LOCUS       NM_001005871            4102 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Rattus norvegicus ATPase plasma membrane Ca2+ transporting 4
            (Atp2b4), mRNA.
ACCESSION   NM_001005871 XM_341122
VERSION     NM_001005871.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4102)
  AUTHORS   Miya,V., Kumar,C., Breed,A.A., Idicula-Thomas,S. and Pathak,B.R.
  TITLE     Mammalian cysteine-rich secretory proteins interact with plasma
            membrane Ca2+ exporter PMCA4b
  JOURNAL   Andrology 12 (5), 1096-1110 (2024)
   PUBMED   37882330
  REMARK    GeneRIF: Mammalian cysteine-rich secretory proteins interact with
            plasma membrane Ca[2+] exporter PMCA4b.
REFERENCE   2  (bases 1 to 4102)
  AUTHORS   Varshney,S., Adela,R., Kachhawa,G., Dada,R., Kulshreshtha,V.,
            Kumari,R., Agarwal,R. and Khadgawat,R.
  TITLE     Disrupted placental vitamin D metabolism and calcium signaling in
            gestational diabetes and pre-eclampsia patients
  JOURNAL   Endocrine 80 (1), 191-200 (2023)
   PUBMED   36477942
REFERENCE   3  (bases 1 to 4102)
  AUTHORS   Ho,P.W., Pang,S.Y., Li,M., Tse,Z.H., Kung,M.H., Sham,P.C. and
            Ho,S.L.
  TITLE     PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay
            in intracellular calcium extrusion
  JOURNAL   Brain Behav 5 (4), e00321 (2015)
   PUBMED   25798335
REFERENCE   4  (bases 1 to 4102)
  AUTHORS   Baggott,R.R., Alfranca,A., Lopez-Maderuelo,D., Mohamed,T.M.,
            Escolano,A., Oller,J., Ornes,B.C., Kurusamy,S., Rowther,F.B.,
            Brown,J.E., Oceandy,D., Cartwright,E.J., Wang,W., Gomez-del
            Arco,P., Martinez-Martinez,S., Neyses,L., Redondo,J.M. and
            Armesilla,A.L.
  TITLE     Plasma membrane calcium ATPase isoform 4 inhibits vascular
            endothelial growth factor-mediated angiogenesis through interaction
            with calcineurin
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (10), 2310-2320 (2014)
   PUBMED   25147342
REFERENCE   5  (bases 1 to 4102)
  AUTHORS   Afroze,T., Yang,G., Khoshbin,A., Tanwir,M., Tabish,T., Momen,A. and
            Husain,M.
  TITLE     Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4)
            mediates cell cycle progression in vascular smooth muscle cells
  JOURNAL   J Biol Chem 289 (10), 7221-7231 (2014)
   PUBMED   24448801
REFERENCE   6  (bases 1 to 4102)
  AUTHORS   Adamo,H.P., Filoteo,A.G., Enyedi,A. and Penniston,J.T.
  TITLE     Mutants in the putative nucleotide-binding region of the plasma
            membrane Ca(2+)-pump. A reduction in activity due to slow
            dephosphorylation
  JOURNAL   J Biol Chem 270 (50), 30111-30114 (1995)
   PUBMED   8530416
REFERENCE   7  (bases 1 to 4102)
  AUTHORS   Keeton,T.P. and Shull,G.E.
  TITLE     Primary structure of rat plasma membrane Ca(2+)-ATPase isoform 4
            and analysis of alternative splicing patterns at splice site A
  JOURNAL   Biochem J 306 (Pt 3) (Pt 3), 779-785 (1995)
   PUBMED   7702574
REFERENCE   8  (bases 1 to 4102)
  AUTHORS   Howard,A., Barley,N.F., Legon,S. and Walters,J.R.
  TITLE     Plasma-membrane calcium-pump isoforms in human and rat liver
  JOURNAL   Biochem J 303 (Pt 1) (Pt 1), 275-279 (1994)
   PUBMED   7945253
REFERENCE   9  (bases 1 to 4102)
  AUTHORS   Howard,A., Legon,S. and Walters,J.R.
  TITLE     Human and rat intestinal plasma membrane calcium pump isoforms
  JOURNAL   Am J Physiol 265 (5 Pt 1), G917-G925 (1993)
   PUBMED   7694502
REFERENCE   10 (bases 1 to 4102)
  AUTHORS   Keeton,T.P., Burk,S.E. and Shull,G.E.
  TITLE     Alternative splicing of exons encoding the calmodulin-binding
            domains and C termini of plasma membrane Ca(2+)-ATPase isoforms 1,
            2, 3, and 4
  JOURNAL   J Biol Chem 268 (4), 2740-2748 (1993)
   PUBMED   8428948
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U15408.1.
