LOCUS       NM_131907               4946 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus ATPase secretory pathway Ca2+ transporting 1
            (Atp2c1), mRNA.
ACCESSION   NM_131907
VERSION     NM_131907.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4946)
  AUTHORS   Tang,J., Wang,R., Fan,Y., Zhang,C. and Kong,Y.
  TITLE     Ultrashort wave alleviates oxygen-glucose deprivation/reoxygenation
            injury via up-regulation of SPCA1 expression in N2a cells
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (5), 641-647 (2023)
   PUBMED   37539566
  REMARK    GeneRIF: Ultrashort wave alleviates oxygen-glucose
            deprivation/reoxygenation injury via up-regulation of SPCA1
            expression in N2a cells.
REFERENCE   2  (bases 1 to 4946)
  AUTHORS   Fan,Y., Zhang,C., Li,T., Peng,W., Yin,J., Li,X., Kong,Y., Lan,C.,
            Wang,R. and Hu,Z.
  TITLE     A New Approach of Short Wave Protection against Middle Cerebral
            Artery Occlusion/Reperfusion Injury via Attenuation of Golgi
            Apparatus Stress by Inhibition of Downregulation of Secretory
            Pathway Ca(2+)-ATPase Isoform 1 in Rats
  JOURNAL   J Stroke Cerebrovasc Dis 25 (7), 1813-1822 (2016)
   PUBMED   27133772
  REMARK    GeneRIF: Short wave therapy protected against focal cerebral I/R
            injury by increasing SPCA1 expression to modulate Golgi apparatus
            stress.
REFERENCE   3  (bases 1 to 4946)
  AUTHORS   Cross,B.M., Hack,A., Reinhardt,T.A. and Rao,R.
  TITLE     SPCA2 regulates Orai1 trafficking and store independent Ca2+ entry
            in a model of lactation
  JOURNAL   PLoS One 8 (6), e67348 (2013)
   PUBMED   23840669
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4946)
  AUTHORS   Leitch,S., Feng,M., Muend,S., Braiterman,L.T., Hubbard,A.L. and
            Rao,R.
  TITLE     Vesicular distribution of Secretory Pathway Ca(2)+-ATPase isoform 1
            and a role in manganese detoxification in liver-derived polarized
            cells
  JOURNAL   Biometals 24 (1), 159-170 (2011)
   PUBMED   20981470
  REMARK    GeneRIF: The secretory pathway Ca(2+)-ATPase isoform 1 (SPCA1) was
            expressed in liver and WIF-B cells.
REFERENCE   5  (bases 1 to 4946)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4946)
  AUTHORS   Fairclough,R.J., Dode,L., Vanoevelen,J., Andersen,J.P.,
            Missiaen,L., Raeymaekers,L., Wuytack,F. and Hovnanian,A.
  TITLE     Effect of Hailey-Hailey Disease mutations on the function of a new
            variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1)
  JOURNAL   J Biol Chem 278 (27), 24721-24730 (2003)
   PUBMED   12707275
REFERENCE   7  (bases 1 to 4946)
  AUTHORS   Ton,V.K., Mandal,D., Vahadji,C. and Rao,R.
  TITLE     Functional expression in yeast of the human secretory pathway
            Ca(2+), Mn(2+)-ATPase defective in Hailey-Hailey disease
  JOURNAL   J Biol Chem 277 (8), 6422-6427 (2002)
   PUBMED   11741891
REFERENCE   8  (bases 1 to 4946)
  AUTHORS   Pruitt,K.D. and Maglott,D.R.
  TITLE     RefSeq and LocusLink: NCBI gene-centered resources
  JOURNAL   Nucleic Acids Res 29 (1), 137-140 (2001)
   PUBMED   11125071
REFERENCE   9  (bases 1 to 4946)
  AUTHORS   Hu,Z., Bonifas,J.M., Beech,J., Bench,G., Shigihara,T., Ogawa,H.,
            Ikeda,S., Mauro,T. and Epstein,E.H. Jr.
