LOCUS       NM_031785               2075 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATPase H+ transporting accessory protein 1
            (Atp6ap1), mRNA.
ACCESSION   NM_031785
VERSION     NM_031785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2075)
  AUTHORS   Abbas,Y.M., Wu,D., Bueler,S.A., Robinson,C.V. and Rubinstein,J.L.
  TITLE     Structure of V-ATPase from the mammalian brain
  JOURNAL   Science 367 (6483), 1240-1246 (2020)
   PUBMED   32165585
REFERENCE   2  (bases 1 to 2075)
  AUTHORS   Miles,A.L., Burr,S.P., Grice,G.L. and Nathan,J.A.
  TITLE     The vacuolar-ATPase complex and assembly factors, TMEM199 and
            CCDC115, control HIF1alpha prolyl hydroxylation by regulating
            cellular iron levels
  JOURNAL   Elife 6, e22693 (2017)
   PUBMED   28296633
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2075)
  AUTHORS   Yang,D.Q., Feng,S., Chen,W., Zhao,H., Paulson,C. and Li,Y.P.
  TITLE     V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast
            differentiation, extracellular acidification, lysosomal
            trafficking, and protease exocytosis in osteoclast-mediated bone
            resorption
  JOURNAL   J Bone Miner Res 27 (8), 1695-1707 (2012)
   PUBMED   22467241
REFERENCE   4  (bases 1 to 2075)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 2075)
  AUTHORS   Hodi,F.S., Schmollinger,J.C., Soiffer,R.J., Salgia,R., Lynch,T.,
            Ritz,J., Alyea,E.P., Yang,J., Neuberg,D., Mihm,M. and Dranoff,G.
  TITLE     ATP6S1 elicits potent humoral responses associated with
            immune-mediated tumor destruction
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6919-6924 (2002)
   PUBMED   11983866
REFERENCE   6  (bases 1 to 2075)
  AUTHORS   Hung,H., Tsai,M.J., Wu,H.C. and Lee,E.H.
  TITLE     Age-dependent increase in C7-1 gene expression in rat frontal
            cortex
  JOURNAL   Brain Res Mol Brain Res 75 (2), 330-336 (2000)
   PUBMED   10686355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031785.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF035387.1, BC070937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               JAXUCZ010000021.1  157231243-157231387
            146-272             JAXUCZ010000021.1  157231685-157231811
            273-347             JAXUCZ010000021.1  157233815-157233889
            348-541             JAXUCZ010000021.1  157234145-157234338
            542-582             JAXUCZ010000021.1  157234895-157234935
            583-668             JAXUCZ010000021.1  157235515-157235600
            669-907             JAXUCZ010000021.1  157235939-157236177
            908-955             JAXUCZ010000021.1  157236855-157236902
            956-1184            JAXUCZ010000021.1  157236991-157237219
            1185-2075           JAXUCZ010000021.1  157237433-157238323
FEATURES             Location/Qualifiers
     source          1..2075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2075
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /note="ATPase H+ transporting accessory protein 1"
                     /db_xref="GeneID:83615"
                     /db_xref="RGD:620423"
     exon            1..145
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1394
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /EC_number="7.1.2.2"
                     /note="V-type proton ATPase subunit S1; V-ATPase subunit
                     S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein;
                     vacuolar proton pump subunit S1; ATPase, H+ transporting,
                     lysosomal accessory protein 1; ATPase, H+ transporting,
                     lysosomal (vacuolar proton pump), subunit 1"
                     /codon_start=1
                     /product="V-type proton ATPase subunit S1 precursor"
                     /protein_id="NP_113973.2"
                     /db_xref="GeneID:83615"
                     /db_xref="RGD:620423"
