LOCUS       NM_013113               2228 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ATPase Na+/K+ transporting subunit beta 1
            (Atp1b1), mRNA.
ACCESSION   NM_013113
VERSION     NM_013113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Nepal,N., Arthur,S., Haynes,J., Palaniappan,B. and Sundaram,U.
  TITLE     Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal
            Epithelial Cells
  JOURNAL   Cells 10 (4), 752 (2021)
   PUBMED   33805551
  REMARK    GeneRIF: Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal
            Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Kalocayova,B., Kovacicova,I., Radosinska,J., Tothova,L.,
            Jagmasevic-Mezesova,L., Fulop,M., Slezak,J., Babal,P., Janega,P.
            and Vrbjar,N.
  TITLE     Alteration of renal Na,K-ATPase in rats following the mediastinal
            gamma-irradiation
  JOURNAL   Physiol Rep 7 (3), e13969 (2019)
   PUBMED   30746862
  REMARK    GeneRIF: Decreased content of the glycosylated form of Atp1b1
            occurs in the renal tissue of irradiated rats.
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   Wen,H., Liu,L., Zhan,L., Liang,D., Li,L., Liu,D., Sun,W. and Xu,E.
  TITLE     Neuroglobin mediates neuroprotection of hypoxic postconditioning
            against transient global cerebral ischemia in rats through
            preserving the activity of Na+/K+ ATPases
  JOURNAL   Cell Death Dis 9 (6), 635 (2018)
   PUBMED   29802248
  REMARK    GeneRIF: Ngb upregulation in CA1 after hypoxic postconditioning
            maintained the membranous level of Atp1b1 through Ngb-Atp1b1
            interaction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Stoica,A., Larsen,B.R., Assentoft,M., Holm,R., Holt,L.M.,
            Vilhardt,F., Vilsen,B., Lykke-Hartmann,K., Olsen,M.L. and
            MacAulay,N.
  TITLE     The alpha2beta2 isoform combination dominates the astrocytic Na+
            /K+ -ATPase activity and is rendered nonfunctional by the
            alpha2.G301R familial hemiplegic migraine type 2-associated
            mutation
  JOURNAL   Glia 65 (11), 1777-1793 (2017)
   PUBMED   28787093
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   Yan,X., Xun,M., Li,J., Wu,L., Dou,X. and Zheng,J.
  TITLE     Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2
            cell apoptosis via suppressing ROS accumulation and MAPKs
            activities by DRm217
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 48 (10), 883-893 (2016)
   PUBMED   27563007
  REMARK    GeneRIF: Data show that Na(+)/K(+)-ATPase's DR-region specific
            monoclonal antibody and direct activator DRm217 increased
            Na(+)/K(+)-ATPase activity and alleviated Ca(2+) level.
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Crambert,G., Hasler,U., Beggah,A.T., Yu,C., Modyanov,N.N.,
            Horisberger,J.D., Lelievre,L. and Geering,K.
  TITLE     Transport and pharmacological properties of nine different human
            Na, K-ATPase isozymes
  JOURNAL   J Biol Chem 275 (3), 1976-1986 (2000)
   PUBMED   10636900
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Liu,B. and Gick,G.
  TITLE     Characterization of the 5' flanking region of the rat
            Na+/K(+)-ATPase beta 1 subunit gene
  JOURNAL   Biochim Biophys Acta 1130 (3), 336-338 (1992)
   PUBMED   1314096
REFERENCE   9  (bases 1 to 2228)
  AUTHORS   Young,R.M., Shull,G.E. and Lingrel,J.B.
  TITLE     Multiple mRNAs from rat kidney and brain encode a single
            Na+,K+-ATPase beta subunit protein
  JOURNAL   J Biol Chem 262 (10), 4905-4910 (1987)
   PUBMED   3031033
REFERENCE   10 (bases 1 to 2228)
  AUTHORS   Mercer,R.W., Schneider,J.W., Savitz,A., Emanuel,J., Benz,E.J. Jr.
            and Levenson,R.
  TITLE     Rat-brain Na,K-ATPase beta-chain gene: primary structure,
            tissue-specific expression, and amplification in ouabain-resistant
            HeLa C+ cells
  JOURNAL   Mol Cell Biol 6 (11), 3884-3890 (1986)
   PUBMED   3025616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078902.1.
