LOCUS       NM_012913               1818 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit beta 3
            (Atp1b3), mRNA.
ACCESSION   NM_012913
VERSION     NM_012913.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Figtree,G.A., Liu,C.C., Bibert,S., Hamilton,E.J., Garcia,A.,
            White,C.N., Chia,K.K., Cornelius,F., Geering,K. and Rasmussen,H.H.
  TITLE     Reversible oxidative modification: a key mechanism of Na+-K+ pump
            regulation
  JOURNAL   Circ Res 105 (2), 185-193 (2009)
   PUBMED   19542013
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Yoshimura,S.H., Iwasaka,S., Schwarz,W. and Takeyasu,K.
  TITLE     Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the
            plasma membrane of HeLa cells
  JOURNAL   J Cell Sci 121 (Pt 13), 2159-2168 (2008)
   PUBMED   18522992
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Liu,L. and Askari,A.
  TITLE     Beta-subunit of cardiac Na+-K+-ATPase dictates the concentration of
            the functional enzyme in caveolae
  JOURNAL   Am J Physiol Cell Physiol 291 (4), C569-C578 (2006)
   PUBMED   16624992
REFERENCE   5  (bases 1 to 1818)
  AUTHORS   Sanchez,G., Nguyen,A.N., Timmerberg,B., Tash,J.S. and Blanco,G.
  TITLE     The Na,K-ATPase alpha4 isoform from humans has distinct enzymatic
            properties and is important for sperm motility
  JOURNAL   Mol Hum Reprod 12 (9), 565-576 (2006)
   PUBMED   16861705
REFERENCE   6  (bases 1 to 1818)
  AUTHORS   Li,J., Codina,J., Petroske,E., Werle,M.J., Willingham,M.C. and
            DuBose,T.D. Jr.
  TITLE     The effect of beta-subunit assembly on function and localization of
            the colonic H+,K+-ATPase alpha-subunit
  JOURNAL   Kidney Int 66 (3), 1068-1075 (2004)
   PUBMED   15327400
REFERENCE   7  (bases 1 to 1818)
  AUTHORS   Helwig,B., Schreurs,K.M., Hansen,J., Hageman,K.S., Zbreski,M.G.,
            McAllister,R.M., Mitchell,K.E. and Musch,T.I.
  TITLE     Training-induced changes in skeletal muscle Na+-K+ pump number and
            isoform expression in rats with chronic heart failure
  JOURNAL   J Appl Physiol (1985) 94 (6), 2225-2236 (2003)
   PUBMED   12562669
  REMARK    GeneRIF: Chronic heart failure-induced alterations in skeletal
            muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression,
            can be partially reversed by exercise training.
REFERENCE   8  (bases 1 to 1818)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   9  (bases 1 to 1818)
  AUTHORS   Crambert,G., Hasler,U., Beggah,A.T., Yu,C., Modyanov,N.N.,
            Horisberger,J.D., Lelievre,L. and Geering,K.
  TITLE     Transport and pharmacological properties of nine different human
            Na, K-ATPase isozymes
  JOURNAL   J Biol Chem 275 (3), 1976-1986 (2000)
   PUBMED   10636900
REFERENCE   10 (bases 1 to 1818)
  AUTHORS   Sangan,P., Kolla,S.S., Rajendran,V.M., Kashgarian,M. and
            Binder,H.J.
