LOCUS       NM_012914               4472 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+
            transporting 3 (Atp2a3), mRNA.
ACCESSION   NM_012914
VERSION     NM_012914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4472)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4472)
  AUTHORS   Searls,Y.M., Loganathan,R., Smirnova,I.V. and Stehno-Bittel,L.
  TITLE     Intracellular Ca2+ regulating proteins in vascular smooth muscle
            cells are altered with type 1 diabetes due to the direct effects of
            hyperglycemia
  JOURNAL   Cardiovasc Diabetol 9, 8 (2010)
   PUBMED   20122173
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4472)
  AUTHORS   Brini,M. and Carafoli,E.
  TITLE     Calcium pumps in health and disease
  JOURNAL   Physiol Rev 89 (4), 1341-1378 (2009)
   PUBMED   19789383
  REMARK    Review article
REFERENCE   4  (bases 1 to 4472)
  AUTHORS   Redondo,P.C., Salido,G.M., Pariente,J.A., Sage,S.O. and Rosado,J.A.
  TITLE     SERCA2b and 3 play a regulatory role in store-operated calcium
            entry in human platelets
  JOURNAL   Cell Signal 20 (2), 337-346 (2008)
   PUBMED   18068335
REFERENCE   5  (bases 1 to 4472)
  AUTHORS   Chaabane,C., Corvazier,E., Bredoux,R., Dally,S., Raies,A.,
            Villemain,A., Dupuy,E., Enouf,J. and Bobe,R.
  TITLE     Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and
            SERCA3f): distinct roles in cell adhesion and ER stress
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1377-1385 (2006)
   PUBMED   16725111
REFERENCE   6  (bases 1 to 4472)
  AUTHORS   Magnino,F., St-Pierre,M., Luthi,M., Hilly,M., Mauger,J.P. and
            Dufour,J.F.
  TITLE     Expression of intracellular calcium channels and pumps after
            partial hepatectomy in rat
  JOURNAL   Mol Cell Biol Res Commun 3 (6), 374-379 (2000)
   PUBMED   11032760
REFERENCE   7  (bases 1 to 4472)
  AUTHORS   Martin,V., Bredoux,R., Corvazier,E., Papp,B. and Enouf,J.
  TITLE     Platelet Ca(2+)ATPases : a plural, species-specific, and multiple
            hypertension-regulated expression system
  JOURNAL   Hypertension 35 (1 Pt 1), 91-102 (2000)
   PUBMED   10642281
REFERENCE   8  (bases 1 to 4472)
  AUTHORS   Poch,E., Leach,S., Snape,S., Cacic,T., MacLennan,D.H. and Lytton,J.
  TITLE     Functional characterization of alternatively spliced human SERCA3
            transcripts
  JOURNAL   Am J Physiol 275 (6), C1449-C1458 (1998)
   PUBMED   9843705
REFERENCE   9  (bases 1 to 4472)
  AUTHORS   Dode,L., Wuytack,F., Kools,P.F., Baba-Aissa,F., Raeymaekers,L.,
            Brike,F., van de Ven,W.J. and Casteels,R.
  TITLE     cDNA cloning, expression and chromosomal localization of the human
            sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 689-699 (1996)
   PUBMED   8809064
  REMARK    Erratum:[Biochem J 1996 Nov 1;319(Pt 3):1008. Brik F [corrected to
            Brike F]]
REFERENCE   10 (bases 1 to 4472)
  AUTHORS   Burk,S.E., Lytton,J., MacLennan,D.H. and Shull,G.E.
