LOCUS       NM_012915                482 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ATP synthase inhibitory factor subunit 1
            (Atp5if1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012915 XM_343371
VERSION     NM_012915.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 482)
  AUTHORS   Wei,Z., Wu,R., Zhang,L. and Xu,P.
  TITLE     ATPIF1 alleviates oxygen glucose deprivation/reoxygenation-induced
            astrocyte injury in vitro: A rat model of ischemic brain injury
  JOURNAL   Adv Clin Exp Med 32 (7), 791-802 (2023)
   PUBMED   36881363
  REMARK    GeneRIF: ATPIF1 alleviates oxygen glucose
            deprivation/reoxygenation-induced astrocyte injury in vitro: A rat
            model of ischemic brain injury.
REFERENCE   2  (bases 1 to 482)
  AUTHORS   Kim,D., Harada,K. and Inoue,M.
  TITLE     Expression and function of mitochondrial inhibitor factor-1 and
            TASK channels in adrenal cells
  JOURNAL   Biochem Biophys Res Commun 645, 17-23 (2023)
   PUBMED   36657294
  REMARK    GeneRIF: Expression and function of mitochondrial inhibitor
            factor-1 and TASK channels in adrenal cells.
REFERENCE   3  (bases 1 to 482)
  AUTHORS   Pavez-Giani,M.G., Sanchez-Aguilera,P.I., Bomer,N., Miyamoto,S.,
            Booij,H.G., Giraldo,P., Oberdorf-Maass,S.U., Nijholt,K.T.,
            Yurista,S.R., Milting,H., van der Meer,P., Boer,R.A., Heller
            Brown,J., Sillje,H.W.H. and Westenbrink,B.D.
  TITLE     ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and
            Promotes Pathological Cardiac Hypertrophy through CaMKIIdelta
  JOURNAL   Int J Mol Sci 22 (9), 4427 (2021)
   PUBMED   33922643
  REMARK    GeneRIF: ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+)
            Handling and Promotes Pathological Cardiac Hypertrophy through
            CaMKIIdelta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 482)
  AUTHORS   Kahancova,A., Sklenar,F., Jezek,P. and Dlaskova,A.
  TITLE     Overexpression of native IF1 downregulates glucose-stimulated
            insulin secretion by pancreatic INS-1E cells
  JOURNAL   Sci Rep 10 (1), 1551 (2020)
   PUBMED   32005857
  REMARK    GeneRIF: Overexpression of native IF1 downregulates
            glucose-stimulated insulin secretion by pancreatic INS-1E cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 482)
  AUTHORS   Kahancova,A., Sklenar,F., Jezek,P. and Dlaskova,A.
  TITLE     Regulation of glucose-stimulated insulin secretion by ATPase
            Inhibitory Factor 1 (IF1)
  JOURNAL   FEBS Lett 592 (6), 999-1009 (2018)
   PUBMED   29380352
  REMARK    GeneRIF: results indicate that IF1 is a negative regulator of
            insulin secretion involved in pancreatic beta-cell glucose sensing.
REFERENCE   6  (bases 1 to 482)
  AUTHORS   Aggeler,R., Coons,J., Taylor,S.W., Ghosh,S.S., Garcia,J.J.,
            Capaldi,R.A. and Marusich,M.F.
  TITLE     A functionally active human F1F0 ATPase can be purified by
            immunocapture from heart tissue and fibroblast cell lines. Subunit
            structure and activity studies
  JOURNAL   J Biol Chem 277 (37), 33906-33912 (2002)
   PUBMED   12110673
REFERENCE   7  (bases 1 to 482)
  AUTHORS   Samuel,D.S., Belote,J.M. and Chan,S.H.
  TITLE     Isolation of the rat F1-ATPase inhibitor gene and its pseudogenes
  JOURNAL   Biochim Biophys Acta 1230 (1-2), 81-85 (1995)
   PUBMED   7612645
REFERENCE   8  (bases 1 to 482)
  AUTHORS   Chapline,C., Ramsay,K., Klauck,T. and Jaken,S.