  TITLE     Colonic H-K-ATPase beta-subunit: identification in apical membranes
            and regulation by dietary K depletion
  JOURNAL   Am J Physiol 276 (2), C350-C360 (1999)
   PUBMED   9950762
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D84450.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D84450.1, BC061719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..1818
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /note="ATPase Na+/K+ transporting subunit beta 3"
                     /db_xref="GeneID:25390"
                     /db_xref="RGD:2172"
     exon            1..254
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..985
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /EC_number="7.2.2.13"
                     /note="Na+/K+ -ATPase beta 3 subunit; ATPB-3;
                     sodium/potassium-dependent ATPase subunit beta-3; ATPase,
                     Na+/K+ transporting, beta 3 polypeptide; ATPase, Na+K+
                     transporting, beta polypeptide 3"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-3"
                     /protein_id="NP_037045.1"
                     /db_xref="GeneID:25390"
                     /db_xref="RGD:2172"
                     /translation="MTKTEKKSFHQSLAEWKLFIYNPTSGEFLGRTSKSWGLILLFYL
                     VFYGFLAALFTFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPPTALDYTYSMSDPHT
                     YKKFVEDLKNFLKPYSVEEQKNLTDCPGGALFHQEGPDYSACQFPVSLLQECSGVNDS
                     NFGYSKGQPCVLVKMNRIIELVPDGAPYITCITKEENIANIVTYPDDGLIDLKYFPYY
                     GKKRHVGYRQPLVAVQVIFGADATKKEVTIECQIDGTRNLKNKNERDKFLGRVSFKVI
                     AHA"
     exon            255..383
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     exon            384..491
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     exon            492..676
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     exon            677..727
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     exon            728..814
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1818
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1818
                     /gene="Atp1b3"
                     /gene_synonym="NKAB3S"
                     /note="31 A nucleotides"
ORIGIN      
        1 ctcctaacgg agagttgttc ccggccgtgc ggtcctccgt cgccgtcgct gggctgcgcc
       61 gccgctgtcg ccaggacgcg ccgccgagcc cctcgtcgcc tctagccccg cggcctccgt
      121 tcacctcaac ttccactcgc ccatcatgac gaagactgag aagaaatcct tccaccagag
      181 cctggccgag tggaagctgt tcatctacaa cccgaccagc ggagagtttc tggggcgcac
      241 ctccaagagc tggggtctca tcttgctctt ctacctagtt ttttatgggt tcttggctgc
      301 actcttcaca ttcaccatgt gggtcatgct ccagactctg aatgacgagg ttccgaagta
      361 ccgagaccag attcctagtc caggacttat ggttttcccc aaaccaccga ctgccttgga
      421 ttatacatac agcatgtctg acccacatac ttataaaaag tttgttgaag acctgaagaa
      481 tttcctaaag ccatattctg tggaagaaca gaagaatctc acagattgcc ctggtggagc
      541 actttttcat caggagggtc cagactatag tgcgtgtcag ttcccagttt ccttgcttca
      601 agaatgtagt ggtgtgaatg attctaattt tggctactcc aaaggacaac cttgtgttct
      661 tgtgaagatg aacagaataa tcgagttagt cccagatgga gctccatata ttacatgtat
      721 aacaaaggaa gaaaacatag caaatatagt aacttatcct gatgatggac ttatagactt
      781 aaagtatttt ccatattatg ggaaaaaacg gcacgttgga tatcgacagc ccctagttgc
      841 cgtccaggtc atatttgggg ccgatgctac caagaaagaa gtaacaattg agtgccaaat
      901 tgatggaacc aggaacctaa aaaacaagaa tgaacgtgac aagttcttgg gacgagtttc
      961 atttaaagtc atagcacatg cctaggagta ggctgtctgc acagagtaaa tgttgtgttg
     1021 tctccattct gtatcagctg gacctgccat tctaggatat gaggccacct gggaggagga
     1081 agtggtatgg gacacacttg ggtgacatca taacatgctt ccagatcata gtgttcagtg
     1141 tcctctgaag taactgcctg ctgcctctgc tgcccttgaa cccatgtacg gtcgccagac
     1201 agggaccagt gagctcccaa tcccaaacat gcagagtggg ggtctcgtcg tcttctgtgt
     1261 gtaattgcca aatgtctaaa gcttcatgtg ctgtgctgtg taaatatttt atggatttaa
     1321 cactggtaac tgtcatattt tgatgccaag aaagttttag ggaaaaaatg gtaccttgcc
     1381 aacatcaagt gactttagct gaagaaatgt gtgagaagtt ctgtatgtga tgaaggagaa
     1441 agggaaataa agtggatctg aaagtactga ccctggttct gcgtacgtgt gagtgagtgc
     1501 ctgtcgtatg ctctagtggt ttttacatgc tgaactagac tatagctgac tgtactgaga
     1561 ggacagactt tctgttgtaa tacatattta aaatactatc ggggtgactg agtgtggaat
     1621 caagcttcca cactcaggtg tcgtagacac atggaagaaa cagtgtttta attaggtgaa
     1681 tgagtaccga tgtttttgct ttgttttgtt ttttgaatga aatgaaattc ccaagacata
     1741 aattgtatag tttttcaaaa tgtcttaagt gcttttattt agtagactat ggaccctaat
     1801 aaaaaaaatg tgaaatac
//
