LOCUS       NM_053381               4175 bp    mRNA    linear   ROD 19-JUL-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting family member beta 4
            (Atp1b4), transcript variant 2, mRNA.
ACCESSION   NM_053381
VERSION     NM_053381.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4175)
  AUTHORS   Pestov,N.B., Ahmad,N., Korneenko,T.V., Zhao,H., Radkov,R.,
            Schaer,D., Roy,S., Bibert,S., Geering,K. and Modyanov,N.N.
  TITLE     Evolution of Na,K-ATPase beta m-subunit into a coregulator of
            transcription in placental mammals
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11215-11220 (2007)
   PUBMED   17592128
  REMARK    GeneRIF: Eutherian Atp1b4 has lost its ancestral function as a
            Na,K-ATPase beta-subunit and associates with transcriptional
            coregulator Ski-interacting protein (SKIP).
REFERENCE   2  (bases 1 to 4175)
  AUTHORS   Zhao,H., Pestov,N.B., Korneenko,T.V., Shakhparonov,M.I. and
            Modyanov,N.N.
  TITLE     Accumulation of beta (m), a structural member of X,K-ATPase
            beta-subunit family, in nuclear envelopes of perinatal myocytes
  JOURNAL   Am J Physiol Cell Physiol 286 (4), C757-C767 (2004)
   PUBMED   14656723
REFERENCE   3  (bases 1 to 4175)
  AUTHORS   Pestov,N.B., Adams,G., Shakhparonov,M.I. and Modyanov,N.N.
  TITLE     Identification of a novel gene of the X,K-ATPase beta-subunit
            family that is predominantly expressed in skeletal and heart
            muscles
  JOURNAL   FEBS Lett 456 (2), 243-248 (1999)
   PUBMED   10456317
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053381.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF158385.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000021.1  121952977-121953119
            144-405             JAXUCZ010000021.1  121957339-121957600
            406-534             JAXUCZ010000021.1  121961502-121961630
            535-639             JAXUCZ010000021.1  121961888-121961992
            640-836             JAXUCZ010000021.1  121966268-121966464
            837-893             JAXUCZ010000021.1  121967459-121967515
            894-989             JAXUCZ010000021.1  121969665-121969760
            990-4175            JAXUCZ010000021.1  121970468-121973653
FEATURES             Location/Qualifiers
     source          1..4175
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq35"
     gene            1..4175
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /note="ATPase Na+/K+ transporting family member beta 4"
                     /db_xref="GeneID:84396"
                     /db_xref="RGD:620994"
     exon            1..143
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1151
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /note="isoform 2 is encoded by transcript variant 2;
                     x/potassium-transporting ATPase subunit beta-m; protein
                     ATP1B4; x,K-ATPase subunit beta-m; ATPase, (Na+)/K+
                     transporting, beta 4 polypeptide"
                     /codon_start=1
                     /product="protein ATP1B4 isoform 2"
                     /protein_id="NP_445833.2"
                     /db_xref="GeneID:84396"
                     /db_xref="RGD:620994"
