LOCUS       NM_001415838            3256 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit a4 (Atp6v0a4),
            mRNA.
ACCESSION   NM_001415838 XM_006236296
VERSION     NM_001415838.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3256)
  AUTHORS   Boyken,J., Gronborg,M., Riedel,D., Urlaub,H., Jahn,R. and Chua,J.J.
  TITLE     Molecular profiling of synaptic vesicle docking sites reveals novel
            proteins but few differences between glutamatergic and GABAergic
            synapses
  JOURNAL   Neuron 78 (2), 285-297 (2013)
   PUBMED   23622064
REFERENCE   2  (bases 1 to 3256)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 3256)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 3256)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 3256)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   6  (bases 1 to 3256)
  AUTHORS   Su,Y., Zhou,A., Al-Lamki,R.S. and Karet,F.E.
  TITLE     The a-subunit of the V-type H+-ATPase interacts with
            phosphofructokinase-1 in humans
  JOURNAL   J Biol Chem 278 (22), 20013-20018 (2003)
   PUBMED   12649290
REFERENCE   7  (bases 1 to 3256)
  AUTHORS   Stover,E.H., Borthwick,K.J., Bavalia,C., Eady,N., Fritz,D.M.,
            Rungroj,N., Giersch,A.B., Morton,C.C., Axon,P.R., Akil,I.,
            Al-Sabban,E.A., Baguley,D.M., Bianca,S., Bakkaloglu,A., Bircan,Z.,
            Chauveau,D., Clermont,M.J., Guala,A., Hulton,S.A., Kroes,H., Li
            Volti,G., Mir,S., Mocan,H., Nayir,A., Ozen,S., Rodriguez
            Soriano,J., Sanjad,S.A., Tasic,V., Taylor,C.M., Topaloglu,R.,
            Smith,A.N. and Karet,F.E.
  TITLE     Novel ATP6V1B1 and ATP6V0A4 mutations in autosomal recessive distal
            renal tubular acidosis with new evidence for hearing loss
  JOURNAL   J Med Genet 39 (11), 796-803 (2002)
   PUBMED   12414817
REFERENCE   8  (bases 1 to 3256)
  AUTHORS   Smith,A.N., Finberg,K.E., Wagner,C.A., Lifton,R.P., Devonald,M.A.,
            Su,Y. and Karet,F.E.
  TITLE     Molecular cloning and characterization of Atp6n1b: a novel fourth
            murine vacuolar H+-ATPase a-subunit gene
  JOURNAL   J Biol Chem 276 (45), 42382-42388 (2001)
   PUBMED   11495928
REFERENCE   9  (bases 1 to 3256)
  AUTHORS   Oka,T., Murata,Y., Namba,M., Yoshimizu,T., Toyomura,T.,
            Yamamoto,A., Sun-Wada,G.H., Hamasaki,N., Wada,Y. and Futai,M.
  TITLE     a4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase
            subunit a
  JOURNAL   J Biol Chem 276 (43), 40050-40054 (2001)
   PUBMED   11498539
REFERENCE   10 (bases 1 to 3256)
  AUTHORS   Smith,A.N., Skaug,J., Choate,K.A., Nayir,A., Bakkaloglu,A.,
            Ozen,S., Hulton,S.A., Sanjad,S.A., Al-Sabban,E.A., Lifton,R.P.,
            Scherer,S.W. and Karet,F.E.
