LOCUS       NM_058213               3456 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus ATPase sarcoplasmic/endoplasmic reticulum Ca2+
            transporting 1 (Atp2a1), mRNA.
ACCESSION   NM_058213
VERSION     NM_058213.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Zhang,J., Liu,H., Li,S., Wu,J. and Sun,J.
  TITLE     SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in
            rats with acute sepsis
  JOURNAL   Mol Med Rep 16 (4), 5015-5022 (2017)
   PUBMED   28765908
  REMARK    GeneRIF: In acute stages of sepsis, the improvement of SERCA
            function could reduce the disequilibrium of calcium homeostasis to
            improve the critical illness myopathy and respiratory failure.
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Stancic,A., Filipovic,M., Ivanovic-Burmazovic,I., Masovic,S.,
            Jankovic,A., Otasevic,V., Korac,A., Buzadzic,B. and Korac,B.
  TITLE     Early energy metabolism-related molecular events in skeletal muscle
            of diabetic rats: The effects of l-arginine and SOD mimic
  JOURNAL   Chem Biol Interact 272, 188-196 (2017)
   PUBMED   28483572
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Ambrosius,B., Pitarokoili,K., Schrewe,L., Pedreiturria,X., Motte,J.
            and Gold,R.
  TITLE     Fingolimod attenuates experimental autoimmune neuritis and
            contributes to Schwann cell-mediated axonal protection
  JOURNAL   J Neuroinflammation 14 (1), 92 (2017)
   PUBMED   28446186
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Anderson,D.M., Makarewich,C.A., Anderson,K.M., Shelton,J.M.,
            Bezprozvannaya,S., Bassel-Duby,R. and Olson,E.N.
  TITLE     Widespread control of calcium signaling by a family of
            SERCA-inhibiting micropeptides
  JOURNAL   Sci Signal 9 (457), ra119 (2016)
   PUBMED   27923914
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3456)
  AUTHORS   Zhang,J.Y., Wu,J., Li,S.T. and Gong,Y.
  TITLE     [Lowered sarcoendoplasmic reticulum calcium uptake and
            diaphragmatic SERCA1 expression contribute to diaphragmatic
            contractile and relaxation dysfunction in septic rats]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 37 (4), 438-443 (2016)
   PUBMED   28446393
REFERENCE   6  (bases 1 to 3456)
  AUTHORS   Odermatt,A., Taschner,P.E., Khanna,V.K., Busch,H.F., Karpati,G.,
            Jablecki,C.K., Breuning,M.H. and MacLennan,D.H.
  TITLE     Mutations in the gene-encoding SERCA1, the fast-twitch skeletal
            muscle sarcoplasmic reticulum Ca2+ ATPase, are associated with
            Brody disease
  JOURNAL   Nat Genet 14 (2), 191-194 (1996)
   PUBMED   8841193
REFERENCE   7  (bases 1 to 3456)
  AUTHORS   Benders,A.A., Wevers,R.A. and Veerkamp,J.H.
  TITLE     Ion transport in human skeletal muscle cells: disturbances in
            myotonic dystrophy and Brody's disease
  JOURNAL   Acta Physiol Scand 156 (3), 355-367 (1996)
   PUBMED   8729696
REFERENCE   8  (bases 1 to 3456)
  AUTHORS   Benders,A.A., Veerkamp,J.H., Oosterhof,A., Jongen,P.J.,
            Bindels,R.J., Smit,L.M., Busch,H.F. and Wevers,R.A.
  TITLE     Ca2+ homeostasis in Brody's disease. A study in skeletal muscle and
            cultured muscle cells and the effects of dantrolene an verapamil
  JOURNAL   J Clin Invest 94 (2), 741-748 (1994)
   PUBMED   8040329
REFERENCE   9  (bases 1 to 3456)
  AUTHORS   Wu,K.D. and Lytton,J.
  TITLE     Molecular cloning and quantification of sarcoplasmic reticulum
            Ca(2+)-ATPase isoforms in rat muscles
  JOURNAL   Am J Physiol 264 (2 Pt 1), C333-C341 (1993)
   PUBMED   8447366
  REMARK    Erratum:[Am J Physiol 1994 Jul;267(1 Pt 1):section C followi]
REFERENCE   10 (bases 1 to 3456)
  AUTHORS   Benders,A.G., van Kuppevelt,T.H., Oosterhof,A., Wevers,R.A. and
            Veerkamp,J.H.
