LOCUS       NM_001110823            4471 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+
            transporting 2 (Atp2a2), transcript variant 3, mRNA.
ACCESSION   NM_001110823 XM_001079470
VERSION     NM_001110823.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4471)
  AUTHORS   Chen,W., Li,M., Lei,X., Cheng,Y., Wu,X., Sun,X., Wu,Y., Li,Z.,
            Luo,G. and Wei,M.
  TITLE     Remote ischemic postconditioning alleviates cerebral ischemic
            injury through SERCA2/endoplasmic reticulum stress-mediated
            apoptosis
  JOURNAL   Microsc Res Tech 87 (3), 424-433 (2024)
   PUBMED   37897375
  REMARK    GeneRIF: Remote ischemic postconditioning alleviates cerebral
            ischemic injury through SERCA2/endoplasmic reticulum
            stress-mediated apoptosis.
REFERENCE   2  (bases 1 to 4471)
  AUTHORS   Gomez-Viquez,N.L., Balderas-Villalobos,J., Bello-Sanchez,M.D.,
            Mayorga-Luna,M., Mailloux-Salinas,P., Garcia-Castaneda,M.,
            Rios-Perez,E.B., Martinez-Avila,M.A., Camacho-Castillo,L.D.C.,
            Bravo,G., Avila,G., Altamirano,J. and Carvajal,K.
  TITLE     Oxidative stress in early metabolic syndrome impairs cardiac RyR2
            and SERCA2a activity and modifies the interplay of these proteins
            during Ca2+ waves
  JOURNAL   Arch Physiol Biochem 129 (5), 1058-1070 (2023)
   PUBMED   33689540
  REMARK    GeneRIF: Oxidative stress in early metabolic syndrome impairs
            cardiac RyR2 and SERCA2a activity and modifies the interplay of
            these proteins during Ca[2+] waves.
REFERENCE   3  (bases 1 to 4471)
  AUTHORS   Hu,T. and Liu,L.
  TITLE     Effects of MiR-214-3p Regulation of SERCA2a Expression on
            Contractility of Cardiomyocytes in Heart Failure Model
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (4), 208-216 (2022)
   PUBMED   35988281
  REMARK    GeneRIF: Effects of MiR-214-3p Regulation of SERCA2a Expression on
            Contractility of Cardiomyocytes in Heart Failure Model.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4471)
  AUTHORS   Chen,J., Liu,Y., Pan,D., Xu,T., Luo,Y., Wu,W., Wu,P., Zhu,H. and
            Li,D.
  TITLE     Estrogen inhibits endoplasmic reticulum stress and ameliorates
            myocardial ischemia/reperfusion injury in rats by upregulating
            SERCA2a
  JOURNAL   Cell Commun Signal 20 (1), 38 (2022)
   PUBMED   35331264
  REMARK    GeneRIF: Estrogen inhibits endoplasmic reticulum stress and
            ameliorates myocardial ischemia/reperfusion injury in rats by
            upregulating SERCA2a.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4471)
  AUTHORS   Celestino-Montes,A., Perez-Trevino,P., Sandoval-Herrera,M.D.,
            Gomez-Viquez,N.L. and Altamirano,J.
  TITLE     Relative role of T-tubules disruption and decreased SERCA2 on
            contractile dynamics of isolated rat ventricular myocytes
  JOURNAL   Life Sci 264, 118700 (2021)
   PUBMED   33130073
  REMARK    GeneRIF: Relative role of T-tubules disruption and decreased SERCA2
            on contractile dynamics of isolated rat ventricular myocytes.
REFERENCE   6  (bases 1 to 4471)
  AUTHORS   Harrer,J.M., Haghighi,K., Kim,H.W., Ferguson,D.G. and Kranias,E.G.
  TITLE     Coordinate regulation of SR Ca(2+)-ATPase and phospholamban
            expression in developing murine heart
  JOURNAL   Am J Physiol 272 (1 Pt 2), H57-H66 (1997)
   PUBMED   9038922
REFERENCE   7  (bases 1 to 4471)
  AUTHORS   Wu,K.D. and Lytton,J.
  TITLE     Molecular cloning and quantification of sarcoplasmic reticulum
            Ca(2+)-ATPase isoforms in rat muscles
  JOURNAL   Am J Physiol 264 (2 Pt 1), C333-C341 (1993)
   PUBMED   8447366
  REMARK    Erratum:[Am J Physiol 1994 Jul;267(1 Pt 1):section C followi]
REFERENCE   8  (bases 1 to 4471)
  AUTHORS   Lompre,A.M., de la Bastie,D., Boheler,K.R. and Schwartz,K.