  TITLE     Mutations in ATP6N1B, encoding a new kidney vacuolar proton pump
            116-kD subunit, cause recessive distal renal tubular acidosis with
            preserved hearing
  JOURNAL   Nat Genet 26 (1), 71-75 (2000)
   PUBMED   10973252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jan 3, 2023 this sequence version replaced XM_006236296.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.10732.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               JAXUCZ010000004.1  67808831-67809092   c
            263-396             JAXUCZ010000004.1  67771226-67771359   c
            397-475             JAXUCZ010000004.1  67770092-67770170   c
            476-570             JAXUCZ010000004.1  67769756-67769850   c
            571-696             JAXUCZ010000004.1  67766703-67766828   c
            697-791             JAXUCZ010000004.1  67766026-67766120   c
            792-918             JAXUCZ010000004.1  67764167-67764293   c
            919-1001            JAXUCZ010000004.1  67761310-67761392   c
            1002-1095           JAXUCZ010000004.1  67760487-67760580   c
            1096-1308           JAXUCZ010000004.1  67757295-67757507   c
            1309-1459           JAXUCZ010000004.1  67754467-67754617   c
            1460-1599           JAXUCZ010000004.1  67751957-67752096   c
            1600-1757           JAXUCZ010000004.1  67750107-67750264   c
            1758-1851           JAXUCZ010000004.1  67747212-67747305   c
            1852-1970           JAXUCZ010000004.1  67741238-67741356   c
            1971-2187           JAXUCZ010000004.1  67737681-67737897   c
            2188-2289           JAXUCZ010000004.1  67734030-67734131   c
            2290-2385           JAXUCZ010000004.1  67732868-67732963   c
            2386-2503           JAXUCZ010000004.1  67730375-67730492   c
            2504-2675           JAXUCZ010000004.1  67729186-67729357   c
            2676-3256           JAXUCZ010000004.1  67727145-67727725   c
FEATURES             Location/Qualifiers
     source          1..3256
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..3256
                     /gene="Atp6v0a4"
                     /note="ATPase H+ transporting V0 subunit a4"
                     /db_xref="GeneID:296981"
                     /db_xref="RGD:1305055"
     exon            1..262
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            263..396
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..2769
                     /gene="Atp6v0a4"
                     /EC_number="7.1.2.2"
                     /note="ATPase, H+ transporting, lysosomal V0 subunit A;
                     V-type proton ATPase 116 kDa subunit a; ATPase, H+
                     transporting, lysosomal V0 subunit A4"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 4"
                     /protein_id="NP_001402767.1"
                     /db_xref="GeneID:296981"
                     /db_xref="RGD:1305055"
                     /translation="MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANV
                     NSFQRKFVNEVRRCESLERILRFLEDEMQNEIIIQVPDKDPGTPLPREMITLETTLEK
                     LEGELQEANQSHQALKKSFLELTELKYLLKKTQDFFETETNLGEDFFVEDTSGLLELR
                     AMPAFMTGKLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIK
                     KNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAERREMLASVNVRLEDLITVITQ
                     TESHRQRLLQEAASNWHSWVIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRH
                     IKKALEQGMELSGSSMVPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGVGSYREIN
                     PAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRY
                     LILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNAHVVEQNPYLQLDPA
                     IPGVYSGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIVHMIFGVILSLFNHIYF
                     RRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCQYDAHTSQKAPSILIHFIGMFLFDY
                     DDSSNAPLYGHQQEVQTFFVIIALVSVPWMLLIKPFILRAKHQKSQLQSFTIHEDAME
                     GPSVKKTAGAHGTKEGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAH
                     AELSEVLWTMVMSIGLRLRGWGGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLH
                     WVEFQNKFYEGAGFKFSPFSFKHVLEGAAEE"
     exon            397..475
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            476..570
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            571..696
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..791
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            792..918
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1001
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1095
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1308
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1459