  TITLE     cDNA cloning, functional expression, and mRNA tissue distribution
            of a third organellar Ca2+ pump
  JOURNAL   J Biol Chem 264 (31), 18561-18568 (1989)
   PUBMED   2553713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M30581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M30581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4472
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..4472
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /note="ATPase sarcoplasmic/endoplasmic reticulum Ca2+
                     transporting 3"
                     /db_xref="GeneID:25391"
                     /db_xref="RGD:2175"
     exon            1..249
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3131
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /EC_number="7.2.2.10"
                     /note="calcium pump 3; SR Ca(2+)-ATPase 3; ATPase, Ca++
                     transporting, ubiquitous"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 3"
                     /protein_id="NP_037046.1"
                     /db_xref="GeneID:25391"
                     /db_xref="RGD:2175"
                     /translation="MEEAHLLSAADVLRRFSVTAEGGLTLEQVTDARERYGPNELPTE
                     EGKSLWELVVEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANA
                     IVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVP
                     ADLRLIEIKSTTLRVDQSILTGESVSVTKHTDAIPDPRAVNQDKKNMLFSGTNIASGK
                     ALGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINI
                     GHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEAEAGACRLHEFTISGTTYTPE
                     GEVRQGEQLVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTDLKGLSRVERAGACNSVIKQLMQKEFTLEFSRDRKSMSVYCTPTRADPKAQ
                     GSKMFVKGAPESVIERCSSVRVGSRTVPLSATSREHILAKIRDWGSGSHTLRCLALAT
                     RDTPPRKEDMQLDDCSQFVQYETGLTFVGCVGMLDPPRPEVAACITRCSRAGIRVVMI
                     TGDNKGTAVAICRRLGIFGDTEDVLGKAYTGREFDDLSPEQQRQACRTARCFARVEPA
                     HKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNF
                     ASIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMEKLPRNPREALISGWLFFRYLAIGVYVGLATVAAATWWF
                     LYDAEGPQVTFHQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALN
                     SVSENQSLLRMPPWLNPWLLGAVVMSMALHFLILLVPPLPLIFQVTPLSGRQWGVVLQ
                     MSLPVILLDEALKYLSRHHVDEKKDLK"
     exon            250..267
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            268..350
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            351..455
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            456..594
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            595..675
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..761
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1226
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1315
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1418
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1550
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1676
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1895
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2231
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2452
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2655
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2741
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2875
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2876..2993
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3111
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..4472
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actgccgtcg gggaaggtcc cagcgcggtc atggcctccc agggcggccg ccccgcctca
       61 agttcgcagc attctgcaca gtagcccgga ggagaagcgg cctggacgtc gcggccggcc
      121 ggggaagcag catggaggag gcgcacctgc tctcggctgc cgacgtgctg cgtcgcttct
      181 cggtgacagc cgagggcggc ttgaccctgg agcaggtgac cgacgcccgg gagcgatacg
      241 gccccaacga actccctact gaggaaggga aatccctgtg ggagctggtg gtggagcagt
      301 ttgaggacct cttggtgcgc atcctgctgc tggcagccct ggtttccttt gtcctggcct
      361 ggtttgagga gggtgaggag accacgacgg ccttcgtgga gcccctcgtc atcatgttaa
      421 tccttgtggc caatgcgatc gtgggagtgt ggcaggaacg caatgctgag agtgccattg
      481 aggccttgaa ggagtatgag cctgagatgg gtaaggtgat ccgctctgac cgcaagggtg
      541 tgcagaggat ccgagccagg gacatcgtcc ctggggacat tgtggaagtg gcagtgggag
      601 acaaggtacc tgctgacctc cgcctcatcg agatcaagtc caccacactt cgagtggacc
      661 agtccatcct gacaggggaa tccgtgtctg tgactaagca cacagatgcc attccagacc
      721 cccgagccgt gaaccaggac aagaagaaca tgctgttttc tggcaccaat attgcatcag