            
            On Oct 22, 2004 this sequence version replaced XM_341122.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U15408.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4102
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="CD"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..4102
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /note="ATPase plasma membrane Ca2+ transporting 4"
                     /db_xref="GeneID:29600"
                     /db_xref="RGD:621305"
     exon            1..360
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3677
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /EC_number="7.2.2.10"
                     /note="plasma membrane calcium pump; ATPase, Ca++
                     transporting, plasma membrane 4; plasma membrane calcium
                     ATPase; plasma membrane Ca2+-ATPases 4"
                     /codon_start=1
                     /product="plasma membrane calcium-transporting ATPase 4"
                     /protein_id="NP_001005871.1"
                     /db_xref="GeneID:29600"
                     /db_xref="RGD:621305"
                     /translation="MTNPSGHNLPANSVAESYEGEFGCTLMDLRKLMELRAADAVTQI
                     SAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMIPPKKPKTFLELVWEALQ
                     DVTLIILEIAAIISLVLSFYRPPGGENEICGHIVSNPEEDEEGETGWIEGAAILASVI
                     IVVFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVKYGD
                     LLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGI
                     NSQTGIIFTLLGANEEEDDEKKKKGKKQGVSENRNKAKTQDGVALEIQPLNSQEGLDS
                     EEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQRR
                     AWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHL
                     DACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSI
                     CINSAYTSKILPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVY
                     TFNSVRKSMSTVIRKPEGGFRVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMVR
                     NVIEPMASEGLRTIGIAYRDFDGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAI
                     NKCKRAGITVRMVTGDNVNTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQ
                     EKLDKVWPRLRVLARSSPTDKHTLVKGIIDSNIGEQRQVVAVTGDGTNDGPALKKADV
                     GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVI
                     VAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLRRRPYGRNKPLISR
                     TMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPLNSPPSQHYTIVFNTFVLMQL
                     FNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQWM
                     WCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEEISKDAEGLEEIDHAEMELRR
                     GQILWVRGLNRIQTQIEVINKFQTGASFKGVLRRQNLSQQLDVKLVPSSYSEAVASVR
                     TSPSTSSAVTPPPVGNQSGQSIS"
     exon            361..558
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            559..816
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            817..942
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1068
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1104
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1266
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1481
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1724
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1966
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2198
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2378
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..2466
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2573
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2765
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2979
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3191
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            3192..3299
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            3300..3476
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3651
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..4102
                     /gene="Atp2b4"
                     /gene_synonym="PMCA4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctactctga aacttattgc acaagatatt gtcaatttat cccctaactg ggctcccaga
       61 gaagaaaaaa gtgggaagaa acgaagaaga gaaggcaaga gacactgctc agttagaggg
      121 gaaactctac atcttctctg gttgagagtc tggtaaccga aggcaagatg acgaatccat
      181 caggacataa cttgccagcc aactcggtag ctgagagcta tgaaggggag tttggctgca
      241 ccttaatgga cctgaggaag ctcatggagc ttcgtgcagc tgatgcagtg acccagatca
      301 gtgcccacta tggaagtgta caagaaatct gcgcaagact gaaaacctcc cctgtagaag
