LOCUS       NM_031604               4006 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting V0 subunit a1 (Atp6v0a1),
            mRNA.
ACCESSION   NM_031604
VERSION     NM_031604.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4006)
  AUTHORS   Tao,T., Liu,Y., Zhang,J., Lai,W. and Long,H.
  TITLE     NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth
            Movement Is Dependent on Atp6v0a1 and Vesicle Release
  JOURNAL   Int J Mol Sci 23 (19), 11440 (2022)
   PUBMED   36232740
  REMARK    GeneRIF: NGF-Induced Upregulation of CGRP in Orofacial Pain Induced
            by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4006)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   3  (bases 1 to 4006)
  AUTHORS   Zhang,J.C., Lu,W., Xie,X.M., Pan,H., Wu,Z.Q. and Yang,G.T.
  TITLE     Mild hypothermia attenuates post-resuscitation brain injury through
            a V-ATPase mechanism in a rat model of cardiac arrest
  JOURNAL   Genet Mol Res 15 (2) (2016)
   PUBMED   27323115
  REMARK    GeneRIF: Mild hypothermia significantly increased V0a1 compared to
            NT-3 h; V0a1 expression was associated with a decrease in the
            cleaved caspase 3 expression. These findings suggested that mild
            hypothermia inhibits CA-induced apoptosis in the hippocampus, which
            may be associated with reduced V-ATPase impairment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4006)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   5  (bases 1 to 4006)
  AUTHORS   Poea-Guyon,S., Ammar,M.R., Erard,M., Amar,M., Moreau,A.W.,
            Fossier,P., Gleize,V., Vitale,N. and Morel,N.
  TITLE     The V-ATPase membrane domain is a sensor of granular pH that
            controls the exocytotic machinery
  JOURNAL   J Cell Biol 203 (2), 283-298 (2013)
   PUBMED   24165939
  REMARK    GeneRIF: V-ATPase membrane domain would allow the exocytotic
            machinery to discriminate fully loaded and acidified vesicles from
            vesicles undergoing neurotransmitter reloading.
REFERENCE   6  (bases 1 to 4006)
  AUTHORS   Poea-Guyon,S., Amar,M., Fossier,P. and Morel,N.
  TITLE     Alternative splicing controls neuronal expression of v-ATPase
            subunit a1 and sorting to nerve terminals
  JOURNAL   J Biol Chem 281 (25), 17164-17172 (2006)
   PUBMED   16621796
  REMARK    GeneRIF: alternative splicing of exon N controls differential
            sorting of a1 variants to nerve terminals or distal dendrites,
            whereas exon C regulates their neuronal expression
REFERENCE   7  (bases 1 to 4006)
  AUTHORS   Chen,X., Matsumoto,H., Hinck,C.S., Al-Hasani,H., St-Denis,J.F.,
            Whiteheart,S.W. and Cushman,S.W.
  TITLE     Demonstration of differential quantitative requirements for NSF
            among multiple vesicle fusion pathways of GLUT4 using a
            dominant-negative ATPase-deficient NSF
  JOURNAL   Biochem Biophys Res Commun 333 (1), 28-34 (2005)
   PUBMED   15935991
  REMARK    GeneRIF: Thus, our data demonstrate that the multiple fusion steps
            in GLUT4 trafficking have differential quantitative requirements
            for NSF activity.
REFERENCE   8  (bases 1 to 4006)
  AUTHORS   Toyomura,T., Murata,Y., Yamamoto,A., Oka,T., Sun-Wada,G.H., Wada,Y.
            and Futai,M.
  TITLE     From lysosomes to the plasma membrane: localization of
            vacuolar-type H+ -ATPase with the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 278 (24), 22023-22030 (2003)
   PUBMED   12672822
REFERENCE   9  (bases 1 to 4006)
  AUTHORS   Toyomura,T., Oka,T., Yamaguchi,C., Wada,Y. and Futai,M.
  TITLE     Three subunit a isoforms of mouse vacuolar H(+)-ATPase.
            Preferential expression of the a3 isoform during osteoclast
            differentiation
  JOURNAL   J Biol Chem 275 (12), 8760-8765 (2000)
   PUBMED   10722719
REFERENCE   10 (bases 1 to 4006)
  AUTHORS   Perin,M.S., Fried,V.A., Stone,D.K., Xie,X.S. and Sudhof,T.C.
  TITLE     Structure of the 116-kDa polypeptide of the clathrin-coated
            vesicle/synaptic vesicle proton pump
  JOURNAL   J Biol Chem 266 (6), 3877-3881 (1991)
   PUBMED   1704894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB787072.1, M58758.1, CB770675.1, CO560122.1 and CB586356.1.