      781 gcaaagccct gggtgtggct gtggccacag gcttgcacac agagctgggc aagattcgga
      841 gccagatggc ggctgtggag cctgagcgga cgccactgca gcgcaagctg gatgaatttg
      901 ggaggcagct gtcccatgcc atctctgtga tctgtgtggc tgtgtgggtc atcaacatcg
      961 gacactttgc tgacccggcc catggtggat cctggctccg tggggcagtc tactacttca
     1021 agattgctgt ggccctggct gtggctgcta tccccgaggg cctcccagca gtcatcacta
     1081 catgcctagc actgggcaca agacgtatgg cacgtaagaa cgccattgtg cggagcctgc
     1141 cctctgtgga gaccctgggc tgcacctcag tcatctgctc tgacaagaca gggacactca
     1201 ccaccaatca aatgtctgtc tgcaggatgt tcgtggtagc tgaagcagag gcaggcgcct
     1261 gtcgtttaca cgaattcacc atttcgggta ccacgtatac cccagagggc gaagtgaggc
     1321 aaggggaaca gcttgtgcgc tgtgggcagt ttgatggact tgtggagctc gcaaccatct
     1381 gtgcactctg caatgattct gcactggact acaatgaggc caagggtgtg tatgagaagg
     1441 taggagaggc cacagagaca gccctcactt gcctggtaga gaagatgaac gtgtttgaca
     1501 cagacctgaa aggactgtcg cgggtcgagc gcgctggtgc ctgcaattcc gtcatcaagc
     1561 aactcatgca gaaggagttc accctcgaat tctcccggga ccggaagtcc atgtctgtgt
     1621 actgcacacc cactcgtgct gaccccaagg cccagggcag caagatgttt gtgaagggag
     1681 ctcctgagag tgtaattgag cgctgcagct cagtccgcgt gggaagccga acagtacccc
     1741 taagcgccac ctccagagag catatcctgg ccaagatccg agactggggc tcaggctctc
     1801 atacattgcg ctgcttagca ctggccacca gggacacacc cccaaggaag gaggacatgc
     1861 aactggatga ctgcagtcag tttgtacagt acgagacagg cctgaccttc gtgggctgcg
     1921 tgggcatgtt agacccaccg agaccagagg tggctgcctg tatcacacgc tgttctcggg
     1981 cgggcattcg agtggtcatg atcacagggg acaacaaagg gacagctgtg gccatctgcc
     2041 gccgacttgg catctttggg gatacggagg atgtgttggg caaggcttac acgggccgag
     2101 aattcgatga cctcagccca gagcagcagc gccaggcttg ccgtaccgcc cgatgctttg
     2161 cccgtgtgga acccgcacat aagtctcgca tcgtggagaa cctccagtcc tttaatgaga
     2221 tcaccgccat gactggcgat ggggtgaatg atgcaccagc cctgaagaag gcagagatcg
     2281 gcatcgccat gggctcaggc actgctgtgg ccaagtcggc agcggagatg gttctgtctg
     2341 atgacaactt tgcctccatt gtggctgcag tggaggaggg cagggccatc tacaacaaca
     2401 tgaagcaatt catccgctac ctcatctcct ccaatgttgg cgaggttgtc tgcatcttcc
     2461 tcacagcaat tctgggcctg cccgaagccc tgatccctgt gcagctgctc tgggtgaacc
     2521 tggtaacaga tggcttacct gccacagccc ttggcttcaa cccacccgat ctggacatca
     2581 tggaaaagct gcctcggaac ccccgggagg ctctcatcag cggctggctt tttttccgct
     2641 atttggctat tggagtgtac gtaggcctgg ctacagtggc tgccgccacc tggtggttcc
     2701 tgtatgacgc tgagggacca caagtcacct tccatcagct gaggaacttc ctgaagtgct
     2761 ctgaagacaa tccactgttt gccggcatcg actgcgaggt ctttgagtca cgcttcccca
     2821 cgaccatggc cttatctgtg cttgtgacca ttgaaatgtg caacgccctt aacagcgtct
     2881 cagagaacca gtcactgctg cgtatgccac cctggctgaa cccttggctg ctgggggctg
     2941 tggtcatgtc catggccctg cattttctca tccttttggt gccgcctctg cccctcattt
     3001 tccaggtgac cccactgagt ggtcgacagt ggggggtggt gcttcagatg tctctgcctg
     3061 tcatcctgct tgacgaggcc ctcaagtatc tgtccaggca tcacgtggat gaaaaaaagg
     3121 acctgaagta aatcctgaga gcagaggggg gtctccagtt cggccctcgg actcatcatg
     3181 tccaagcact tgtcctggtc ccacccctgc ctcctcactc agccacctgt ctcctgctga
     3241 acgtaacagg cctgaaacaa caccggccat ttctaggccc tgttccaggg tcctgtctcc
     3301 attcctgtcc tccctacagc tctggcccag aagttgagcc caggagggga agctgagaag
     3361 ccagagctgc ctgaagggcc accacccatt tcccccacag atctgcagcc ttcccctgct
     3421 cggaggtggg catttgcttg gtagctagtg cctctgccct gatggagggc tcatgggggc
     3481 cgtcttactg actctgacct cttgcttagt ttgggtctgg agcctggtca gctctgggaa
     3541 ggaggagtcc gaggggacca tctgggtcca gctgtgaaca tgaggggcag ccccttccac
     3601 ttggctcagc ttccaccaag tccactcctg tgtctgttta tgtatctgct ggccccaggg
     3661 agttgaagga tcacagacag ataggaacat aaggagcagc gggggcaggc ctggacaagg
     3721 actcctttcc caggagtcag cctccactgg ctggctgggc tcagcactag tcccaccttg
     3781 aggctcactt cctcggctca ggttggctca gggatcctaa ctttacagtc catgcccctg
     3841 gtgcctgaga ctccaggcat ccctgggtcc atgtcagctt ctcctgccac gaagcctggg
     3901 gtgataccgt gtcacttgct gcagggctgg gtgattctaa acctcctgga cccctggcat
     3961 tactctttgc cctcttttcc tatcatgcat gtctgagtca gagagatgtc actaggaagt
     4021 gactccacaa tcctccccta cctccccact gaaaggaagc atctgatggg ggtctatcag
     4081 atgaatgtgt attggtcttt gggatctttt ttgcctctta accctgctgt tgctcctttg
     4141 acaaaagcta gctaagcatc atgggaaacg gagaaagcgc ctgtcagtgt gacttagctc
     4201 ttccctgact gtgtataata tgattatttt atatgtaaat caaggttcac atcactgtcc
     4261 tgacacctgg tagcaaaagt cccctcagcc tacccagaag acagatgaac tccatgtata
     4321 cctgcccact ctcctgccca tcctccctcc cctctggcag gttctggagg ggcctcagag
     4381 agaaaccgag tttggaggga tggcttggca ggaacagagc cctgtgccca cttgctgatc
     4441 atttcttgtg gagaaataaa ggcgtgcgtc tg
//
