LOCUS       NM_012507               3014 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit beta 2
            (Atp1b2), mRNA.
ACCESSION   NM_012507
VERSION     NM_012507.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3014)
  AUTHORS   Pan,B., Wang,Y., Shi,Y., Yang,Q., Han,B., Zhu,X. and Liu,Y.
  TITLE     Altered expression levels of miR-144-3p and ATP1B2 are associated
            with schizophrenia
  JOURNAL   World J Biol Psychiatry 23 (9), 666-676 (2022)
   PUBMED   34989308
  REMARK    GeneRIF: Altered expression levels of miR-144-3p and ATP1B2 are
            associated with schizophrenia.
REFERENCE   2  (bases 1 to 3014)
  AUTHORS   Stoica,A., Larsen,B.R., Assentoft,M., Holm,R., Holt,L.M.,
            Vilhardt,F., Vilsen,B., Lykke-Hartmann,K., Olsen,M.L. and
            MacAulay,N.
  TITLE     The alpha2beta2 isoform combination dominates the astrocytic Na+
            /K+ -ATPase activity and is rendered nonfunctional by the
            alpha2.G301R familial hemiplegic migraine type 2-associated
            mutation
  JOURNAL   Glia 65 (11), 1777-1793 (2017)
   PUBMED   28787093
REFERENCE   3  (bases 1 to 3014)
  AUTHORS   Batiuk,M.Y., de Vin,F., Duque,S.I., Li,C., Saito,T., Saido,T.,
            Fiers,M., Belgard,T.G. and Holt,M.G.
  TITLE     An immunoaffinity-based method for isolating ultrapure adult
            astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
  JOURNAL   J Biol Chem 292 (21), 8874-8891 (2017)
   PUBMED   28373281
REFERENCE   4  (bases 1 to 3014)
  AUTHORS   Liu,Y., Zuo,S., Li,X., Fan,J., Cao,X., Yu,X. and Yang,Q.
  TITLE     Interaction between V-ATPase B2 and (Pro) renin Receptors in
            Promoting the progression of Renal Tubulointerstitial Fibrosis
  JOURNAL   Sci Rep 6, 25035 (2016)
   PUBMED   27121029
  REMARK    GeneRIF: From the data the authors assume that activation of (Pro)
            renin receptor (P)RR and V-ATPase may play an important role in
            tubulointerstitial fibrosis with possible involvement of
            interaction of V-ATPase B2 subunit and (P)RR.
            Erratum:[Sci Rep. 2016 Jun 10;6:27677. doi: 10.1038/srep27677.
            PMID: 27282103]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3014)
  AUTHORS   Kao,L., Kurtz,L.M., Shao,X., Papadopoulos,M.C., Liu,L., Bok,D.,
            Nusinowitz,S., Chen,B., Stella,S.L., Andre,M., Weinreb,J.,
            Luong,S.S., Piri,N., Kwong,J.M., Newman,D. and Kurtz,I.
  TITLE     Severe neurologic impairment in mice with targeted disruption of
            the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5
            gene)
  JOURNAL   J Biol Chem 286 (37), 32563-32574 (2011)
   PUBMED   21705333
REFERENCE   6  (bases 1 to 3014)
  AUTHORS   Magyar,J.P., Bartsch,U., Wang,Z.Q., Howells,N., Aguzzi,A.,
            Wagner,E.F. and Schachner,M.
  TITLE     Degeneration of neural cells in the central nervous system of mice
            deficient in the gene for the adhesion molecule on Glia, the beta 2
            subunit of murine Na,K-ATPase
  JOURNAL   J Cell Biol 127 (3), 835-845 (1994)
   PUBMED   7525597
REFERENCE   7  (bases 1 to 3014)
  AUTHORS   Muller-Husmann,G., Gloor,S. and Schachner,M.
  TITLE     Functional characterization of beta isoforms of murine Na,K-ATPase.
            The adhesion molecule on glia (AMOG/beta 2), but not beta 1,
            promotes neurite outgrowth
  JOURNAL   J Biol Chem 268 (35), 26260-26267 (1993)
   PUBMED   7504672
REFERENCE   8  (bases 1 to 3014)
  AUTHORS   Kawakami,K., Okamoto,H., Yagawa,Y. and Nagano,K.