            
            On Oct 13, 2005 this sequence version replaced NM_031604.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: M58758.1, DQ286421.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMD00132261, SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               CB787072.1         34-210
            178-246             M58758.1           50-118
            247-354             CB787072.1         281-388
            355-1243            M58758.1           227-1115
            1244-1332           CB770675.1         115-203
            1333-2805           M58758.1           1205-2677
            2806-3347           CO560122.1         83-624
            3348-3405           M58758.1           3219-3276
            3406-3418           CB586356.1         298-310
            3419-4006           M58758.1           3289-3876
FEATURES             Location/Qualifiers
     source          1..4006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..4006
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /note="ATPase H+ transporting V0 subunit a1"
                     /db_xref="GeneID:29757"
                     /db_xref="RGD:68405"
     exon            1..96
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            97..275
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2675
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /EC_number="7.1.2.2"
                     /note="V-type proton ATPase 116 kDa subunit a; ATPase, H+
                     transporting, lysosomal noncatalytic accessory protein 1a;
                     v-H+ATPase subunit a1; vacuolar proton pump subunit 1;
                     vacuolar adenosine triphosphatase subunit Ac116; vacuolar
                     proton translocating ATPase 116 kDa subunit a; V-ATPase
                     116 kDa subunit a1; clathrin-coated vesicle/synaptic
                     vesicle proton pump 116 kDa subunit; ATPase, H+
                     transporting, lysosomal V0 subunit A1; ATPase, H+
                     transporting, lysosomal (vacuolar proton pump)
                     non-catalytic accessory protein 1A (110/116kD); ATPase, H+
                     transporting, lysosomal (vacuolar proton pump)
                     noncatalytic accessory protein 1 (110/160 kDa); ATPase, H+
                     transporting, lysosomal V0 subunit a; V-type proton ATPase
                     116 kDa subunit a1; V-ATPase 116 kDa subunit a 1"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 1"
                     /protein_id="NP_113792.2"
                     /db_xref="GeneID:29757"
                     /db_xref="RGD:68405"
                     /translation="MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDV
                     NVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFE
                     KIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPNEM
                     GRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKS
                     VFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTE
                     DHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQ
                     FALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPA
                     PYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSMVFSGRYII
                     LLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETLLGSSVLQLNPAIP
                     GVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKP
                     LNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPES
                     GNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLGTLNFGGIRVGNG
                     PTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYL
                     RLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLS
                     AFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE"
     exon            276..354
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            355..452
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            453..581
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            582..664
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            665..791
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            792..874
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            875..968
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1181
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1332
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1472
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1630
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1721
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1840
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2057
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2165
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2273
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2291
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2409
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2581
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..3999
                     /gene="Atp6v0a1"
