LOCUS       NM_053775               5312 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit a2 (Atp6v0a2),
            mRNA.
ACCESSION   NM_053775 XM_222145
VERSION     NM_053775.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Miles,A.L., Burr,S.P., Grice,G.L. and Nathan,J.A.
  TITLE     The vacuolar-ATPase complex and assembly factors, TMEM199 and
            CCDC115, control HIF1alpha prolyl hydroxylation by regulating
            cellular iron levels
  JOURNAL   Elife 6, e22693 (2017)
   PUBMED   28296633
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5312)
  AUTHORS   Saw,N.M., Kang,S.Y., Parsaud,L., Han,G.A., Jiang,T.,
            Grzegorczyk,K., Surkont,M., Sun-Wada,G.H., Wada,Y., Li,L. and
            Sugita,S.
  TITLE     Vacuolar H(+)-ATPase subunits Voa1 and Voa2 cooperatively regulate
            secretory vesicle acidification, transmitter uptake, and storage
  JOURNAL   Mol Biol Cell 22 (18), 3394-3409 (2011)
   PUBMED   21795392
  REMARK    GeneRIF: Voa1 and Voa2 cooperatively regulate the acidification and
            transmitter uptake/storage of dense-core vesicles, whereas they
            might not be as critical for exocytosis as recently proposed.
REFERENCE   3  (bases 1 to 5312)
  AUTHORS   Sun-Wada,G.H., Tabata,H., Kawamura,N., Aoyama,M. and Wada,Y.
  TITLE     Direct recruitment of H+-ATPase from lysosomes for phagosomal
            acidification
  JOURNAL   J Cell Sci 122 (Pt 14), 2504-2513 (2009)
   PUBMED   19549681
REFERENCE   4  (bases 1 to 5312)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   5  (bases 1 to 5312)
  AUTHORS   Poea-Guyon,S., Amar,M., Fossier,P. and Morel,N.
  TITLE     Alternative splicing controls neuronal expression of v-ATPase
            subunit a1 and sorting to nerve terminals
  JOURNAL   J Biol Chem 281 (25), 17164-17172 (2006)
   PUBMED   16621796
REFERENCE   6  (bases 1 to 5312)
  AUTHORS   Ahmed,F., Torrado,M., Zinovieva,R.D., Senatorov,V.V., Wistow,G. and
            Tomarev,S.I.
  TITLE     Gene expression profile of the rat eye iridocorneal angle: NEIBank
            expressed sequence tag analysis
  JOURNAL   Invest Ophthalmol Vis Sci 45 (9), 3081-3090 (2004)
   PUBMED   15326124
REFERENCE   7  (bases 1 to 5312)
  AUTHORS   Toyomura,T., Murata,Y., Yamamoto,A., Oka,T., Sun-Wada,G.H., Wada,Y.
            and Futai,M.
  TITLE     From lysosomes to the plasma membrane: localization of
            vacuolar-type H+ -ATPase with the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 278 (24), 22023-22030 (2003)
   PUBMED   12672822
REFERENCE   8  (bases 1 to 5312)
  AUTHORS   Sun-Wada,G.H., Imai-Senga,Y., Yamamoto,A., Murata,Y., Hirata,T.,
            Wada,Y. and Futai,M.
  TITLE     A proton pump ATPase with testis-specific E1-subunit isoform
            required for acrosome acidification
  JOURNAL   J Biol Chem 277 (20), 18098-18105 (2002)
   PUBMED   11872743
REFERENCE   9  (bases 1 to 5312)
  AUTHORS   Okada,H., Attanucci,J., Giezeman-Smits,K.M., Brissette-Storkus,C.,
            Fellows,W.K., Gambotto,A., Pollack,L.F., Pogue-Geile,K.,
            Lotze,M.T., Bozik,M.E. and Chambers,W.H.