  TITLE     Regulation of Na+,K(+)-ATPase. II. Cloning and analysis of the
            5'-flanking region of the rat NKAB2 gene encoding the beta 2
            subunit
  JOURNAL   Gene 91 (2), 271-274 (1990)
   PUBMED   2170236
REFERENCE   9  (bases 1 to 3014)
  AUTHORS   Martin-Vasallo,P., Dackowski,W., Emanuel,J.R. and Levenson,R.
  TITLE     Identification of a putative isoform of the Na,K-ATPase beta
            subunit. Primary structure and tissue-specific expression
  JOURNAL   J Biol Chem 264 (8), 4613-4618 (1989)
   PUBMED   2538450
REFERENCE   10 (bases 1 to 3014)
  AUTHORS   Antonicek,H., Persohn,E. and Schachner,M.
  TITLE     Biochemical and functional characterization of a novel neuron-glia
            adhesion molecule that is involved in neuronal migration
  JOURNAL   J Cell Biol 104 (6), 1587-1595 (1987)
   PUBMED   2438288
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087034.1, CB768236.1 and DV720762.1.
            
            On Oct 11, 2007 this sequence version replaced NM_012507.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087034.1, J04629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN12840111
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2133              BC087034.1         1-2133
            2134-2331           CB768236.1         205-402
            2332-2957           BC087034.1         2332-2957
            2958-2977           DV720762.1         446-465
            2978-3014           BC087034.1         2976-3012
FEATURES             Location/Qualifiers
     source          1..3014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..3014
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /note="ATPase Na+/K+ transporting subunit beta 2"
                     /db_xref="GeneID:24214"
                     /db_xref="RGD:2171"
     exon            1..684
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     CDS             573..1445
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /EC_number="7.2.2.13"
                     /note="sodium/potassium-dependent ATPase subunit beta-2;
                     ATPase, Na+K+ transporting, beta polypeptide 2; ATPase,
                     Na+/K+ transporting, beta 2 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-2"
                     /protein_id="NP_036639.2"
                     /db_xref="GeneID:24214"
                     /db_xref="RGD:2171"
                     /translation="MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWAFILLFY
                     LVFYGFLTAMFTLTMWVMLQTVSDHTPKYQDRLATPGLMIRPKTENLDVIVNISDTES
                     WDQHVQKLNKFLEPYNDSIQAQKNDVCRPGRYYEQPDNGVLNYPKRACQFNRTQLGNC
                     SGIGDPTHYGYSTGQPCVFIKMNRVINFYAGANQSMNVTCVGKKDEDAENLGHFIMFP
                     ANGNIDLMYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDK
                     FAGRVAFKLRINKA"
     exon            685..813
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     exon            814..918
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1124
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1181
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1280
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..2978
                     /gene="Atp1b2"
                     /gene_synonym="Amog; ATPB2; ATPB2S; RATATPB2S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccgattgg gggcccctat ccttgccagc cccccccccc actgctcgtc cccgccccag
       61 ctcccactgg ctgggccaac tgtggtgtgg ctgtcgccgt ttgtcggagg agccttaatc
      121 ggccacctgc cgcgttccac tgcctcttta catctcggat ttcggggcgg ctccctcccc