  TITLE     Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey
            disease
  JOURNAL   Nat Genet 24 (1), 61-65 (2000)
   PUBMED   10615129
REFERENCE   10 (bases 1 to 4946)
  AUTHORS   Gunteski-Hamblin,A.M., Clarke,D.M. and Shull,G.E.
  TITLE     Molecular cloning and tissue distribution of alternatively spliced
            mRNAs encoding possible mammalian homologues of the yeast secretory
            pathway calcium pump
  JOURNAL   Biochemistry 31 (33), 7600-7608 (1992)
   PUBMED   1380825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC086994.1.
            
            On Dec 26, 2004 this sequence version replaced NM_131907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086994.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..4946
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /note="ATPase secretory pathway Ca2+ transporting 1"
                     /db_xref="GeneID:170699"
                     /db_xref="RGD:621311"
     exon            1..287
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..473
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..3227
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /EC_number="7.2.2.10"
                     /note="calcium-transporting ATPase 2C1; ATP-dependent
                     Ca(2+) pump PMR1; ATPase, Ca++-sequestering; secretory
                     pathway Ca(2+)-ATPase 1; ATPase, Ca++ transporting, type
                     2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; secretory pathway
                     Ca(2+)-transporting ATPase type 1"
                     /codon_start=1
                     /product="calcium-transporting ATPase type 2C member 1"
                     /protein_id="NP_571982.2"
                     /db_xref="GeneID:170699"
                     /db_xref="RGD:621311"
                     /translation="MKVARFQKIPNVENETMIPVLTSKRASELAVSEVAGLLQADLQN
                     GLNKSEVSHRRAFHGWNEFDISEDEPLWKKYISQFKNPLIMLLLASAVISVLMRQFDD
                     AVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECHCVREGKLEHTLARDLVPGDT
                     VCLSVGDRVPADLRLFEAVDLSIDESSLTGETTPCSKVTAPQPAATNGDLASRSNIAF
                     MGTLVRCGKAKGIVIGTGENSEFGEVFKMMQAEEAPKTPLQKSMDLLGKQLSFYSFGI
                     IGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKK
                     LPIVETLGCCNVICSDKTGTLTKNEMTVTHILTSDGLHAEVTGVGYNQFGEVIVDGDV
                     VHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGALIALAMKMGLDGLQQDYIRKA
                     EYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYCTTYNSKGQTLALTQQQRD
                     LYQQEKAQMGSAGLRVLALASGPDLGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSI
                     KMITGDSQETAIAIASRLGLYSKTSQSVSGEEVDTMEVQHLSQIVPKVAVFYRASPRH
                     KMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDF
                     QTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINII
                     MDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGTLFVFWREL
                     RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNKMFCYAVLGSIMGQL
                     LVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVSEIIKKVERSREKTQKNATSTPS
                     SFLEV"
     exon            474..584
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..701
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            702..791
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..827
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..889
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..998
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1154
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1223
