LOCUS       NM_012510               1484 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+/K+ transporting subunit beta (Atp4b),
            mRNA.
ACCESSION   NM_012510
VERSION     NM_012510.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1484)
  AUTHORS   Lahner,E., Marzinotto,I., Brigatti,C., Davidson,H., Wenzlau,J.,
            Piemonti,L., Annibale,B. and Lampasona,V.
  TITLE     Measurement of Autoantibodies to Gastric H+,K+-ATPase (ATP4A/B)
            Using a Luciferase Immunoprecipitation System (LIPS)
  JOURNAL   Methods Mol Biol 1901, 113-131 (2019)
   PUBMED   30539573
REFERENCE   2  (bases 1 to 1484)
  AUTHORS   Aasarod,K.M., Stunes,A.K., Mosti,M.P., Ramezanzadehkoldeh,M.,
            Viggaklev,B.I., Reseland,J.E., Skallerud,B.H., Fossmark,R. and
            Syversen,U.
  TITLE     Effects of the Histamine 1 Receptor Antagonist Cetirizine on the
            Osteoporotic Phenotype in H(+) /K(+) ATPase Beta Subunit KO Mice
  JOURNAL   J Cell Biochem 117 (9), 2089-2096 (2016)
   PUBMED   26869358
REFERENCE   3  (bases 1 to 1484)
  AUTHORS   Arapis,K., Cavin,J.B., Gillard,L., Cluzeaud,F., Letteron,P.,
            Ducroc,R., Le Beyec,J., Hourseau,M., Couvelard,A., Marmuse,J.P., Le
            Gall,M. and Bado,A.
  TITLE     Remodeling of the residual gastric mucosa after roux-en-y gastric
            bypass or vertical sleeve gastrectomy in diet-induced obese rats
  JOURNAL   PLoS One 10 (3), e0121414 (2015)
   PUBMED   25822172
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1484)
  AUTHORS   Raja,U.M., Gopal,G. and Rajkumar,T.
  TITLE     Intragenic DNA methylation concomitant with repression of ATP4B and
            ATP4A gene expression in gastric cancer is a potential serum
            biomarker
  JOURNAL   Asian Pac J Cancer Prev 13 (11), 5563-5568 (2012)
   PUBMED   23317218
REFERENCE   5  (bases 1 to 1484)
  AUTHORS   Bakkelund,K.E., Waldum,H.L., Nordrum,I.S., Hauso,O. and Fossmark,R.
  TITLE     Long-term gastric changes in achlorhydric H(+)/K(+)-ATPase beta
            subunit deficient mice
  JOURNAL   Scand J Gastroenterol 45 (9), 1042-1047 (2010)
   PUBMED   20476858
REFERENCE   6  (bases 1 to 1484)
  AUTHORS   Callaghan,J.M., Khan,M.A., Alderuccio,F., van Driel,I.R.,
            Gleeson,P.A. and Toh,B.H.
  TITLE     Alpha and beta subunits of the gastric H+/K(+)-ATPase are
            concordantly targeted by parietal cell autoantibodies associated
            with autoimmune gastritis
  JOURNAL   Autoimmunity 16 (4), 289-295 (1993)
   PUBMED   7517707
REFERENCE   7  (bases 1 to 1484)
  AUTHORS   Maeda,M., Oshiman,K., Tamura,S., Kaya,S., Mahmood,S., Reuben,M.A.,
            Lasater,L.S., Sachs,G. and Futai,M.
  TITLE     The rat H+/K(+)-ATPase beta subunit gene and recognition of its
            control region by gastric DNA binding protein
  JOURNAL   J Biol Chem 266 (32), 21584-21588 (1991)
   PUBMED   1657972
REFERENCE   8  (bases 1 to 1484)
  AUTHORS   Newman,P.R. and Shull,G.E.
  TITLE     Rat gastric H,K-ATPase beta-subunit gene: intron/exon organization,
            identification of multiple transcription initiation sites, and
            analysis of the 5'-flanking region
  JOURNAL   Genomics 11 (2), 252-262 (1991)
   PUBMED   1663070
REFERENCE   9  (bases 1 to 1484)
  AUTHORS   Canfield,V.A., Okamoto,C.T., Chow,D., Dorfman,J., Gros,P.,
            Forte,J.G. and Levenson,R.
  TITLE     Cloning of the H,K-ATPase beta subunit. Tissue-specific expression,
            chromosomal assignment, and relationship to Na,K-ATPase beta
            subunits
  JOURNAL   J Biol Chem 265 (32), 19878-19884 (1990)
   PUBMED   1978834
REFERENCE   10 (bases 1 to 1484)
  AUTHORS   Shull,G.E.