      361 gtctgtctgg gaaccctgca gatttggaga agcgtagact tgtttttggg aagaacatga
      421 tacctccgaa aaagcccaag acgttcttag aattagtgtg ggaagccctg caggatgtca
      481 cactcatcat cctggagatc gcagccatca tatccctggt cctgtccttc taccggcctc
      541 ctggcgggga aaatgaaatc tgtggccaca ttgtaagtaa cccagaagaa gatgaggaag
      601 gagaaactgg ctggattgaa ggggcagcca ttcttgcctc ggtgatcatt gtggtattcg
      661 tgacagcctt caacgactgg agcaaagaga agcagttccg ggggctgcag agtcgcattg
      721 agcttgagca aaaattctcc attatccgga atggtcagct tatacaactc ccagtggctg
      781 agattgtggt gggagatatt gcccaggtca aatacggtga cctgctgcct gccgacggaa
      841 tcctaatcca gggaaatgat ctgaagattg acgagagctc tttgacagga gaatcagatc
      901 atgtcaagaa gactctggac aaagacccca tgttgctctc agggactcat gtgatggaag
      961 gctctggacg gatggtggtg actgctgtgg gaatcaattc ccagactgga atcatcttca
     1021 ccctcttagg ggctaatgag gaagaagacg atgagaaaaa gaagaaaggt aaaaaacaag
     1081 gagtctctga aaatcgcaac aaagcaaaaa cccaggatgg agtggccttg gaaatccagc
     1141 cactcaacag ccaggagggg ctcgatagtg aggaaaagga gaagaaagca agcaagggac
     1201 ccaagaagga gaagtcggtc ctgcagggca agctcacacg cctggctgtg cagatcggga
     1261 aggcaggtct gatcatgtct atcctcacag tcctcatcct gattctatac ttcgtggttg
     1321 acaatttcgt gatacagcgc cgggcatggc ttcctgagtg cactcctgtg tacatccagt
     1381 attttgtcaa gttcttcatc atcggagtca ctgtactggt agtggctgtg ccagaggggc
     1441 tgccactggc tgtcaccatc tcgttggcct actctgtaaa gaaaatgatg aaggacaaca
     1501 acttggtccg gcacttggac gcctgtgaga cgatgggcaa cgccacagcc atctgctctg
     1561 ataagacggg cacgctgacc atgaaccgca tgaccgtggt acaagcttac attgggggca
     1621 ctcactaccg ccagatccca aaacctgacg acctcccacc caacgttctg gacctcatag
     1681 tcaacagcat ctgtatcaac tctgcttaca cttctaagat tctgcctcca gagaaagagg
     1741 gaggcctccc ccggcaagta ggcaacaaga cagagtgtgg actgctgggc tttgtcacag
     1801 acctgaagca ggactaccaa gcagttcgca gtgagatgcc cgaggagaag ctcttcaagg
     1861 tgtacacctt caactcagtg cgcaagtcca tgagcaccgt catcaggaag ccggaagggg
     1921 gcttccgcgt gttcagcaag ggcgcctccg agataatgct gcgcaagtgt gatcggatcc
     1981 tgaacaagga aggaggaatt gtaccattca aaactaagga ccgagacaat atggtacgca
     2041 acgtcattga gcccatggcc agtgaaggac tccggaccat cggcatagct taccgagatt
     2101 ttgatggtga agagccctcg tgggaaaatg agaatgagat cttcactggg ctggtctgca
     2161 ttgcagtggt gggcattgag gaccctgtgc gcccagaggt accagatgcc attaacaagt
     2221 gcaaacgggc tggcattact gtcaggatgg tgacaggtga caacgtcaac acagccaggg
     2281 ccatcgccac caaatgtggc atcttgactc ctggtgatga cttcctgtgt ctggaaggga
     2341 aagaattcaa cagactcata cgcaatgaga agggcgaggt cgaacaagaa aagctggaca
     2401 aggtctggcc caggcttcgg gtactggcac gatcttctcc cacagacaag cacacattgg
     2461 tgaaaggtat cattgacagc aatattgggg aacagaggca ggtggtggct gtcaccggtg
     2521 atggaaccaa tgatggaccg gctctaaaga aagcagatgt cggttttgct atgggcattg
     2581 caggcacaga tgtggctaag gaggcatcag acatcatcct gactgatgac aacttcacca
     2641 gcattgtgaa ggcagtgatg tggggccgga acgtatacga cagcatttcc aagttcctgc
     2701 agttccagct cactgtcaac gtggtggccg tgattgtggc tttctctgga gcctgcatca
     2761 ctcaggattc cccactgaaa gcggtgcaga tgctgtgggt gaacctgatc atggacacgt
     2821 ttgcttctct ggccctggcc acagagcccc cgaccgattc cctgctgagg cgtcgcccct
     2881 atgggcgaaa caagcccctg atctctcgca caatgatgaa gaacatcctg ggccacgcgg
     2941 tgtatcagct cggaatcgtc ttcctcctcg tctttgctgg cgacaaactg tttgacattg
     3001 acagtgggag gaaggcgcct ctcaattcac cacccagcca gcactacacc attgttttca
     3061 acacgtttgt gctgatgcaa ctcttcaacg agatcaactc tcggaagatc catggcgaga
     3121 agaatgtctt tgcaggtgtc taccgcaaca tcattttctg ctctgttgtt ttaggcacgt
     3181 tcttctgcca gatcttgatc gtggaagtgg gaggtaagcc cttcagctgc acaaacctca
     3241 ccatggagca gtggatgtgg tgtctcttta tagggatcgg agaacttttg tggggccagg
     3301 tcatctctgc aatacctacc aagtctctaa agttcctgaa agaggcgggc catggcagtg
     3361 acaaagagga gatcagcaag gacgctgagg ggctggaaga gatcgaccat gccgagatgg
     3421 agcttcgccg aggccagatc ctctgggtcc gtggcctgaa ccggattcag actcagattg
     3481 aagtaattaa caaattccag acgggagcct cttttaaggg agtcctaagg cgacagaact
     3541 tgagtcaaca acttgatgta aaactggttc ctagctccta ttcagaagca gttgcgtcag
     3601 tcagaacctc cccctccacc tcttctgccg ttacacctcc tcctgtgggc aatcagagtg
     3661 gtcaaagtat ttcatagttt ccgagacgtc attcataaat ccaagaacca ggtctccatc
     3721 cacagcttca tgacccaacc tgagtacgcc gcagacgatg aaatgtcaca gtccttcctg
     3781 aatcaagagg aaagtccttc gttggcttct aagtcgcgga ttaccaagcg cctgtcggat
     3841 gctgaaactg tttcacagaa caacacgaat aacaatgccg tggactgcca ccaagtgcaa
     3901 atcgttgcct cccatcccaa cagccctcta caaagccagg agacaccggt ctgaacgtcc
     3961 atcctctgag taccgtccct gctctcccct ttttctcttc atctgtccta tctgtatgtg
     4021 atggtgggac ttgtcattgt ttcatcagct gctcctaagc atgtgagaac ccccacctga
     4081 ccatgaagaa gcacagacct ac
//