  TITLE     Immunization with an antigen identified by cytokine tumor
            vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma
            in vivo
  JOURNAL   Cancer Res 61 (6), 2625-2631 (2001)
   PUBMED   11289140
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Oct 12, 2022 this sequence version replaced NM_053775.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.46303.1,
                                           SRR26643297.39867.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               JAXUCZ010000012.1  37640646-37640860   c
            216-294             JAXUCZ010000012.1  37636803-37636881   c
            295-392             JAXUCZ010000012.1  37634099-37634196   c
            393-530             JAXUCZ010000012.1  37632626-37632763   c
            531-619             JAXUCZ010000012.1  37631196-37631284   c
            620-746             JAXUCZ010000012.1  37629107-37629233   c
            747-829             JAXUCZ010000012.1  37626061-37626143   c
            830-923             JAXUCZ010000012.1  37624909-37625002   c
            924-1136            JAXUCZ010000012.1  37624089-37624301   c
            1137-1287           JAXUCZ010000012.1  37622017-37622167   c
            1288-1424           JAXUCZ010000012.1  37620241-37620377   c
            1425-1612           JAXUCZ010000012.1  37619691-37619878   c
            1613-1703           JAXUCZ010000012.1  37619505-37619595   c
            1704-1822           JAXUCZ010000012.1  37618670-37618788   c
            1823-2033           JAXUCZ010000012.1  37616372-37616582   c
            2034-2153           JAXUCZ010000012.1  37614716-37614835   c
            2154-2273           JAXUCZ010000012.1  37614152-37614271   c
            2274-2391           JAXUCZ010000012.1  37613400-37613517   c
            2392-2563           JAXUCZ010000012.1  37612464-37612635   c
            2564-5312           JAXUCZ010000012.1  37608211-37610959   c
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q15"
     gene            1..5312
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /note="ATPase H+ transporting V0 subunit a2"
                     /db_xref="GeneID:116455"
                     /db_xref="RGD:621006"
     exon            1..215
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..2669
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /EC_number="7.1.2.1"
                     /note="T-cell expressing clone j6; ATPase, H+
                     transporting, lysosomal V0 subunit A2; V-type proton
                     ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa
                     subunit a2"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 2"
                     /protein_id="NP_446227.2"
                     /db_xref="GeneID:116455"
                     /db_xref="RGD:621006"
                     /translation="MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNV
                     SSFQRKFVGEVKRCEELERILVYLVQEITRADIPLPEGEASPPAPPVKHVLEMQEQLQ
                     KLEVELREVTKNKEKLRKNLLELVEYTHMLRVTKTFLKRNVEFEPTYEEFPALESDSL
                     LDYSCMQRLGAKLGFVSGLIQQGKVEAFERMLWRACKGYTIVTYAELDEALEDPETGE
                     VIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNTAEERREIQEGLNTRIQDLYTV
                     LHKTEDYLRQVLCKAAESVCSRVIQVRKMKAIYHMLNMCSFDVTNKCLIAEVWCPEVD
                     LPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVDAYGVGSYR
                     EVNPALFTIITFPFLFGVMFGDLGHGFVMFLFALLLVLNENHPRLSQSQEILRMFFDG
                     RYILLLMGLFSVYTGLIYNDCFSKSLNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDST
                     IRHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFG
                     VILGIFNHLHFRKKFNIYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSREAPSIL
                     IEFINMFLFPSSETHGLYPGQAHVQKVLLALTVLAVPVLFLGKPLFLLWLHNGRSCFG
                     VSRSGYTLVRKDSEEEVSLLGSQDIEEGNNRMEEGCREMTCEEFNFGEILMTQAIHSI
                     EYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDNTYGVLLLLPVMTFFA
                     VLTVFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFSKDDSIA
                     "
     exon            216..294
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            295..392
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            393..530
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            531..619
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            620..746
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            747..829
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            830..923
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1136
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1287
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1424
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1612
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1703
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1822
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2033
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2153
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2273
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2391
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2563
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..5312
                     /gene="Atp6v0a2"
                     /gene_synonym="Cc1-3; J6b7; Tj6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atctgtggcg gccgctgagc ggtggccgcg gtggcagcgg aggagagccc catggtgcga
       61 gtgtgcgggc cgaggaggct gaacgaggct gcgccgccat gggctccctc ttccgtagcg
      121 agagcatgtg cctggcgcag ctcttcctgc agtcgggcac ggcctacgag tgtctgagcg
      181 cgcttggcga gaagggcctg gtgcagttcc gagacctcaa ccaaaatgta agttctttcc
      241 aaagaaaatt cgttggtgag gtaaagaggt gtgaagaact agaacgaata ttggtgtacc
      301 tggtgcagga aatcaccaga gctgatattc ccctgcctga gggagaggcc agtcctcccg
      361 caccacctgt taaacatgtt ctagaaatgc aggagcagct gcagaagctc gaggtggagc
      421 tcagagaagt caccaagaac aaggagaagc tgaggaagaa cctgctggag ctggtggagt
      481 atacccacat gctgagggtc accaagacct tccttaaacg gaacgtggag tttgagccaa
      541 cttacgaaga gttccccgcc ttagagagcg actctctgtt ggactacagc tgcatgcagc
      601 ggctgggcgc caagctggga ttcgtttctg gcctgattca gcaaggcaaa gtggaagcat
      661 ttgaaagaat gctgtggcgg gcctgcaaag ggtacaccat tgtgacctat gcagagctgg
      721 acgaggccct ggaagaccct gagacgggtg aagtcataaa gtggtatgtg ttcctgatct
      781 cgttttgggg agagcagatt ggccacaagg ttaagaagat ctgtgactgt taccactgcc
      841 acatctaccc gtatccaaac acggccgagg agcgcaggga gatccaggag gggctcaata
      901 ctcggatcca agacctttac actgtgctgc acaaaacgga ggactacctg cggcaagtgc
      961 tgtgcaaggc tgccgagtcc gtgtgcagcc gtgtgataca ggtgcggaag atgaaagcca
     1021 tctaccacat gctcaacatg tgcagctttg acgtcaccaa caagtgcctc atagctgagg
     1081 tctggtgccc cgaggtggac ctgcccggct tgcgcagagc gctggaggaa ggctcgagag
     1141 aaagtggagc tacaatcccc tcgttcatga acacaatccc tacgaaagaa acgccgccca
     1201 ctctgatccg caccaacaaa ttcactgaag gtttccagaa catcgtggat gcctacggtg
     1261 ttgggagcta cagagaagtg aacccagctt tgttcaccat catcaccttc ccgttcctgt
     1321 ttggcgtgat gtttggtgac ttggggcacg gctttgtcat gttcctgttt gccctcttac
     1381 tggtgttgaa tgagaatcac cccagactaa gccagtcaca ggagatcctt aggatgttct
     1441 ttgatggccg atatatcctg ctgctgatgg ggctgttctc cgtgtacacc ggcctcatct
     1501 acaacgactg cttctccaag tccctgaacc tctttggctc tgggtggaac gtgtctgcca
     1561 tgtacagttc cagccactcc ccagaggagc aaaggaaaat ggtgctttgg aatgacagca
     1621 ccatcaggca cagcaggacg ctgcagctgg acccaaacat ccctggagtt ttccgaggcc
     1681 cctacccttt cggcatcgat cctatttgga acctggccac aaatcgcctc acgttcctca
     1741 actccttcaa gatgaagatg tctgtgattt taggaatttt tcacatgacc tttggtgtca
     1801 ttctgggaat atttaaccac ttgcacttca ggaagaagtt caacatctac ctggtctcgg
     1861 tccccgagat cctgtttatg ctctgcatct ttgggtacct gattttcatg atcatctaca
     1921 agtggctggc gtactcggca gagacctcca gagaggcccc cagcatcctc atcgagttca
     1981 ttaacatgtt cctgttcccg tccagtgaga cacacggcct ctacccgggg caggcacacg
     2041 tccagaaggt gttgttggct ctcaccgtgc tggctgtccc tgtgctcttc ttgggaaagc
