LOCUS       NM_012509               3456 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase H+/K+ transporting subunit alpha (Atp4a),
            mRNA.
ACCESSION   NM_012509 XM_001076500 XM_341834
VERSION     NM_012509.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Liu,Z., Liu,S., Guo,J., Sun,L., Wang,S., Wang,Y., Qiu,W. and Lv,J.
  TITLE     Identification and Analysis of Key Genes Driving Gastric Cancer
            Through Bioinformatics
  JOURNAL   Genet Test Mol Biomarkers 25 (1), 1-11 (2021)
   PUBMED   33470887
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Barone,S., Amlal,H., Kujala,M., Xu,J., Karet,F., Blanchard,A.,
            Kere,J. and Soleimani,M.
  TITLE     Regulation of the basolateral chloride/base exchangers AE1 and
            SLC26A7 in the kidney collecting duct in potassium depletion
  JOURNAL   Nephrol Dial Transplant 22 (12), 3462-3470 (2007)
   PUBMED   17804457
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Mathews,P.M., Claeys,D., Jaisser,F., Geering,K., Horisberger,J.D.,
            Kraehenbuhl,J.P. and Rossier,B.C.
  TITLE     Primary structure and functional expression of the mouse and frog
            alpha-subunit of the gastric H(+)-K(+)-ATPase
  JOURNAL   Am J Physiol 268 (5 Pt 1), C1207-C1214 (1995)
   PUBMED   7762614
  REMARK    Erratum:[Am J Physiol 1995 Oct;269(4 Pt 1):section C followi]
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Ahn,K.Y. and Kone,B.C.
  TITLE     Expression and cellular localization of mRNA encoding the 'gastric'
            isoform of H(+)-K(+)-ATPase alpha-subunit in rat kidney
  JOURNAL   Am J Physiol 268 (1 Pt 2), F99-F109 (1995)
   PUBMED   7840253
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Cantley,L.G., Zhou,X.M., Cunha,M.J., Epstein,J. and Cantley,L.C.
  TITLE     Ouabain-resistant transfectants of the murine ouabain resistance
            gene contain mutations in the alpha-subunit of the Na,K-ATPase
  JOURNAL   J Biol Chem 267 (24), 17271-17278 (1992)
   PUBMED   1324928
REFERENCE   7  (bases 1 to 3456)
  AUTHORS   Oshiman,K., Motojima,K., Mahmood,S., Shimada,A., Tamura,S.,
            Maeda,M. and Futai,M.
  TITLE     Control region and gastric specific transcription of the rat
            H+,K(+)-ATPase alpha subunit gene
  JOURNAL   FEBS Lett 281 (1-2), 250-254 (1991)
   PUBMED   1849840
REFERENCE   8  (bases 1 to 3456)
  AUTHORS   Newman,P.R., Greeb,J., Keeton,T.P., Reyes,A.A. and Shull,G.E.
  TITLE     Structure of the human gastric H,K-ATPase gene and comparison of
            the 5'-flanking sequences of the human and rat genes
  JOURNAL   DNA Cell Biol 9 (10), 749-762 (1990)
   PUBMED   2176086
REFERENCE   9  (bases 1 to 3456)
  AUTHORS   Shull,G.E. and Lingrel,J.B.
