LOCUS       XM_039090640            8455 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus ATPase plasma membrane Ca2+
            transporting 4 (Atp2b4), transcript variant X1, mRNA.
ACCESSION   XM_039090640
VERSION     XM_039090640.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051348.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_039090640.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..8455
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /note="ATPase plasma membrane Ca2+ transporting 4; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 47 ESTs, 2 long SRA reads, 13 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 214 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:29600"
                     /db_xref="RGD:621305"
     CDS             873..4484
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 4
                     isoform X1"
                     /protein_id="XP_038946568.1"
                     /db_xref="GeneID:29600"
                     /db_xref="RGD:621305"
                     /translation="MTNPSGHNLPANSVAESYEGEFGCTLMDLRKLMELRAADAVTQI
                     SAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQ
                     DVTLIILEIAAIISLVLSFYRPPGGENEICGHIVSNPEEDEEGETGWIEGAAILASVI
                     IVVFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGD
                     LLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGI
                     NSQTGIIFTLLGANEEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGLDS
                     EEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRR
                     AWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL
                     DACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSI
                     CINSAYTSKILPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVY
                     TFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMVR
                     NVIEPMASEGLRTIGIAYRDFDGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAI
                     NKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQ
                     EKLDKVWPRLRVLARSSPTDKHTLVKGIIDSNIGEQRQVVAVTGDGTNDGPALKKADV
                     GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI
                     VAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISR
                     TMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQL
                     FNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWM
                     WCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEEISKDAEGLEEIDHAEMELRR
                     GQILWVRGLNRIQTQIRVVKVFHSFRDVIHKSKNQVSIHSFMTQPEYAADDEMSQSFL
                     NQEESPSLASKSRITKRLSDAETVSQNNTNNNAVDCHQVQIVASHPNSPLQSQETPV"
ORIGIN      
        1 ctggggagcc ccagtctggc cggagttggc tggagctgtt gccatgacaa gcattttctt
       61 aagacagctc tgctgttgag tcggtcctag gctgggggtg gggtgggggc acgaacttct
      121 taggggtcca tccctccgaa gacagcgaga tcagacaccc gcccagctcc ctgcacccat
      181 tttcttccag ggaaggtcct tcttcgcaag gaagggttgg ggaagaagac ccagcccact
      241 ccccccggct gtagctgaaa ggccagagcg caaagccagc atcactaggt ggtttgccac
      301 agtggggaga gcggtgggtg gtcaccccac cctactcggt cggtccatgg aaacgcgcag
      361 ggacggtccc gctcggagac acctggatct ttgctagaaa gagagaggcc tagccatcat
      421 cgttatccag ggagccctcc tctttctgct gacgccaccc taccatcgaa actgctggtt