  TITLE     Characterization and expression of the rat heart sarcoplasmic
            reticulum Ca2+-ATPase mRNA
  JOURNAL   FEBS Lett 249 (1), 35-41 (1989)
   PUBMED   2542094
REFERENCE   9  (bases 1 to 4471)
  AUTHORS   Komuro,I., Kurabayashi,M., Shibazaki,Y., Takaku,F. and Yazaki,Y.
  TITLE     Molecular cloning and characterization of a Ca2+ + Mg2+-dependent
            adenosine triphosphatase from rat cardiac sarcoplasmic reticulum.
            Regulation of its expression by pressure overload and developmental
            stage
  JOURNAL   J Clin Invest 83 (4), 1102-1108 (1989)
   PUBMED   2522936
REFERENCE   10 (bases 1 to 4471)
  AUTHORS   Gunteski-Hamblin,A.M., Greeb,J. and Shull,G.E.
  TITLE     A novel Ca2+ pump expressed in brain, kidney, and stomach is
            encoded by an alternative transcript of the slow-twitch muscle
            sarcoplasmic reticulum Ca-ATPase gene. Identification of cDNAs
            encoding Ca2+ and other cation-transporting ATPases using an
            oligonucleotide probe derived from the ATP-binding site
  JOURNAL   J Biol Chem 263 (29), 15032-15040 (1988)
   PUBMED   2844797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            J04022.1, BE119640.1, J04024.1, CK356454.1, CK358684.1 and
            AA900747.1.
            
            On Jun 20, 2009 this sequence version replaced NM_001110823.1.
            
            Transcript Variant: This variant (3) encodes the longer isoform
            (b), also known as SERCA2B.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04024.1, J04022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 J04022.1           1-4
            5-268               BE119640.1         94-357              c
            269-1084            J04024.1           1-816
            1085-1767           CK356454.1         44-726
            1768-2857           J04024.1           1500-2589
            2858-3486           CK358684.1         43-671
            3487-4169           J04024.1           3219-3901
            4170-4471           AA900747.1         1-302               c
FEATURES             Location/Qualifiers
     source          1..4471
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..4471
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /note="ATPase sarcoplasmic/endoplasmic reticulum Ca2+
                     transporting 2"
                     /db_xref="GeneID:29693"
                     /db_xref="RGD:2174"
     exon            1..624
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..3638
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /EC_number="7.2.2.10"
                     /note="isoform b is encoded by transcript variant 3;
                     ATPase, Ca++ transporting, slow twitch 2;
                     sarcoplasmic/endoplasmic reticulum calcium ATPase 2;
                     calcium pump 2; SR Ca(2+)-ATPase 2; endoplasmic reticulum
                     class 1/2 Ca(2+) ATPase; sarco(endo)plasmic reticulum
                     Ca(2+)-dependent ATPase 2; ATPase, Ca++ transporting,
                     cardiac muscle, slow twitch 2"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 2 isoform b"
                     /protein_id="NP_001104293.1"
                     /db_xref="GeneID:29693"
                     /db_xref="RGD:2174"
                     /translation="MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAE
                     EGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVEPFVILLILVANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVP
                     ADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINI
                     GHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFTITGSTYAPI
                     GEVQKDDKPVKCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
                     KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSM
                     SKMFVKGAPEGVIDRCTHIRVGSTKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATH
                     DNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMIT
                     GDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELSPSAQRDACLNARCFARVEPSH
                     KSKIVEFLQSFDEITAMTGDGVNDAPALKKSEIGIAMGSGTAVAKTASEMVLADDNFS
                     TIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVT
                     DGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFI
                     AADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNS
                     LSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNLTQWLMVLKI
                     SLPVILMDETLKFVARNYLEPGKECAQPATKPSCSLSACTDGISWPFVLLIMPLVVWV
                     YSTDTNFSDMFWS"
     exon            625..642
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            643..725
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            726..830
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            831..969
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1050
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1136
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1601
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1690
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1793
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1925
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2048
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2267
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2603
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2824
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3027
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            3028..3113
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3247
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            3248..3365
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
     exon            3366..4455
                     /gene="Atp2a2"
                     /gene_synonym="Serca2; SercaII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccgtc cccgacgcca cctcccgtct cctccgccgc agtttcctcc gccgctgtcg
       61 ggggtgcaga gctgaggggc tcgggcaggc gcgccgcgca gctcctctcc agtcgcccgc
      121 ctcgccgtcc tccccaccga gggctcgccc gggcgcccct cctcagccgc gccgggtctc
      181 ctcagcgcag cgccgcggcc tgcgctacct gcggccggct ggcaacagag gcaacgcaca
      241 ctcgcggcgg ggcgggaggc tcgcagcccc tcgggcgggc tcggcgaggc ccggccgcgt
      301 gcggcggttt ctgggggagg gggctcgggt gattcagcgc ccggtcaggc ggaagcggcc
      361 gccgccgcgg aggaggagga gaaagaggag gggacagctg tccgcgcccg ggcgcccgcg
      421 gtggcacgag cccgcggccc gagtgcgagg cggaggcgag gaggccgcgg ggacgcgagg
      481 cgaggccggc cggggccccc gcagccatgg agaacgctca cacaaagacc gtggaggagg
      541 tgctgggcca cttcggcgtc aacgagagca cggggctgag cctggagcag gtcaagaagc
      601 tcaaggagag atggggctcc aacgaattgc cggctgaaga aggaaagacc ttgctggaac
      661 ttgtgatcga gcagtttgaa gacttactag ttagaatttt attgctggca gcatgtatat
      721 ctttcgtttt ggcttggttc gaagaaggtg aagaaacgat tacagccttt gtagaacctt
      781 ttgtaattct gcttatattg gtagccaatg caattgtggg tgtatggcag gagagaaacg
      841 ctgaaaatgc aatagaagct cttaaggagt atgaacctga aatgggcaag gtgtatcgac
      901 aggacagaaa gagtgtgcag cggattaaag cgaaagatat agttcctggg gatatagtgg
      961 aaattgctgt tggtgacaaa gttccggctg acattagatt gacatccatc aagtctacaa
     1021 ctctgagagt tgaccagtcg attcttacag gtgaatctgt ctcggtcatc aagcatactg
     1081 accctgtccc tgacccacga gctgttaatc aagacaaaaa gaacatgctc ttttctggca
     1141 caaacatcgc tgctggcaaa gctatgggag tggtggtggc gactggagtc aatactgaga
     1201 tcggcaagat ccgggatgaa atggttgcaa cagaacagga gagaacaccc ctacagcaga
     1261 agctggacga gtttggggaa cagctttcca aagttatctc cctcatttgc attgcagtct
     1321 ggatcatcaa catcgggcat ttcaatgacc cagttcatgg tggctcttgg atcagaggtg