  TITLE     Molecular cloning of the rat stomach (H+ + K+)-ATPase
  JOURNAL   J Biol Chem 261 (36), 16788-16791 (1986)
   PUBMED   3023364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Sep 13, 2022 this sequence version replaced NM_012509.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.1422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000001.1  95089122-95089164
            44-184              JAXUCZ010000001.1  95089259-95089399
            185-244             JAXUCZ010000001.1  95089517-95089576
            245-448             JAXUCZ010000001.1  95089910-95090113
            449-562             JAXUCZ010000001.1  95091575-95091688
            563-815             JAXUCZ010000001.1  95091908-95092160
            816-1084            JAXUCZ010000001.1  95092326-95092594
            1085-1283           JAXUCZ010000001.1  95093221-95093419
            1284-1393           JAXUCZ010000001.1  95093738-95093847
            1394-1528           JAXUCZ010000001.1  95093924-95094058
            1529-1721           JAXUCZ010000001.1  95094375-95094567
            1722-1897           JAXUCZ010000001.1  95095375-95095550
            1898-2034           JAXUCZ010000001.1  95096387-95096523
            2035-2185           JAXUCZ010000001.1  95096607-95096757
            2186-2354           JAXUCZ010000001.1  95096851-95097019
            2355-2509           JAXUCZ010000001.1  95097119-95097273
            2510-2633           JAXUCZ010000001.1  95099369-95099492
            2634-2779           JAXUCZ010000001.1  95099783-95099928
            2780-2913           JAXUCZ010000001.1  95101041-95101174
            2914-3015           JAXUCZ010000001.1  95101484-95101585
            3016-3107           JAXUCZ010000001.1  95101679-95101770
            3108-3456           JAXUCZ010000001.1  95101929-95102277
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3456
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /note="ATPase H+/K+ transporting subunit alpha"
                     /db_xref="GeneID:24216"
                     /db_xref="RGD:2177"
     exon            1..43
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..3136
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /EC_number="7.2.2.19"
                     /note="gastric H,K-ATPase catalytic subunit; ATPase H+/K+
                     transporting alpha subunit; ATPase, H+/K+ exchanging,
                     alpha polypeptide; proton pump; gastric H(+)/K(+) ATPase
                     subunit alpha; hydrogen/potassium-exchanging ATPase 4A;
                     ATPase, H+/K+ transporting, alpha polypeptide;
                     H+,K+-ATPase alpha subunit"
                     /codon_start=1
                     /product="potassium-transporting ATPase alpha chain 1"
                     /protein_id="NP_036641.1"
                     /db_xref="GeneID:24216"
                     /db_xref="RGD:2177"
                     /translation="MGKAENYELYSVELGTGPGGNMAAKMSKKKAGGGGGKKKEKLEN
                     MKKEMEMNDHQLSVSELEQKYQTSATKGLKASLAAELLLRDGPNALRPPRGTPEYVKF
                     ARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLALALIAVVVVTGCFGYYQ
                     EFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILSA
                     QGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTI
                     IGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYTFLRAMVFF
                     MAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLT
                     QNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAV
                     PVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDP
                     RDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFC
                     QLYLNEKDYPPGYTFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVI
                     MVTGDHPITAKAIAASVGIISEGSETVEDIAARLRMPVDQVNKKDARACVINGMQLKD
                     MDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADI
                     GVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELT
                     PYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPRRDRLVN
                     EPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFPLLCVGLRPQWEDHHLQDLQDSYGQ
                     EWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVIAIVFQ
                     VCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEIRKLGVRCCPGSWWDQ
                     ELYY"
     exon            44..184
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            185..244
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            245..448
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            449..562
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            563..815
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1084
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1283
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1393
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1528
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1721
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1897