      481 gttgctaagg ttgcccccat ggtaacatgc ctatcctgtt tacacttcta tatgaacaag
      541 tagtctaaac taggaaccta cgtactctgg acaaccattt ccgtctctac ccagaggaca
      601 ccaatcatcg tgacactacg tccgtcttct actaagttcc cccaacctct tcctcctctc
      661 actagtagac ttaatacaga agaaaggatc tctaggcctg gtgttgctac tctgaaactt
      721 attgcacaag atattgtcaa tttatcccct aactgggctc ccagagaaga aaaaagtggg
      781 aagaaacgaa gaagagaagg caagagacac tgctcagtta gaggggaaac tctacatctt
      841 ctctggttga gagtctggta accgaaggca agatgacgaa tccatcagga cataacttgc
      901 cagccaactc ggtagctgag agctatgaag gggagtttgg ctgcacctta atggacctga
      961 ggaagctcat ggagcttcgt gcagctgatg cagtgaccca gatcagtgcc cactatggaa
     1021 gtgtacaaga aatctgcgca agactgaaaa cctcccctgt agaaggtctg tctgggaacc
     1081 ctgcagattt ggagaagcgt agacttgttt ttgggaagaa catgatacct ccgaaaaagc
     1141 ccaagacgtt cttagaatta gtgtgggaag ccctgcagga tgtcacactc atcatcctgg
     1201 agatcgcagc catcatatcc ctggtcctgt ccttctaccg gcctcctggc ggggaaaatg
     1261 aaatctgtgg ccacattgta agtaacccag aagaagatga ggaaggagaa actggctgga
     1321 ttgaaggggc agccattctt gcctcggtga tcattgtggt attcgtgaca gccttcaacg
     1381 actggagcaa agagaagcag ttccgggggc tgcagagtcg cattgagctt gagcaaaaat
     1441 tctccattat ccggaatggt cagcttatac aactcccagt ggctgagatt gtggtgggag
     1501 atattgccca ggtcaaatac ggtgacctgc tgcctgccga cggaatccta atccagggaa
     1561 atgatctgaa gattgacgag agctctttga caggagaatc agatcatgtc aagaagactc
     1621 tggacaaaga ccccatgttg ctctcaggga ctcatgtgat ggaaggctct ggacggatgg
     1681 tggtgactgc tgtgggaatc aattcccaga ctggaatcat cttcaccctc ttaggggcta
     1741 atgaggaaga agacgatgag aaaaagaaga aaggtaaaaa acaaggagtc tctgaaaatc
     1801 gcaacaaagc aaaaacccag gatggagtgg ccttggaaat ccagccactc aacagccagg
     1861 aggggctcga tagtgaggaa aaggagaaga aagcaagcaa gggacccaag aaggagaagt
     1921 cggtcctgca gggcaagctc acacgcctgg ctgtgcagat cgggaaggca ggtctgatca
     1981 tgtctatcct cacagtcctc atcctgattc tatacttcgt ggttgacaat ttcgtgatac
     2041 agcgccgggc atggcttcct gagtgcactc ctgtgtacat ccagtatttt gtcaagttct
     2101 tcatcatcgg agtcactgta ctggtagtgg ctgtgccaga ggggctgcca ctggctgtca
     2161 ccatctcgtt ggcctactct gtaaagaaaa tgatgaagga caacaacttg gtccggcact
     2221 tggacgcctg tgagacgatg ggcaacgcca cagccatctg ctctgataag acgggcacgc
     2281 tgaccatgaa ccgcatgacc gtggtacaag cttacattgg gggcactcac taccgccaga
     2341 tcccaaaacc tgacgacctc ccacccaacg ttctggacct catagtcaac agcatctgta
     2401 tcaactctgc ttacacttct aagattctgc ctccagagaa agagggaggc ctcccccggc
     2461 aagtaggcaa caagacagag tgtggactgc tgggctttgt cacagacctg aagcaggact
     2521 accaagcagt tcgcagtgag atgcccgagg agaagctctt caaggtgtac accttcaact
     2581 cagtgcgcaa gtccatgagc accgtcatca ggaagccgga agggggcttc cgcgtgttca
     2641 gcaagggcgc ctccgagata atgctgcgca agtgtgatcg gatcctgaac aaggaaggag
     2701 gaattgtacc attcaaaact aaggaccgag acaatatggt acgcaacgtc attgagccca
     2761 tggccagtga aggactccgg accatcggca tagcttaccg agattttgat ggtgaagagc
     2821 cctcgtggga aaatgagaat gagatcttca ctgggctggt ctgcattgca gtggtgggca
     2881 ttgaggaccc tgtgcgccca gaggtaccag atgccattaa caagtgcaaa cgggctggca
     2941 ttactgtcag gatggtgaca ggtgacaacg tcaacacagc cagggccatc gccaccaaat
     3001 gtggcatctt gactcctggt gatgacttcc tgtgtctgga agggaaagaa ttcaacagac
     3061 tcatacgcaa tgagaagggc gaggtcgaac aagaaaagct ggacaaggtc tggcccaggc