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1299
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1366
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1491
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1589
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1685
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1775
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1880
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2037
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2208
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2306
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2357
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2524
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2593
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2710
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2858
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2954
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3096
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..4915
                     /gene="Atp2c1"
                     /gene_synonym="Spca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcggtgg gcggcgggcg gtgtagtgca gggagcgccg ggcggcgggc ggcagggagg
       61 ggcggagcgc aggaggtgga ggcgggagca gagctgctcg gccgtgcgcg gagacgcgcg
      121 gagccggcgg gccaagcttg acgggcccct cgccgctcct cctctcccct ccctgccacc
      181 atcctgctcg ttctcctccg gacgcggctg ggctccgtgt ggcgccaccg tgccgccagc
      241 agtgcccgtt cgcccgaggc gcgtggggcg cccccgcagc cccgcgaatg ctgctgctag
      301 gggtggtggg agcagccgtg ggacgcgtgg ccgggagcgg gggtgacagc ctgggattcc
      361 agggtcttct cttccttgtc ctcctcctct cctctctatt cccagtgtgg ccgtggctga
      421 cactaaagac tttgtagcca tcaaccagag tgcagtttcg atggaaaatg aaggttgcac
      481 gatttcaaaa gatccctaat gttgaaaatg agacaatgat ccctgtactg acatccaaga
      541 gagcaagtga gttagcagtc agtgaggtcg caggccttct ccaggctgat cttcagaatg
      601 gcttaaacaa atctgaagtt agtcataggc gagccttcca tggctggaat gagtttgata
      661 tcagtgaaga tgaaccatta tggaagaagt acatttctca gtttaaaaat cccctcatca
      721 tgctgcttct ggcttcggca gtcatcagcg ttttaatgcg tcagtttgat gatgccgtca
      781 gtatcactgt ggcaatactg attgttgtca ccgtggcctt tgttcaggaa tatcgttcag
      841 aaaaatcttt agaagaatta agtaaacttg tgccaccaga atgccattgt gttcgtgaag
      901 gaaaattgga gcatacactt gcccgagact tggttccagg tgatacagtt tgtctgtctg
      961 tgggggacag agttcctgct gacttacgct tattcgaggc cgtggatctt tccatcgatg
     1021 agtctagctt gacaggagag acaactcctt gttctaaggt gaccgctcct caaccagctg
     1081 ctaccaatgg ggatcttgca tcaagaagta acattgcctt catggggact ctggtcagat
     1141 gtggcaaagc aaagggtatt gtcattggaa caggagagaa ttctgaattt ggagaggtct
     1201 ttaagatgat gcaggcagaa gaagcaccaa aaacgcctct gcagaagagc atggacctct
     1261 tgggcaagca gctgtccttt tactcctttg gtataatagg tatcatcatg ttggttggct
     1321 ggttactagg gaaagacatt ctggaaatgt tcactattag tgtaagtttg gctgtagctg
     1381 caattcctga aggtctgcct attgtggtca cagtgacact agcccttggt gttatgagaa
     1441 tggtgaagaa aagggctatt gtaaagaaat tgcctattgt tgaaacgctg ggctgctgta
     1501 atgtgatttg ttcagataaa actggaaccc tgacgaagaa tgagatgact gttactcaca
     1561 tcctcacttc agacggcctg catgctgagg ttactggagt tggctacaat cagtttggtg
     1621 aagtgattgt tgatggtgat gttgttcatg gattctataa cccagctgtt agcagaattg
     1681 ttgaggcggg ctgtgtgtgc aacgatgctg tcattaggaa caacactctg atgggaaagc
     1741 caactgaagg agccttaatc gctctcgcga tgaagatggg tcttgatgga ctgcaacaag
     1801 actatatcag aaaagctgaa taccctttta gttctgagca gaaatggatg gctgttaagt
     1861 gtgtgcaccg aacacagcag gacagaccag agatttgttt tatgaagggt gcttatgagc
     1921 aggtgattaa gtattgtact acgtacaaca gcaaagggca gactttggca cttacccagc
     1981 agcagagaga tttgtaccaa caagagaagg cccagatggg ctcggcagga ctccgagttc