     2101 cgctctttct gctgtggctg cacaatgggc gcagttgctt cggcgtgagc cggagcggct
     2161 acacgctcgt gaggaaggac agcgaggaag aggtgtctct cctaggcagc caggacatag
     2221 aggaggggaa caaccgcatg gaagagggct gccgagaaat gacctgtgag gagtttaact
     2281 tcggggagat cctgatgact caggccatcc actccatcga gtactgcctt ggctgcatct
     2341 ccaacactgc gtcctacctg aggctttggg ctctcagcct ggcacacgca cagctctcgg
     2401 atgtgctgtg ggccatgctg atgcgtgtag gcctgcgtgt ggacaacact tacggggtcc
     2461 tgctgctgct gcccgtcatg actttctttg cagttctgac cgtttttatc cttctggtca
     2521 tggaagggct ttctgcattt ctccacgcca tccggcttca ctgggtagaa tttcagaaca
     2581 aattctacgt tggtgcaggt accaaattcg ttcctttctc cttcagtctg ctgtcctcca
     2641 agttcagtaa agatgacagc atagcatgac ctcatgccgc agccagcccg ctctgactga
     2701 cggagaacga tcatgtcata gaactcactc aagtcagaac tcacggtggg gacgctctac
     2761 cctccttgat tgccttacga ttcagccaaa tggttctgga agagacacct ctccctcatg
     2821 ttgaagattt tgtaaaaccc agcactccgg acacagaaat ttcattggtt tttattatga
     2881 gcaaatataa gtgaatgcca acgctacttc agagttattt tttaaaatgt aagattggag
     2941 gagagaagcc atctgaacag ctagccaaaa atggtctaag atacttcatt ccttttcaac
     3001 tttaaaaaaa aaaaaaaacc atgaagttac tccatcgcaa gatgtcagat gatattttcc
     3061 aacagctcga gttaagcata gttttttcca gaccttactg ctgggtcatc ggcagttcct
     3121 gctcgagatg tgtgcgagcc ctccctgact gccctccgaa ctaccggaag ggcagtgtga
     3181 cagtctgctc ttctgttgac aattggaggc gatgggacaa agtgacacaa caatggctct
     3241 cctgcttttt aaagatgctt gtcctctacc cttgtgtaag agcagtcatg acagccgcac
     3301 attctgaaag atgaccaacc gtcctgagcc ttaaaaccca ggggagacag gtgaagagcc
     3361 gtgtgtattt ttatagcaaa gagcaaatga agatatttta ccacagagac cgtgcttcta
     3421 cttgagcaga attatttttt actttcgcac taattctgaa taaaggtccg atggccacag
     3481 tttaatttcc aaagcggttg aggttagctg gaaactgact gtcactaatc tgttagttta
     3541 ttatctcggt gtaacgtcac ctgtccctgt gctgctccgt gttcagtgag gttggctcag
     3601 tccctggaac gctgacccat gtcatagtct tagaaattat gttcactttc acatcttatg
     3661 ttacgtgatt ttagctaagt ctgtcagaaa gaaatcagag gctggggtgt ggcctgattg
     3721 tcagatctcc agaagcactt cacccggggg tgctggcact cagccggtct tccaagcact
     3781 tagaagcagg aggatcagga agttcagggt tacccttggc tatgtgatag gtttgaggcc
     3841 agcctgggct aagtgacacc ctgaagaacg aacggagtct aagtcatctc tgccatttta
     3901 aactgctgag ctccattcga ctgcaggccc ctccagctcc gtgtggtaga gtgggtccct
     3961 ttcactaaaa gccaagcctc tggcagccag aatttaaccg catcctgggt cctttacgac
     4021 ctctcggccg agaggcaggg gctgcctgtg ccgcagccgg aggctaaagt cagatctccc
     4081 cagctgctgt ggagtccgag cccacggcag tgaggctcca cctctgtgtc ccatgtccca
     4141 gcttcccgca gctgtgatga gctggtgctg cccagagtga gacctgccct tacctgaacc
     4201 aggtgtcacc cccatgtcac tcttgtgact gtgtccccag ggtctttggt cacctcagag
     4261 ataactgaat ccagggacaa gaaccaaaca ggagatgcag tttctgccat atttgctgtc
     4321 cctgttgtct tttttttttt tttttccgga gctgaggacc gaacccaggg ccttgcgcct
     4381 gctaggcaag cgctctacca ctgagctaaa tccccaaccc cctagggcct cttttctaac
     4441 tggcatcact tactgggtac agaactcaga gcaagaacga cttctcagct gaagcctgtt
     4501 gcagttatag agaatgtcct cgcataaagt cactcctttt gtgaaccctc tttcaatata
     4561 atggggagca ttctcacagg ggaagcaaga agctgtctgg aggtgtcaca tgttcatctc
     4621 cctagaacaa tgtcaacgga accacgtcac atagacttaa gctggtggga aggcccaata
     4681 cagccaggag aggcatgcaa agggctttga gctcctgcac tctccctcct tcataggacc
     4741 tgggacagac tcctttcccc ccacatcctc ccctggcctt ggttctggag tgggtctgta
     4801 ctctatgctt ggagacattt aatgccaccc gtgcaggcat tggcatagtt ctcagatgga
     4861 tggcaccaca ggtctgcaat gctggccatg ggtataaagg ccattcggac ccagtgctgt
     4921 atctgcagga gtgtactcag gcacagacta tccattggta acttacaggg ctggcacgtc
     4981 aagccgtgac taaaatcaaa cccagctcca gggccacatt tctctatgga gggtgtaagt
     5041 ctggatttgc tcacctgcca cactatccag gcaggcttca gaactctcct gatgctggga
     5101 ggaggcagtt tgcagtaaat gcttgctcta acacatcaag aagtcctcag acaatacaac
     5161 tccacaggat cgaggctgag ttccggagcg gaaactacgg gagccggcca ggactgcatt
     5221 gtactgatac atgcatggaa ggactaatct gcctgtcagt attgaacttc cttttgctag
     5281 tgacaaaata aatgtatatt tttgagatgc ca
//
