LOCUS       NM_023093               1871 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus ATP synthase F1 subunit alpha (Atp5f1a), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_023093 XM_341631
VERSION     NM_023093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Xiong,X., Wu,Q., Zhang,L., Gao,S., Li,R., Han,L., Fan,M., Wang,M.,
            Liu,L., Wang,X., Zhang,C., Xin,Y., Li,Z., Huang,C. and Yang,J.
  TITLE     Chronic stress inhibits testosterone synthesis in Leydig cells
            through mitochondrial damage via Atp5a1
  JOURNAL   J Cell Mol Med 26 (2), 354-363 (2022)
   PUBMED   34894202
  REMARK    GeneRIF: Chronic stress inhibits testosterone synthesis in Leydig
            cells through mitochondrial damage via Atp5a1.
            Erratum:[J Cell Mol Med. 2023 Oct;27(20):3213-3214. doi:
            10.1111/jcmm.17829.. PMID: 37724039]
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Kumar,V., A,A.K., Sanawar,R., Jaleel,A., Santhosh Kumar,T.R. and
            Kartha,C.C.
  TITLE     Chronic Pressure Overload Results in Deficiency of Mitochondrial
            Membrane Transporter ABCB7 Which Contributes to Iron Overload,
            Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac
            Function
  JOURNAL   Sci Rep 9 (1), 13170 (2019)
   PUBMED   31511561
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Chomova,M., Balazova,M. and Muchova,J.
  TITLE     Diabetes-induced abnormalities of mitochondrial function in rat
            brain cortex: the effect of n-3 fatty acid diet
  JOURNAL   Mol Cell Biochem 435 (1-2), 109-131 (2017)
   PUBMED   28526935
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Martin,J., Balmer,M.L., Rajendran,S., Maurhofer,O., Dufour,J.F. and
            St-Pierre,M.V.
  TITLE     Nutritional stress exacerbates hepatic steatosis induced by
            deletion of the histidine nucleotide-binding (Hint2) mitochondrial
            protein
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 310 (7), G497-G509 (2016)
   PUBMED   26767982
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Gburek,J., Konopska,B., Juszczynska,K., Piwowar,A., Dziegiel,P.,
            Borska,S., Tolosano,E. and Golab,K.
  TITLE     Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase
  JOURNAL   J Physiol Pharmacol 66 (6), 823-830 (2015)
   PUBMED   26769832
  REMARK    GeneRIF: Hemoglobin - a novel ligand of hepatocyte ectopic
            F1-ATPase
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Bianchet,M.A., Hullihen,J., Pedersen,P.L. and Amzel,L.M.
  TITLE     The 2.8-A structure of rat liver F1-ATPase: configuration of a
            critical intermediate in ATP synthesis/hydrolysis
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11065-11070 (1998)
   PUBMED   9736690
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Yotov,W.V. and St-Arnaud,R.
  TITLE     Cloning and functional expression analysis of the alpha subunit of
            mouse ATP synthase
  JOURNAL   Biochem Biophys Res Commun 191 (1), 142-148 (1993)
   PUBMED   7916601
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Bianchet,M., Ysern,X., Hullihen,J., Pedersen,P.L. and Amzel,L.M.
  TITLE     Mitochondrial ATP synthase. Quaternary structure of the F1 moiety
            at 3.6 A determined by x-ray diffraction analysis
  JOURNAL   J Biol Chem 266 (31), 21197-21201 (1991)
   PUBMED   1834656
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Lee,J.H., Garboczi,D.N., Thomas,P.J. and Pedersen,P.L.
  TITLE     Mitochondrial ATP synthase. cDNA cloning, amino acid sequence,
            overexpression, and properties of the rat liver alpha subunit
  JOURNAL   J Biol Chem 265 (8), 4664-4669 (1990)
   PUBMED   2137825
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Pedersen,P.L., Williams,N. and Hullihen,J.
  TITLE     Mitochondrial ATP synthase: dramatic Mg2+-induced alterations in
            the structure and function of the F1-ATPase moiety
  JOURNAL   Biochemistry 26 (26), 8631-8637 (1987)
   PUBMED   2894844
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061830.1.