     2041 ttgcactggc gtctggtccg gacctggggc agctgacctt ccttggcctg gtaggaatca
     2101 ttgaccctcc gagaactggt gtgaaagaag ccgtcacaac actcattgcc tcaggagtct
     2161 ccatcaaaat gatcacagga gactctcagg agactgcaat tgcaatcgct agtcgtctgg
     2221 gattgtattc taaaacttca cagtctgtgt ctggagaaga agtagataca atggaagtcc
     2281 agcacctttc acagatagtg ccaaaggttg cagtatttta cagagcaagc ccaagacaca
     2341 agatgaaaat tattaagtct ctacaaaaga acgggtcagt tgtagccatg acaggagatg
     2401 gggtaaatga tgcagtggct ctgaaggctg cagatattgg agttgcaatg ggccagactg
     2461 gcacagatgt ttgcaaagag gctgcggaca tgatcttggt ggatgatgat ttccaaacta
     2521 taatgtctgc aatagaagag ggtaaaggca tttataataa cattaaaaat tttgttagat
     2581 ttcaactgag cacgagtata gcagcattaa ctttaatctc attggctacg ttaatgaact
     2641 ttcctaaccc tctcaatgca atgcagattt tgtggatcaa tattataatg gatggacccc
     2701 cagctcagag ccttggagta gagccagtgg ataaagatgt cattcgaaaa ccccctcgga
     2761 actggaagga cagcattttg acaaaaaact tgatccttaa aatacttgtt tcatcaataa
     2821 tcattgtctg tgggactttg tttgtcttct ggcgagagct tcgagacaat gtgataacac
     2881 cccgagacac aacaatgact ttcacttgct tcgtgttttt tgatatgttc aatgcactga
     2941 gttccagatc tcagactaag tctgtgtttg agattggact ctgcagtaat aagatgttct
     3001 gctatgcggt tcttggatcc atcatggggc agttgcttgt tatctacttc ccgcctctgc
     3061 agaaggtttt tcagaccgag agcctcagta ttctggatct gttgtttctt ttgggtctca
     3121 cttcatcagt gtgcattgtg tctgaaatta taaagaaggt tgaaaggagc agggaaaaga
     3181 ctcagaagaa cgctacttca acaccatcgt cttttcttga agtatgatgc atattgcatt
     3241 ttttttttca tttgcaaact aggaattgca gtctgggaat catttagaag ggcaagttca
     3301 agaggataat gaagatttaa ggacttttaa actttccatt gactaaaaat gaccattaat
     3361 gttaaagact tgatttgaac cttgttggta gtcccaaatg aaattatgca actttgaata
     3421 acacgttcct tgatttgaat tggcttttgc aatcgattgg aacttcaaca tatggtcaag
     3481 tactgaatta aaaaagtaca aaaggcaaaa cgtgaacacc ttctgcactt agagttctaa
     3541 tgtacaaata cactatctgt cttagatgga tataaatatt ttttttattt ttaaatattg
     3601 tactatttat ggttgtgggg ctttcttact aatacactca ataaatgcac tcagtcattt
     3661 caaaggcatt ctatttggtt tagaaattgc caggagtgcc atatttcagc taccatgttt
     3721 cctttttcct gcaatgtacg caaatgatac cttgtgctac catttttata tttcaagttt
     3781 tttatttttt atttttgcac aggatgtgac cactgtctaa tcactgttct ttttttttgt
     3841 gactgaaaag catatactgc aattgaagta aatgtttgct cttcttagta agtgtacatg
     3901 gttgttttgg ttttttgtag tggttttcca cagaggtgtg agtctttgac ctagcaggat
     3961 tagttcaggc tgttgttgca ttacagttag agtaattgta cttaacacag tcaaagagtc
     4021 aaaaacaaca aaggctggat ggaatttcaa acagactatg ttaacacgtc cttgtttagg
     4081 ttaatacagt tctactttgt cagtgtcatc ttgtcatttc ttctttataa atcaaacact
     4141 tcagctaaat aattgacctt tattactgtt tcatatttgt atttttaagt ctatttctta
     4201 gagagtatag actaccatac ttagaaaatc aaaagtccca aactcagaga gataggacat
     4261 gaaccagggt gtccatcaga agatcctgtg caggccttgc tcctccgaat cctctaggca
     4321 gccgctttgg cctagattgt agcacaaccc tgagtctgtc ccttctgccg tttgttggga
     4381 tccgtcttct tcttttggta tgcttgggaa atagatggat ttgctttgtg taaaccatca
     4441 gtttttataa gagcttgaca aaataaaggt aagtgttgaa tcttgtattt cataaactgt
     4501 cagaattaac tgttctgagc ttgttcaata ttactggtga gtgttaacgc tgctgcgctg
     4561 tcgttgatag gagaactctg ttgtctgagt ctgtactact gaagcatgaa cgtaaggagc
     4621 cagatgtctg actttgtctt aatctctcag gctcaactgt cagtgtacat tgttctgtct
     4681 cattaggtgg gacgtgaggt cactgtcaac caactcatag aggtttgatg tctcatagca
     4741 aaattttata atggtttttt acattctgtt ccaaacttga aaactacata ttaagtgcat
     4801 attcagtctt gtttgtttta cagtagaggt tgagaatatg actcatgaaa tgaatgtgcc
     4861 tatcttttca cttggtattg aactataaaa ataaagtgag tttttcataa gttcaaaaaa
     4921 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
