LOCUS       NP_037046                999 aa            linear   ROD 03-APR-2024
DEFINITION  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [Rattus
            norvegicus].
ACCESSION   NP_037046
VERSION     NP_037046.1
DBSOURCE    REFSEQ: accession NM_012914.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 999)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 999)
  AUTHORS   Searls,Y.M., Loganathan,R., Smirnova,I.V. and Stehno-Bittel,L.
  TITLE     Intracellular Ca2+ regulating proteins in vascular smooth muscle
            cells are altered with type 1 diabetes due to the direct effects of
            hyperglycemia
  JOURNAL   Cardiovasc Diabetol 9, 8 (2010)
   PUBMED   20122173
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 999)
  AUTHORS   Brini,M. and Carafoli,E.
  TITLE     Calcium pumps in health and disease
  JOURNAL   Physiol Rev 89 (4), 1341-1378 (2009)
   PUBMED   19789383
  REMARK    Review article
REFERENCE   4  (residues 1 to 999)
  AUTHORS   Redondo,P.C., Salido,G.M., Pariente,J.A., Sage,S.O. and Rosado,J.A.
  TITLE     SERCA2b and 3 play a regulatory role in store-operated calcium
            entry in human platelets
  JOURNAL   Cell Signal 20 (2), 337-346 (2008)
   PUBMED   18068335
REFERENCE   5  (residues 1 to 999)
  AUTHORS   Chaabane,C., Corvazier,E., Bredoux,R., Dally,S., Raies,A.,
            Villemain,A., Dupuy,E., Enouf,J. and Bobe,R.
  TITLE     Sarco/endoplasmic reticulum Ca2+ATPase type 3 isoforms (SERCA3b and
            SERCA3f): distinct roles in cell adhesion and ER stress
  JOURNAL   Biochem Biophys Res Commun 345 (4), 1377-1385 (2006)
   PUBMED   16725111
REFERENCE   6  (residues 1 to 999)
  AUTHORS   Magnino,F., St-Pierre,M., Luthi,M., Hilly,M., Mauger,J.P. and
            Dufour,J.F.
  TITLE     Expression of intracellular calcium channels and pumps after
            partial hepatectomy in rat
  JOURNAL   Mol Cell Biol Res Commun 3 (6), 374-379 (2000)
   PUBMED   11032760
REFERENCE   7  (residues 1 to 999)
  AUTHORS   Martin,V., Bredoux,R., Corvazier,E., Papp,B. and Enouf,J.
  TITLE     Platelet Ca(2+)ATPases : a plural, species-specific, and multiple
            hypertension-regulated expression system
  JOURNAL   Hypertension 35 (1 Pt 1), 91-102 (2000)
   PUBMED   10642281
REFERENCE   8  (residues 1 to 999)
  AUTHORS   Poch,E., Leach,S., Snape,S., Cacic,T., MacLennan,D.H. and Lytton,J.
  TITLE     Functional characterization of alternatively spliced human SERCA3
            transcripts
  JOURNAL   Am J Physiol 275 (6), C1449-C1458 (1998)
   PUBMED   9843705
REFERENCE   9  (residues 1 to 999)
  AUTHORS   Dode,L., Wuytack,F., Kools,P.F., Baba-Aissa,F., Raeymaekers,L.,
            Brike,F., van de Ven,W.J. and Casteels,R.
  TITLE     cDNA cloning, expression and chromosomal localization of the human
            sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene
  JOURNAL   Biochem J 318 (Pt 2) (Pt 2), 689-699 (1996)
   PUBMED   8809064
  REMARK    Erratum:[Biochem J 1996 Nov 1;319(Pt 3):1008. Brik F [corrected to
            Brike F]]
REFERENCE   10 (residues 1 to 999)
  AUTHORS   Burk,S.E., Lytton,J., MacLennan,D.H. and Shull,G.E.