     1381 ccatctacta ctttaagatt gcagtggccc tggctgttgc tgccatccct gagggtctgc
     1441 ctgctgtcat caccacctgc ttggctcttg gaactcgaag gatggcaaag aaaaatgcta
     1501 ttgttcgaag tctgccttct gtggaaaccc ttggttgtac ttctgttatc tgctcagaca
     1561 agaccggcac acttaccaca aaccagatgt ccgtctgcag gatgttcatt ctggacaaag
     1621 tagaaggtga tacttgttcc cttaatgagt ttaccataac tggatcaacc tatgcaccca
     1681 ttggagaagt gcaaaaagat gacaagccag tgaaatgcca tcagtatgac gggcttgtag
     1741 agttagcaac gatctgtgct ctgtgtaatg actctgcttt ggattacaat gaggcgaagg
     1801 gtgtgtatga aaaagttgga gaagccacag agactgctct cacgtgcctg gtagagaaga
     1861 tgaatgtatt cgacacggag ctgaagggac tttctaaaat agaacgcgcc aacgcctgca
     1921 actcggtcat aaaacagctc atgaagaagg aattcacgct agagttttca cgtgatagaa
     1981 aatcaatgtc cgtctactgt acaccaaaca aaccgagccg gacgtccatg agcaagatgt
     2041 ttgtgaaggg tgctccagaa ggtgtcatcg acaggtgcac ccacatccga gttggaagta
     2101 ccaaggtccc catgacgcct ggtgttaaac agaagattat gtctgtcatt cgggagtggg
     2161 gcagtggcag cgacacactg cggtgcctgg ctctggccac tcatgacaac ccgctgagga
     2221 gagaggagat gcacctggaa gattctgcga acttcatcaa atatgagacc aatctgactt
     2281 tcgttggctg tgtgggcatg ctggaccctc ccaggattga agtggcctct tctgtgaagc
     2341 tgtgccggca agcgggcatc cgagtcatca tgatcactgg ggataacaaa ggcactgctg
     2401 tggccatctg tcgccgcatt ggcatctttg ggcaggatga ggatgtgaca tcaaaggctt
     2461 ttacagggcg agaatttgat gaattaagcc cctcagccca gagagacgcc tgcttaaatg
     2521 cccgttgttt tgctcgagtt gaaccttccc acaagtctaa gatcgttgag ttcctgcagt
     2581 cctttgatga gatcacagct atgactggtg atggtgtgaa cgacgcgccc gctctgaaga
     2641 agtcggaaat cgggattgcc atgggctcag ggactgcagt ggctaagacg gcctctgaga
     2701 tggtgctggc cgacgacaac ttctccacca tcgtggccgc tgttgaggag gggcgcgcca
     2761 tctacaacaa catgaagcag ttcatccgct acctcatctc ctccaacgtg ggggaggtgg
     2821 tctgtatctt cctgacggca gcccttgggt ttcctgaagc tttgattcct gtccagttac
     2881 tctgggtcaa tctggtgacg gatggtctgc ctgccactgc gctggggttc aatcctccag
     2941 atctggacat catgaacaaa cccccacgga acccaaaaga accgctgatc agcgggtggc
     3001 tctttttccg ttacctggct attggctgtt atgttggcgc tgccaccgtg ggtgctgctg
     3061 cgtggtggtt catcgctgct gacggtggtc cgagagtctc cttctaccag ctgagtcatt
     3121 tcctgcagtg taaggaggac aacccagact tcgaaggagt ggattgtgca atctttgagt
     3181 ccccgtatcc gatgacaatg gcactttctg ttctagtcac catagagatg tgcaatgccc
     3241 tcaacagctt gtctgaaaac cagtccctgc tgaggatgcc cccctgggag aacatctggc
     3301 tcgtgggctc catctgcttg tccatgtccc ttcacttctt gatcctctac gtggaacctt
     3361 tgccactcat tttccagatc acaccgctga atctgaccca gtggctgatg gtgctgaaaa
     3421 tctccctgcc tgtgatcctc atggacgaga cgctcaagtt tgtggcccga aactacctgg
     3481 agcctggtaa agagtgtgcg cagcctgcca ccaaaccctc ctgctccctg tcggcatgca
     3541 ccgacggcat ttcctggccc tttgtgctgc tcattatgcc cctggtggtc tgggtctaca
     3601 gcacagacac taactttagt gatatgttct ggtcttgact gacagcgcta catgcagaag
     3661 atgtttaact taatcaatta attttttatt gtttaaagca actgtctatt tctgctgaat
     3721 tttcacatga acatattggc tggtgaagga ggtttcatat ctagattttg ttttgctttt
     3781 tctgactcca gtgggacaag attttccttt tttttataca cataattaaa gtgtccattg
     3841 acatgtacag agaactaaca ctattttatg cagatatttt tttgtagatg aaaaaagcat
     3901 gtacagtgtt ctgtttcata ctcatacttg tacaaagatc gttgagccag cagacattgt
     3961 cagcaagtta attggcagca gacttaggaa atgaatgtgt gtggttttta aaagaaaaaa
     4021 aactaaatag catgtattgt gtcttttgca tgattctctg gatttaattt ggtatcacag
     4081 tctaattttt attcataagc caatttttct gcactgagca gagtcctgct acctcagtca
     4141 gtatttttgg tttgccactc cctgcaccct cagcctctgt cacccccagc ccaccctggc
     4201 ccgctcggct gcttctgtag gtctgatggt tctgtttaca tctgtcttca cgaggtttgc
     4261 ctgtctcgct tgtgcagaaa acattgctcc agatccaatc gactgggttt ctgtcccttc
     4321 gcctagtttt taaggttatt tatttaaatg tctaatgtat tttattgtaa cagacattgt
     4381 tttgccaaca ttgcctattc agtggcactt cacaatctag tttaaaagaa aaataaaaca
     4441 ttttaaatgg acagaaaaaa aaaaaaaaaa a
//