  TITLE     Adenosine triphosphatases during maturation of cultured human
            skeletal muscle cells and in adult human muscle
  JOURNAL   Biochim Biophys Acta 1112 (1), 89-98 (1992)
   PUBMED   1329967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_058213.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99223.1, BC168245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-282               JAXUCZ010000001.1  190475129-190475410 c
            283-300             JAXUCZ010000001.1  190474818-190474835 c
            301-383             JAXUCZ010000001.1  190474398-190474480 c
            384-488             JAXUCZ010000001.1  190472906-190473010 c
            489-627             JAXUCZ010000001.1  190471504-190471642 c
            628-708             JAXUCZ010000001.1  190469836-190469916 c
            709-794             JAXUCZ010000001.1  190469043-190469128 c
            795-1092            JAXUCZ010000001.1  190468606-190468903 c
            1093-1259           JAXUCZ010000001.1  190468060-190468226 c
            1260-1348           JAXUCZ010000001.1  190465231-190465319 c
            1349-1451           JAXUCZ010000001.1  190464900-190465002 c
            1452-1583           JAXUCZ010000001.1  190464528-190464659 c
            1584-1709           JAXUCZ010000001.1  190461898-190462023 c
            1710-1928           JAXUCZ010000001.1  190461577-190461795 c
            1929-2264           JAXUCZ010000001.1  190459889-190460224 c
            2265-2485           JAXUCZ010000001.1  190459518-190459738 c
            2486-2688           JAXUCZ010000001.1  190459218-190459420 c
            2689-2774           JAXUCZ010000001.1  190458944-190459029 c
            2775-2908           JAXUCZ010000001.1  190458724-190458857 c
            2909-3026           JAXUCZ010000001.1  190458462-190458579 c
            3027-3144           JAXUCZ010000001.1  190458191-190458308 c
            3145-3186           JAXUCZ010000001.1  190457869-190457910 c
            3187-3456           JAXUCZ010000001.1  190457198-190457467 c
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3456
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /note="ATPase sarcoplasmic/endoplasmic reticulum Ca2+
                     transporting 1"
                     /db_xref="GeneID:116601"
                     /db_xref="RGD:621293"
     exon            1..282
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3149
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /EC_number="7.2.2.10"
                     /note="calcium pump 1; ATPase, Ca++ transporting, cardiac
                     muscle, fast twitch 1; SR Ca(2+)-ATPase 1;
                     sarco/endoplasmic reticulum calcium ATPase 1;
                     sarco/endoplasmic reticulum calcium ATPase 1a;
                     sarco/endoplasmic reticulum calcium ATPase 1b; endoplasmic
                     reticulum class 1/2 Ca(2+) ATPase"
                     /codon_start=1
                     /product="sarcoplasmic/endoplasmic reticulum calcium
                     ATPase 1"
                     /protein_id="NP_478120.1"
                     /db_xref="GeneID:116601"
                     /db_xref="RGD:621293"
                     /translation="MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAE
                     EGKSLWELVVEQFEDLLVRILLLAACISFVLAWFEEGEETVTAFVEPFVILLILIANA
                     IVGVWQERNAENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVP
                     ADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGK
                     AVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQLSKVISLICVAVWLINI
                     GHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVR
                     SLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDICSLNEFSITGSTYAPE
                     GEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVE
                     KMNVFNTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAV
                     GNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALAT
                     RDTPPKREEMVLDDSAKFMEYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMI
                     TGDNKGTAIAICRRIGIFSENEEVADRAYTGREFDDLPLAEQREACRRACCFARVEPS
                     HKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNF
                     STIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLV
                     TDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAATVGAAAWWF
                     LYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMCNALN
                     SLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLK
                     ISLPVIGLDELLKFIARNYLEG"
     exon            283..300
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..383
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..488
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..627
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..708
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..794
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1092
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1259
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1348
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1451