  TITLE     cDNA cloning, functional expression, and mRNA tissue distribution
            of a third organellar Ca2+ pump
  JOURNAL   J Biol Chem 264 (31), 18561-18568 (1989)
   PUBMED   2553713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M30581.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M30581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..999
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     Protein         1..999
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 3"
                     /EC_number="7.2.2.10"
                     /note="calcium pump 3; SR Ca(2+)-ATPase 3; ATPase, Ca++
                     transporting, ubiquitous"
                     /calculated_mol_wt=109229
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q93084; propagated from
                     UniProtKB/Swiss-Prot (P18596.3)"
     Region          5..989
                     /region_name="P-type_ATPase_SERCA"
                     /note="sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA),
                     similar to mammalian ATP2A1-3/SERCA1-3; cd02083"
                     /db_xref="CDD:319778"
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q64518; propagated from
                     UniProtKB/Swiss-Prot (P18596.3)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q64518; propagated from
                     UniProtKB/Swiss-Prot (P18596.3)"
     Site            49..69
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            90..110
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            254..273
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            296..313
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            order(309,796,800)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Site            order(351..353,442,487,489,492,494,515..517,560,562,
                     625..627,678,684,703,706)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:319778"
     Region          370..400
                     /region_name="Interaction with phospholamban 1.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q64518; propagated from
                     UniProtKB/Swiss-Prot (P18596.3)"
     Site            662
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q93084; propagated from
                     UniProtKB/Swiss-Prot (P18596.3)"
     Site            758..777
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            order(768,771,799..800,908)
                     /site_type="other"
                     /note="Ca binding site [ion binding]"
                     /db_xref="CDD:319778"
     Region          788..808
                     /region_name="Interaction with phospholamban 2.
                     /evidence=ECO:0000250|UniProtKB:P04191"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            788..808
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            829..851
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            898..917
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            931..949
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     Site            965..985
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P18596.3)"
     CDS             1..999
                     /gene="Atp2a3"
                     /gene_synonym="SERCA3"
                     /coded_by="NM_012914.1:132..3131"
                     /db_xref="GeneID:25391"
                     /db_xref="RGD:2175"
ORIGIN      
        1 meeahllsaa dvlrrfsvta eggltleqvt darerygpne lpteegkslw elvveqfedl
       61 lvrilllaal vsfvlawfee geetttafve plvimlilva naivgvwqer naesaiealk
      121 eyepemgkvi rsdrkgvqri rardivpgdi vevavgdkvp adlrlieiks ttlrvdqsil
      181 tgesvsvtkh tdaipdprav nqdkknmlfs gtniasgkal gvavatglht elgkirsqma
      241 avepertplq rkldefgrql shaisvicva vwvinighfa dpahggswlr gavyyfkiav
      301 alavaaipeg lpavittcla lgtrrmarkn aivrslpsve tlgctsvics dktgtlttnq
      361 msvcrmfvva eaeagacrlh eftisgttyt pegevrqgeq lvrcgqfdgl velaticalc
      421 ndsaldynea kgvyekvgea tetaltclve kmnvfdtdlk glsrveraga cnsvikqlmq
      481 keftlefsrd rksmsvyctp tradpkaqgs kmfvkgapes viercssvrv gsrtvplsat
      541 srehilakir dwgsgshtlr clalatrdtp prkedmqldd csqfvqyetg ltfvgcvgml
      601 dpprpevaac itrcsragir vvmitgdnkg tavaicrrlg ifgdtedvlg kaytgrefdd
      661 lspeqqrqac rtarcfarve pahksriven lqsfneitam tgdgvndapa lkkaeigiam
      721 gsgtavaksa aemvlsddnf asivaaveeg raiynnmkqf irylissnvg evvcifltai
      781 lglpealipv qllwvnlvtd glpatalgfn ppdldimekl prnprealis gwlffrylai
      841 gvyvglatva aatwwflyda egpqvtfhql rnflkcsedn plfagidcev fesrfpttma
      901 lsvlvtiemc nalnsvsenq sllrmppwln pwllgavvms malhflillv pplplifqvt
      961 plsgrqwgvv lqmslpvill dealkylsrh hvdekkdlk
//
