LOCUS       NP_037245                304 aa            linear   ROD 03-APR-2024
DEFINITION  sodium/potassium-transporting ATPase subunit beta-1 [Rattus
            norvegicus].
ACCESSION   NP_037245
VERSION     NP_037245.2
DBSOURCE    REFSEQ: accession NM_013113.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 304)
  AUTHORS   Nepal,N., Arthur,S., Haynes,J., Palaniappan,B. and Sundaram,U.
  TITLE     Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal
            Epithelial Cells
  JOURNAL   Cells 10 (4), 752 (2021)
   PUBMED   33805551
  REMARK    GeneRIF: Mechanism of Na-K-ATPase Inhibition by PGE2 in Intestinal
            Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 304)
  AUTHORS   Kalocayova,B., Kovacicova,I., Radosinska,J., Tothova,L.,
            Jagmasevic-Mezesova,L., Fulop,M., Slezak,J., Babal,P., Janega,P.
            and Vrbjar,N.
  TITLE     Alteration of renal Na,K-ATPase in rats following the mediastinal
            gamma-irradiation
  JOURNAL   Physiol Rep 7 (3), e13969 (2019)
   PUBMED   30746862
  REMARK    GeneRIF: Decreased content of the glycosylated form of Atp1b1
            occurs in the renal tissue of irradiated rats.
REFERENCE   3  (residues 1 to 304)
  AUTHORS   Wen,H., Liu,L., Zhan,L., Liang,D., Li,L., Liu,D., Sun,W. and Xu,E.
  TITLE     Neuroglobin mediates neuroprotection of hypoxic postconditioning
            against transient global cerebral ischemia in rats through
            preserving the activity of Na+/K+ ATPases
  JOURNAL   Cell Death Dis 9 (6), 635 (2018)
   PUBMED   29802248
  REMARK    GeneRIF: Ngb upregulation in CA1 after hypoxic postconditioning
            maintained the membranous level of Atp1b1 through Ngb-Atp1b1
            interaction.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 304)
  AUTHORS   Stoica,A., Larsen,B.R., Assentoft,M., Holm,R., Holt,L.M.,
            Vilhardt,F., Vilsen,B., Lykke-Hartmann,K., Olsen,M.L. and
            MacAulay,N.
  TITLE     The alpha2beta2 isoform combination dominates the astrocytic Na+
            /K+ -ATPase activity and is rendered nonfunctional by the
            alpha2.G301R familial hemiplegic migraine type 2-associated
            mutation
  JOURNAL   Glia 65 (11), 1777-1793 (2017)
   PUBMED   28787093
REFERENCE   5  (residues 1 to 304)
  AUTHORS   Yan,X., Xun,M., Li,J., Wu,L., Dou,X. and Zheng,J.
  TITLE     Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2
            cell apoptosis via suppressing ROS accumulation and MAPKs
            activities by DRm217
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 48 (10), 883-893 (2016)
   PUBMED   27563007
  REMARK    GeneRIF: Data show that Na(+)/K(+)-ATPase's DR-region specific
            monoclonal antibody and direct activator DRm217 increased
            Na(+)/K(+)-ATPase activity and alleviated Ca(2+) level.
REFERENCE   6  (residues 1 to 304)
  AUTHORS   MacPhee,D.J., Jones,D.H., Barr,K.J., Betts,D.H., Watson,A.J. and
            Kidder,G.M.
  TITLE     Differential involvement of Na(+),K(+)-ATPase isozymes in
            preimplantation development of the mouse
  JOURNAL   Dev Biol 222 (2), 486-498 (2000)
   PUBMED   10837135
REFERENCE   7  (residues 1 to 304)
  AUTHORS   Crambert,G., Hasler,U., Beggah,A.T., Yu,C., Modyanov,N.N.,
            Horisberger,J.D., Lelievre,L. and Geering,K.
  TITLE     Transport and pharmacological properties of nine different human
            Na, K-ATPase isozymes
  JOURNAL   J Biol Chem 275 (3), 1976-1986 (2000)
   PUBMED   10636900
REFERENCE   8  (residues 1 to 304)
  AUTHORS   Liu,B. and Gick,G.
  TITLE     Characterization of the 5' flanking region of the rat
            Na+/K(+)-ATPase beta 1 subunit gene
  JOURNAL   Biochim Biophys Acta 1130 (3), 336-338 (1992)
   PUBMED   1314096
REFERENCE   9  (residues 1 to 304)
  AUTHORS   Young,R.M., Shull,G.E. and Lingrel,J.B.
  TITLE     Multiple mRNAs from rat kidney and brain encode a single
            Na+,K+-ATPase beta subunit protein
  JOURNAL   J Biol Chem 262 (10), 4905-4910 (1987)
   PUBMED   3031033
REFERENCE   10 (residues 1 to 304)
  AUTHORS   Mercer,R.W., Schneider,J.W., Savitz,A., Emanuel,J., Benz,E.J. Jr.
            and Levenson,R.
  TITLE     Rat-brain Na,K-ATPase beta-chain gene: primary structure,
            tissue-specific expression, and amplification in ouabain-resistant
            HeLa C+ cells
  JOURNAL   Mol Cell Biol 6 (11), 3884-3890 (1986)
   PUBMED   3025616
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078902.1.
            
            On Jun 10, 2007 this sequence version replaced NP_037245.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078902.1, J02701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132299, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..304
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q23"
     Protein         1..304
                     /product="sodium/potassium-transporting ATPase subunit
                     beta-1"
                     /EC_number="3.6.1.3"
                     /note="Na,K-ATPase beta 1 subunit;
                     sodium/potassium-dependent ATPase subunit beta-1; ATPase,
                     Na+/K+ transporting, beta 1 polypeptide"
                     /calculated_mol_wt=35071
     Region          1..304
                     /region_name="Na_K_ATPase_bet"
                     /note="Sodium Potassium ATPase beta subunit; TIGR01107"
                     /db_xref="CDD:273446"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (P07340.1)"
     Site            35..62
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P07340.1)"
     Site            101
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P14094; propagated from
                     UniProtKB/Swiss-Prot (P07340.1)"
     Site            158
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (P07340.1)"
     Region          191..304
                     /region_name="immunoglobulin-like. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P07340.1)"
     Site            193
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (P07340.1)"
     Site            266
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P07340.1)"
     CDS             1..304
                     /gene="Atp1b1"
                     /gene_synonym="ATPBS"
                     /coded_by="NM_013113.2:137..1051"
                     /db_xref="GeneID:25650"
                     /db_xref="RGD:2170"
ORIGIN      
        1 margkakeeg swkkfiwnse kkeflgrtgg swfkillfyv ifygclagif igtiqvmllt
       61 iselkptyqd rvappgltqi pqiqkteisf rpndpksyea yvlniirfle kykdsaqkdd
      121 mifedcgsmp sepkergefn hergerkvcr fkldwlgncs glndesygyk egkpciiikl
      181 nrvlgfkpkp pknesletyp ltmkynpnvl pvqctgkrde dkdkvgniey fgmggfygfp
      241 lqyypyygkl lqpkylqpll avqftnltld teirieckay genigysekd rfqgrfdvki
      301 evks
//
