LOCUS       NM_080481                289 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATP synthase membrane subunit e (Atp5me), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_080481
VERSION     NM_080481.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 289)
  AUTHORS   Hou,Q., Yan,F., Li,X., Liu,H., Yang,X. and Dong,X.
  TITLE     ATP5me alleviates high glucose-induced myocardial cell injury
  JOURNAL   Int Immunopharmacol 129, 111626 (2024)
   PUBMED   38320353
  REMARK    GeneRIF: ATP5me alleviates high glucose-induced myocardial cell
            injury.
REFERENCE   2  (bases 1 to 289)
  AUTHORS   Meyer,B., Wittig,I., Trifilieff,E., Karas,M. and Schagger,H.
  TITLE     Identification of two proteins associated with mammalian ATP
            synthase
  JOURNAL   Mol Cell Proteomics 6 (10), 1690-1699 (2007)
   PUBMED   17575325
REFERENCE   3  (bases 1 to 289)
  AUTHORS   Aggeler,R., Coons,J., Taylor,S.W., Ghosh,S.S., Garcia,J.J.,
            Capaldi,R.A. and Marusich,M.F.
  TITLE     A functionally active human F1F0 ATPase can be purified by
            immunocapture from heart tissue and fibroblast cell lines. Subunit
            structure and activity studies
  JOURNAL   J Biol Chem 277 (37), 33906-33912 (2002)
   PUBMED   12110673
REFERENCE   4  (bases 1 to 289)
  AUTHORS   Ko,Y.H., Hullihen,J., Hong,S. and Pedersen,P.L.
  TITLE     Mitochondrial F(0)F(1) ATP synthase. Subunit regions on the F1
            motor shielded by F(0), Functional significance, and evidence for
            an involvement of the unique F(0) subunit F(6)
  JOURNAL   J Biol Chem 275 (42), 32931-32939 (2000)
   PUBMED   10887193
REFERENCE   5  (bases 1 to 289)
  AUTHORS   Higuti,T., Kuroiwa,K., Kawamura,Y. and Yoshihara,Y.
  TITLE     Complete amino acid sequence of subunit e of rat liver
            mitochondrial H(+)-ATP synthase
  JOURNAL   Biochemistry 31 (49), 12451-12454 (1992)
   PUBMED   1463732
REFERENCE   6  (bases 1 to 289)
  AUTHORS   Higuti,T., Yoshihara,Y., Kuroiwa,K., Kawamura,Y., Toda,H. and
            Sakiyama,F.
  TITLE     A simple, rapid method for purification of epsilon-subunit,
            coupling factor 6, subunit d, and subunit e from rat liver H(+)-ATP
            synthase and determination of the complete amino acid sequence of
            epsilon-subunit
  JOURNAL   J Biol Chem 267 (31), 22658-22661 (1992)
   PUBMED   1429613
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13121.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13121.1, CF977223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..289
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /note="ATP synthase membrane subunit e"
                     /db_xref="GeneID:140608"
                     /db_xref="RGD:621377"
     exon            1..51
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..231
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /EC_number="3.6.1.14"
                     /note="ATPase subunit e; ATP synthase, H+ transporting,
                     mitochondrial F1F0 complex, subunit e; ATP synthase, H+
                     transporting, mitochondrial Fo complex, subunit E; ATP
                     synthase, H+ transporting, mitochondrial F0 complex,
                     subunit E"
                     /codon_start=1
                     /product="ATP synthase subunit e, mitochondrial"
                     /protein_id="NP_536729.1"
                     /db_xref="GeneID:140608"
                     /db_xref="RGD:621377"
                     /translation="MVPPVQVSPLIKFGRYSALILGMAYGAKRYSYLKPRAEEERRIA
                     AEEKKRLDELKRIERELAEAEDVSIFK"
     exon            52..106
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /inference="alignment:Splign:2.1.0"
     exon            107..205
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /inference="alignment:Splign:2.1.0"
     exon            206..289
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      289
                     /gene="Atp5me"
                     /gene_synonym="Atp5i; Atp5k"
ORIGIN      
        1 gaggtcacgg acaaaatggt gcccccggtt caggtctctc cgctcatcaa gttcggccgg
       61 tactccgctc tgatcctcgg catggcatac ggcgccaagc gctacagtta cttaaaaccc
      121 cgggcagagg aggagagaag aatagcagcg gaggaaaaaa agagactaga tgagttgaaa
      181 cggattgaga gagaactggc agaagctgaa gatgtcagca ttttcaagtg aggcggcagt
      241 gatcttgctt ttctcttgtc gttgaggatg aataaagctt cattgtgtg
//