            
            On Jun 10, 2007 this sequence version replaced NM_013113.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078902.1, J02701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     gene            1..2228
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /note="ATPase Na+/K+ transporting subunit beta 1"
                     /db_xref="GeneID:25650"
                     /db_xref="RGD:2170"
     exon            1..233
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1051
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /EC_number="3.6.1.3"
                     /note="Na,K-ATPase beta 1 subunit;
                     sodium/potassium-dependent ATPase subunit beta-1; ATPase,
                     Na+/K+ transporting, beta 1 polypeptide"
                     /codon_start=1
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1"
                     /protein_id="NP_037245.2"
                     /db_xref="GeneID:25650"
                     /db_xref="RGD:2170"
                     /translation="MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYG
                     CLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYV
                     LNIIRFLEKYKDSAQKDDMIFEDCGSMPSEPKERGEFNHERGERKVCRFKLDWLGNCS
                     GLNDESYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPLTMKYNPNVLPVQCTGKR
                     DEDKDKVGNIEYFGMGGFYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTLDTEIRIE
                     CKAYGENIGYSEKDRFQGRFDVKIEVKS"
     exon            234..362
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            363..518
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            519..703
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            704..787
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            788..2203
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagcggca gcggcgcgtc tcgcctttgg agacagagcc gggccgcggg gacaccgagc
       61 agtcgccgcg aggacgccag ggcgcgcgca gcactcgctt tccctcggcc tcggccgcca
      121 ctgctgagca gacaccatgg cccgcggaaa agccaaggag gaaggcagct ggaagaaatt
      181 catctggaac tcggagaaga aggagttttt gggcaggacc ggtggtagtt ggtttaagat
      241 ccttctgttc tacgtgatat tctatggctg cctggccggc atcttcatcg ggaccatcca
      301 agtgatgctg cttaccatca gtgagctgaa acccacgtac caggaccgtg tggccccgcc
      361 aggattgaca cagattcctc agatccaaaa gactgaaatt tccttccgtc ctaatgaccc
      421 caagagctac gaggcctatg tgctaaacat catcaggttc ctggaaaagt acaaagattc
      481 ggcccagaag gacgacatga ttttcgagga ttgtggcagt atgcccagtg aacccaagga
      541 gcggggagag ttcaatcatg aacgaggaga gcgcaaggtg tgcaggttca agcttgactg
      601 gctggggaac tgctctggtc tcaatgatga atcctacggc tacaaagagg ggaagccctg
      661 tatcattatc aagctcaacc gagtgctggg cttcaaacct aagcctccca agaatgaatc
      721 cttggagact taccctctga cgatgaagta taatccaaac gtcctacctg tccagtgcac
      781 tggcaagcgc gatgaggata aggataaagt tggaaacata gagtactttg ggatgggcgg
      841 attctatggc tttcctctgc agtactatcc ctactacggc aaactcctgc agcccaagta
      901 cctgcagccc ctgctggccg tgcagttcac caacctcacc ttggacactg aaatccgcat
      961 tgagtgtaag gcgtatggtg agaacattgg gtacagtgag aaagaccgtt ttcagggacg
     1021 ctttgatgta aaaattgaag ttaagagctg atcacaagca caaatctttc ccactagcca
     1081 tttaataagt taaagaaaaa gatacacaaa cctactagtc ttgaacaaac tgtcatacgt
     1141 atgggaccta cacttaatct ctatgcttta cactagcttc tgcatttaat aggttagaat
     1201 gtaaatttaa agtgtagcaa tagcaacaaa atatttattc tactgtaaat gacaaaagaa
     1261 aaaaataaaa attgagcctt gggacgtgcc catttttact gtaattagac tccgtaactg
     1321 acttgtagtg agcagtgttc tggcccctaa gtatcgccgc cgtctgtttt atttagtgta
     1381 cagtactata ggtgcgcact ctggtcattt tccaagccat gttttatcat atctgttttc
     1441 tactttccgt gagcgaggtt tgctgtccaa ggtgtaaata ctcatgggaa taaaactggc
     1501 atggtacttt cccttccttt ctcattttct tggctctgag atttcaaagg taacggccca
     1561 tcaacaagca tttttaacac actccatagt ctttccctgt ggtatcaggt ctttactatt
     1621 gtttttcttt gtttcctggg gctggggggt gggctgtcgt gggggaactg ccctttaaat
     1681 tctaagtgac gctgcagaaa aacaacggtg atgggttgtg ttgtgctccg tgctgagtgc
     1741 tgtctcgcca tctctcccct tgtcctccag tgtgctccga agctgtgtct gatctggatc
     1801 tgcccgtcac tttggctagt gatggggcta gttaatttgc ttagtacatt tccttttcct
     1861 tctttccttt ctctggaggc atcatgtgct ggtgctgtgt ctttatgaat gttttaacca
     1921 ttttcatggt ggaagaattt tatatttatg cagttgtaca attttatttt tttctgcaag
     1981 aaaaagtgta atgtatgaaa taaaccaaag tcacttgttt gaaaataaaa tctttatttt
     2041 gaactttata aaaagcaatg cagtacccca tagactggtg ttaaatgttg tctacagtgc
     2101 aaatccatgt tctagcatat gtaatgattg ccaggagtac agtgctcttg ttggtcttgt
     2161 gtcagtcagg ttaacacaat ggacaataaa agaatgaaca cataaaaaaa aaaaaaaaaa
     2221 aaaaaaaa
//
