LOCUS       NM_138883                707 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus ATP synthase peripheral stalk subunit OSCP
            (Atp5po), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_138883
VERSION     NM_138883.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 707)
  AUTHORS   Gauba,E., Chen,H., Guo,L. and Du,H.
  TITLE     Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase
            dysfunction via OSCP in Alzheimer's disease
  JOURNAL   Neurobiol Dis 121, 138-147 (2019)
   PUBMED   30266287
REFERENCE   2  (bases 1 to 707)
  AUTHORS   Bruggemann,M., Gromes,A., Poss,M., Schmidt,D., Klumper,N.,
            Tolkach,Y., Dietrich,D., Kristiansen,G., Muller,S.C. and
            Ellinger,J.
  TITLE     Systematic Analysis of the Expression of the Mitochondrial ATP
            Synthase (Complex V) Subunits in Clear Cell Renal Cell Carcinoma
  JOURNAL   Transl Oncol 10 (4), 661-668 (2017)
   PUBMED   28672194
REFERENCE   3  (bases 1 to 707)
  AUTHORS   De Rasmo,D., Micelli,L., Santeramo,A., Signorile,A., Lattanzio,P.
            and Papa,S.
  TITLE     cAMP regulates the functional activity, coupling efficiency and
            structural organization of mammalian FOF1 ATP synthase
  JOURNAL   Biochim Biophys Acta 1857 (4), 350-358 (2016)
   PUBMED   26775111
REFERENCE   4  (bases 1 to 707)
  AUTHORS   Comelli,M., Domenis,R., Buso,A. and Mavelli,I.
  TITLE     F1FO ATP Synthase Is Expressed at the Surface of Embryonic Rat
            Heart-Derived H9c2 Cells and Is Affected by Cardiac-Like
            Differentiation
  JOURNAL   J Cell Biochem 117 (2), 470-482 (2016)
   PUBMED   26223201
REFERENCE   5  (bases 1 to 707)
  AUTHORS   Jarr,K.U., Eschricht,S., Burkly,L.C., Preusch,M., Katus,H.A.,
            Frey,N. and Chorianopoulos,E.
  TITLE     TNF-like weak inducer of apoptosis aggravates left ventricular
            dysfunction after myocardial infarction in mice
  JOURNAL   Mediators Inflamm 2014, 131950 (2014)
   PUBMED   24692845
REFERENCE   6  (bases 1 to 707)
  AUTHORS   Zheng,J. and Ramirez,V.D.
  TITLE     Purification and identification of an estrogen binding protein from
            rat brain: oligomycin sensitivity-conferring protein (OSCP), a
            subunit of mitochondrial F0F1-ATP synthase/ATPase
  JOURNAL   J Steroid Biochem Mol Biol 68 (1-2), 65-75 (1999)
   PUBMED   10215039
REFERENCE   7  (bases 1 to 707)
  AUTHORS   Golden,T.R. and Pedersen,P.L.
  TITLE     The oligomycin sensitivity conferring protein of rat liver
            mitochondrial ATP synthase: arginine 94 is important for the
            binding of OSCP to F1
  JOURNAL   Biochemistry 37 (39), 13871-13881 (1998)
   PUBMED   9753477
REFERENCE   8  (bases 1 to 707)
  AUTHORS   Guerrieri,F., Kalous,M., Adorisio,E., Turturro,N., Santoro,G.,
            Drahota,Z. and Cantatore,P.
  TITLE     Hypothyroidism leads to a decreased expression of mitochondrial
            F0F1-ATP synthase in rat liver
  JOURNAL   J Bioenerg Biomembr 30 (3), 269-276 (1998)
   PUBMED   9733093
REFERENCE   9  (bases 1 to 707)
  AUTHORS   Prescott,M., Higuti,T., Nagley,P. and Devenish,R.J.
  TITLE     The functional expression of a rat cDNA encoding OSCP in the yeast
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 207 (3), 943-949 (1995)
   PUBMED   7864899
REFERENCE   10 (bases 1 to 707)
  AUTHORS   Higuti,T., Kuroiwa,K., Kawamura,Y., Morimoto,K. and Tsujita,H.
  TITLE     Molecular cloning and sequence of cDNAs for the import precursors
            of oligomycin sensitivity conferring protein, ATPase inhibitor
            protein, and subunit c of H(+)-ATP synthase in rat mitochondria
  JOURNAL   Biochim Biophys Acta 1172 (3), 311-314 (1993)
   PUBMED   8448208
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13127.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13127.1, BC060544.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..707
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..707
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /note="ATP synthase peripheral stalk subunit OSCP"
                     /db_xref="GeneID:192241"
                     /db_xref="RGD:621379"
     exon            1..40
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..646
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /EC_number="7.1.2.2"
                     /note="ATP synthase subunit O, mitochondrial; oligomycin
                     sensitivity conferral protein; sperm flagella protein 4;
                     ATP synthase, H+ transporting, mitochondrial F1 complex, O
                     subunit (oligomycin sensitivity conferring protein)"
                     /codon_start=1
                     /product="ATP synthase subunit O, mitochondrial precursor"
                     /protein_id="NP_620238.1"
                     /db_xref="GeneID:192241"
                     /db_xref="RGD:621379"
                     /translation="MAAPATSVLSRQVRSFSTSVVRPFSKLVRPPVQVYGIEGRYATA
                     LYSAASKQKRLDQVEKELLRVGQLLKDPKVSLAVLNPYIKRSIKVKSLKDITTKEKFS
                     PLTANLMNLLAENGRLGNTQGVISAFSTIMSVHRGEVPCTVTTAFPLDEAVLSELKTV
                     LNSFLSKGQILNLEVKTDPSIMGGMIVRIGEKYVDMSAKSKIQKLSKAMRDLL"
     exon            41..91
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     exon            92..202
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     exon            203..332
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     exon            333..445
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     exon            446..532
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     exon            533..707
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      707
                     /gene="Atp5po"
                     /gene_synonym="Atp5o; Atpo; Oscp"
ORIGIN      
        1 aaagatggcc gcaccagcaa catccgtgct gtcccgacag gtgcggagtt tcagcacatc
       61 tgtggtcagg cccttttcga agcttgtaag gccccctgtc caggtctacg gcatcgaagg
      121 ccgctatgca accgccctgt actctgctgc gtctaagcag aaaaggctgg accaggtgga
      181 aaaggagttg ctgcgagtgg ggcaactctt gaaggacccc aaggtgtccc ttgctgttct
      241 gaacccctac attaagcgct ccatcaaagt gaaaagcctg aaggacatca ctacaaagga
      301 aaaattctct ccgctgacgg ccaacctcat gaatttactt gctgaaaatg gtcgcctagg
      361 caacacccag ggcgtcatct ctgccttctc caccatcatg agtgtccacc gtggagaagt
      421 gccgtgcaca gtgaccacag cgtttccttt agatgaagct gttctctctg agttaaagac
      481 agtgctgaat agcttcctga gtaaaggcca gatactgaac ctggaggtca agactgaccc
      541 atcaatcatg ggtgggatga ttgtccgaat tggagagaaa tacgttgata tgtctgcaaa
      601 gagcaagatt cagaagctca gcaaggccat gcgggatctg ctctgagaga ctgtcacctg
      661 tgtgagcgct tgtctttgga gcacaataaa atgcttcctg aacagag
//
