LOCUS       NM_001007091            1170 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting accessory protein 2
            (Atp6ap2), mRNA.
ACCESSION   NM_001007091 XM_001060853 XM_217592
VERSION     NM_001007091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1170)
  AUTHORS   Taguchi,T., Kimura,K., Suzuki,A., Fujishima,R., Shimizu,N.,
            Hoshiyama,A., Masaki,T., Inoue,M., Kato,Y., Satomi,T., Takano,K.,
            Imada,T., Sasaki,S. and Miyatsuka,T.
  TITLE     ATP6AP2 is robustly expressed in pancreatic beta cells and
            neuroendocrine tumors, and plays a role in maintaining cellular
            viability
  JOURNAL   Sci Rep 13 (1), 9260 (2023)
   PUBMED   37286698
  REMARK    GeneRIF: ATP6AP2 is robustly expressed in pancreatic beta cells and
            neuroendocrine tumors, and plays a role in maintaining cellular
            viability.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1170)
  AUTHORS   Yildirim,D., Bender,O., Karagoz,Z.F., Helvacioglu,F., Bilgic,M.A.,
            Akcay,A. and Ruzgaresen,N.B.
  TITLE     Role of autophagy and evaluation the effects of microRNAs 214, 132,
            34c and prorenin receptor in a rat model of focal segmental
            glomerulosclerosis
  JOURNAL   Life Sci 280, 119671 (2021)
   PUBMED   34087284
  REMARK    GeneRIF: Role of autophagy and evaluation the effects of microRNAs
            214, 132, 34c and prorenin receptor in a rat model of focal
            segmental glomerulosclerosis.
REFERENCE   3  (bases 1 to 1170)
  AUTHORS   Figueiredo,M., Daryadel,A., Sihn,G., Muller,D.N., Popova,E.,
            Rouselle,A., Nguyen,G., Bader,M. and Wagner,C.A.
  TITLE     The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated
            endocytosis and lysosomal function in the renal proximal tubule
  JOURNAL   Pflugers Arch 473 (8), 1229-1246 (2021)
   PUBMED   34228176
  REMARK    GeneRIF: The (pro)renin receptor (ATP6ap2) facilitates
            receptor-mediated endocytosis and lysosomal function in the renal
            proximal tubule.
REFERENCE   4  (bases 1 to 1170)
  AUTHORS   Yu,S., Dong,X., Yang,M., Yu,Q., Xiong,J., Chen,J., Dong,B. and
            Su,Q.
  TITLE     (Pro)renin receptor involves in myocardial fibrosis and oxidative
            stress in diabetic cardiomyopathy via the PRR-YAP pathway
  JOURNAL   Sci Rep 11 (1), 3259 (2021)
   PUBMED   33547400
  REMARK    GeneRIF: (Pro)renin receptor involves in myocardial fibrosis and
            oxidative stress in diabetic cardiomyopathy via the PRR-YAP
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1170)
  AUTHORS   Urushihara,M., Kondo,S., Kinoshita,Y., Ozaki,N., Jamba,A.,
            Nagai,T., Fujioka,K., Hattori,T. and Kagami,S.
  TITLE     (Pro)renin receptor promotes crescent formation via the ERK1/2 and
            Wnt/beta-catenin pathways in glomerulonephritis
  JOURNAL   Am J Physiol Renal Physiol 319 (4), F571-F578 (2020)
   PUBMED   32830537
  REMARK    GeneRIF: (Pro)renin receptor promotes crescent formation via the
            ERK1/2 and Wnt/beta-catenin pathways in glomerulonephritis.
REFERENCE   6  (bases 1 to 1170)
  AUTHORS   Muller,D.N., Klanke,B., Feldt,S., Cordasic,N., Hartner,A.,
            Schmieder,R.E., Luft,F.C. and Hilgers,K.F.
  TITLE     (Pro)renin receptor peptide inhibitor 'handle-region' peptide does
            not affect hypertensive nephrosclerosis in Goldblatt rats
  JOURNAL   Hypertension 51 (3), 676-681 (2008)
   PUBMED   18212268
  REMARK    GeneRIF: Blockade of the (pro)renin receptor (P)RR with
            'handle-region' peptide (HRP) does not improve target organ damage
            in renovascular hypertensive rats.
REFERENCE   7  (bases 1 to 1170)
  AUTHORS   Huang,Y., Wongamorntham,S., Kasting,J., McQuillan,D., Owens,R.T.,
            Yu,L., Noble,N.A. and Border,W.
  TITLE     Renin increases mesangial cell transforming growth factor-beta1 and
            matrix proteins through receptor-mediated, angiotensin
            II-independent mechanisms
  JOURNAL   Kidney Int 69 (1), 105-113 (2006)
   PUBMED   16374430
REFERENCE   8  (bases 1 to 1170)
  AUTHORS   Ramser,J., Abidi,F.E., Burckle,C.A., Lenski,C., Toriello,H.,
            Wen,G., Lubs,H.A., Engert,S., Stevenson,R.E., Meindl,A.,
            Schwartz,C.E. and Nguyen,G.