     3121 ttcgggtact ggcacgatct tctcccacag acaagcacac attggtgaaa ggtatcattg
     3181 acagcaatat tggggaacag aggcaggtgg tggctgtcac cggtgatgga accaatgatg
     3241 gaccggctct aaagaaagca gatgtcggtt ttgctatggg cattgcaggc acagatgtgg
     3301 ctaaggaggc atcagacatc atcctgactg atgacaactt caccagcatt gtgaaggcag
     3361 tgatgtgggg ccggaacgta tacgacagca tttccaagtt cctgcagttc cagctcactg
     3421 tcaacgtggt ggccgtgatt gtggctttct ctggagcctg catcactcag gattccccac
     3481 tgaaagcggt gcagatgctg tgggtgaacc tgatcatgga cacgtttgct tctctggccc
     3541 tggccacaga gcccccgacc gattccctgc tgaggcgtcg cccctatggg cgaaacaagc
     3601 ccctgatctc tcgcacaatg atgaagaaca tcctgggcca cgcggtgtat cagctcggaa
     3661 tcgtcttcct cctcgtcttt gctggcgaca aactgtttga cattgacagt gggaggaagg
     3721 cgcctctcaa ttcaccaccc agccagcact acaccattgt tttcaacacg tttgtgctga
     3781 tgcaactctt caacgagatc aactctcgga agatccatgg cgagaagaat gtctttgcag
     3841 gtgtctaccg caacatcatt ttctgctctg ttgttttagg cacgttcttc tgccagatct
     3901 tgatcgtgga agtgggaggt aagcccttca gctgcacaaa cctcaccatg gagcagtgga
     3961 tgtggtgtct ctttataggg atcggagaac ttttgtgggg ccaggtcatc tctgcaatac
     4021 ctaccaagtc tctaaagttc ctgaaagagg cgggccatgg cagtgacaaa gaggagatca
     4081 gcaaggacgc tgaggggctg gaagagatcg accatgccga gatggagctt cgccgaggcc
     4141 agatcctctg ggtccgtggc ctgaaccgga ttcagactca gatcagagtg gtcaaagtat
     4201 ttcatagttt ccgagacgtc attcataaat ccaagaacca ggtctccatc cacagcttca
     4261 tgacccaacc tgagtacgcc gcagacgatg aaatgtcaca gtccttcctg aatcaagagg
     4321 aaagtccttc gttggcttct aagtcgcgga ttaccaagcg cctgtcggat gctgaaactg
     4381 tttcacagaa caacacgaat aacaatgccg tggactgcca ccaagtgcaa atcgttgcct
     4441 cccatcccaa cagccctcta caaagccagg agacaccggt ctgaacgtcc atcctctgag
     4501 taccgtccct gctctcccct ttttctcttc atctgtccta tctgtatgtg atggtgggac
     4561 ttgtcattgt ttcatcagct gctcctaagc atgtgagaac ccccacctga ccatgaagaa
     4621 gcacagacct acatggattc ggtcagacct tgggcaggta acagtagctc cgctccccag
     4681 gcgtaccagt tgtcatttta aagaagtagt gacaatcctc ttagcgtcgc ccaacccaaa
     4741 gtctccccag catcccccac acatgccacc acccccttct gacttggaga tttcacaagc
     4801 taagtcgtgg gctcggtgag agacaaacgc cccatgttcg cgtttcagta gagtgactat
     4861 ccttaaaatg ttctttccta ttttgaaaat gtgcacacta aggcctctag ctctttctgc
     4921 ccttcagtct gacgtccccc agggttcttt ggatctcacc tgccccttac catcttccct
     4981 ttcatccact cttcccactc tctttatgtc gtggtaatta caagaatgga aagggcatgg
     5041 ccaaactgag tcaatttgac ccttactggc cccagtagaa cctttcattt tgttccagag
     5101 gcaggcagat ttcttttcta aaatggtctt tttggagcaa atgagctagt gaaatatttc
     5161 cctattctta ccaggtcagc accaacttct gaatgtcttc ttgggtggat aggggttttt
     5221 aagtgccagg gaaatcagcc atgaccatag gcctgagctt ccttcttgcc tggggtggta
     5281 gcaaagagtg agggggccat gaccctgcct tccagctgct cgaggagctt caggatcaac
     5341 atggggcagg cctaggacca gaagtcactg aagcagacta ctttcaaggg tttcatttgt
     5401 ttgccaaggc tctcccagag caggagcttc cttctgtcgt gggaggcgag gatgaatgtt
     5461 aagaaccctt gggaaggact aaagcgccag tccttcagga gctacacttt gttgtgtccc
     5521 acaacatttt ccgtctctaa ggaggtcccc aacttttgca aacattctaa cgttgaagag
     5581 aggaggcgcc caaacagcat gctgagtcaa ggggctaaag gccctccctg gaaagcttcc
     5641 tgcccccacc cccaacctct ctgtcttcac ataccctcct ccagggtctg tctccactgc
     5701 tgcctgggaa agtctgtgcc tttctgccct gaacactgcc cagagcaccc tctgcccagc
     5761 agcctctcgg gagccgggaa cttcaccaaa agggactttg ccttactggg atgaggagga