                     /translation="MRRQLRSRRAPAFPYGYRYRLDDQDEVNHNYLADEEEEAEEEAQ
                     VMMVPGLEEEEEEEEGKEEEEEREEEEGQGQSTGNAWWRKLQIVNEYLWDPEKRMSLA
                     RTGQSRSLILVIYFFFYASLAAVITLFIYMLFLAISPYMPTFTEQVKPPGVMIRPFAH
                     SLNFNFNVSEPETWQRYVISLNGFLQGYNDSLQEEMNIDCPPGQYFIQDGDEDEDKKA
                     CQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPEFGDPVKVSCKVQKGDEN
                     NIRSINYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQEVPVQCQLKGKG
                     IVNDVINDRFVGRIIFTLNIET"
     exon            144..405
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            406..534
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            535..639
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            640..836
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            837..893
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            894..989
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
     exon            990..4175
                     /gene="Atp1b4"
                     /gene_synonym="Ac2-628"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtctcct gtaccagcag aagctccagg accctgtcct acacgcctgc ctctgcggca
       61 tcttggccca ctgaacagcc atgagacggc aactccgctc cagaagggcg ccggcctttc
      121 cttatggtta ccgctacaga cttgatgatc aggatgaagt gaatcacaac tacttagcgg
      181 acgaagagga ggaagcagaa gaagaggctc aggtgatgat ggtgcctggt ctggaggaag
      241 aggaagaaga ggaggaagga aaagaggagg aggaagaaag ggaggaagaa gaaggtcagg
      301 gtcagtcaac aggcaatgcc tggtggcgga aattgcagat cgtgaatgaa tacctgtggg
      361 acccggagaa aaggatgtct ctggcccgaa caggtcagag tcggagtctt attttagtca
      421 tttacttctt cttctatgcc tccctggctg ccgtgatcac cctattcata tatatgctgt
      481 tcctagccat cagtccttac atgccgacct tcacggagca ggtgaaacct cctggagtta
      541 tgatcagacc cttcgctcat agccttaact tcaacttcaa cgtttctgaa cctgaaactt
      601 ggcagcgtta tgtcattagc ctaaatggct ttctccaggg ctataatgac agtcttcaag
      661 aggaaatgaa tatagattgt cctcccggtc agtacttcat ccaagatgga gatgaagatg
      721 aggacaagaa ggcctgccaa tttaaacgct ccttcctgaa gaattgctct gggctggagg
      781 accccacttt tggatattct actggacagc cttgcatcct tctcaagatg aaccggattg
      841 taggctttcg tcctgaattt ggagatcctg tgaaggtgtc ctgcaaagtt cagaaaggtg
      901 atgaaaacaa cattcgatcc atcaattact acccggagtc agcttctttt gacctccgct
      961 actaccctta ctatggcaaa ctgactcacg ttaactacac ctccccgctg gtggcaatgc
     1021 attttacaga cgtggtgaag aaccaagaag tgcctgtaca gtgccagctg aagggcaaag
     1081 gcatcgtaaa tgacgtcatc aatgatcgtt tcgtcgggag gataatcttt accctgaaca
     1141 tagaaaccta ggaactccag ggggccactc ccaccagctc tgattctgat tctgttctat
     1201 ccctggtagc acctcaatcc ttttttcttt ttcagttatg acacagccag atggacacct
     1261 aaaacagcag atcatctttc cttgcctttg acgtgtgtat gacgtgatat tgtgggacct
     1321 gcttgggttt ttttaaggtc atcttctctc ctgatgacaa atattaattt cctttccttc
     1381 acttcgaatt aagacctatt cttgctgcta gaagtctcac tatctacaaa aacagtattt
     1441 gatagcattt accattgtca ggagaatgtt ctatcatgct ttctaaaaat gtgttggttt
     1501 tagaggtgat attattccca gacaggcgga taatctaacc gacctatacc cacctttaaa
     1561 actgcctgtc aaggtctttc cttagaaacc aacatcagac caacccagac tactactctc
