pump), subunit C; ATPase, H+ transporting, lysosomal V0
                     subunit C; V-type proton ATPase 16 kDa proteolipid
                     subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar
                     proton pump 16 kDa proteolipid subunit; ATPase, H+
                     transporting, lysosomal 16kDa, V0 subunit c; V-ATPase 16
                     kDa proteolipid subunit c; vacuolar proton pump 16 kDa
                     proteolipid subunit c"
                     /codon_start=1
                     /product="V-type proton ATPase 16 kDa proteolipid subunit
                     c"
                     /protein_id="NP_570836.1"
                     /db_xref="GeneID:170667"
                     /db_xref="RGD:621394"
                     /translation="MADIKNNPEYSSFFGVMGASSAMVFSAMGAAYGTAKSGTGIAAM
                     SVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLTDGITLYRSFLQLGAGLSVGLS
                     GLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK"
     exon            266..449
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6l"
                     /inference="alignment:Splign:2.1.0"
     exon            450..1185
                     /gene="Atp6v0c"
                     /gene_synonym="Atp6c; Atp6l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atatcatgtg acgcgagcgc ggccgccatc ttgctctgcg gtgctggtat ttagagcgca
       61 gcgcctgact ggcggggtcg ccttcgcatc cgccgcttcg agaatcttct ttcgtctgct
      121 cgctctctct cccgtcgtcc tagcccgccg ccgcctgctg agcttgccct ctccccgctt
      181 gcagacatgg ctgacatcaa gaacaacccc gaatattctt cgtttttcgg tgtcatgggc
      241 gcctcgtccg ccatggtctt cagcgccatg ggagctgcct atggcacagc caagagtggc
      301 actggcatcg cagccatgtc ggtcatgagg ccagagctga tcatgaagtc catcatccca
      361 gtggttatgg ctgggatcat cgccatctac ggcctggtgg ttgcagtact tatcgctaac
      421 tccctgactg atggcatcac cctctacagg agttttcttc aactgggtgc tggcctgagt
      481 gtggggctga gtggcctggc tgctggcttt gccattggca ttgtcggaga tgctggtgtc
      541 cggggcactg cccagcagcc tcgactgttc gtgggcatga tcctgatcct catctttgcg
      601 gaggtgcttg gcctctacgg tctcatcgtg gccctaatcc tctccacaaa gtagtctttt
      661 tccaccacca gtcacaggat aggatgtaaa gatcacccct cctcattcca gaaggaacag
      721 cctgacacat gcacgggcag ctgccccctc agtagttggt cttgtaaatg tgcagtgtcc
      781 tagtgcccat tgtctgttgc cccgccttgc ccctactgcc ccgtgctgtg gacatctggg
      841 cccactcatc tcccacccag gcccctgacc agtgacgatt tcagcctctg gtcaccccac
      901 ccatcgccct agagtgcgcc ttgtgtataa gaatgaatta gagttgtcat ttttctcttc
      961 actggatgtt tatttataaa agatttgacc tattcatgtg tctgtggagc agccctgtct
     1021 cccaactcta tagtaatcat tagtagactg ttgccttgtg gggttcctgt tgctgagact
     1081 ccttggatgg agccaccctg cccccagccc tgaacagccg ggggagggta gagagttcct
     1141 cagagctggc tcccagctgt gtccaataaa agttctcgga tgtga
//