  TITLE     Interaction cloning of protein kinase C substrates
  JOURNAL   J Biol Chem 268 (10), 6858-6861 (1993)
   PUBMED   8463212
REFERENCE   9  (bases 1 to 482)
  AUTHORS   Higuti,T., Kuroiwa,K., Kawamura,Y., Morimoto,K. and Tsujita,H.
  TITLE     Molecular cloning and sequence of cDNAs for the import precursors
            of oligomycin sensitivity conferring protein, ATPase inhibitor
            protein, and subunit c of H(+)-ATP synthase in rat mitochondria
  JOURNAL   Biochim Biophys Acta 1172 (3), 311-314 (1993)
   PUBMED   8448208
REFERENCE   10 (bases 1 to 482)
  AUTHORS   Lebowitz,M.S. and Pedersen,P.L.
  TITLE     Regulation of the mitochondrial ATP synthase/ATPase complex: cDNA
            cloning, sequence, overexpression, and secondary structural
            characterization of a functional protein inhibitor
  JOURNAL   Arch Biochem Biophys 301 (1), 64-70 (1993)
   PUBMED   8442667
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_012915.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13122.1, CK840154.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000005.1  150026551-150026677 c
            128-219             JAXUCZ010000005.1  150026368-150026459 c
            220-482             JAXUCZ010000005.1  150022960-150023222 c
FEATURES             Location/Qualifiers
     source          1..482
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..482
                     /gene="Atp5if1"
                     /gene_synonym="Atpi; Atpif1; IF1PA"
                     /note="ATP synthase inhibitory factor subunit 1"
                     /db_xref="GeneID:25392"
                     /db_xref="RGD:2181"
     exon            1..127
                     /gene="Atp5if1"
                     /gene_synonym="Atpi; Atpif1; IF1PA"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..364
                     /gene="Atp5if1"
                     /gene_synonym="Atpi; Atpif1; IF1PA"
                     /note="ATPase inhibitor, mitochondrial; IF1; IF(1);
                     inhibitor of F(1)F(o)-ATPase; ATPase inhibitor (rat
                     mitochondrial IF1 protein); ATPase inhibitory factor 1;
                     ATP synthase F1 subunit epsilon"
                     /codon_start=1
                     /product="ATPase inhibitor, mitochondrial precursor"
                     /protein_id="NP_037047.2"
                     /db_xref="GeneID:25392"
                     /db_xref="RGD:2181"
                     /translation="MAGSALAVRARLGVWGMRVLQTRGFGSDSSESMDSGAGSIREAG
                     GAFGKREKAEEDRYFREKTREQLAALKKHHEDEIDHHSKEIERLQKQIERHKKKIKYL
                     KNSEH"
     exon            128..219
                     /gene="Atp5if1"
                     /gene_synonym="Atpi; Atpif1; IF1PA"
                     /inference="alignment:Splign:2.1.0"
     exon            220..482
                     /gene="Atp5if1"
                     /gene_synonym="Atpi; Atpif1; IF1PA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaccacgcc cgcaacgcga gctgagcaac gccgaagata atggcaggct cggcgttggc
       61 ggttcgggct cggctcggtg tctggggtat gagggtcctg caaacccgag gcttcggctc
      121 ggactcgtcg gagagcatgg attcgggcgc tggctccatc cgagaagctg gtggggcctt
      181 cgggaaacga gagaaggctg aagaggatcg gtacttccga gagaagacta gagagcagct
      241 ggctgccttg aagaagcacc atgaagatga gattgaccac cattcgaagg agatagagcg
      301 tctgcaaaaa cagatcgaac ggcataagaa gaagattaaa tacctaaaga atagtgagca
      361 ttgagtgcac acagtcagtc tctcacagag tggccagtat cattccccac ttctatagag
      421 attgttttga atgattgatg tttgacctgt gtgctactaa cagataataa attatcacca
      481 gg
//