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1583
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1709
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1928
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2264
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2485
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2688
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2774
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2908
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..3026
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3144
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3145..3186
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3456
                     /gene="Atp2a1"
                     /gene_synonym="Serca1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggggtcaga acttcgtgga aaggagaaga atctgggggg gcaagcaaga aaaaggaagg
       61 agcccaggtt aacaggcagg tggatacact gaagaagtcc ccccacaagt gagaggcccc
      121 taagaaggaa tacatcaccc cctggccccc aagaagggag cagaatggag gccgcacact
      181 ccaagtccac agaggaatgt ttgtcctatt ttggggtgag cgagaccaca ggccttaccc
      241 cagaccaagt taagcggcat ctggaaaaat acggccccaa tgagctccct gctgaggaag
      301 gcaagtctct gtgggagttg gtggtagagc agttcgaaga cctgctggtg cggattctcc
      361 tcctggctgc ctgcatttcc tttgtgctgg cctggtttga ggaaggtgag gaaactgtca
      421 ctgcctttgt ggagcctttt gtcattctct tgatcctcat tgccaacgcc attgtggggg
      481 tttggcagga acggaatgca gagaatgcca tcgaggcgct gaaggaatat gaacccgaga
      541 tggggaaggt ctatcgggct gaccgaaagt cagtgcaaag gatcaaggct cgggacatcg
      601 tccctgggga cattgtggag gtggctgttg gggacaaagt ccctgcagac atccgaatcc
      661 tctccatcaa atccaccacc ctccgggtcg accagtccat cctgacagga gagtctgtat
      721 ctgtcatcaa gcacacagac cctgtccctg atccccgagc tgtcaaccag gacaagaaga
      781 acatgctctt ctcgggtacc aacattgcag ccggcaaggc cgtaggcatc gtggccacca
      841 ctggtgtgag tactgagatt ggcaagatcc gagaccaaat ggctgccact gagcaggaca
      901 agaccccgct tcagcagaag cttgatgagt ttggggaaca gctgtccaag gtcatctctc
      961 tcatctgtgt ggctgtctgg cttatcaaca ttggtcactt caacgaccct gtccatgggg
     1021 gctcctggtt ccggggggcc atttactact tcaagattgc tgtagccttg gctgtggcag
     1081 ccatcccaga agggcttcct gctgtcatca ccacctgctt ggccttgggt acccgccgga
     1141 tggcaaagaa gaacgccatc gtgaggagtt tgccctctgt ggagaccctg ggctgtacct
     1201 ctgtcatctg ttctgacaaa acagggaccc tcaccaccaa ccagatgtca gtttgcaaga
     1261 tgttcatcat tgacaaagtg gatggggata tctgctcact gaacgagttc tccatcactg
     1321 gctctactta tgctcctgag ggagaagttt tgaagaatga taagccagtc cgagcagggc
     1381 agtatgacgg gctggtggaa cttgctacca tctgtgccct ctgcaatgac tcctccttgg
     1441 actttaatga gaccaaaggt gtctatgaga aggtgggcga ggccaccgag acagccctca
     1501 ccaccttggt ggagaagatg aatgtgttca acacggaagt gagaagcctc tccaaagtgg
     1561 agcgggctaa tgcctgcaac tcggtgatcc gccaactaat gaagaaggaa ttcaccctgg
     1621 aattttcccg agacaggaag tctatgtctg tctactgctc cccagccaag tcttcacggg
     1681 ctgctgtagg caacaagatg tttgtcaagg gtgcccctga gggcgtcatt gaccgctgta
     1741 actatgtgcg tgttggcaca acccgtgtgc cactgacagg ccctgtgaag gagaagatca
     1801 tgtcggtgat caaggagtgg ggtactggtc gggataccct acggtgcctg gcactggcca
     1861 cccgggacac accccccaaa cgggaggaaa tggttctgga tgactcagcc aagttcatgg
     1921 agtatgagat ggacctgacg tttgttggtg tggtgggcat gttggatcca ccccgtaagg
     1981 aggtcacagg ctctatccag ctgtgtcgtg atgccgggat ccgagtgatc atgatcactg
     2041 gggacaacaa gggtaccgcc atcgccatct gccgacgaat tggcatcttt tcggagaatg
     2101 aggaagtggc agaccgtgcc tacactggcc gtgagtttga tgatctgccc ctggctgagc
     2161 agcgggaagc ctgcagacgc gcctgctgct tcgctcgtgt ggagccctca cataagtcca
     2221 agattgtgga gtacctgcag tcctatgatg agatcacagc catgacaggg gatggtgtca
     2281 atgatgcccc tgctctgaag aaggcggaga ttggcattgc catgggatct ggtactgctg
     2341 tggctaagac tgcctccgag atggtactgg ctgatgataa cttctccacc attgtggctg
     2401 ccgtggagga aggccgtgcc atctacaaca acatgaagca gttcatccgc tacctcattt
     2461 cctccaatgt gggcgaggtg gtctgtatct tcttgacagc agccttgggg ctgcctgagg
     2521 ccttgatccc tgtgcagctg ctatgggtga acttggtgac tgatgggctc cctgctactg
     2581 ccctggggtt caacccacct gacctggaca tcatggaccg tccccccagg agtcccaagg
     2641 agcctcttat cagtggctgg ctctttttcc gctacatggc aattgggggc tacgtgggtg
     2701 cagccactgt gggagcagct gcctggtggt tcttgtatgc agaggatggg cctcatgtca
     2761 gctaccatca actgactcat ttcatgcagt gcactgagca taaccctgaa tttgatggcc
     2821 tggactgcga ggtctttgaa gcccccgagc ccatgaccat ggccttgtct gtgttggtga
     2881 ccatcgagat gtgcaacgcc ctcaacagcc tgtctgagaa ccagtcccta ctgcggatgc
     2941 cgccctgggt gaacatctgg cttctcggtt ccatctgcct gtccatgtcc ctccacttcc
     3001 tcatcctcta tgttgacccc ctgccgatga tcttcaagct ccgggccctg gactttaccc
     3061 agtggctcat ggtcctcaag atctcacttc cagtcatcgg gctagatgag cttctcaagt
     3121 tcattgctcg gaactatctg gagggataac cacccccctc ctccatgtct ttgaaccgtg
     3181 tcacagatcc agaagacgaa agaaggaagt aaccagccct tgtgccctgt cttccccacc
     3241 ctaatggcaa ggcgtcttca gccaaagctg aagcacagag ccttcttccc cttgattctg
     3301 tttataaata aagttcccca ccctcgtccc cttcagcaac ctgctctccc tctgaacctt
     3361 gtaaatcccc ttcccgacct cacgacctca cggggcttac agggacaagg caactagctg
     3421 actgcttatt tattgaaaat aaatgacaga aaagtc
//