  TITLE     A unique exonic splice enhancer mutation in a family with X-linked
            mental retardation and epilepsy points to a novel role of the renin
            receptor
  JOURNAL   Hum Mol Genet 14 (8), 1019-1027 (2005)
   PUBMED   15746149
REFERENCE   9  (bases 1 to 1170)
  AUTHORS   Ichihara,A., Hayashi,M., Kaneshiro,Y., Suzuki,F., Nakagawa,T.,
            Tada,Y., Koura,Y., Nishiyama,A., Okada,H., Uddin,M.N., Nabi,A.H.,
            Ishida,Y., Inagami,T. and Saruta,T.
  TITLE     Inhibition of diabetic nephropathy by a decoy peptide corresponding
            to the 'handle' region for nonproteolytic activation of prorenin
  JOURNAL   J Clin Invest 114 (8), 1128-1135 (2004)
   PUBMED   15489960
REFERENCE   10 (bases 1 to 1170)
  AUTHORS   Nguyen,G., Delarue,F., Burckle,C., Bouzhir,L., Giller,T. and
            Sraer,J.D.
  TITLE     Pivotal role of the renin/prorenin receptor in angiotensin II
            production and cellular responses to renin
  JOURNAL   J Clin Invest 109 (11), 1417-1427 (2002)
   PUBMED   12045255
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB188298.1.
            
            On or before Sep 18, 2011 this sequence version replaced
            XM_217592.5, XM_001060853.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB188298.1, BC079339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1170
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..1170
                     /gene="Atp6ap2"
                     /note="ATPase H+ transporting accessory protein 2"
                     /db_xref="GeneID:302526"
                     /db_xref="RGD:1561269"
     exon            1..125
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1138
                     /gene="Atp6ap2"
                     /note="renin receptor; renin/prorenin receptor; ATPase,
                     H(+)-transporting, lysosomal-interacting protein 2;
                     ATPase, H+ transporting, lysosomal accessory protein 2"
                     /codon_start=1
                     /product="renin receptor precursor"
                     /protein_id="NP_001007092.1"
                     /db_xref="GeneID:302526"
                     /db_xref="RGD:1561269"
                     /translation="MAVLVVLLSSLVSSALANEFSILRSPGSVVFRNGNWPIPGDRIP
                     DVAALSMGFSVKEDLSWPGLAVGNLFHRPRATIMVTVKGVDKLALPTGSVISYPLENA
                     VPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLF
                     QENSVLNSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELA
                     GLDELGKRYGEDSEQFRDASRILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLVR
                     KSRTILETKQENTQSPYNLAYKYNLEYSVVFNLVLWIMTGLALAVIITSYNIWNMDPG
                     YDSIIYRMTNQKIRMD"
     exon            126..256
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            257..388
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            389..484
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            485..622
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            623..676
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..826
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            827..946
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1170
                     /gene="Atp6ap2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtcactcgg tctgactgcg gtgctcgctc gagtcccggc gtcccttttc gtgtggctca
       61 tctccgcttt agcagccgtg gcaccatggc tgtgcttgtc gttctcctct cttctctggt
      121 gtcgagtgct ttagcgaatg aatttagcat attaagatcg ccagggtctg ttgttttccg
      181 aaatggaaat tggcctatac caggagatcg aatcccagat gtagctgcac tgtccatggg
      241 cttctctgtg aaggaagacc tgtcttggcc agggcttgct gtgggcaacc tattccaccg
      301 gccccgggct accattatgg tgacagtgaa gggggtagat aaactggctc tccccacagg
      361 cagcgtcatc tcttaccctt tggagaatgc agttcccttt agtcttgaca gtgtggccaa
      421 ttccattcac tccttatttt cggaggagac tcctgtagtt ttgcagttgg cccccagtga
      481 ggaaagagtg tatatggtgg ggaaagcaaa ctctgtattt gaagaccttt cagtcacatt
      541 gcgtcagctc cgtaatcgcc tgtttcaaga aaactctgtt ctcaactcgc tccccctcaa
      601 ttctctgagt aggaataatg aagttgacct gctatttctt tctgaactgc aagtgctgca
      661 tgatatttca agtttgttgt ctcgtcataa gcatctcgcc aaggatcatt ctcccgactt
      721 gtattcactg gagctggcag gtttggatga gcttgggaag cgttatggag aagactctga
      781 acaattccgg gatgcttctc ggatccttgt tgatgctctc caaaagtttg cagatgacat
      841 gtacagtctc tatggtggga atgcagtggt agagttggtg actgtcaaat cattcgacac
      901 atccctggtg aggaagtcaa ggaccatcct tgagacgaaa caagagaaca cccaaagtcc
      961 ctacaacctt gcgtataagt ataatttgga gtattcggtg gttttcaact tggtactgtg
     1021 gattatgact ggcttggcct tggctgtgat aatcacctct tacaacattt ggaatatgga
     1081 tcctggatat gatagcatca tttataggat gacaaaccag aagattcgaa tggattgatt
     1141 ttccttatgc tagacttact tagacaacag
//