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2034
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2185
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2354
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2509
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2633
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2779
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2780..2913
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3015
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3107
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3456
                     /gene="Atp4a"
                     /gene_synonym="Hka; Hkatpc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagaccaaa gagggcagag caccagccac catggggaag gcagagaatt atgaattgta
       61 ctcagtggaa ctggggactg gccctggtgg gaacatggct gccaagatga gcaagaagaa
      121 ggcgggaggc gggggaggca agaagaagga gaagctagag aacatgaaga aggagatgga
      181 gatgaacgac caccagttgt cagtgtctga gctggagcag aagtaccaga ccagtgccac
      241 caagggcctg aaggcgagtc tggcagctga gctgctgctg agggatgggc ccaatgcact
      301 ccggccacct cggggcaccc ctgagtacgt gaagttcgcc cggcagctgg caggcggtct
      361 gcagtgcctc atgtgggtgg ctgcagccat ctgcctcatt gcctttgcga ttcaggccag
      421 cgagggagac ctgaccactg atgacaattt gtacctggcg ttggcactca ttgctgtggt
      481 tgtggtcact ggctgttttg gctactacca ggagttcaag agcacaaata tcatcgccag
      541 cttcaagaat cttgtacccc agcaagccac agtgatccga gacggggata agttccagat
      601 caacgcggat cagcttgtgg tgggcgacct ggtagagatg aaaggcgggg accgcgtccc
      661 agcagacatc cgaattctgt cagcccaggg ctgcaaggtg gacaactcct cgcttactgg
      721 agagtctgaa ccgcagaccc gctcacctga gtgtacacac gagagtcccc ttgagacccg
      781 caacatcgcc ttcttctcca ccatgtgtct ggagggcacg gcgcagggct tggtggtgag
      841 caccggtgat cgcaccatca ttggacgcat cgcctctctg gcttcgggtg tggaaaacga
      901 gaagactcct atcgcgatcg agatcgaaca ttttgtggac atcattgctg gcctggccat
      961 cctcttcggt gccacattct ttgtggtggc catgtgtatc ggctatacct tccttcgggc
     1021 catggtcttc ttcatggcca ttgtggtagc ctatgtgcct gaggggctgc tggctactgt
     1081 cacggtctgc ctgtcactga cagcaaagag gctggccagt aaaaactgtg tggtcaaaaa
     1141 tctggaagca gtggagaccc tgggttccac gtcagtcatc tgctcagaca agacaggaac
     1201 tcttactcag aaccgcatga cggtgtctca tctatggttt gacaaccata tccacacggc
     1261 ggacaccaca gaagaccagt cagggcaaac gttcgaccaa tcgtcggaga cctggcgggc
     1321 gctgtgccgc gtgctcaccc tgtgcaaccg cgctgccttc aagtctggcc aggacgccgt
     1381 gccagtgccc aagcgcatcg tgatcggaga cgcatctgag actgcgctgc tcaagttctc
     1441 ggagttgacg ttgggcaacg ccatgggtta tcgggaccgc ttccccaaag tttgcgagat
     1501 ccccttcaac tccaccaaca agtttcagct gtccattcac actctggagg atccgcgcga
     1561 cccccggcac ttgctggtga tgaagggcgc cccagagcgc gtgctggagc gttgcagctc
     1621 catcctcatc aagggccagg agctgcccct ggacgagcaa tggcgtgagg ccttccagac
     1681 agcctacctt agcctgggag gcctaggcga acgcgttctt ggtttctgcc agctctacct
     1741 gaatgagaag gactacccgc ctggctacac ctttgatgtg gaggccatga actttccaag
     1801 tagtggcctc tgctttgcgg gacttgtatc catgattgac cctccccggg ccaccgttcc
     1861 agatgctgtg ctcaaatgcc gtacggcagg catccgggtg atcatggtga ctggtgacca
     1921 tcccatcaca gccaaggcca ttgcagccag tgtggggatc atctcggaag gcagcgagac
     1981 agtggaagac atcgccgccc gcctccgaat gcctgtagac caggttaata agaaggatgc
     2041 ccgggcctgt gtgatcaatg gcatgcagtt gaaggacatg gacccatctg agctggtgga
     2101 ggcgctgcgc acccaccctg agatggtgtt tgctcgaacc agtcctcagc agaagctggt
     2161 gattgtggag agctgtcagc gactgggtgc cattgtggct gtaacagggg atggtgtgaa
     2221 tgactcccca gccctgaaga aggctgacat tggtgtagcc atgggcattg ctggctccga
     2281 tgctgctaaa aatgctgctg acatgatctt gctggatgac aacttcgctt ccattgtgac
     2341 gggcgtggag cagggccgac tgatctttga caacctgaag aaatccatcg cctatacact
     2401 gaccaagaac attccagaac tgacacccta ccttatctat atcactgtca gtgtgcccct
     2461 accccttggg tgtatcacca ttctcttcat agaactctgc acagatatct ttccatctgt
     2521 gtccctggca tatgaaaagg ccgagagtga catcatgcac ctgcgcccac ggaaccccag
     2581 gcgggaccgg ttggtcaatg aacccctggc tgcttattcc tattttcaga ttggtgccat
     2641 tcagtcattt gccggctttg ctgactactt cacggccatg gcccaggagg gctggttccc
     2701 tctgctgtgt gtggggctgc gaccacaatg ggaggaccac catctacaag atcttcaaga
     2761 cagctacggc caggaatgga catttggtca gcgtctgtac cagcagtaca cctgttacac
     2821 cgtgttcttc atcagcatcg agatgtgcca gatcgctgat gtcctcatcc gcaagacacg
     2881 ccgcctctcc gctttccagc agggattctt caggaacagg atcctggtga tcgccatcgt
     2941 gtttcaggtc tgcattggct gcttcctgtg ctactgccca gggatgccca acatcttcaa
     3001 cttcatgccc atccggttcc agtggtggct ggtccccatg ccctttggcc ttctcatctt
     3061 tgtctatgat gagatccgga aacttggagt tcgctgttgc ccagggagct ggtgggacca
     3121 ggaactctac tattagaggg gtaatcacct ctccatccac tatcagctgg gacaaaacat
     3181 cgtgtaatct gtccccagcc ctatggaact gtgcccactt ctgcagccca tgacaccatt
     3241 ggagggactc taccctttac ccctttcact ccatagtccc acacccagga aagtactggg
     3301 atgggagggg ctaaacagcg gttggcagct cctgtggagg tgtgtccatc tcaaggactc
     3361 catctggaca agagggttgt gtggggctct gttacaaatt cctcatgttc tgctggacag
     3421 taataaagcc atgtcatatc acctgcatag tcttaa
//