     1621 tctacagaac tttatatctg aggtaggggt tgaaaatttg gctgtctccc ataggtgaca
     1681 atctccaaca ctgatttaaa gactacatta ttttcaacca ggacagcagg acagcaagca
     1741 gtgctgacag gttactgatc tgggctagag atgaagactt tctgtgagac ttttgtgagg
     1801 agagttagat cctagtgcaa gtgcgaagaa ctcttagcat agggtgtgct tggttgttga
     1861 gtgctctgta gttttaccat ccaaggcaaa caggtttttc tgcactccgg gcagaagaga
     1921 aaacatgaaa aatcttcttt ggtctaattt tcttggccca tgtgcttgat agttgtgtgg
     1981 ttttctttga gatcagcagc gatgggtgcc ttgaaacacc cccccaccaa cccagctaca
     2041 accttgggga ttgaaattag ggttctccag ctaaaacata gcaagacaga aagcttctgt
     2101 caggcctccc taaagccagt gctcattagc cagttttgca tctactttta aaaaaccaca
     2161 ggaggcagat gtgtatccag gttgtggatc agccaagttg ctttggtttt atctttggcc
     2221 atgtgaccat tccaatcgct tcttaacacc tccaccaggg ggagggctgg gacaaaaaga
     2281 ggaggcaagc attacagact agtatagtgt ctcagggtcc aaagcaagct taaattccac
     2341 ttaccaggct gcagagtctg aatctactct acaatgttta gcttctccca aaacagggaa
     2401 ctggaggact gatggggaaa cttggctaca atacaggatg acaagagacc taaaaatagt
     2461 acatggaaat gctatgggga acgtgaggca caatggctct ctctctctcc agctgagaaa
     2521 gtagcagagg aaattaccca ttggaagcca taagcatgaa gacatcgtgt ggtttgggaa
     2581 ttctgaacag ttcacatgag agctcagagg aaggatgagg agagtggatt gcacaagtat
     2641 ttagggacat ggagaggaag ggagtcttta aagtgtttta atcagggaat tcctgtgagc
     2701 atatttgcat ttgatcaaga gcactggggc agtcataaca tcaggagtga atcggtaaac
     2761 agaaaggaca aaaccaagac aggaatgtga ggagaggagg aagagtggaa aaatgacccc
     2821 aggattttga gccgggctaa aatcagtgcg atagtgatat tgatcataga gatgaggtat
     2881 aaaagagaaa ggttggaaag ggagttgtca agaacacttt ggggtagttt tatcttgtgg
     2941 tttcctctgg tcagacactg atatggagat atgaacactt gtaaagtaaa agagaaggaa
     3001 agcagaagac aaaagcaact tctgattaag tgagctcatt taggaaatat ttaatcttgg
     3061 gaacttgagc cggttgagta aacactaacc cagctcctaa catggtgctc ttctctgggt
     3121 cttgtggcag aatggacagc tattagttcc tcttgggaat ctcccttata gagcccttct
     3181 aaatactctc catagactag cgaggggcag acagcattta acaagcagca aaagatgagc
     3241 ccgacagcaa ggctacataa gactccaaca cagaactccc aactcctctg gagttacctt
     3301 ctcaccaaat ttcagtttcc tagcctttga atggaaaacg aataaaagtg agaacgctgg
     3361 agatcattta aaaatggcct tcatcaaaac ctcaagactc aatagcaaaa gagtatacag
     3421 cattgatctg gaaaggatct ttaaggaaaa caacctgcat tgcatctgac tccaggtcca
     3481 gtgctctctc tactcagagc tgctgcttac ggggaagcag catcttttga aaaatcaata
     3541 gagcgtatcc caaacattct gaaacatgtc aaacgtgagt taaaaatagt taacatttca
     3601 caggaatcca actactggtg ctatatttta tacacaatat atggtcctgt tgaatatgtt
     3661 taactattag ataaggaatt aggaatgatt ttgtcatatg tgtttctcat tcagtggcag
     3721 atataatgtc aacagtttca aagaagtatt aaaaactact acgacagttt gggctgtcag
     3781 ctggaacatg aaaaatagct ttcttataca aaaatggata ttatacagaa ctggattaat
     3841 gagtatgttc gttcatgtgc aattctaact gttcaataaa tttctggttg attaatttaa
     3901 atgggctccc atactgtgcc gtaccaggat ttgatttcta taccatctgt tgcaatgcac
     3961 ttggctttac ttgattgtca atgagaaata ctacttccac acggcttcat ggttttgttc
     4021 ttgctatata ctttgtgtat aagttttcac ttttcactcc tttgaaatta ttttaaagaa
     4081 ctctttctta ggcatccatt tacttggggt cttcatgtag aaaatgttta tactgttttg
     4141 gggagttggt gacaacaata aatgaaatta aaagg
//