                     /gene_synonym="Atp6n1; Atp6n1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagccttgct tgcgtacgct ggtccgcgac tctgctcagc ctgagccggg ggctttgctg
       61 cggcggctgc ggtcgcggcg gcggagcggg cgagaggtta attctcaagc caccgccttg
      121 tctctcgcct cagattggag tgaacaacca tcgccaccat gggggagctt ttccgaagcg
      181 aggagatgac cctggcccag ctctttctcc agtccgaagc tgcttattgt tgtgtcagtg
      241 aattaggaga acttggaaag gttcagttcc gggatttaaa tccagatgtg aatgttttcc
      301 agaggaaatt tgtgaatgaa gttagaagat gtgaagaaat ggatcgaaaa ctccggtttg
      361 ttgagaaaga gataagaaaa gctaacatcc caattatgga cactggagag aacccggagg
      421 tgccctttcc cagggacatg atcgacttgg aggccaattt cgagaagatc gaaaacgaac
      481 tgaaggaaat caacactaac caggaagctc taaagcgaaa cttcctggaa ctgactgaat
      541 taaaatttat actgcgcaaa actcagcagt ttttcgatga gatggcggat ccagacctgt
      601 tggaagagtc ctcatcactc ttggagccaa acgagatggg aagaggcgcg cctttacgac
      661 ttggcttcgt agctggtgtg attaaccggg aacggatccc gacctttgag cgcatgcttt
      721 ggcgagtgtg ccgagggaat gtgttcctga gacaggctga aatcgaaaac ccgctggagg
      781 atcccgtgac tggcgactac gtgcacaagt ccgtgttcat catttttttc caaggtgacc
      841 agctgaaaaa cagggtcaag aaaatctgtg aagggttccg agcctccctc tatccctgtc
      901 ctgagactcc acaggagaga aaagaaatgg cttccggagt caataccagg atcgacgatc
      961 tccaaatggt tctgaatcag acagaggacc accgccagag ggttctgcag gcggctgcta
     1021 agaacatccg ggtgtggttc atcaaggtgc ggaagatgaa agctatctac cataccctga
     1081 acctctgcaa catcgatgtg acgcagaagt gcctgatcgc ggaagtctgg tgccccgtca
     1141 ctgacctgga ctccatccag tttgcactgc gaaggggcac ggagcacagc ggttccactg
     1201 tcccctccat tctgaacagg atgcagacaa accagacacc cccgacgtat aacaaaacca
     1261 acaagttcac gcacggcttc cagaacatag tggatgctta tgggatcggc acttaccgag
     1321 aaattaaccc agctccgtac accgtcatca ccttcccctt tctgtttgct gtgatgtttg
     1381 gagattttgg gcacggcatt ttgatgactc tgtttgctgt gtggatggtg ttgagggaga
     1441 gccggatcct ctcccagaag aacgagaatg agatgtttag catggtgttc agcggccgat
     1501 acattatcct tctgatggga ctgttctcca tctacactgg actcatctac aatgactgct
     1561 tttccaagtc tctgaatatc tttgggtcat catggagcgt acggccaatg ttcaccatag
     1621 ggaactggac ggaggagacg ctcctgggga gttctgtcct ccagctgaac ccagctatcc
     1681 ctggagtctt tggtggccct tacccatttg gcattgatcc gatttggaac atcgcaacca
     1741 acaagctgac cttcctcaac tccttcaaga tgaagatgtc agttattctt gggatcatcc
     1801 acatgctgtt cggggtcagc ctgagccttt tcaaccacat ctatttcaag aagcccctga
     1861 acatctactt tggctttatt cccgagataa tcttcatgtc ctcgctgttt ggctacctgg
     1921 tcatcctcat cttttacaag tggacagcct acgatgccca ctcgtctaga aatgccccga
     1981 gcctcctgat ccatttcata aacatgttcc tcttctccta cccagagtct ggtaacgcaa
     2041 tgctgtactc tggacagaaa ggaattcagt gtttcctcat agtggtggca atgctctgtg
     2101 tcccctggat gctgctgttt aagccgttga tccttcgcca tcagtacctg aggaagaagc
     2161 atttgggaac tctcaacttt ggtgggatca gggtgggcaa cggaccgaca gaggaggatg
     2221 ctgaaattat tcagcatgac cagctctcca cccattcaga ggacgcagaa gagcctaccg
     2281 aggacgaagt gtttgacttt ggcgacacca tggtccacca ggccatccac accattgagt
     2341 actgcttggg ctgcatctcc aacactgcgt cctacctgcg gctctgggcc ctcagcctgg
     2401 cccatgcaca gctctctgaa gtactctgga ccatggtgat ccacatcggc ctgcatgtcc
     2461 ggagtctggc agggggactg gggctgtttt tcatcttcgc tgcctttgcc accctgaccg
     2521 tggccatcct gctgatcatg gaaggcctct cagccttcct ccacgcactg cgattacact
     2581 gggtggaatt ccagaacaaa ttctacactg ggactggttt caagttcctc cccttctcct
     2641 ttgagcacat tcgggaaggg aagtttgatg agtgagtctc aggcagggcg catgctcaga
     2701 gcagctctcc tgcctgcctc tacagtgact gtgtctcttg cctgctggtt gtgatccctg
     2761 gatactcggg cgtttgtgtc accctacaac ccctgtcccc gctgtgactc atttaggtag
     2821 tgctggcctt ccctgggtct ctttatccca agccttgggt gttacgtaca gactttcgac
     2881 tgagagctgg atggctgtgc ctgataccca cccatcccca tggcaccact tggcctcctg
     2941 gcctccagac agatagccct attccatccc ctaatggtga gccaacctgc acagacacat
     3001 aggggcacgg agccctcagg atgcaagggg tccctcatca gtccaggagt tcttggtcac
     3061 gccttggagg aagatggcaa tgggttctct cctagaaggg gatattgctt atggaacata
     3121 cccgactccg ctggcaggga cagtcaggaa gatgctgctg tcaccctttg tccagcctct
     3181 ccagtgagta ttcaggaaac tcagttggcc ctacctgggc catctcaaag gttccaggat
     3241 aacccccacc ctcctagccc ccaccctcct aaacactctc ctcccccagc cctgttggca
     3301 cagcatagct agcatccgta ggaatgggag ggtcgcactg acttgcagca ccgggcttcc
     3361 ggaccttaga ttcccttctc tgtcagtgcg tgaatgggcc ttgcccaaca ctacacccca
     3421 aggcagaagt taaaattggc acactcccgg catatccctg agcccttctg caccctgatc
     3481 atgatgtcct gaggctgtgg tcagtaaggt tggttctgcc ggcaggcctg ccttgatctg
     3541 cccacttatt actccctctc caatccccat gctgacccca ggtttcagga gtggcgtcct
     3601 ggacagggaa ggtcagtgtc atttacaatt tgctaatcag aggcgactgt tgggctacca
     3661 gagcagatgt gggagcgctg ctaagccctt gccgcctacc tcatgtactg tggatctcag
     3721 acccttctaa tcatgtgctg actcccgaaa ttcactcact gccttccctg tggaggtaat
     3781 actaaatcag caaggcccct cccctccccc accctggcgc tcttgagccg ctcccacggt
     3841 gaattgttca gagcccctct gtccttttgt gcccagttta catgatgatc tctgctgttt
     3901 acagagaggc ccacagcaga ggtctctgtg gggaccctgc ccaaggcctt ctgttcagac
     3961 attcttatcc ggaataaagt gtgtttgact ctgacaaaaa aaaaaa
//