                     /translation="MMAATVVSRIRTGTRWAPVLWLLLSLVAVAAAVAAEQQVPLVLW
                     SSDRDLWAPVADTHEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGV
                     FGNKQDSAFSNLENALDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLKE
                     LKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLESEDVPYTAALTAV
                     RPSRVARDVAMVAGGLGRQLLQTQVASPAIHPPVSYNDTAPRILFWAQNFSVAYKDEW
                     KDLTSLTFGVENLNLTGSFWNDSFAMLSLTYEPLFGATVTFKFILASRFYPVSARYWF
                     TMERLEIHSNGSVAHFNVSQVTGPSIYSFHCEYVSSLSKKGSLLVTNVPSLWQMTLHN
                     FQIQAFNVTGEQFSYASDCAGFFSPGIWMGLLTTLFMLFIFTYGLHMILSLKTMDRFD
                     DHKGPTITLTQIV"
     exon            146..272
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..347
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..541
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..582
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..668
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..907
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            908..955
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1184
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..2075
                     /gene="Atp6ap1"
                     /gene_synonym="Atp6s1; C7-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatgatggc ggcaacagtg gtatctcgga tacgaaccgg gacacggtgg gctccagtcc
       61 tgtggctgct tctgtcgttg gtggcagtgg cggcagcagt ggctgcggag cagcaggtgc
      121 cactggtact gtggtcgagt gaccgggacc tctgggctcc tgtggccgac acacatgagg
      181 gtcatattac cagcgatatg cagctttcta cctacttaga ccctgccctg gagctgggcc
      241 cccgcaatgt attgctgttc ctgcaggaca agctaagcat tgaggatttc acagcatacg
      301 gtggtgtgtt tggaaataaa caggacagtg ccttttctaa cctggagaat gccctggact
      361 tggccccctc ctcactggta cttcctgctg tggactggta tgcaatcagc actctgacca
      421 cctacctaca ggagaagctt ggggctagtc ccttgcatgt ggatctagct accctaaagg
      481 agctgaagct caatgccagc cttcctgccc tgctgctcat ccgtctgccc tacacagcca
      541 gctccggtct gatggcgccc agggaggtcc ttacaggtaa tgatgaggtc atcggacagg
      601 tactgagcac acttgagtct gaagatgttc cttacaccgc ggctcttact gcagtccgcc
      661 cttctagagt ggcccgtgat gtagccatgg tggctggggg tctaggtcgc cagctgcttc
      721 agactcaggt ggcatcacct gcgatccatc ctcctgtgag ttacaatgac actgccccaa
      781 ggatcctgtt ttgggcacaa aacttctctg tggcatacaa agacgaatgg aaagacttga
      841 cctccctcac ctttggtgtg gagaatctta acttgaccgg ctccttctgg aatgactcct
      901 ttgccatgct ttcactgacc tatgaaccac tctttggtgc aacagtgaca ttcaagttca
      961 ttctggctag tcgcttctac ccagtatctg cccgatattg gtttaccatg gaacgacttg
     1021 aaatccacag caatggctcg gttgcccatt tcaatgtttc ccaagtcaca ggacctagta
     1081 tctattcttt ccactgtgag tacgtcagca gtctgagcaa gaaaggcagt ctccttgtga
     1141 ccaacgtgcc ctccctctgg cagatgactc ttcataactt ccagatccaa gccttcaatg
     1201 tgactggtga acagttctcc tatgctagcg actgtgctgg cttcttctct ccgggcatct
     1261 ggatggggct gctcaccacc ctcttcatgc ttttcatatt cacctatggt ctgcacatga
     1321 tactcagcct aaagaccatg gatcgctttg atgaccacaa gggccccacc atcactttga
     1381 cccagattgt gtgacatata ccagagaggg attgagggag tattggtgtc taggtttcca
     1441 ttttgtgaca cagtggatgg aaaggtttgt cctcttccta ctatagcatg aaccctacat
     1501 acaccaccct cagcctgtct tgcttcctct ttcctggaca gggacttccc tgaggctatc
     1561 ccccacttct accaacaaag tgtattattc ttcatagata aatcttccag gcttcatcaa
     1621 gaggggaagg gaccttaatt ctagggtgcc cccctttccc tttctcctta tttattcttg
     1681 cccctctgct attatttcgt gctgtttata gtgcttttgt gtagtaaata ctcactcccc
     1741 aagctttatg gagctttcca gcaatagcca tgaacttgag gtcccttgaa tttgagaggt
     1801 gtggaaaggc tagttaactg tccagcttag cctttatggg tttttttttt tttttggcgg
     1861 gtgggggtta agaatgagcg gtacactggg gtttatttct gtgacctgag aaggaagaaa
     1921 tcaccacgag aactggagaa caaagtgtac tcattgggtt tctggtttgt tctcacaagg
     1981 attgcctgtc aagaagccag aagtatgtgt gtgtgtgtgt ggggggggtg tgctctgttg
     2041 tttcattcct aataaaataa agacgtgttg ccatg
//