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1599
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1757
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1851
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1970
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2187
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2289
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2385
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2503
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2675
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..3256
                     /gene="Atp6v0a4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttggaaag atgttgggtc aaggttctgg gcgcagggca gtgtgctcct gtcttaattc
       61 acactaagtt tgccactagt ggagtcctcg ccatgtcatt tctacctcca aagtaagtca
      121 tcagagtctg ctcgtccaca tctggtccag gcgggagtac gaggaagtcc gcttctacac
      181 ccgtgcgcac aaacacgtcc gtgtgggaca gtccattgag cttcgtcatt agtccagcct
      241 attacagaca ttcctggaac agactaaggc tgggccaaca tggcgtctgt gtttcgaagt
      301 gaggagatgt gcttatccca agtgtttctc caggtggagg ctgcatactg ctgtgtggct
      361 gagctggggg agcttggttt ggttcaattc aaagatctga acgcaaatgt aaacagcttc
      421 cagaggaagt ttgtgaatga ggtccgaaga tgcgagtcac tggagagaat cctccgtttt
      481 ctggaagatg agatgcaaaa tgagattata atccaagtgc ctgacaagga tccagggacc
      541 cctctgcccc gggaaatgat caccctggag actactctgg agaagttgga aggagagcta
      601 caggaagcca accagagcca tcaggctttg aagaagagct ttttggaact gacagagctc
      661 aaatacctcc tgaagaaaac ccaggacttt tttgagacag aaaccaactt aggtgaagat
      721 ttctttgttg aagacacttc aggtctcttg gagctaagag ccatgcctgc attcatgact
      781 ggaaagttgg ggttcacggc cggtgtgata aacagggaga ggatggcttc cttcgagagg
      841 ctgctgtgga gagtttgccg gggaaacgta tatttgaagt tcagcgagat ggacacactt
      901 ctggaggatc ctgtgacgaa agaagaaatt aaaaagaata tattcatcat attttatcaa
      961 ggagaacagc tcaggctgaa aatcaagaag atctgtgatg ggtttcgtgc taccatctac
     1021 ccctgcccgg agcatgcagc cgagcgcaga gagatgctgg ccagtgtcaa tgtgaggctg
     1081 gaagacttaa tcactgtcat tacccaaaca gagtctcacc gacagcgcct actgcaggaa
     1141 gcagcttcca actggcactc gtgggtcatc aaagtacaga agatgaaggc cgtctaccac
     1201 gtgctgaaca tgtgcaacat cgacgtcacc cagcagtgca tcattgctga gatctggttc
     1261 cctgtagcag acactagaca cattaagaag gccctggagc aaggcatgga actcagtggc
     1321 tcctccatgg tccccatcat gacagaagtg gaaactaaaa cagaccctcc caccttcaat
     1381 aggaccaata aatttacagc tggcttccag aacattgtcg atgcatatgg tgtaggtagc
     1441 taccgagaga taaacccagc cccctatact atcatcacct tccccttcct gttcgctgtg
     1501 atgtttggag actgtggtca cgggatggtg atgctgatgg ccgccctgtg gatggtccta
     1561 aatgagagac acttgctggc tcagaagagc accaatgaga tgtggaacat cttcttcaat
     1621 gggcgctatc tgatcctcct catgggcatc ttctccatct acaccggctt gatctacaac
     1681 gactgtttct ccaaatcttt taacatcttt ggctcctctt ggagtgtcca gcctatgttc
     1741 agaaacggca cgtggaatgc tcatgtcgtg gaacagaatc cgtatttgca gctggatccg
     1801 gccatcccag gagtgtattc tggaaatccc tacccatttg ggattgatcc gatttggaac
     1861 ctggcttcaa acaaactcac atttttaaac tcctacaaga tgaagatgtc ggtcatcctg
     1921 ggaatcgttc atatgatctt cggtgttatc ctcagcctct tcaatcacat ctacttcaga
     1981 cgaaccctca acatcattct gcagttcatc cccgagatga tttttatgct gagtctgttt
     2041 ggatacctgg ttttcatgat cattttcaag tggtgtcaat atgatgccca cacatcccag
     2101 aaggcaccca gcatcctcat ccacttcatc ggcatgtttc tgtttgacta cgatgactcg
     2161 tccaacgcac ccctgtacgg ccatcagcaa gaagtccaga ctttctttgt cattatagcg
     2221 ttggtgtctg tgccgtggat gcttttgatt aagccattta tccttagagc caagcaccag
     2281 aaatctcagc tgcagtcctt cacgatccat gaggatgcca tggagggccc ctctgttaag
     2341 aagactgcag gtgcccatgg gacgaaggaa ggacacgagg aggagttcaa ctttggagac
     2401 atctttgtcc accaagccat ccacaccatt gagtactgcc tgggctgcat ctccaataca
     2461 gcctcatatc ttcggctgtg ggctctcagc ttggctcacg cagagctgtc cgaggtactg
     2521 tggaccatgg tgatgagcat cggccttcgc ctccgaggct ggggagggct cgttggtgtc
     2581 ttcatcattt ttgccgtctt cgccgtcctc acagttgcca tcctcctcgt tatggagggc
     2641 ctctcagcct ttctgcacgc cctccggctg cattgggtgg aattccagaa caagttctac
     2701 gagggggccg gcttcaagtt ctcccccttc tcctttaagc acgtcctgga aggggcggct
     2761 gaggagtagg cctgcctgct tccgggtgca ggtgaaagct gaagaagttc tctctgacgc
     2821 cagcccaggc caggtgtccg cggccgcagc ccttctcagc tgtctcaagt gtgaggctgt
     2881 gtaaagtgca gtattcggca ggactcagcc acttaactga ggggccactt tggggaatca
     2941 tttagacttc atgtgtagtc ttcgtgatca gatactaaaa taactgggaa atgggggtgg
     3001 gggctgcact agaccgttat cttcctgtga tagtttattt ttattctcct ttattctggt
     3061 ttgagacaag gtctctctag ctttcctgtc tgggaaataa ccacaccgcc aacgatgtcc
     3121 ttgaccttga actcggctcc tcctgcctct ctacttctca aatgctgaga ggacaggctt
     3181 gagctcctcg cctggagtcc ctgcagtatt tcaagtgtta tggtcgtgaa aataaacatc
     3241 tgccttgttc accgtt
//