      181 catctttccc tgcttctttg caccccgctt tttctgcgtt tcgctcgaat tttggagccg
      241 tctggttttg cacccctttt tgttttgctt ttaggcggtg tgtggggtga aggtgccttg
      301 gcatcccttc ctctggttat ctttccctgt tttgacagcc cccctttcta tcgcagtcgg
      361 gggacctagc ctcggtgcac ctccgccgca ctgccagcag accacagcgc gtggctgtgc
      421 accccggaat ttgcaacagc tgcatatctg tgatcggagt ctccctcgcc tcgctcccgc
      481 gctcattcgg tgcgtggagg gcttcagcgc gcaacgcccc ggcttctccg cagcccccag
      541 cagcgcgccg ggactcgccc cgtgcctcca agatggtcat ccaaaaagag aagaagagct
      601 gcgggcaggt ggttgaggag tggaaggagt tcgtgtggaa tcctcggacg caccagttca
      661 tggggcgcac cgggaccagc tgggccttca tcctcctctt ctacctcgtc ttctatggtt
      721 tcctcacggc catgttcacc ctcaccatgt gggtaatgct gcagaccgtc tctgaccata
      781 cccccaagta ccaggatcga ctggccacac caggcttgat gattcgaccc aagactgaga
      841 accttgatgt cattgtcaac attagcgaca ctgaaagctg ggatcagcat gttcagaagc
      901 tcaacaagtt cttggagcct tacaacgact ccatccaagc tcaaaagaat gatgtctgcc
      961 gtcctgggcg atattatgag caacccgata atggggttct gaactatcca aaacgtgcct
     1021 gccagttcaa ccggacccag ctgggcaatt gctctggcat tggggaccct actcactatg
     1081 gttacagcac cgggcagccc tgtgtcttca tcaaaatgaa ccgggtcatc aacttctatg
     1141 caggggcaaa ccagagcatg aacgttacct gtgttgggaa gaaagatgaa gatgctgaga
     1201 atcttggaca cttcatcatg ttccctgcca atggcaacat cgacctgatg tattttccct
     1261 actatggcaa aaagttccat gtaaactata cacagccctt ggtggctgtg aagttcctga
     1321 atgtgacccc caatgtggag gtgaatgtag aatgccgaat taacgctgcc aatattgcca
     1381 cggatgacga gcgggacaag tttgctggcc gcgtggcctt caagcttcga atcaacaaag
     1441 cctgaggctc cccaccccct ctcacccata ccctcctgtg gatgcttctg gaatgtcctt
     1501 gaccctgcct gatccctccc tcacccgccc caaaggtatt ttttataaca gagctatgac
     1561 ttgtctgagc ctcacaccct tgcctcaact tctctaccta gcctgacgtc cacacgattt
     1621 ccaacatctt ccaaccgtag cttagccaga gacagagagg agtcaggagt tttctagttc
     1681 aggagctgga gttgttaccg ggcgacagat gacttaccca gcatgcacaa gggcctctgc
     1741 actgatggag ttgttctagt ctgagttgat gaatgagatg cccttacagc tcctgtttca
     1801 gtttctactc ccatcccccg agagttatag agaagcggtc ccatccaccc ggcctctgcc
     1861 gccacatatc ccacgccccg ttccagccat ttgcttctca ggggtgaata ttgttttccc
     1921 tccctttaca acgctctagc cgcttttctt ttatctctcc acacttctgt caccatagcc
     1981 agtatcttgg tggctttggc ttctggttcc tccagcagtt ctgtcctcac ctctccctta
     2041 tcttcctccc ctctgaaaag ctgccatttg tagctcacta caggttggtt ctgtggcctt
     2101 ttccgtcctt cctggtacat cctgcttctc cctcaactga ctccaaagga ggactggaag
     2161 agaagtctcg cggaatgctt ctagaaaatt ctctagtagg cctagacttt taacttcttc
     2221 ctagtccctc ctgtcatcca aacaactcct actcaggcgg gcttgacctg ctctgaatat
     2281 ccactttgtt tttaaactaa tggctccctt cccccactgg ccttcccaga atatctttca
     2341 agttctcctt cccagggagc tctgggggag gggccgctgt cttggctcta tccccagtgg
     2401 ccaccttgga aacgtcagct ggctgggggg gactccctga gcccagatct acccaccccc
     2461 atcctctctc tggctactcc ttgcaagttg ctaacgggtc actaatgtct tccctttctg
     2521 catgccagcc cgaaaacttc agacaccctc ctccagctca gctctgaatt tcttggctcc
     2581 gcctccttca aactctttcc cctttaaaaa acaaacaaac aaacaaaaac aaacaacccc
     2641 tagaatgccc ctagaatgtt aagaaagagc cgcctgtacc aagttttctt ccaccatagc
     2701 tgcgttttcc tctggtctct ctgcttctct ttatccttcc taacctccct cctcttcact
     2761 gcagccccat cctgtcctca agtggattct tccctctttc ctcccactgg atctgtatct
     2821 cttccctttg ggtatccagc tcttcctgcc cgttcatctt cccggtggtc tcctgaagtt
     2881 atttaatgcc tgtgtcagaa ctactgtaag aggataaagt acaataaaat gggagcgatt
     2941 atatatatat atatatataa atgtatatca aacacagaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaaaaaaaaa aaaa
//