            
            On Jan 3, 2004 this sequence version replaced XM_341631.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061830.1, J05266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..1871
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /note="ATP synthase F1 subunit alpha"
                     /db_xref="GeneID:65262"
                     /db_xref="RGD:619993"
     exon            1..109
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1711
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /note="ATP synthase subunit alpha, mitochondrial;
                     mitochondrial H+-ATP synthase alpha subunit; ATP synthase,
                     H+ transporting, mitochondrial F1 complex, alpha subunit
                     1, cardiac muscle"
                     /codon_start=1
                     /product="ATP synthase subunit alpha, mitochondrial
                     precursor"
                     /protein_id="NP_075581.1"
                     /db_xref="GeneID:65262"
                     /db_xref="RGD:619993"
                     /translation="MLSVRIAAAVARALPRRAGLVSKNALGSSFVGTRNLHASNTRLQ
                     KTGTAEMSSILEERILGADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGL
                     KGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGDELLGRVVDALGNAIDG
                     KGPVGSKIRRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGK
                     TSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVS
                     ATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGR
                     EAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQ
                     IFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFG
                     SDLDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFE
                     SAFLSHVVSQHQSLLGNIRSDGKISEQSDAKLKEIVTNFLAGFEP"
     exon            110..188
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            189..358
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..532
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..699
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            700..848
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1000
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1225
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1333
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1478
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1629
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1847
                     /gene="Atp5f1a"
                     /gene_synonym="Atp5a1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgtccgga ggctgcggct gcagaagatc tctccaagaa gctgcaagga tgctgtccgt
       61 gcgcatcgcc gcggccgtgg cccgtgccct ccctcgacgg gcgggactgg tctccaaaaa
      121 tgccttgggg tcatcttttg ttggtacaag aaatctccat gcctctaaca ctcgacttca
      181 gaagactggc actgccgaga tgtcctccat tctcgaggag cggatccttg gagctgatac
      241 ttctgttgac cttgaagaga ctggccgtgt cttaagcatt ggtgatggta ttgcccgagt
      301 gcatggactg aggaacgttc aagctgagga gatggtagag ttttcttccg gcttaaaggg
      361 tatgtccctg aacttggaac ccgacaatgt tggagttgtc gtgtttggga atgacaagct
      421 aattaaagaa ggtgatatcg tgaagagaac aggagccatc gtggacgttc cagttggcga
      481 tgaactgttg ggccgtgtag ttgatgccct gggaaatgcc attgatggga agggtccagt
      541 tggttccaag attcgcagac gagtgggcct gaaagcccct ggaattatcc cccgaatctc
      601 tgtgcgggaa ccaatgcaga cgggcatcaa ggctgtggat agcctggtgc cgattggccg
      661 aggtcagcgt gagctgatta ttggagacag acagaccggg aaaacctcga ttgctattga
      721 cacaatcatc aaccagaagc gtttcaatga tgggactgac gagaagaaga aactgtactg
      781 catctacgtt gctattggtc agaaacggtc caccgttgct cagttggtga agagactgac
      841 agacgcagat gccatgaagt acaccattgt ggtgtcagcc actgcctctg atgctgcccc
      901 gcttcagtac ttggctcctt actccggctg ctccatggga gagtatttcc gagataatgg
      961 caagcacgct ctgatcatct atgacgactt atccaagcag gctgttgctt accgccagat
     1021 gtctctgctg ctccgccgac ccccgggtcg agaggcctat cccggtgatg tgttttacct
     1081 acactctcgc ctgctggaga gagcagccaa gatgaacgat tcctttggtg gtggctcttt
     1141 gactgcctta ccagtcattg aaacacaggc tggtgatgtg tccgcctaca ttccaacaaa
     1201 cgttatttcc atcaccgatg gacagatctt cttggaaaca gaattgttct ataaaggcat
     1261 ccgccctgcc attaatgtgg gcttgtctgt gtcccgtgtc ggatctgccg cccagaccag
     1321 agccatgaag caggtggcag gcaccatgaa gctggagttg gcccagtacc gggaggtcgc
     1381 tgcttttgcc cagtttggtt ctgatctgga tgctgccact cagcagctct tgagccgtgg
     1441 cgtgcgcctg accgagctgc taaagcaagg acagtactct cccatggcta ttgaagaaca
     1501 ggtggctgtc atctatgcag gcgtccgggg ttatcttgat aaactggagc ccagtaagat
     1561 cacaaagttc gagagtgctt tcttgtctca tgttgtgagc cagcaccaga gcctcttggg
     1621 caatatcagg tctgatggga aaatctcaga acagtcggat gcaaagctga aggaaatcgt
     1681 aacaaacttc ttggctgggt ttgaacctta aagccctgcc actgtcacca gacactgctt
     1741 tggttttgtc atttattgtg gtaaaatcag caccatttgt aaaggtttac tcttgtactc
     1801 cctgatgtac agaaatcaca tgaataaaag ttccatattg agtgctaaaa aaaaaaaaaa
     1861 aaaaaaaaaa a
//