  TITLE     cDNA cloning of the beta-subunit of the rat gastric H,K-ATPase
  JOURNAL   J Biol Chem 265 (21), 12123-12126 (1990)
   PUBMED   2165052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M35535.1.
            
            On Jun 9, 2003 this sequence version replaced NM_012510.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35535.1, M55655.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1484
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1484
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /note="ATPase H+/K+ transporting subunit beta"
                     /db_xref="GeneID:24217"
                     /db_xref="RGD:2178"
     exon            1..287
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1060
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /note="ATPase, H+,K+-transporting, beta / (gastric
                     H,K-ATPase beta subunit), defined by SSR; proton pump beta
                     chain; gastric H(+)/K(+) ATPase subunit beta; ATPase
                     H+K+-transporting beta / (gastric HK-ATPase beta subunit)
                     defined by SSR; ATPase, H+/K+ transporting, beta
                     polypeptide; ATPase, H+/K+ exchanging, beta polypeptide;
                     ATPase H+/K+ transporting beta subunit"
                     /codon_start=1
                     /product="potassium-transporting ATPase subunit beta"
                     /protein_id="NP_036642.2"
                     /db_xref="GeneID:24217"
                     /db_xref="RGD:2178"
                     /translation="MAALQEKKSCSQRMAEFRQYCWNPDTGQMLGRTPARWVWISLYY
                     AAFYVVMTGLFALCIYVLMQTIDPYTPDYQDQLKSPGVTLRPDVYGERGLQISYNISE
                     NSSWAGLTHTLHSFLAGYTPASQQDSINCSSEKYFFQETFSAPNHTKFSCKFTADMLQ
                     NCSGLVDPSFGFEEGKPCFIIKMNRIVKFLPSNNTAPRVDCTFQDDPQKPRKDIEPLQ
                     VQYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKFLNVPKNTQVLIVCKIMADHVTFD
                     NPHDPYEGKVEFKLTIQK"
     exon            288..416
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     exon            417..530
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..730
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..787
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..898
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1484
                     /gene="Atp4b"
                     /gene_synonym="S76401S1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacttctg ggacagtgga ggacagatag cacgcaagcc ccagccctcc cttatgttta
       61 tagaggcgat agcggagaac tgatagctgg ttctgatgcc tttggcctca cacagaggag
      121 actataagcc ccagaggacg ctccctgggc ccagtccagg caagcaggag aggacatggc
      181 agccctgcag gagaagaagt catgcagcca gcgcatggcc gaattccggc aatactgttg
      241 gaacccggac actgggcaga tgctgggccg caccccagcc cggtgggtgt ggatcagcct
      301 gtactatgca gctttctacg tggtcatgac tgggctcttt gccttgtgca tctatgtgct
      361 gatgcagacc attgatccct acacccccga ctaccaggac cagttaaagt caccgggggt
      421 aaccttgaga ccggatgtgt atggggaaag agggctgcag atttcctaca acatctctga
      481 aaacagctcc tgggctggcc tcacacacac cctccacagc ttcttagcgg gctacacccc
      541 agcatcccag caggacagca tcaactgttc gtctgaaaag tacttcttcc aggagacctt
      601 ttctgctccg aaccatacca agttctcctg caagttcacg gcggacatgc tacagaattg
      661 ctcaggcctg gtggacccca gtttcggctt tgaggaggga aagccctgct tcattattaa
      721 aatgaacagg attgtcaagt tcctgcccag caacaacacg gctccccgag tggactgcac
      781 cttccaggat gacccccaaa agccccggaa ggacattgaa cccctgcagg tccagtacta
      841 tccccccaat ggtaccttca gtctccacta cttcccctac tacggcaaga aagcacagcc
      901 ccactacagc aaccctctgg tggcggcaaa gttcctcaac gtccccaaaa acacgcaagt
      961 cctcatcgtg tgcaagatca tggcggacca cgtgaccttc gacaaccccc acgaccccta
     1021 tgaagggaag gtggagttca agctcacaat acagaagtaa ggagtaggcg tggctgtcca
     1081 ccccagagcc tggtggaccc tgagggacca ctcttcctga ctgacatcat cggctggcca
     1141 gcatgcacgg ccacttcatg gttcagagct gacaccactg cccatctgcc gacagcagga
     1201 agtgctcctt cccagcactc cctgagcacc accagctttg aactgaaacc cgacgtgcgc
     1261 acgcacgttt gcaatcccgt gcggttaaca caggaaccca gagtccggct accactaagg
     1321 gacaacccat ctgtagggca tttctatcct gtgaccattt gtctgtcctg cactttgata
     1381 tgaactatgg gtccacatca gtgtaacact ggtcaccccg gcctccagtt tgtgcttctg
     1441 gggccacagc ccctaggtca ttaaaacaaa ctatagtaaa gtta
//