     5821 agcacaggtg ctccatgtgt atctcggctg gctgatttaa gcatgtttgt gcagtggatc
     5881 gagtcgatgt ccccaagtcc catccactgt tgggttagtg aagcctgcct ccctctttct
     5941 agggtgatga gaataagagg gcgagtgagg ctcatgaaaa cagccagatt tccacttggg
     6001 aaagaacggt aaaatgagcc tgaccacctg tagtcttttt tctagcaatc ttcctcccac
     6061 cccacctttc acccaagctg ccaggggagg gtgagcgaag gaacaaacac catttcacac
     6121 ccgttccagc acagcccatc attataggaa gtagagagaa ggtttggatt cggattttgt
     6181 aaggcttaca tacttcagca atcttccctc atgggggggg ggggcatctc cctcgaggtg
     6241 ttagctgttc aactatattt aagtacatta gaagatttga ttctgtcagc tcttttatta
     6301 cctcagatca ttttttttta aagcaagcca ataacaagtt tcaaaggcca ttttaccatc
     6361 cttgctccca aaagactctt gtggtgcctg acaggttact cctgagggct tgtgtctact
     6421 ttttcaaaag tcaacatgtt tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     6481 ttttcagtaa tttccatagt aagagagaaa atatagaaat attatgcaaa aaatatagtt
     6541 ttctttagct cagaaactga catttacgag tcagccatat atgtatatat atatattgtt
     6601 taaagaattt caaataatgt gccaccatgc cacgccgtgg agaggagcac accaccagct
     6661 gtttggcatg acaggtgact cagtacgttt gtaactggtt aaaacaacga cagcaaccaa
     6721 tataccatac ttcctttttc caaacggcca tctttatatt taggggaaaa aaattgttgg
     6781 gttctagact tttttttaat ataaattttg ttgatatgga attgagtgag ttcaagtgtt
     6841 tctgtgcata tgtttttata tgttcttgtc tattcagttt cagtaatcca ggtggcagtg
     6901 agtaaatatg atataagtta atgacacttt cccctaaatg gtgctccgga tttgaaagag
     6961 gtctgatggg aggaagagaa tatatcctag agccctcttt tgataaacct ggacaaacgg
     7021 gtaaaaacct gcaggtagtg agggaaacac ccacaaagag gctccttagc tgtctgtcag
     7081 gccatggatg gatgctgcct tggaggagag cagacttgtt ggtactcagg agcaaggatc
     7141 agttgggttt ctgtttcttg aggaattagc aaacagagta gtatcaatga tggctggtct
     7201 ctcctagtca gcaagggtac tctgacgtgg ggtccgcatt tctttatgtt ttcccctttc
     7261 ccctccccct ggagagatgc cactagtgag gttttgtgta tgactctgag ttgtaacatc
     7321 ctgctgtttt tgtctgatac agcaggtggg ggccagagct ccaaactgga aaagatcaat
     7381 gtaacagcaa tggttacttc tagctctgtc tgacagtctc aggactaggt ccttctcaac
     7441 agttctacga tatcctctgt ggcagttttc ccatcccaaa agttgtagga gagaccagct
     7501 agaagccttc tgggcacttg tgggttcccc ggggttggat ttctttttgc cttcaagctt
     7561 taggggagag tttcaaagat caatccgagg ggttacctca ctgctgaaag ccctagggaa
     7621 gttgagtgtg ccagaatcct ctcccagatc ctcctctttc tccccatccc ccttgcctta
     7681 caattgaagc tacctgtggc accatcccaa tctgcacatt caatcacttt ctgcatctag
     7741 ggtccacccc atggcactgg taggggtggg cccttgcaat gcctgctgtt ctaaagccat
     7801 tccagcctcc tcctcagaat agaccagatc ctctccctcc cttccattta gctgagagcc
     7861 agaacttttg ccttcccagg tctacagttc tgcctgctgc cccctttctt cttggttggg
     7921 agaggtgatg ggaggtgaga cccctgcagc tgaatgggcc tttggcccag agtttctccc
     7981 catatgtata tatgccatat gtaaataaat atgccacata tgtgctgaca aatcgctcta
     8041 cgccatcttt tctaatgggc atgcagatag gaattttgag ttcttctcag caactggtat
     8101 aatgagcact ggtatttttg tacaaaacta aaaggaaaaa aaaaagaaaa ttgactttcg
     8161 cggtctacat gtcagacatt acgatatcaa agcaatgtgt atcctagcgt gtgtggccgt
     8221 agtttgcagc tcagctgaac agtgcaccca atctgtattt gcatttgata ttatttaagc
     8281 tctatgtata atgttttgca tgtatttata tggctcttgg gagggggggg atgctataaa
     8341 ccgacaaatc tgtactacaa atgtgttctc caactgacac gggaagaaag ggagttttaa
     8401 agggtgtaac tttttggaac caataaagct ttctgctgat gaacagaaac caaca
//
